NZ600999A - Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants - Google Patents
Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactantsInfo
- Publication number
- NZ600999A NZ600999A NZ600999A NZ60099910A NZ600999A NZ 600999 A NZ600999 A NZ 600999A NZ 600999 A NZ600999 A NZ 600999A NZ 60099910 A NZ60099910 A NZ 60099910A NZ 600999 A NZ600999 A NZ 600999A
- Authority
- NZ
- New Zealand
- Prior art keywords
- mole
- fatty acids
- esters
- solvent mixture
- group
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000004094 surface-active agent Substances 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 title 1
- 229940046008 vitamin d Drugs 0.000 title 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 4
- 239000000194 fatty acid Substances 0.000 abstract 4
- 229930195729 fatty acid Natural products 0.000 abstract 4
- 150000004665 fatty acids Chemical class 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 3
- 239000011877 solvent mixture Substances 0.000 abstract 3
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 3
- 239000008158 vegetable oil Substances 0.000 abstract 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 201000004681 Psoriasis Diseases 0.000 abstract 2
- 125000005456 glyceride group Chemical group 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical class OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 abstract 1
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- DTXXSJZBSTYZKE-ZDQKKZTESA-N Maxacalcitol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](OCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C DTXXSJZBSTYZKE-ZDQKKZTESA-N 0.000 abstract 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 1
- 241001303601 Rosacea Species 0.000 abstract 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 abstract 1
- 229960002535 alfacalcidol Drugs 0.000 abstract 1
- LWQQLNNNIPYSNX-UROSTWAQSA-N calcipotriol Chemical compound C1([C@H](O)/C=C/[C@@H](C)[C@@H]2[C@]3(CCCC(/[C@@H]3CC2)=C\C=C\2C([C@@H](O)C[C@H](O)C/2)=C)C)CC1 LWQQLNNNIPYSNX-UROSTWAQSA-N 0.000 abstract 1
- 229960002882 calcipotriol Drugs 0.000 abstract 1
- 229960005084 calcitriol Drugs 0.000 abstract 1
- 235000020964 calcitriol Nutrition 0.000 abstract 1
- 239000011612 calcitriol Substances 0.000 abstract 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- -1 glycol monoalkyl ethers Chemical class 0.000 abstract 1
- 150000002334 glycols Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 229950006319 maxacalcitol Drugs 0.000 abstract 1
- 229940057917 medium chain triglycerides Drugs 0.000 abstract 1
- 239000004530 micro-emulsion Substances 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 239000012188 paraffin wax Substances 0.000 abstract 1
- 229960000987 paricalcitol Drugs 0.000 abstract 1
- BPKAHTKRCLCHEA-UBFJEZKGSA-N paricalcitol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1C[C@@H](O)C[C@H](O)C1 BPKAHTKRCLCHEA-UBFJEZKGSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000004700 rosacea Diseases 0.000 abstract 1
- 229960004907 tacalcitol Drugs 0.000 abstract 1
- BJYLYJCXYAMOFT-RSFVBTMBSA-N tacalcitol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CC[C@@H](O)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C BJYLYJCXYAMOFT-RSFVBTMBSA-N 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK2009000265 | 2009-12-22 | ||
| US29310510P | 2010-01-07 | 2010-01-07 | |
| PCT/DK2010/000182 WO2011076207A2 (en) | 2009-12-22 | 2010-12-22 | Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ600999A true NZ600999A (en) | 2014-06-27 |
Family
ID=43618132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ600999A NZ600999A (en) | 2009-12-22 | 2010-12-22 | Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20120322776A1 (https=) |
| EP (1) | EP2515865B1 (https=) |
| JP (1) | JP5873439B2 (https=) |
| CN (1) | CN102781425B (https=) |
| AU (1) | AU2010335654B2 (https=) |
| BR (1) | BR112012015433B8 (https=) |
| CA (1) | CA2785251A1 (https=) |
| IL (1) | IL220514A (https=) |
| MX (1) | MX2012007229A (https=) |
| NZ (1) | NZ600999A (https=) |
| RU (1) | RU2560677C2 (https=) |
| WO (1) | WO2011076207A2 (https=) |
| ZA (1) | ZA201204620B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5570442B2 (ja) * | 2011-01-24 | 2014-08-13 | 株式会社シャネル化粧品技術開発研究所 | 水中油型乳化組成物及びその製造方法 |
| EP2925364A1 (en) | 2012-11-30 | 2015-10-07 | Leo Pharma A/S | A method of inhibiting the expression of il-22 in activated t-cells |
| ES2669246T3 (es) * | 2013-12-19 | 2018-05-24 | Universiteit Gent | Cuantificación de glucocorticoides en escamas, espinas, radios de aletas u otolitos de peces como biomarcadores de estrés crónico |
| CN104666312B (zh) * | 2015-02-12 | 2017-11-07 | 重庆华邦制药有限公司 | 含有卡泊三醇和二丙酸倍他米松的制剂 |
| CN106265511A (zh) * | 2016-08-22 | 2017-01-04 | 江苏知原药业有限公司 | 一种性能优异的卡泊三醇倍他米松自微乳制剂 |
| CN106265485A (zh) * | 2016-08-22 | 2017-01-04 | 江苏知原药业有限公司 | 一种稳定性改善的卡泊三醇组合物 |
| CN106442841B (zh) * | 2016-12-16 | 2018-09-14 | 上海景峰制药有限公司 | 一种药物中阳离子表面活性剂的分离检测方法 |
| EP3639854B1 (en) | 2017-06-16 | 2026-01-07 | The Doshisha | Mtor-inhibitor-containing medicine for treating or preventing fuchs' endothelial corneal dystrophy |
| KR102678365B1 (ko) * | 2018-03-20 | 2024-06-26 | 재단법인 경기도경제과학진흥원 | 콜레칼시페롤의 가용화 조성물 및 그 제조방법 |
| EP3741378A1 (de) | 2019-05-23 | 2020-11-25 | Dimitrios Tsakouridis | Zusammensetzung zur topischen behandlung und pflege der psoriatischen haut |
| CA3091554A1 (en) * | 2020-08-28 | 2022-02-28 | Triple Hair Inc. | Formulations for reducing hair loss and/or increasing hair regrowth |
| JP2024163642A (ja) * | 2023-05-12 | 2024-11-22 | アピ株式会社 | 外用組成物 |
| JP7633712B2 (ja) * | 2023-05-12 | 2025-02-20 | アピ株式会社 | 外用組成物 |
| CN118304279B (zh) * | 2024-03-27 | 2025-04-25 | 青岛双鲸药业股份有限公司 | 一种骨化三醇自微乳口溶膜及其制备方法 |
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| US5766628A (en) * | 1992-02-24 | 1998-06-16 | Merz + Co. Gmbh & Co. | Bath and shower composition having vesicle-forming properties and method for the production and use thereof |
| GB9300763D0 (en) | 1993-01-15 | 1993-03-03 | Leo Pharm Prod Ltd | Chemical compound |
| TW438603B (en) | 1993-04-19 | 2001-06-07 | Advanced Skin Res Kenkyusho Kk | Microemulsion preparation containing peptide pharmaceuticals |
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| GB9602111D0 (en) * | 1996-02-02 | 1996-04-03 | Unilever Plc | Personal care composition |
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| CA2685516A1 (en) | 2007-05-11 | 2008-11-20 | Sonneborn Inc. | Petrolatums having silicone-like properties |
| US20080299156A1 (en) * | 2007-06-01 | 2008-12-04 | L'oreal | Skin care compositions containing a high internal phase emulsion |
| RU2544011C2 (ru) | 2008-12-19 | 2015-03-10 | Лео Фарма А/С | Триазолопиридины в качестве ингибиторов фосфодиэстеразы для лечения кожных заболеваний |
| WO2011000765A1 (en) * | 2009-06-29 | 2011-01-06 | Glaxo Group Limited | New medical use |
-
2010
- 2010-12-22 BR BR112012015433A patent/BR112012015433B8/pt active IP Right Grant
- 2010-12-22 WO PCT/DK2010/000182 patent/WO2011076207A2/en not_active Ceased
- 2010-12-22 US US13/518,320 patent/US20120322776A1/en not_active Abandoned
- 2010-12-22 CA CA2785251A patent/CA2785251A1/en not_active Abandoned
- 2010-12-22 AU AU2010335654A patent/AU2010335654B2/en active Active
- 2010-12-22 RU RU2012130421/15A patent/RU2560677C2/ru active
- 2010-12-22 CN CN201080063418.7A patent/CN102781425B/zh active Active
- 2010-12-22 JP JP2012545090A patent/JP5873439B2/ja active Active
- 2010-12-22 NZ NZ600999A patent/NZ600999A/en unknown
- 2010-12-22 EP EP10803218.6A patent/EP2515865B1/en active Active
- 2010-12-22 MX MX2012007229A patent/MX2012007229A/es active IP Right Grant
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2012
- 2012-06-19 IL IL220514A patent/IL220514A/en active IP Right Grant
- 2012-06-21 ZA ZA2012/04620A patent/ZA201204620B/en unknown
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2016
- 2016-07-19 US US15/214,216 patent/US20160324875A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2515865B1 (en) | 2016-12-14 |
| AU2010335654B2 (en) | 2015-04-09 |
| RU2560677C2 (ru) | 2015-08-20 |
| BR112012015433A2 (pt) | 2016-03-15 |
| ZA201204620B (en) | 2013-09-25 |
| BR112012015433B1 (pt) | 2019-04-24 |
| CA2785251A1 (en) | 2011-06-30 |
| MX2012007229A (es) | 2012-07-30 |
| HK1177899A1 (en) | 2013-08-30 |
| RU2012130421A (ru) | 2014-01-27 |
| CN102781425B (zh) | 2014-08-13 |
| WO2011076207A3 (en) | 2012-03-01 |
| JP2013515018A (ja) | 2013-05-02 |
| AU2010335654A1 (en) | 2012-07-26 |
| BR112012015433B8 (pt) | 2020-03-03 |
| US20160324875A1 (en) | 2016-11-10 |
| EP2515865A2 (en) | 2012-10-31 |
| CN102781425A (zh) | 2012-11-14 |
| JP5873439B2 (ja) | 2016-03-01 |
| WO2011076207A2 (en) | 2011-06-30 |
| IL220514A (en) | 2017-01-31 |
| US20120322776A1 (en) | 2012-12-20 |
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