OA10908A - Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1H)-indol-2-one(=ziprasidone) its preparation and its use as dopamine d2 antagonist - Google Patents

Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1H)-indol-2-one(=ziprasidone) its preparation and its use as dopamine d2 antagonist Download PDF

Info

Publication number
OA10908A
OA10908A OA9800205A OA9800205A OA10908A OA 10908 A OA10908 A OA 10908A OA 9800205 A OA9800205 A OA 9800205A OA 9800205 A OA9800205 A OA 9800205A OA 10908 A OA10908 A OA 10908A
Authority
OA
OAPI
Prior art keywords
ziprasidone
chloro
benzisothiazol
indol
dihydro
Prior art date
Application number
OA9800205A
Other languages
English (en)
French (fr)
Inventor
Frank R Busch
Carol A Rose
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of OA10908A publication Critical patent/OA10908A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
OA9800205A 1996-05-07 1998-10-30 Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1H)-indol-2-one(=ziprasidone) its preparation and its use as dopamine d2 antagonist OA10908A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1653796P 1996-05-07 1996-05-07

Publications (1)

Publication Number Publication Date
OA10908A true OA10908A (en) 2001-10-26

Family

ID=21777622

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9800205A OA10908A (en) 1996-05-07 1998-10-30 Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1H)-indol-2-one(=ziprasidone) its preparation and its use as dopamine d2 antagonist

Country Status (46)

Country Link
US (1) US6110918A (no)
EP (1) EP0904273B1 (no)
JP (1) JP3102896B2 (no)
KR (1) KR100333214B1 (no)
CN (1) CN1092658C (no)
AP (1) AP838A (no)
AR (1) AR007003A1 (no)
AT (1) ATE236902T1 (no)
AU (1) AU730856C (no)
BG (1) BG63601B1 (no)
BR (1) BR9708932A (no)
CA (1) CA2252895C (no)
CO (1) CO4940465A1 (no)
CZ (1) CZ289216B6 (no)
DE (1) DE69720719T2 (no)
DK (1) DK0904273T3 (no)
DZ (1) DZ2221A1 (no)
EA (1) EA001180B1 (no)
EG (1) EG24401A (no)
ES (1) ES2192264T3 (no)
GT (1) GT199700042A (no)
HK (1) HK1017893A1 (no)
HN (1) HN1997000040A (no)
HR (1) HRP970235B1 (no)
HU (1) HU229057B1 (no)
ID (1) ID17504A (no)
IL (1) IL126590A (no)
IS (1) IS2301B (no)
MA (1) MA26427A1 (no)
ME (1) ME00901B (no)
MY (1) MY128051A (no)
NO (1) NO312513B1 (no)
NZ (2) NZ332219A (no)
OA (1) OA10908A (no)
PL (1) PL188164B1 (no)
PT (1) PT904273E (no)
SI (1) SI0904273T1 (no)
SK (1) SK282674B6 (no)
TN (1) TNSN97073A1 (no)
TR (1) TR199802241T2 (no)
TW (1) TW427989B (no)
UA (1) UA47467C2 (no)
UY (1) UY24543A1 (no)
WO (1) WO1997042190A1 (no)
YU (1) YU49398B (no)
ZA (1) ZA973875B (no)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1996000101A (es) * 1996-02-28 1997-06-26 Inc Pfizer Terapia combinada para la osteoporosis
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
TW491847B (en) 1996-05-07 2002-06-21 Pfizer Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
IL127497A (en) * 1997-12-18 2002-07-25 Pfizer Prod Inc Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
ES2204067T3 (es) * 1998-05-26 2004-04-16 Pfizer Products Inc. Medicamento para el tratamiento del glaucoma y de la retinopatia isquemica.
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
EP1712222A3 (en) 1999-12-23 2012-06-20 Pfizer Products Inc. Pharmaceutical compositions providing enhanced drug concentrations
DE60124093D1 (de) * 2000-06-02 2006-12-07 Pfizer Prod Inc S-methyl-dihydro-ziprasidon zur Behandlung von Augenerkrankungen.
AR032641A1 (es) * 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd Agonista de subtipo de receptor 5-ht 1a.
US7053092B2 (en) 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
US8703772B2 (en) 2001-09-25 2014-04-22 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US20040048876A1 (en) * 2002-02-20 2004-03-11 Pfizer Inc. Ziprasidone composition and synthetic controls
UY27668A1 (es) * 2002-02-20 2003-10-31 Pfizer Prod Inc Composición de ziprasidona y controles sintéticos
US7488729B2 (en) 2002-12-04 2009-02-10 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof
WO2004050655A1 (en) * 2002-12-04 2004-06-17 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride
JP2007502856A (ja) * 2003-05-16 2007-02-15 ファイザー・プロダクツ・インク 精神病性障害および抑うつ性障害の治療
CA2625837A1 (en) * 2003-05-16 2004-11-25 Pfizer Products Inc. Method for enhancing cognition using ziprasidone
WO2004100955A1 (en) * 2003-05-16 2004-11-25 Pfizer Products Inc. Anxiety treatments with ziprasidone
EP1546146A1 (en) * 2003-06-03 2005-06-29 Teva Pharmaceutical Industries Limited POLYMORPHIC FORMS OF ZIPRASIDONE HCl AND PROCESSES FOR THEIR PREPARATION
AU2004268663B2 (en) * 2003-09-02 2010-12-09 Pfizer Products Inc. Sustained release dosage forms of ziprasidone
WO2005040160A2 (en) * 2003-10-24 2005-05-06 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
US20050197347A1 (en) * 2003-12-18 2005-09-08 Judith Aronhime Polymorphic form B2 of ziprasidone base
EP1703898A2 (en) * 2003-12-31 2006-09-27 Alpharma, Inc. Ziprasidone formulations
ATE451367T1 (de) * 2004-02-27 2009-12-15 Ranbaxy Lab Ltd Verfahren zur herstellung von ziprasidon
WO2006026426A2 (en) * 2004-08-27 2006-03-09 University Of Kentucky Research Foundation Amyloid peptide inactivating enzyme to treat alzheimer’s disease peripherally
ES2250001B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Proceso para la purificacion de ziprasidona.
US7777037B2 (en) * 2004-10-27 2010-08-17 Dr. Reddy's Laboratories Limited Ziprasidone process
JP5324098B2 (ja) * 2004-11-16 2013-10-23 アルケルメス ファーマ アイルランド リミテッド 注射可能なナノ粒子のオランザピン製剤
EP1863806A1 (en) * 2005-02-11 2007-12-12 Teva Pharmaceutical Industries Ltd Amorphous ziprasidone mesylate
US20080254114A1 (en) * 2005-03-03 2008-10-16 Elan Corporation Plc Controlled Release Compositions Comprising Heterocyclic Amide Derivative Nanoparticles
ITMI20050346A1 (it) 2005-03-07 2006-09-08 Dipharma Spa Forma solida di ziprasidone cloridrato
EP1858891A2 (en) * 2005-03-14 2007-11-28 Teva Pharmaceutical Industries Ltd. Crystalline forms of ziprasidone mesylate
US20060270685A1 (en) * 2005-03-14 2006-11-30 Judith Aronhime Anhydrous ziprasidone mesylate and a process for its preparation
KR20100017109A (ko) * 2007-05-18 2010-02-16 싸이도우스 엘엘씨. 지프라시돈 제제
KR100948126B1 (ko) * 2007-12-10 2010-03-18 씨제이제일제당 (주) 결정형의 지프라시돈 술폰산염, 그 제조방법, 및 그것를포함하는 약제학적 조성물
CN102234273B (zh) * 2010-04-21 2015-08-05 上海医药工业研究院 甲磺酸齐拉西酮半水合物及其制备方法
SI23610A (sl) 2011-01-13 2012-07-31 Diagen@d@o@o Nove adicijske soli ziprasidona postopek za njihovo pripravo in njihova uporaba v terapiji
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
US5312925A (en) * 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5359068A (en) * 1993-06-28 1994-10-25 Pfizer Inc. Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one

Also Published As

Publication number Publication date
KR20000010822A (ko) 2000-02-25
NO985193L (no) 1998-11-06
IL126590A (en) 2001-11-25
HU229057B1 (en) 2013-07-29
YU17397A (sh) 2000-10-30
NZ332219A (en) 2005-02-25
AR007003A1 (es) 1999-10-13
IS4878A (is) 1998-10-23
IL126590A0 (en) 1999-08-17
AU730856B2 (en) 2001-03-15
JPH11509865A (ja) 1999-08-31
TW427989B (en) 2001-04-01
ATE236902T1 (de) 2003-04-15
SK282674B6 (sk) 2002-11-06
HK1017893A1 (en) 1999-12-03
DE69720719D1 (de) 2003-05-15
AU730856C (en) 2001-11-15
CA2252895C (en) 2002-08-20
AU1936897A (en) 1997-11-26
NZ508303A (en) 2001-07-27
PL329880A1 (en) 1999-04-12
PT904273E (pt) 2003-06-30
TNSN97073A1 (fr) 2005-03-15
EG24401A (en) 2009-04-29
BR9708932A (pt) 1999-08-03
GT199700042A (es) 1998-10-02
ME00901B (me) 2005-11-28
HRP970235A2 (en) 1998-06-30
CZ349498A3 (cs) 1999-09-15
NO312513B1 (no) 2002-05-21
UY24543A1 (es) 2000-09-29
CN1216990A (zh) 1999-05-19
ES2192264T3 (es) 2003-10-01
CN1092658C (zh) 2002-10-16
EP0904273B1 (en) 2003-04-09
EP0904273A1 (en) 1999-03-31
MY128051A (en) 2007-01-31
CO4940465A1 (es) 2000-07-24
EA199800909A1 (ru) 1999-04-29
BG102893A (en) 1999-09-30
CA2252895A1 (en) 1997-11-13
DK0904273T3 (da) 2003-07-07
HN1997000040A (es) 1997-06-05
AP838A (en) 2000-05-03
WO1997042190A1 (en) 1997-11-13
DE69720719T2 (de) 2003-11-06
AP9700978A0 (en) 1997-07-31
JP3102896B2 (ja) 2000-10-23
US6110918A (en) 2000-08-29
HUP9902808A3 (en) 2000-04-28
DZ2221A1 (fr) 2002-12-03
YU49398B (sh) 2005-11-28
TR199802241T2 (no) 1999-02-22
CZ289216B6 (cs) 2001-12-12
ZA973875B (en) 1998-11-06
SI0904273T1 (en) 2003-08-31
EA001180B1 (ru) 2000-10-30
UA47467C2 (uk) 2002-07-15
SK150598A3 (en) 2000-03-13
MA26427A1 (fr) 2004-12-20
HUP9902808A2 (hu) 2000-03-28
BG63601B1 (bg) 2002-06-28
IS2301B (is) 2007-10-15
ID17504A (id) 1998-01-08
HRP970235B1 (en) 2002-08-31
NO985193D0 (no) 1998-11-06
PL188164B1 (pl) 2004-12-31
KR100333214B1 (ko) 2002-06-20

Similar Documents

Publication Publication Date Title
OA10908A (en) Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1H)-indol-2-one(=ziprasidone) its preparation and its use as dopamine d2 antagonist
AU731267B2 (en) Mesylate dihydrate salts of 5-(2-(4-(1,2-benzis othiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2 (1H)-indol-2-one (=ziprasidone), its preparation and its use as dopamine D2 antagonist
JP2024099797A (ja) ７－シクロペンチル－２－（５－ピペラジン－１－イル－ピリジン－２－イルアミノ）－７Ｈ－ピロロ［２，３－ｄ］ピリミジン－６－カルボン酸ジメチルアミドのコハク酸塩の新規な結晶形態
CA2883014A1 (en) Derivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents
NZ508304A (en) Mesylate dihydrate salt of 5-(2-(4-(1,2 benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1H)-indol-2-one ( ziprasidone) useful as dopamine D2 antagonist
MXPA98009242A (en) Salt mesylate trihydrate 5 - (- 2- (4- (1,2-benzoisotiazol-3-il) -1-piperazinil) ethyl) -6-chlorine-1,3-dihydro-2h-indol-2-