DE69631330D1 - C-4' modifizierte adenosinkinaseinhibitoren - Google Patents

C-4' modifizierte adenosinkinaseinhibitoren

Info

Publication number
DE69631330D1
DE69631330D1 DE69631330T DE69631330T DE69631330D1 DE 69631330 D1 DE69631330 D1 DE 69631330D1 DE 69631330 T DE69631330 T DE 69631330T DE 69631330 T DE69631330 T DE 69631330T DE 69631330 D1 DE69631330 D1 DE 69631330D1
Authority
DE
Germany
Prior art keywords
kinase inhibitors
adenosine kinase
modified adenosine
modified
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69631330T
Other languages
English (en)
Other versions
DE69631330T2 (de
Inventor
Serge H Boyer
Mark D Erion
Bheemarao G Ugarkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metabasis Therapeutics Inc
Original Assignee
Sicor Inc
Gensia Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc, Gensia Sicor Inc filed Critical Sicor Inc
Application granted granted Critical
Publication of DE69631330D1 publication Critical patent/DE69631330D1/de
Publication of DE69631330T2 publication Critical patent/DE69631330T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
DE69631330T 1995-06-07 1996-06-07 C-4' modifizierte adenosinkinaseinhibitoren Expired - Fee Related DE69631330T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US486161 1995-06-07
US08/486,161 US5674998A (en) 1989-09-15 1995-06-07 C-4' modified adenosine kinase inhibitors
PCT/US1996/010404 WO1996040705A1 (en) 1995-06-07 1996-06-07 C-4' modified adenosine kinase inhibitors

Publications (2)

Publication Number Publication Date
DE69631330D1 true DE69631330D1 (de) 2004-02-19
DE69631330T2 DE69631330T2 (de) 2004-10-28

Family

ID=23930844

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69631330T Expired - Fee Related DE69631330T2 (de) 1995-06-07 1996-06-07 C-4' modifizierte adenosinkinaseinhibitoren

Country Status (24)

Country Link
US (1) US5674998A (de)
EP (1) EP0832091B1 (de)
JP (1) JPH11507387A (de)
KR (1) KR19990022740A (de)
CN (1) CN1190401A (de)
AP (1) AP9701165A0 (de)
AT (1) ATE257841T1 (de)
AU (1) AU6178396A (de)
BG (1) BG102163A (de)
BR (1) BR9609013A (de)
CA (1) CA2220642A1 (de)
CZ (1) CZ392797A3 (de)
DE (1) DE69631330T2 (de)
EA (1) EA199800009A1 (de)
HU (1) HUP9802193A3 (de)
IL (1) IL122335A0 (de)
IS (1) IS4621A (de)
MX (1) MX9709859A (de)
NO (1) NO975585L (de)
OA (1) OA10639A (de)
PL (1) PL323904A1 (de)
SK (1) SK166097A3 (de)
TR (1) TR199701539T1 (de)
WO (1) WO1996040705A1 (de)

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US7863444B2 (en) 1997-03-19 2011-01-04 Abbott Laboratories 4-aminopyrrolopyrimidines as kinase inhibitors
US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
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US6831069B2 (en) 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
US7071199B1 (en) 1999-09-17 2006-07-04 Abbott Gmbh & Cco. Kg Kinase inhibitors as therapeutic agents
SK3812002A3 (en) 1999-09-17 2003-09-11 Abbott Gmbh & Co Kg Pyrazolopyrimidines as therapeutic agents
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WO2001058920A2 (fr) * 2000-02-10 2001-08-16 Mitsui Chemicals, Inc. Procede de production selective d'un anomere derive d'un sucre 1-phosphoryle
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
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EP2557080A1 (de) 2006-04-04 2013-02-13 The Regents of The University of California Verfahren zur Identifizierung von PI3-Kinase-Antagonisten
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US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
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WO2010006072A2 (en) 2008-07-08 2010-01-14 The Regents Of The University Of California Mtor modulators and uses thereof
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WO2010045542A2 (en) 2008-10-16 2010-04-22 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
EP2427195B1 (de) 2009-05-07 2019-05-01 Intellikine, LLC Heterocyclische verbindungen und ihre verwendung
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JP6130305B2 (ja) 2011-02-23 2017-05-17 インテリカイン， エルエルシー キナーゼ阻害剤の組み合わせおよびそれらの使用
JP6027610B2 (ja) 2011-07-19 2016-11-16 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環式化合物及びその使用
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EP2751112B1 (de) 2011-09-02 2019-10-09 The Regents of The University of California Substituierte pyrazolo[3,4-d]pyrimidine und ihre verwendung
CN107459544B (zh) 2011-12-22 2021-03-16 詹森生物制药有限公司 取代的核苷、核苷酸及其类似物
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
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CN104995192A (zh) 2012-09-26 2015-10-21 加利福尼亚大学董事会 Ire1的调节
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Also Published As

Publication number Publication date
KR19990022740A (ko) 1999-03-25
EP0832091A1 (de) 1998-04-01
WO1996040705A1 (en) 1996-12-19
OA10639A (en) 2002-09-17
HUP9802193A2 (hu) 1999-05-28
EP0832091B1 (de) 2004-01-14
DE69631330T2 (de) 2004-10-28
US5674998A (en) 1997-10-07
IS4621A (is) 1997-11-26
CN1190401A (zh) 1998-08-12
BR9609013A (pt) 1999-12-14
CZ392797A3 (cs) 1999-04-14
ATE257841T1 (de) 2004-01-15
AU6178396A (en) 1996-12-30
PL323904A1 (en) 1998-04-27
CA2220642A1 (en) 1996-12-19
IL122335A0 (en) 1998-04-05
JPH11507387A (ja) 1999-06-29
AP9701165A0 (en) 1998-01-31
TR199701539T1 (xx) 1998-04-21
HUP9802193A3 (en) 1999-10-28
NO975585L (no) 1998-02-05
EA199800009A1 (ru) 1998-06-25
NO975585D0 (no) 1997-12-03
SK166097A3 (en) 1999-06-11
MX9709859A (es) 1998-08-30
BG102163A (en) 1998-10-30

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Owner name: METABASIS THERAPEUTICS,INC.(N.D.GES.D.STAATES DELA

8339 Ceased/non-payment of the annual fee