OA11088A - Atropisomers of 3-heteroaryl-4(3H)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions - Google Patents
Atropisomers of 3-heteroaryl-4(3H)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions Download PDFInfo
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- OA11088A OA11088A OA9900186A OA9900186A OA11088A OA 11088 A OA11088 A OA 11088A OA 9900186 A OA9900186 A OA 9900186A OA 9900186 A OA9900186 A OA 9900186A OA 11088 A OA11088 A OA 11088A
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- Prior art keywords
- alkyl
- fluoro
- carbon
- methyl
- nitrogen
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- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940080313 sodium starch Drugs 0.000 description 1
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 description 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- FEQPHYCEZKWPNE-UHFFFAOYSA-K trichlororhodium;triphenylphosphane Chemical compound Cl[Rh](Cl)Cl.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 FEQPHYCEZKWPNE-UHFFFAOYSA-K 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3854097P | 1997-02-28 | 1997-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA11088A true OA11088A (en) | 2002-03-15 |
Family
ID=21900535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA9900186A OA11088A (en) | 1997-02-28 | 1999-08-20 | Atropisomers of 3-heteroaryl-4(3H)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US6380204B1 (da) |
| EP (1) | EP0964860B1 (da) |
| JP (1) | JP3299990B2 (da) |
| KR (1) | KR20000075812A (da) |
| CN (1) | CN1248254A (da) |
| AP (1) | AP9801202A0 (da) |
| AR (1) | AR011886A1 (da) |
| AT (1) | ATE264854T1 (da) |
| AU (1) | AU732448B2 (da) |
| BG (1) | BG103687A (da) |
| BR (1) | BR9807807A (da) |
| CA (1) | CA2282279C (da) |
| CO (1) | CO4950615A1 (da) |
| DE (1) | DE69823339T2 (da) |
| DK (1) | DK0964860T3 (da) |
| DZ (1) | DZ2438A1 (da) |
| EA (1) | EA001961B1 (da) |
| ES (1) | ES2218801T3 (da) |
| GT (1) | GT199800039A (da) |
| HN (1) | HN1998000028A (da) |
| HR (1) | HRP980108B1 (da) |
| HU (1) | HUP0000935A3 (da) |
| ID (1) | ID23435A (da) |
| IL (1) | IL130897A0 (da) |
| IS (1) | IS5141A (da) |
| MA (1) | MA24485A1 (da) |
| NO (1) | NO994178L (da) |
| NZ (1) | NZ336627A (da) |
| OA (1) | OA11088A (da) |
| PA (1) | PA8446901A1 (da) |
| PE (1) | PE57999A1 (da) |
| PL (1) | PL335307A1 (da) |
| PT (1) | PT964860E (da) |
| SK (1) | SK113199A3 (da) |
| TN (1) | TNSN98034A1 (da) |
| TR (1) | TR199902094T2 (da) |
| TW (1) | TW530055B (da) |
| UA (1) | UA58536C2 (da) |
| WO (1) | WO1998038187A1 (da) |
| ZA (1) | ZA981665B (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323208B1 (en) * | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
| JPH11279158A (ja) * | 1998-02-09 | 1999-10-12 | Pfizer Prod Inc | キナゾリン―４―オン誘導体の製造方法 |
| US6890930B1 (en) * | 1999-09-28 | 2005-05-10 | 3-Dimensional Pharmaceuticals, Inc. | Quinazolinones |
| CA2534405A1 (en) * | 2003-08-08 | 2005-02-17 | Ulysses Pharmaceutical Products Inc. | Halogenated quinazolinyl nitrofurans as antibacterial agents |
| US20080146562A1 (en) * | 2003-08-08 | 2008-06-19 | Ulysses Pharmaceutical Products Inc., | Halogenated quinazolinyl nitrofurans as antibacterial agents |
| GB0416730D0 (en) | 2004-07-27 | 2004-09-01 | Novartis Ag | Organic compounds |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| TWI409070B (zh) * | 2005-11-04 | 2013-09-21 | Hydra Biosciences Inc | 用於調節ｔｒｐｖ３功能之化合物 |
| MX2009003673A (es) * | 2006-10-04 | 2009-04-22 | Pfizer Prod Inc | Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio. |
| WO2008140750A1 (en) * | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Compounds for modulating trpv3 function |
| WO2010111432A1 (en) * | 2009-03-24 | 2010-09-30 | Calistoga Pharmaceuticals Inc. | Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| JP5718323B2 (ja) * | 2009-05-29 | 2015-05-13 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 放射標識されたｐｄｅ１０阻害剤 |
| US9216177B2 (en) | 2011-02-28 | 2015-12-22 | Drexel University | Small molecular inhibitors of RAD51 recombinase and methods thereof |
| AU2021212754A1 (en) | 2020-01-29 | 2022-08-04 | Kamari Pharma Ltd. | Compounds and compositions for use in treating skin disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1298603A (en) * | 1970-04-06 | 1972-12-06 | Karamchand Premchand Private | Quinazolinone derivatives |
| US4183931A (en) * | 1977-09-08 | 1980-01-15 | Research Corporation | 2-Ketoalkyl-4(3H)-quinazolinones |
| WO1992013535A1 (en) | 1991-02-06 | 1992-08-20 | Research Corporation Technologies, Inc. | Anticonvulsant substituted quinazolones |
| ES2184960T3 (es) | 1996-05-15 | 2003-04-16 | Pfizer | Nuevas pirimidin-4-onas-(5,6)-heteroaril condensadas 2,3 disustituidas. |
| KR100375155B1 (ko) | 1996-05-15 | 2003-08-19 | 화이자 인코포레이티드 | 신규한2,3-이치환된-4(3에이치)-퀴나졸리논 |
-
1998
- 1998-02-06 NZ NZ336627A patent/NZ336627A/xx unknown
- 1998-02-06 WO PCT/IB1998/000151 patent/WO1998038187A1/en not_active Application Discontinuation
- 1998-02-06 EA EA199900689A patent/EA001961B1/ru not_active IP Right Cessation
- 1998-02-06 PT PT98901424T patent/PT964860E/pt unknown
- 1998-02-06 PL PL98335307A patent/PL335307A1/xx unknown
- 1998-02-06 TR TR1999/02094T patent/TR199902094T2/xx unknown
- 1998-02-06 EP EP98901424A patent/EP0964860B1/en not_active Expired - Lifetime
- 1998-02-06 IL IL13089798A patent/IL130897A0/xx unknown
- 1998-02-06 ID IDW990935D patent/ID23435A/id unknown
- 1998-02-06 HU HU0000935A patent/HUP0000935A3/hu unknown
- 1998-02-06 JP JP53744998A patent/JP3299990B2/ja not_active Expired - Fee Related
- 1998-02-06 US US09/380,114 patent/US6380204B1/en not_active Expired - Fee Related
- 1998-02-06 DK DK98901424T patent/DK0964860T3/da active
- 1998-02-06 DE DE69823339T patent/DE69823339T2/de not_active Expired - Fee Related
- 1998-02-06 SK SK1131-99A patent/SK113199A3/sk unknown
- 1998-02-06 CN CN98802796A patent/CN1248254A/zh active Pending
- 1998-02-06 BR BR9807807-0A patent/BR9807807A/pt not_active Application Discontinuation
- 1998-02-06 ES ES98901424T patent/ES2218801T3/es not_active Expired - Lifetime
- 1998-02-06 KR KR1019997007885A patent/KR20000075812A/ko active IP Right Grant
- 1998-02-06 AU AU57759/98A patent/AU732448B2/en not_active Ceased
- 1998-02-06 AT AT98901424T patent/ATE264854T1/de not_active IP Right Cessation
- 1998-02-06 CA CA002282279A patent/CA2282279C/en not_active Expired - Fee Related
- 1998-02-09 HN HN1998000028A patent/HN1998000028A/es unknown
- 1998-02-17 PA PA19988446901A patent/PA8446901A1/es unknown
- 1998-02-19 GT GT199800039A patent/GT199800039A/es unknown
- 1998-02-23 PE PE1998000127A patent/PE57999A1/es not_active Application Discontinuation
- 1998-02-25 CO CO98010303A patent/CO4950615A1/es unknown
- 1998-02-25 TN TNTNSN98034A patent/TNSN98034A1/fr unknown
- 1998-02-25 DZ DZ980048A patent/DZ2438A1/xx active
- 1998-02-25 MA MA24979A patent/MA24485A1/fr unknown
- 1998-02-25 TW TW087102713A patent/TW530055B/zh not_active IP Right Cessation
- 1998-02-26 AR ARP980100872A patent/AR011886A1/es unknown
- 1998-02-26 AP APAP/P/1998/001202A patent/AP9801202A0/en unknown
- 1998-02-27 HR HR980108A patent/HRP980108B1/xx not_active IP Right Cessation
- 1998-02-27 ZA ZA9801665A patent/ZA981665B/xx unknown
- 1998-06-02 UA UA99084850A patent/UA58536C2/uk unknown
-
1999
- 1999-07-30 IS IS5141A patent/IS5141A/is unknown
- 1999-08-20 OA OA9900186A patent/OA11088A/fr unknown
- 1999-08-24 BG BG103687A patent/BG103687A/xx unknown
- 1999-08-27 NO NO994178A patent/NO994178L/no unknown
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