NZ587134A - Protopanaxadiol-type ginsenoside compositions and uses thereof - Google Patents
Protopanaxadiol-type ginsenoside compositions and uses thereofInfo
- Publication number
- NZ587134A NZ587134A NZ587134A NZ58713409A NZ587134A NZ 587134 A NZ587134 A NZ 587134A NZ 587134 A NZ587134 A NZ 587134A NZ 58713409 A NZ58713409 A NZ 58713409A NZ 587134 A NZ587134 A NZ 587134A
- Authority
- NZ
- New Zealand
- Prior art keywords
- ginsenoside
- subject
- composition
- acetaldehyde
- disease
- Prior art date
Links
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US2331008P | 2008-01-24 | 2008-01-24 | |
| PCT/US2009/000431 WO2009094177A1 (en) | 2008-01-24 | 2009-01-23 | Protopanaxadiol-type ginsenoside compositions and uses thereof |
Publications (1)
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| NZ587134A true NZ587134A (en) | 2012-04-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| NZ587134A NZ587134A (en) | 2008-01-24 | 2009-01-23 | Protopanaxadiol-type ginsenoside compositions and uses thereof |
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| DK (1) | DK2254569T3 (enExample) |
| ES (1) | ES2400491T3 (enExample) |
| MY (1) | MY160074A (enExample) |
| NZ (1) | NZ587134A (enExample) |
| TW (1) | TWI440463B (enExample) |
| WO (1) | WO2009094177A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5563285B2 (ja) * | 2009-12-14 | 2014-07-30 | ライオン株式会社 | 飲食品、医薬品、又は医薬部外品、並びに、プロトパナキサトリオールの安定化方法、及びプロトパナキサジオールの安定化方法 |
| WO2013078371A2 (en) | 2011-11-22 | 2013-05-30 | The Johns Hopkins University | Methods and compositions for reducing alcohol toxicity |
| KR101446743B1 (ko) * | 2012-06-11 | 2014-10-01 | 한국생명공학연구원 | 실리마린을 유효성분으로 포함하는 알콜성 위궤양 예방 및 치료용 조성물 |
| CN102727508B (zh) * | 2012-07-15 | 2014-09-24 | 浙江大学 | 人参二醇皂苷组分制备及在防治帕金森氏病中的药物用途 |
| US11338120B2 (en) | 2012-08-29 | 2022-05-24 | Palo Alto Investors LP | Methods and devices for treating parasympathetic bias mediated conditions |
| WO2014178803A1 (en) * | 2013-04-29 | 2014-11-06 | Alkoçlar Erdal Can | A composition for use in the treatment of alcohol addiction |
| KR101621356B1 (ko) * | 2014-09-05 | 2016-05-17 | 한국과학기술원 | 진세노사이드 f2의 간 질환 예방 또는 치료 용도 |
| KR102299294B1 (ko) * | 2014-10-28 | 2021-09-07 | 로버스트 씨드 테크놀로지 에이 앤드 에프 악티에볼라그 | 종자 프라이밍을 위한 개선된 방법 |
| ES2926494T3 (es) * | 2015-03-26 | 2022-10-26 | Sen Jam Pharmaceutical Llc | Combinación de naproxeno y fexofenadina para inhibir los síntomas asociados con veisalgia |
| KR101641477B1 (ko) * | 2016-01-19 | 2016-07-20 | 이국진 | 홍삼 추출물을 이용한 커피나무의 재배방법 |
| CN106619669B (zh) * | 2016-12-02 | 2019-03-29 | 延边大学 | 原人参二醇皂苷在制备防治炎症疾病的药物中的应用 |
| CN106511360A (zh) * | 2016-12-02 | 2017-03-22 | 上海芮范生物科技有限公司 | 一种含有人参皂苷Rg3和水飞蓟素的组合物及药物 |
| CN107441104B (zh) * | 2017-08-24 | 2023-07-21 | 浙江大学 | 人参二醇皂苷Rb组分防治糖尿病并发症及代谢紊乱相关疾病的医药用途 |
| KR102053208B1 (ko) * | 2018-03-15 | 2019-12-06 | 숙명여자대학교 산학협력단 | 진세노사이드 Rb1 및 Rb2를 유효성분으로 함유하는 근육 재생용 조성물 |
| KR102138252B1 (ko) * | 2018-05-16 | 2020-07-29 | 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 | 효모의 nadph 관련 생합성 경로의 개량을 통한 진세노사이드 생산 증대 |
| CN111053782B (zh) * | 2018-10-17 | 2024-07-05 | 株式会社爱茉莉太平洋 | 包含人参皂苷的组合物 |
| US11000538B2 (en) * | 2018-10-31 | 2021-05-11 | Amorepacific Corporation | Composition for enhancing exercise ability or anti-fatigue comprising novel ginsenoside |
| KR102672902B1 (ko) * | 2018-10-31 | 2024-06-10 | (주)아모레퍼시픽 | 신규 진세노사이드를 포함하는 숙취 해소용 조성물 |
| CN109758464B (zh) * | 2019-03-21 | 2019-10-25 | 淮阴师范学院 | 越南人参皂苷r4在制备神经退行性疾病治疗药物中的应用 |
| KR20220081351A (ko) | 2019-10-10 | 2022-06-15 | 조브리어스 파르마 에이에스 | 개선된 숙취해소 조성물, 이의 제조 및 용도 |
| KR102654669B1 (ko) * | 2021-06-30 | 2024-04-04 | 경희대학교 산학협력단 | 실리디아닌을 포함하는 인삼 금 나노에멀젼 및 이의 용도 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1574806A (en) | 1976-06-03 | 1980-09-10 | Inverni Della Beffa Spa | Production of purified ginseng extracts and pharmaceutical compositions containing the extracts |
| US4966893A (en) | 1989-01-13 | 1990-10-30 | Pang Peter K T | Method for treatment of senile dementia |
| JPH04316448A (ja) | 1991-04-12 | 1992-11-06 | Iwatani Internatl Corp | 人参微粉末の製造方法 |
| US5547671A (en) * | 1995-09-20 | 1996-08-20 | Duthinh; Phu | Anti-intoxication composition |
| JP3656972B2 (ja) * | 1997-02-14 | 2005-06-08 | 丸善製薬株式会社 | アルコール臭低減剤 |
| US6083932A (en) | 1997-04-18 | 2000-07-04 | Cv Technologies Inc. | Pharmaceutical compositions derived from ginseng and methods of treatment using same |
| KR20010023208A (ko) | 1997-08-28 | 2001-03-26 | 브루스, 제임스 에이취 | 허브 추출물의 화학 및 약리학적 표준화 |
| KR20020035855A (ko) | 1999-08-30 | 2002-05-15 | 마쯔오 미쯔요시 | 약용인삼을 포함하는 뇌세포 또는 신경세포 보호제 |
| CA2307393A1 (en) * | 2000-05-01 | 2001-11-01 | The University Of British Columbia | Ginsenoside chemotherapy |
| CN1167424C (zh) * | 2000-11-18 | 2004-09-22 | 唐修文 | 三七人参皂甙肠溶片 |
| US7011096B2 (en) * | 2001-08-31 | 2006-03-14 | Philip Morris Usa Inc. | Oxidant/catalyst nanoparticles to reduce carbon monoxide in the mainstream smoke of a cigarette |
| US20030185910A1 (en) * | 2002-02-08 | 2003-10-02 | Taik Koo Yun | Cancer preventive composition comprising ginsenoside glycosides of red ginseng |
| US6936283B2 (en) * | 2003-07-25 | 2005-08-30 | Langeland Bjoern T. | Composition for stimulation of specific metallo-enzymes |
| US7186517B2 (en) * | 2003-08-01 | 2007-03-06 | Aesgen, Inc. | Compositions and methods for monitoring breast cancer treatment |
| CN100563668C (zh) * | 2003-08-18 | 2009-12-02 | 株式会社柳柳 | 使用醋的人参制剂及其加工 |
| KR20050081247A (ko) * | 2004-02-12 | 2005-08-18 | 이처준 | 홍삼 및 흑삼을 이용한 해장국 제조 방법. |
| US20080021083A1 (en) * | 2004-03-03 | 2008-01-24 | Daley Thomas E | 4-Methylpyrazole Formulations for Inhibiting Ethanol Intolerance |
| KR100547253B1 (ko) | 2004-05-29 | 2006-01-26 | 박명환 | 암 예방 및 치료에 유효한 진세노사이드 유도체 |
| CN1698879B (zh) * | 2005-06-21 | 2010-08-11 | 蔺益民 | 具有解酒护肝功能的产品及制备方法和用途 |
| PL1909600T3 (pl) * | 2005-07-29 | 2012-09-28 | Tima Found | Kompozycja spowalniająca metabolizm alkoholu i ograniczająca ryzyko chorób wywołanych alkoholem |
-
2009
- 2009-01-23 MY MYPI2010003500A patent/MY160074A/en unknown
- 2009-01-23 EP EP09704632A patent/EP2254569B1/en not_active Not-in-force
- 2009-01-23 CA CA2713104A patent/CA2713104C/en not_active Expired - Fee Related
- 2009-01-23 WO PCT/US2009/000431 patent/WO2009094177A1/en not_active Ceased
- 2009-01-23 DK DK09704632.0T patent/DK2254569T3/da active
- 2009-01-23 NZ NZ587134A patent/NZ587134A/en not_active IP Right Cessation
- 2009-01-23 KR KR1020167010378A patent/KR20160048228A/ko not_active Withdrawn
- 2009-01-23 CN CN2009801101030A patent/CN101977600B/zh not_active Expired - Fee Related
- 2009-01-23 AU AU2009206753A patent/AU2009206753B2/en not_active Ceased
- 2009-01-23 TW TW098103157A patent/TWI440463B/zh not_active IP Right Cessation
- 2009-01-23 US US12/863,979 patent/US8440632B2/en not_active Expired - Fee Related
- 2009-01-23 KR KR1020107018644A patent/KR101648987B1/ko not_active Expired - Fee Related
- 2009-01-23 JP JP2010544334A patent/JP5523348B2/ja not_active Expired - Fee Related
- 2009-01-23 ES ES09704632T patent/ES2400491T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009206753A1 (en) | 2009-07-30 |
| AU2009206753B2 (en) | 2014-07-03 |
| CN101977600B (zh) | 2013-02-27 |
| KR101648987B1 (ko) | 2016-08-17 |
| US8440632B2 (en) | 2013-05-14 |
| CA2713104A1 (en) | 2009-07-30 |
| TW200936144A (en) | 2009-09-01 |
| ES2400491T3 (es) | 2013-04-10 |
| HK1144772A1 (en) | 2011-03-11 |
| WO2009094177A1 (en) | 2009-07-30 |
| DK2254569T3 (da) | 2013-02-25 |
| TWI440463B (zh) | 2014-06-11 |
| KR20160048228A (ko) | 2016-05-03 |
| CN101977600A (zh) | 2011-02-16 |
| KR20100111300A (ko) | 2010-10-14 |
| JP5523348B2 (ja) | 2014-06-18 |
| JP2011510075A (ja) | 2011-03-31 |
| EP2254569B1 (en) | 2012-11-28 |
| US20110065659A1 (en) | 2011-03-17 |
| MY160074A (en) | 2017-02-15 |
| CA2713104C (en) | 2016-07-12 |
| EP2254569A1 (en) | 2010-12-01 |
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