NZ705827A - Method of synthesizing thyroid hormone analogs and polymorphs thereof - Google Patents

Method of synthesizing thyroid hormone analogs and polymorphs thereof

Info

Publication number
NZ705827A
NZ705827A NZ705827A NZ70582713A NZ705827A NZ 705827 A NZ705827 A NZ 705827A NZ 705827 A NZ705827 A NZ 705827A NZ 70582713 A NZ70582713 A NZ 70582713A NZ 705827 A NZ705827 A NZ 705827A
Authority
NZ
New Zealand
Prior art keywords
polymorphs
thyroid hormone
compounds
hormone analogs
formula
Prior art date
Application number
NZ705827A
Other languages
English (en)
Inventor
Rebecca Taub
D Hester
Robert Duguid
Martha Kelly
Anna Chasnoff
Gang Dong
Edwin Crow
Charles Reynolds
Duk Choi
Lianhe Shu
Ping Wang
Original Assignee
Madrigal Pharmaceuticals Inc
F Hoffmann La Roche Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madrigal Pharmaceuticals Inc, F Hoffmann La Roche Ltd filed Critical Madrigal Pharmaceuticals Inc
Priority to NZ73964513A priority Critical patent/NZ739645A/en
Publication of NZ705827A publication Critical patent/NZ705827A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
NZ705827A 2012-09-17 2013-09-17 Method of synthesizing thyroid hormone analogs and polymorphs thereof NZ705827A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ73964513A NZ739645A (en) 2012-09-17 2013-09-17 Form i of compound a, process for its preparation, and its use in the manufacture of a medicament for treating thyroid hormone resistance-associated diseases

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261702137P 2012-09-17 2012-09-17
US201361790432P 2013-03-15 2013-03-15
PCT/US2013/060177 WO2014043706A1 (en) 2012-09-17 2013-09-17 Method of synthesizing thyroid hormone analogs and polymorphs thereof

Publications (1)

Publication Number Publication Date
NZ705827A true NZ705827A (en) 2018-07-27

Family

ID=50278769

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ705827A NZ705827A (en) 2012-09-17 2013-09-17 Method of synthesizing thyroid hormone analogs and polymorphs thereof
NZ73964513A NZ739645A (en) 2012-09-17 2013-09-17 Form i of compound a, process for its preparation, and its use in the manufacture of a medicament for treating thyroid hormone resistance-associated diseases

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ73964513A NZ739645A (en) 2012-09-17 2013-09-17 Form i of compound a, process for its preparation, and its use in the manufacture of a medicament for treating thyroid hormone resistance-associated diseases

Country Status (24)

Country Link
US (8) US9266861B2 (Direct)
EP (4) EP4023641B1 (Direct)
JP (8) JP6616688B2 (Direct)
KR (4) KR20200023528A (Direct)
CN (2) CN108101851A (Direct)
AR (1) AR092872A1 (Direct)
AU (1) AU2013315017C1 (Direct)
BR (2) BR112015005891A2 (Direct)
CA (3) CA3090070C (Direct)
DK (3) DK4406594T3 (Direct)
ES (2) ES2907926T3 (Direct)
FI (1) FI4406594T3 (Direct)
IL (7) IL288133B2 (Direct)
IN (1) IN2015DN03133A (Direct)
LT (1) LT4406594T (Direct)
MX (2) MX395148B (Direct)
MY (1) MY170520A (Direct)
NZ (2) NZ705827A (Direct)
PT (1) PT4406594T (Direct)
RU (2) RU2018128393A (Direct)
SG (3) SG10201705984XA (Direct)
TW (4) TWI804870B (Direct)
WO (1) WO2014043706A1 (Direct)
ZA (1) ZA201501795B (Direct)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2018128393A (ru) * 2012-09-17 2019-03-14 Мадригал Фармасьютикалз, Инк. Способ синтеза аналогов гормонов щитовидной железы и их полиморфов
JP2019533019A (ja) * 2016-10-18 2019-11-14 マドリガル ファーマシューティカルズ インコーポレイテッドＭａｄｒｉｇａｌ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Ｔｈｒ−ベータアゴニストで肝臓障害又は脂質障害を治療する方法
EP3725779A4 (en) * 2018-01-23 2021-02-24 Shenzhen TargetRx, Inc. SUBSTITUTED PYRIDAZINONE COMPOUND
US11964964B2 (en) * 2018-06-12 2024-04-23 Xizang Haisco Pharmaceutical Co., Ltd. Thyroid hormone receptor agonists and uses thereof
CN110627773B (zh) * 2018-06-22 2021-03-19 海创药业股份有限公司 氘代mgl-3196化合物及其用途
AR115666A1 (es) * 2018-07-02 2021-02-10 Madrigal Pharmaceuticals Inc Formas sólidas de 2-(3,5-dicloro-4-((5-isopropil-6-oxo-1,6-dihidropiridazin-3-il)oxi)fenil)-3,5-dioxo-2,3,4,5-tetrahidro-1,2,4-triazin-6-carbonitrilo
US12391677B2 (en) 2018-10-12 2025-08-19 InventisBio Co., Ltd. Thyroid hormone receptor agonists
CN111320609A (zh) 2018-12-13 2020-06-23 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
EP3927693A4 (en) * 2019-02-21 2023-04-05 Nanjing Ruijie Pharma Co., Ltd. NOVEL COMPOUNDS AND THEIR USES AS THYROID HORMONE RECEPTOR AGONISTS
RS66686B1 (sr) * 2019-05-08 2025-05-30 Aligos Therapeutics Inc Modulatori thr-beta sa glavnom diokso-1,2,4-triazil grupom
WO2020228577A1 (zh) * 2019-05-10 2020-11-19 深圳微芯生物科技股份有限公司 一种哒嗪酮衍生物及其应用
WO2020239076A1 (zh) * 2019-05-29 2020-12-03 南京明德新药研发有限公司 作为甲状腺素受体-β激动剂的哒嗪酮类衍生物及其应用
CN112442013B (zh) * 2019-09-04 2022-07-26 广东东阳光药业有限公司 一种作为甲状腺激素β受体激动剂的化合物及其用途
AU2020346057A1 (en) 2019-09-12 2022-04-21 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
WO2021063367A1 (zh) * 2019-09-30 2021-04-08 苏州科睿思制药有限公司 一种Resmetirom晶型及其制备方法和用途
CN112707892A (zh) * 2019-10-24 2021-04-27 苏州泽璟生物制药股份有限公司 哒嗪酮或哒嗪类化合物及其衍生物和药物组合物
TWI763147B (zh) 2019-11-26 2022-05-01 大陸商昆藥集團股份有限公司 1，2，4-三嗪-3，5-二酮類化合物及其製備方法和應用
WO2021121210A1 (zh) * 2019-12-16 2021-06-24 江苏恒瑞医药股份有限公司 并环类衍生物、其制备方法及其在医药上的应用
CN114787153A (zh) 2019-12-26 2022-07-22 苏州科睿思制药有限公司 一种Resmetirom晶型及其制备方法和用途
CN116056709A (zh) * 2020-08-27 2023-05-02 益方生物科技(上海)股份有限公司 哒嗪酮化合物
CN116171275B (zh) * 2020-09-10 2025-09-05 苏州科睿思制药有限公司 Resmetirom的晶型及其制备方法和用途
EP4204419A1 (en) 2020-10-19 2023-07-05 Teva Pharmaceuticals International GmbH Solid state forms of resmetirom
CN114437042A (zh) * 2020-11-03 2022-05-06 深圳微芯生物科技股份有限公司 酞嗪类化合物的晶型及其制备方法
CN114437034A (zh) * 2020-11-06 2022-05-06 深圳微芯生物科技股份有限公司 一种酞嗪类化合物的可药用盐、晶型及其制备方法
WO2022165227A1 (en) 2021-02-01 2022-08-04 Madrigal Pharmaceuticals, Inc. Therapeutic combinations of rosuvastatin and resmetirom for the treatment of liver disorders or lipid disorders
CN114907327A (zh) * 2021-02-10 2022-08-16 杭州领业医药科技有限公司 Resmetirom的晶型及其制备方法和用途
CN115073429A (zh) * 2021-03-15 2022-09-20 昆药集团股份有限公司 一种1，2，4-三嗪-3，5-二酮类化合物的盐型、晶型及其制备方法
TW202337470A (zh) 2021-09-27 2023-10-01 美商瑪德瑞高製藥公司 用於縮減肝臟體積之瑞美替隆
WO2024165571A2 (en) 2023-02-06 2024-08-15 E-Therapeutics Plc Inhibitors of expression and/or function
EP4568664A1 (en) 2023-04-07 2025-06-18 Terns Pharmaceuticals, Inc. Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating a liver disorder or a cardiometabolic disease
CN116768802B (zh) * 2023-05-25 2025-11-21 杭州科巢生物科技有限公司 一种瑞司美替罗的合成方法
WO2024263714A1 (en) 2023-06-22 2024-12-26 Madrigal Pharmaceuticals, Inc. BIOMARKERS FOR TREATING LIVER DISORDERS WITH THR-β AGONISTS AND RELATED USES
CN119613386A (zh) * 2023-09-14 2025-03-14 杭州科巢生物科技有限公司 一种瑞司美替罗1,4-二氧六环溶剂化合物及其制备方法
CN117263870A (zh) * 2023-09-21 2023-12-22 江西同和药业股份有限公司 一种Resmetirom关键中间体III的制备方法
WO2025083699A2 (en) 2023-10-16 2025-04-24 Cipla Limited Resmetirom polymorphs and process thereof
WO2025125576A2 (en) 2023-12-15 2025-06-19 E-Therapeutics Plc Inhibitors of expression and/or function
WO2025133348A1 (en) 2023-12-22 2025-06-26 E-Therapeutics Plc Inhibitors of expression and/or function
WO2025164161A1 (ja) * 2024-01-29 2025-08-07 シオノギファーマ株式会社 カンナビジオールの溶媒和物及びカンナビジオールの精製方法
WO2025171032A1 (en) 2024-02-06 2025-08-14 Madrigal Pharmaceuticals, Inc. Methods for treating a fatty liver disease
US12377104B1 (en) 2024-02-06 2025-08-05 Madrigal Pharmaceuticals, Inc. Methods for treating a fatty liver disease
WO2025191457A1 (en) * 2024-03-13 2025-09-18 Morepen Laboratories Limited Process for the preparation of pyridazinone derivative
CN119306670A (zh) * 2024-10-12 2025-01-14 北京海美桐医药科技有限公司 瑞司美替罗中间体、其合成方法和瑞司美替罗的合成方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5615272A (en) * 1979-07-17 1981-02-14 Ishihara Sangyo Kaisha Ltd N-benzoyl-n'-phenylurea compound, its preparation, and insecticide containing the same
GB0028429D0 (en) 2000-11-22 2001-01-10 Astrazeneca Ab Therapy
ES2328571T3 (es) * 2003-01-28 2009-11-16 Academisch Ziekenhuis Leiden Inhibidores de peptidos de toxinas derivados de ll-37.
EP1608629A1 (en) 2003-03-24 2005-12-28 F. Hoffmann-La Roche Ag Benzyl-pyridazinons as reverse transcriptase inhibitors
ITRM20030363A1 (it) 2003-07-24 2005-01-25 Fernando Goglia Composizioni comprendenti la 3, 5diiodotironina e uso farmaceutico di esse.
US20050287667A1 (en) 2004-06-01 2005-12-29 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
US7807647B2 (en) * 2004-06-01 2010-10-05 Pronai Therapeutics, Inc. Methods and compositions for cancer therapy
ES2441718T3 (es) 2004-11-02 2014-02-06 Northwestern University Compuestos de piridazina, composiciones y métodos
ES2349131T3 (es) 2005-07-21 2010-12-28 F. Hoffmann-La Roche Ag Derivados de piridazinona como agonistas del receptor de la hormona tiroidea.
KR101152965B1 (ko) 2007-06-06 2012-06-08 토렌트 파마슈티칼스 리미티드 신규한 화합물
US8076334B2 (en) * 2007-09-20 2011-12-13 Hoffmann-La Roche Inc. Prodrugs of thyroid hormone analogs
RU2018128393A (ru) * 2012-09-17 2019-03-14 Мадригал Фармасьютикалз, Инк. Способ синтеза аналогов гормонов щитовидной железы и их полиморфов
US8858502B2 (en) 2012-10-10 2014-10-14 Alcon Research, Ltd. Systems and methods for external pressure sensing
EP3105234A4 (en) 2014-02-14 2017-11-08 Cempra Pharmaceuticals, Inc. Compositions and methods for treating diabetes and liver diseases
JP2019533019A (ja) 2016-10-18 2019-11-14 マドリガル ファーマシューティカルズ インコーポレイテッドＭａｄｒｉｇａｌ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Ｔｈｒ−ベータアゴニストで肝臓障害又は脂質障害を治療する方法
US11964964B2 (en) 2018-06-12 2024-04-23 Xizang Haisco Pharmaceutical Co., Ltd. Thyroid hormone receptor agonists and uses thereof
AR115666A1 (es) 2018-07-02 2021-02-10 Madrigal Pharmaceuticals Inc Formas sólidas de 2-(3,5-dicloro-4-((5-isopropil-6-oxo-1,6-dihidropiridazin-3-il)oxi)fenil)-3,5-dioxo-2,3,4,5-tetrahidro-1,2,4-triazin-6-carbonitrilo
US12391677B2 (en) 2018-10-12 2025-08-19 InventisBio Co., Ltd. Thyroid hormone receptor agonists
CN111320609A (zh) 2018-12-13 2020-06-23 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途

Also Published As

Publication number Publication date
EP4406594B1 (en) 2025-09-10
WO2014043706A8 (en) 2017-10-19
JP6765408B2 (ja) 2020-10-07
US20210161904A1 (en) 2021-06-03
NZ739645A (en) 2019-11-29
LT4406594T (lt) 2025-12-29
TWI804870B (zh) 2023-06-11
SG10201705984XA (en) 2017-08-30
HK1212682A1 (en) 2016-06-17
CA3111317C (en) 2023-08-29
CA3111317A1 (en) 2014-03-20
IL275393B (en) 2022-01-01
KR20180131647A (ko) 2018-12-10
DK4406594T3 (da) 2025-11-03
JP2025179154A (ja) 2025-12-09
EP4023641A3 (en) 2022-09-14
EP2895466A1 (en) 2015-07-22
AU2013315017B2 (en) 2017-07-27
CA2884481C (en) 2021-04-27
AR092872A1 (es) 2015-05-06
US20240148742A1 (en) 2024-05-09
TW202134217A (zh) 2021-09-16
ES2795450T3 (es) 2020-11-23
RU2018128393A3 (Direct) 2019-04-16
EP4023641A2 (en) 2022-07-06
EP4406594A2 (en) 2024-07-31
JP7436542B2 (ja) 2024-02-21
IL237628A0 (en) 2015-04-30
MY170520A (en) 2019-08-08
JP2024056793A (ja) 2024-04-23
KR102363776B1 (ko) 2022-02-15
IL314360B2 (en) 2025-09-01
KR20210083381A (ko) 2021-07-06
CA2884481A1 (en) 2014-03-20
CN105008335B (zh) 2018-12-21
WO2014043706A1 (en) 2014-03-20
EP4406594A3 (en) 2024-11-06
JP2018080188A (ja) 2018-05-24
RU2015114327A (ru) 2016-11-10
IL314360B1 (en) 2025-05-01
SG10202006058QA (en) 2020-08-28
CN105008335A (zh) 2015-10-28
IL320269A (en) 2025-06-01
BR112015005891A2 (pt) 2017-08-08
IL259610B (en) 2020-06-30
US20180228807A1 (en) 2018-08-16
JP6616688B2 (ja) 2019-12-04
KR20200023528A (ko) 2020-03-04
JP7038745B2 (ja) 2022-03-18
KR20150056630A (ko) 2015-05-26
US20150203473A1 (en) 2015-07-23
MX2015003418A (es) 2016-04-04
KR101966490B1 (ko) 2019-08-14
US10376517B2 (en) 2019-08-13
US9266861B2 (en) 2016-02-23
TWI652260B (zh) 2019-03-01
IL265030B (en) 2020-07-30
TW201946917A (zh) 2019-12-16
JP2022078218A (ja) 2022-05-24
RU2018128393A (ru) 2019-03-14
TWI681957B (zh) 2020-01-11
BR122021024202B1 (pt) 2022-05-17
US20190381053A1 (en) 2019-12-19
DK2895466T3 (da) 2020-06-08
CA3090070C (en) 2023-01-24
JP6532931B2 (ja) 2019-06-19
PT4406594T (pt) 2025-11-28
JP2020015739A (ja) 2020-01-30
US20230210856A1 (en) 2023-07-06
AU2013315017C1 (en) 2017-11-23
EP4023641B1 (en) 2024-05-01
US9968612B2 (en) 2018-05-15
JP6899413B2 (ja) 2021-07-07
ZA201501795B (en) 2021-10-27
JP2019048856A (ja) 2019-03-28
AU2013315017A1 (en) 2015-04-02
DK3689853T3 (da) 2022-03-07
US10894050B2 (en) 2021-01-19
IL275393A (en) 2020-07-30
CN108101851A (zh) 2018-06-01
MX364661B (es) 2019-05-03
IL288133B1 (en) 2024-08-01
IL288133B2 (en) 2024-12-01
EP2895466A4 (en) 2016-08-10
IL314360A (en) 2024-09-01
EP3689853B1 (en) 2021-11-24
FI4406594T3 (fi) 2025-11-26
TW201906835A (zh) 2019-02-16
US11564926B2 (en) 2023-01-31
RU2668960C2 (ru) 2018-10-05
TWI755628B (zh) 2022-02-21
US20240122936A1 (en) 2024-04-18
MX2018014924A (es) 2020-09-02
TW201425300A (zh) 2014-07-01
IN2015DN03133A (Direct) 2015-10-02
JP2015535817A (ja) 2015-12-17
MX395148B (es) 2025-03-24
IL259610A (en) 2018-07-31
EP3689853A1 (en) 2020-08-05
KR102138750B1 (ko) 2020-07-29
US20160243126A1 (en) 2016-08-25
ES2907926T3 (es) 2022-04-27
JP2020109090A (ja) 2020-07-16
EP2895466B1 (en) 2020-03-25
CA3090070A1 (en) 2014-03-20
US11986481B2 (en) 2024-05-21
IL237628B (en) 2019-07-31
SG11201501907YA (en) 2015-04-29
IL288133A (en) 2022-01-01

Similar Documents

Publication Publication Date Title
NZ705827A (en) Method of synthesizing thyroid hormone analogs and polymorphs thereof
MX350892B (es) Síntesis de compuesto antiviral.
PH12015502839B1 (en) Antiviral compounds
PH12012501438A1 (en) Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
IN2014MN02459A (Direct)
PH12015500644A1 (en) Novel rig-i ligands and methods for producing them
WO2012031045A3 (en) Phosphonate ester derivatives and methods of synthesis thereof
MX2010009860A (es) Sintesis total de salinosporamida a y sus analogos.
MX2014014138A (es) Procedimiento nuevo para la preparacion de acido 2-ciclopentil-6-metoxi-isonicotinico.
IN2014DN00144A (Direct)
PT2462098E (pt) Processos para a preparação de derivados de ácido 1-(2- halobifenil-4-il)-ciclopropanocarboxílico
IN2015MN00013A (Direct)
TN2012000436A1 (en) Agomelatine hydrobromide hydrate and preparation thereof
EA201391721A1 (ru) Способ получения полиморфной формы i эторикоксиба
MX348274B (es) Procedimiento de preparacion de cloruros de 1-alquil-3-fluoroalqui l-1h-pirazol-4-carbonilo.
WO2012115402A3 (en) Crystalline form of docetaxel and process for preparation thereof
PH12013500609A1 (en) Novel method of preparing benzoimidazole derivatives
MX355336B (es) Metodo para preparar un compuesto mediante la reaccion de adicion de michael novedosa usando agua o varios acidos como aditivo.
WO2013046233A3 (en) Process for the preparation of octreotide acetate
GR1007722B (el) Μεθοδος για την παρασκευη της αριπιπραζολης
GEP20156369B (en) New process for synthesis of ivabradine and addition salts therewith pharmaceutically acceptable acid
IN2013DE02989A (Direct)
PH12014501760B1 (en) Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro[5.5]undecanes
IN2013DE00241A (Direct)
IN2012DE00267A (Direct)

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 SEP 2020 BY COMPUTER PACKAGES INC

Effective date: 20190831

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 SEP 2021 BY COMPUTER PACKAGES INC

Effective date: 20200901

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 SEP 2022 BY COMPUTER PACKAGES INC

Effective date: 20210830

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 SEP 2023 BY COMPUTER PACKAGES INC

Effective date: 20220830

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 SEP 2024 BY COMPUTER PACKAGES INC

Effective date: 20230830

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 SEP 2025 BY COMPUTER PACKAGES INC

Effective date: 20240830

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 17 SEP 2026 BY COMPUTER PACKAGES INC

Effective date: 20250830