OA10639A - C-4' modified adenosine kinase inhibitors - Google Patents

C-4' modified adenosine kinase inhibitors Download PDF

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Publication number
OA10639A
OA10639A OA70150A OA70150A OA10639A OA 10639 A OA10639 A OA 10639A OA 70150 A OA70150 A OA 70150A OA 70150 A OA70150 A OA 70150A OA 10639 A OA10639 A OA 10639A
Authority
OA
OAPI
Prior art keywords
compound
phenyl
amino
guanidino
optionally
Prior art date
Application number
OA70150A
Other languages
English (en)
Inventor
Serg H Boyer
Mark D Erion
Bheemarao G Ugarkar
Original Assignee
Gensia Sicor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gensia Sicor filed Critical Gensia Sicor
Publication of OA10639A publication Critical patent/OA10639A/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14Pyrrolo-pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
OA70150A 1995-06-07 1997-12-03 C-4' modified adenosine kinase inhibitors OA10639A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/486,161 US5674998A (en) 1989-09-15 1995-06-07 C-4' modified adenosine kinase inhibitors

Publications (1)

Publication Number Publication Date
OA10639A true OA10639A (en) 2002-09-17

Family

ID=23930844

Family Applications (1)

Application Number Title Priority Date Filing Date
OA70150A OA10639A (en) 1995-06-07 1997-12-03 C-4' modified adenosine kinase inhibitors

Country Status (24)

Country Link
US (1) US5674998A (cs)
EP (1) EP0832091B1 (cs)
JP (1) JPH11507387A (cs)
KR (1) KR19990022740A (cs)
CN (1) CN1190401A (cs)
AP (1) AP9701165A0 (cs)
AT (1) ATE257841T1 (cs)
AU (1) AU6178396A (cs)
BG (1) BG102163A (cs)
BR (1) BR9609013A (cs)
CA (1) CA2220642A1 (cs)
CZ (1) CZ392797A3 (cs)
DE (1) DE69631330T2 (cs)
EA (1) EA199800009A1 (cs)
HU (1) HUP9802193A3 (cs)
IL (1) IL122335A0 (cs)
IS (1) IS4621A (cs)
MX (1) MX9709859A (cs)
NO (1) NO975585L (cs)
OA (1) OA10639A (cs)
PL (1) PL323904A1 (cs)
SK (1) SK166097A3 (cs)
TR (1) TR199701539T1 (cs)
WO (1) WO1996040705A1 (cs)

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US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
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EP1212326A4 (en) * 1999-08-27 2003-08-20 Icn Pharmaceuticals NUCLEOSIDE ANALOGS OF PYRROLO 2,3-d] PYRIMIDINE
US6831069B2 (en) 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
US7071199B1 (en) 1999-09-17 2006-07-04 Abbott Gmbh & Cco. Kg Kinase inhibitors as therapeutic agents
CZ2002936A3 (cs) 1999-09-17 2002-10-16 Abbott Gmbh & Co. Kg Pyrazolopyrimidiny jako terapeutické prostředky
BR0016415A (pt) * 1999-12-16 2002-12-24 Alcon Inc Inibidores de adenosina cinase para o tratamento de dano retinal e de nervo ótico
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US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US7414036B2 (en) * 2002-01-25 2008-08-19 Muscagen Limited Compounds useful as A3 adenosine receptor agonists
AU2002951247A0 (en) * 2002-09-06 2002-09-19 Alchemia Limited Compounds that interact with kinases
BRPI0400869B8 (pt) * 2004-03-02 2021-05-25 Univ Estadual Campinas Unicamp novos compostos derivados de 4-anilinoquinazolinas com propriedade inibidora de adenosinacinases
WO2006068760A2 (en) 2004-11-19 2006-06-29 The Regents Of The University Of California Anti-inflammatory pyrazolopyrimidines
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EA031335B1 (ru) 2006-02-02 2018-12-28 Миллениум Фармасьютикалз, Инк. Производные пирролопиримидинов
US7585868B2 (en) 2006-04-04 2009-09-08 The Regents Of The University Of California Substituted pyrazolo[3,4-D]pyrimidines as kinase antagonists
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US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
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Also Published As

Publication number Publication date
AP9701165A0 (en) 1998-01-31
EP0832091B1 (en) 2004-01-14
US5674998A (en) 1997-10-07
PL323904A1 (en) 1998-04-27
CN1190401A (zh) 1998-08-12
DE69631330T2 (de) 2004-10-28
SK166097A3 (en) 1999-06-11
NO975585L (no) 1998-02-05
NO975585D0 (no) 1997-12-03
EA199800009A1 (ru) 1998-06-25
EP0832091A1 (en) 1998-04-01
JPH11507387A (ja) 1999-06-29
ATE257841T1 (de) 2004-01-15
TR199701539T1 (xx) 1998-04-21
WO1996040705A1 (en) 1996-12-19
MX9709859A (es) 1998-08-30
BR9609013A (pt) 1999-12-14
CA2220642A1 (en) 1996-12-19
HUP9802193A3 (en) 1999-10-28
HUP9802193A2 (hu) 1999-05-28
AU6178396A (en) 1996-12-30
IL122335A0 (en) 1998-04-05
BG102163A (en) 1998-10-30
IS4621A (is) 1997-11-26
DE69631330D1 (de) 2004-02-19
KR19990022740A (ko) 1999-03-25
CZ392797A3 (cs) 1999-04-14

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