OA10235A - Novel polycyclic systems and derivatives thereof as neurotransmitter release enhancers useful in the treatment of cognitive disorders - Google Patents
Novel polycyclic systems and derivatives thereof as neurotransmitter release enhancers useful in the treatment of cognitive disorders Download PDFInfo
- Publication number
- OA10235A OA10235A OA60720A OA60720A OA10235A OA 10235 A OA10235 A OA 10235A OA 60720 A OA60720 A OA 60720A OA 60720 A OA60720 A OA 60720A OA 10235 A OA10235 A OA 10235A
- Authority
- OA
- OAPI
- Prior art keywords
- methyl
- pyridinyl
- fluoro
- bis
- indeno
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4401293A | 1993-04-08 | 1993-04-08 | |
US08/216,881 US5594001A (en) | 1993-04-08 | 1994-03-28 | Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
OA10235A true OA10235A (en) | 1997-10-07 |
Family
ID=26721086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA60720A OA10235A (en) | 1993-04-08 | 1995-10-06 | Novel polycyclic systems and derivatives thereof as neurotransmitter release enhancers useful in the treatment of cognitive disorders |
Country Status (21)
Country | Link |
---|---|
US (1) | US5990132A (no) |
EP (1) | EP0693069A1 (no) |
JP (1) | JPH08509713A (no) |
CN (2) | CN1058495C (no) |
AU (1) | AU690906B2 (no) |
BR (1) | BR9405954A (no) |
CA (1) | CA2160112A1 (no) |
CZ (1) | CZ251995A3 (no) |
FI (1) | FI954775A (no) |
HU (1) | HUT74104A (no) |
IL (1) | IL109237A (no) |
LV (1) | LV11179B (no) |
NO (1) | NO308745B1 (no) |
NZ (1) | NZ265183A (no) |
OA (1) | OA10235A (no) |
PL (1) | PL178570B1 (no) |
RO (1) | RO115162B1 (no) |
RU (1) | RU2152944C1 (no) |
SI (1) | SI9420022A (no) |
SK (1) | SK124695A3 (no) |
WO (1) | WO1994024131A1 (no) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5750528A (en) * | 1995-02-01 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Blockade of neuronal m-channels as a therapeutic approach to the treatment of neurological disease |
US6262081B1 (en) | 1998-07-10 | 2001-07-17 | Dupont Pharmaceuticals Company | Composition for and method of treating neurological disorders |
JP5581607B2 (ja) * | 2008-06-05 | 2014-09-03 | 住友化学株式会社 | 高分子化合物及びそれを用いた有機トランジスタ |
PT2909204T (pt) | 2012-10-12 | 2019-03-21 | Dana Farber Cancer Inst Inc | Inibidores de gsk3 e métodos de utilização dos mesmos |
KR101560061B1 (ko) * | 2012-11-30 | 2015-10-15 | 주식회사 엘지화학 | 신규한 화합물 및 이를 이용한 유기 전자 소자 |
US9593113B2 (en) | 2013-08-22 | 2017-03-14 | Bristol-Myers Squibb Company | Imide and acylurea derivatives as modulators of the glucocorticoid receptor |
WO2015027015A1 (en) | 2013-08-22 | 2015-02-26 | Bristol-Myers Squibb Company | Imidazole-derived modulators of the glucocorticoid receptor |
DK3102555T3 (da) | 2014-02-05 | 2021-08-09 | VM Oncology LLC | Sammensætninger af forbindelser og anvendelser deraf |
GB201417369D0 (en) * | 2014-10-01 | 2014-11-12 | Redx Pharma Ltd | Compounds |
MA46899A (fr) * | 2016-11-07 | 2021-04-14 | Univ Vanderbilt | Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4 |
CN110958882B (zh) | 2017-04-05 | 2023-08-29 | 布罗德研究所股份有限公司 | 作为糖原合酶激酶3(gsk3)抑制剂的三环化合物及其用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1052346A (no) * | 1964-09-09 | |||
US4760083A (en) * | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
US5173489A (en) * | 1986-04-10 | 1992-12-22 | The Dupont Merck Pharmaceutical Co. | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers |
JPH06503095A (ja) * | 1991-05-29 | 1994-04-07 | ファイザー・インコーポレーテッド | 三環式ポリヒドロキシ系のチロシンキナーゼ阻害薬 |
ES2100523T3 (es) * | 1992-01-16 | 1997-06-16 | Du Pont Merck Pharma | Nuevos liberadores de neurotransmisores utiles para la potenciacion de las facultades cognoscitivas. |
RU2051151C1 (ru) * | 1992-01-16 | 1995-12-27 | Дзе Дюпон Мерк Фармасьютикал Компани | Азотсодержащие гетероциклические производные флуорена |
US5272269A (en) * | 1992-01-16 | 1993-12-21 | The Du Pont Merck Pharmaceutical Company | Disubstituted polycyclic systems and preparative methods therefor |
US5185447A (en) * | 1992-01-29 | 1993-02-09 | Du Pont Merck Pharmaceutical Company | Polycyclic ketones and preparative methods therefor |
US5359070A (en) * | 1993-02-11 | 1994-10-25 | The Du Pont Merck Pharmaceutical Company | Unsymmetrical bis-imides as anticancer agents |
-
1994
- 1994-04-04 JP JP6523257A patent/JPH08509713A/ja active Pending
- 1994-04-04 RU RU95120594/04A patent/RU2152944C1/ru active
- 1994-04-04 NZ NZ265183A patent/NZ265183A/en unknown
- 1994-04-04 RO RO95-01753A patent/RO115162B1/ro unknown
- 1994-04-04 HU HU9502929A patent/HUT74104A/hu unknown
- 1994-04-04 SI SI9420022A patent/SI9420022A/sl unknown
- 1994-04-04 WO PCT/US1994/003673 patent/WO1994024131A1/en not_active Application Discontinuation
- 1994-04-04 CN CN94191713A patent/CN1058495C/zh not_active Expired - Fee Related
- 1994-04-04 AU AU65549/94A patent/AU690906B2/en not_active Ceased
- 1994-04-04 BR BR9405954A patent/BR9405954A/pt not_active Application Discontinuation
- 1994-04-04 PL PL94310997A patent/PL178570B1/pl unknown
- 1994-04-04 CA CA002160112A patent/CA2160112A1/en not_active Abandoned
- 1994-04-04 SK SK1246-95A patent/SK124695A3/sk unknown
- 1994-04-04 EP EP94913355A patent/EP0693069A1/en not_active Withdrawn
- 1994-04-04 CZ CZ952519A patent/CZ251995A3/cs unknown
- 1994-04-06 IL IL109237A patent/IL109237A/en not_active IP Right Cessation
-
1995
- 1995-10-06 FI FI954775A patent/FI954775A/fi unknown
- 1995-10-06 NO NO953989A patent/NO308745B1/no not_active IP Right Cessation
- 1995-10-06 OA OA60720A patent/OA10235A/en unknown
- 1995-10-09 LV LVP-95-302A patent/LV11179B/en unknown
-
1996
- 1996-06-17 US US08/664,631 patent/US5990132A/en not_active Expired - Fee Related
-
2000
- 2000-01-08 CN CN00100940A patent/CN1295072A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1122135A (zh) | 1996-05-08 |
LV11179B (en) | 1997-06-20 |
FI954775A0 (fi) | 1995-10-06 |
NZ265183A (en) | 1997-11-24 |
NO953989L (no) | 1995-12-07 |
CN1058495C (zh) | 2000-11-15 |
AU690906B2 (en) | 1998-05-07 |
JPH08509713A (ja) | 1996-10-15 |
PL310997A1 (en) | 1996-01-22 |
HUT74104A (en) | 1996-11-28 |
IL109237A0 (en) | 1994-07-31 |
NO308745B1 (no) | 2000-10-23 |
BR9405954A (pt) | 1995-12-26 |
EP0693069A1 (en) | 1996-01-24 |
WO1994024131A1 (en) | 1994-10-27 |
NO953989D0 (no) | 1995-10-06 |
LV11179A (lv) | 1996-04-20 |
CZ251995A3 (en) | 1996-01-17 |
CN1295072A (zh) | 2001-05-16 |
FI954775A (fi) | 1995-10-06 |
US5990132A (en) | 1999-11-23 |
HU9502929D0 (en) | 1995-11-28 |
SK124695A3 (en) | 1996-06-05 |
RO115162B1 (ro) | 1999-11-30 |
RU2152944C1 (ru) | 2000-07-20 |
CA2160112A1 (en) | 1994-10-27 |
IL109237A (en) | 1998-02-08 |
AU6554994A (en) | 1994-11-08 |
PL178570B1 (pl) | 2000-05-31 |
SI9420022A (en) | 1996-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69826883T2 (de) | Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren | |
TW201718493A (zh) | 作為magl抑制劑的胺基甲酸1,1,1-三氟-3-羥基丙烷-2-基酯衍生物及胺基甲酸1,1,1-三氟-4-羥基丁烷-2-基酯衍生物 | |
NO884835L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive tetrahydro-furo-og-tieno (2,3.-c)pyridiner. | |
RU2190612C2 (ru) | Новые производные индол-2,3-дион-3-оксима | |
CA2579059A1 (en) | Chemical compounds | |
NO313630B1 (no) | Atropisomere av 3-aryl-4(3H)-kinazolinoner og deres anvendelse samt farmasöytisk blanding | |
US5594001A (en) | Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders | |
OA10235A (en) | Novel polycyclic systems and derivatives thereof as neurotransmitter release enhancers useful in the treatment of cognitive disorders | |
JPH01249769A (ja) | 向精神性ヘテロビシクロアルキルピペラジン誘導体 | |
CN101489984A (zh) | 氨基茚满衍生物或其盐 | |
NZ334201A (en) | Bisindolylmaleimide derivative linked via an indolyl nitrogen to an alkyl terminated with an aryl or heteroaryl | |
JP7299382B2 (ja) | Tnf活性のモジュレーターとしての縮合五環式イミダゾール誘導体 | |
CA2144636A1 (en) | 3,3'- disubstituted-1,3-dihydro-2h-pyrrolo [2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man | |
EP1025100B1 (de) | 3-substituierte tetrahydropyridopyrimidinon-derivate, ihre herstellung und verwendung | |
EP0623132B1 (en) | Disubstituted polycyclic systems as cognition enhancers | |
DE60210262T2 (de) | Halogenierte aminobenzophenonen und aminobenzoylpyridinen als inhibitoren von il-1 und tnf | |
CN115466289A (zh) | 具有tyk2抑制活性的化合物,包含其的药物组合物,及其应用 | |
KR19990082192A (ko) | 축합 2,3-벤조디아제핀 유도체 및 에이엠피에이 수용체 억제제로서의 그 용도 | |
DE19746612A1 (de) | 2-Substituierte 1,2-Benzisothiazol-Derivate, ihre Herstellung und Verwendung | |
NO860048L (no) | Octahydroindolizin-forbindelser med analgetisk virkning. | |
NO140186B (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive, nye 2-(2-pyridyl)-3-(p-klorfenyl)-propylaminer | |
WO1993021185A1 (en) | Substituted nitrogen containing spiro compounds for use in treating cognitive deficits | |
US5308851A (en) | Bispyridyl-containing heterocycles useful for treating cognitive disorders | |
CN117769547A (zh) | 3-芳氧基-3-五元杂芳基-丙胺类化合物的制备方法 |