DK2254569T3 - Ginsenosid-sammensætninger af protopanaxadiol-typen og anvendelser deraf - Google Patents
Ginsenosid-sammensætninger af protopanaxadiol-typen og anvendelser derafInfo
- Publication number
- DK2254569T3 DK2254569T3 DK09704632.0T DK09704632T DK2254569T3 DK 2254569 T3 DK2254569 T3 DK 2254569T3 DK 09704632 T DK09704632 T DK 09704632T DK 2254569 T3 DK2254569 T3 DK 2254569T3
- Authority
- DK
- Denmark
- Prior art keywords
- applications
- protopanaxadiol type
- ginsenoside compositions
- ginsenoside
- protopanaxadiol
- Prior art date
Links
- PYXFVCFISTUSOO-HKUCOEKDSA-N (20S)-protopanaxadiol Chemical group C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@H]([C@@](C)(O)CCC=C(C)C)[C@H]4[C@H](O)C[C@@H]3[C@]21C PYXFVCFISTUSOO-HKUCOEKDSA-N 0.000 title 1
- PYXFVCFISTUSOO-UHFFFAOYSA-N betulafolienetriol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC(C(C)(O)CCC=C(C)C)C4C(O)CC3C21C PYXFVCFISTUSOO-UHFFFAOYSA-N 0.000 title 1
- 229940089161 ginsenoside Drugs 0.000 title 1
- 229930182494 ginsenoside Natural products 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- SWQINCWATANGKN-UHFFFAOYSA-N protopanaxadiol Natural products CC(CCC=C(C)C)C1CCC2(C)C1C(O)CC1C3(C)CCC(O)C(C)(C)C3CCC21C SWQINCWATANGKN-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2331008P | 2008-01-24 | 2008-01-24 | |
| PCT/US2009/000431 WO2009094177A1 (en) | 2008-01-24 | 2009-01-23 | Protopanaxadiol-type ginsenoside compositions and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2254569T3 true DK2254569T3 (da) | 2013-02-25 |
Family
ID=40578016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09704632.0T DK2254569T3 (da) | 2008-01-24 | 2009-01-23 | Ginsenosid-sammensætninger af protopanaxadiol-typen og anvendelser deraf |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8440632B2 (enExample) |
| EP (1) | EP2254569B1 (enExample) |
| JP (1) | JP5523348B2 (enExample) |
| KR (2) | KR20160048228A (enExample) |
| CN (1) | CN101977600B (enExample) |
| AU (1) | AU2009206753B2 (enExample) |
| CA (1) | CA2713104C (enExample) |
| DK (1) | DK2254569T3 (enExample) |
| ES (1) | ES2400491T3 (enExample) |
| MY (1) | MY160074A (enExample) |
| NZ (1) | NZ587134A (enExample) |
| TW (1) | TWI440463B (enExample) |
| WO (1) | WO2009094177A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5563285B2 (ja) * | 2009-12-14 | 2014-07-30 | ライオン株式会社 | 飲食品、医薬品、又は医薬部外品、並びに、プロトパナキサトリオールの安定化方法、及びプロトパナキサジオールの安定化方法 |
| WO2013078371A2 (en) | 2011-11-22 | 2013-05-30 | The Johns Hopkins University | Methods and compositions for reducing alcohol toxicity |
| KR101446743B1 (ko) * | 2012-06-11 | 2014-10-01 | 한국생명공학연구원 | 실리마린을 유효성분으로 포함하는 알콜성 위궤양 예방 및 치료용 조성물 |
| CN102727508B (zh) * | 2012-07-15 | 2014-09-24 | 浙江大学 | 人参二醇皂苷组分制备及在防治帕金森氏病中的药物用途 |
| US11338120B2 (en) | 2012-08-29 | 2022-05-24 | Palo Alto Investors LP | Methods and devices for treating parasympathetic bias mediated conditions |
| WO2014178803A1 (en) * | 2013-04-29 | 2014-11-06 | Alkoçlar Erdal Can | A composition for use in the treatment of alcohol addiction |
| KR101621356B1 (ko) * | 2014-09-05 | 2016-05-17 | 한국과학기술원 | 진세노사이드 f2의 간 질환 예방 또는 치료 용도 |
| KR102299294B1 (ko) * | 2014-10-28 | 2021-09-07 | 로버스트 씨드 테크놀로지 에이 앤드 에프 악티에볼라그 | 종자 프라이밍을 위한 개선된 방법 |
| ES2926494T3 (es) * | 2015-03-26 | 2022-10-26 | Sen Jam Pharmaceutical Llc | Combinación de naproxeno y fexofenadina para inhibir los síntomas asociados con veisalgia |
| KR101641477B1 (ko) * | 2016-01-19 | 2016-07-20 | 이국진 | 홍삼 추출물을 이용한 커피나무의 재배방법 |
| CN106619669B (zh) * | 2016-12-02 | 2019-03-29 | 延边大学 | 原人参二醇皂苷在制备防治炎症疾病的药物中的应用 |
| CN106511360A (zh) * | 2016-12-02 | 2017-03-22 | 上海芮范生物科技有限公司 | 一种含有人参皂苷Rg3和水飞蓟素的组合物及药物 |
| CN107441104B (zh) * | 2017-08-24 | 2023-07-21 | 浙江大学 | 人参二醇皂苷Rb组分防治糖尿病并发症及代谢紊乱相关疾病的医药用途 |
| KR102053208B1 (ko) * | 2018-03-15 | 2019-12-06 | 숙명여자대학교 산학협력단 | 진세노사이드 Rb1 및 Rb2를 유효성분으로 함유하는 근육 재생용 조성물 |
| KR102138252B1 (ko) * | 2018-05-16 | 2020-07-29 | 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 | 효모의 nadph 관련 생합성 경로의 개량을 통한 진세노사이드 생산 증대 |
| CN111053782B (zh) * | 2018-10-17 | 2024-07-05 | 株式会社爱茉莉太平洋 | 包含人参皂苷的组合物 |
| US11000538B2 (en) * | 2018-10-31 | 2021-05-11 | Amorepacific Corporation | Composition for enhancing exercise ability or anti-fatigue comprising novel ginsenoside |
| KR102672902B1 (ko) * | 2018-10-31 | 2024-06-10 | (주)아모레퍼시픽 | 신규 진세노사이드를 포함하는 숙취 해소용 조성물 |
| CN109758464B (zh) * | 2019-03-21 | 2019-10-25 | 淮阴师范学院 | 越南人参皂苷r4在制备神经退行性疾病治疗药物中的应用 |
| KR20220081351A (ko) | 2019-10-10 | 2022-06-15 | 조브리어스 파르마 에이에스 | 개선된 숙취해소 조성물, 이의 제조 및 용도 |
| KR102654669B1 (ko) * | 2021-06-30 | 2024-04-04 | 경희대학교 산학협력단 | 실리디아닌을 포함하는 인삼 금 나노에멀젼 및 이의 용도 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1574806A (en) | 1976-06-03 | 1980-09-10 | Inverni Della Beffa Spa | Production of purified ginseng extracts and pharmaceutical compositions containing the extracts |
| US4966893A (en) | 1989-01-13 | 1990-10-30 | Pang Peter K T | Method for treatment of senile dementia |
| JPH04316448A (ja) | 1991-04-12 | 1992-11-06 | Iwatani Internatl Corp | 人参微粉末の製造方法 |
| US5547671A (en) * | 1995-09-20 | 1996-08-20 | Duthinh; Phu | Anti-intoxication composition |
| JP3656972B2 (ja) * | 1997-02-14 | 2005-06-08 | 丸善製薬株式会社 | アルコール臭低減剤 |
| US6083932A (en) | 1997-04-18 | 2000-07-04 | Cv Technologies Inc. | Pharmaceutical compositions derived from ginseng and methods of treatment using same |
| KR20010023208A (ko) | 1997-08-28 | 2001-03-26 | 브루스, 제임스 에이취 | 허브 추출물의 화학 및 약리학적 표준화 |
| KR20020035855A (ko) | 1999-08-30 | 2002-05-15 | 마쯔오 미쯔요시 | 약용인삼을 포함하는 뇌세포 또는 신경세포 보호제 |
| CA2307393A1 (en) * | 2000-05-01 | 2001-11-01 | The University Of British Columbia | Ginsenoside chemotherapy |
| CN1167424C (zh) * | 2000-11-18 | 2004-09-22 | 唐修文 | 三七人参皂甙肠溶片 |
| US7011096B2 (en) * | 2001-08-31 | 2006-03-14 | Philip Morris Usa Inc. | Oxidant/catalyst nanoparticles to reduce carbon monoxide in the mainstream smoke of a cigarette |
| US20030185910A1 (en) * | 2002-02-08 | 2003-10-02 | Taik Koo Yun | Cancer preventive composition comprising ginsenoside glycosides of red ginseng |
| US6936283B2 (en) * | 2003-07-25 | 2005-08-30 | Langeland Bjoern T. | Composition for stimulation of specific metallo-enzymes |
| US7186517B2 (en) * | 2003-08-01 | 2007-03-06 | Aesgen, Inc. | Compositions and methods for monitoring breast cancer treatment |
| CN100563668C (zh) * | 2003-08-18 | 2009-12-02 | 株式会社柳柳 | 使用醋的人参制剂及其加工 |
| KR20050081247A (ko) * | 2004-02-12 | 2005-08-18 | 이처준 | 홍삼 및 흑삼을 이용한 해장국 제조 방법. |
| US20080021083A1 (en) * | 2004-03-03 | 2008-01-24 | Daley Thomas E | 4-Methylpyrazole Formulations for Inhibiting Ethanol Intolerance |
| KR100547253B1 (ko) | 2004-05-29 | 2006-01-26 | 박명환 | 암 예방 및 치료에 유효한 진세노사이드 유도체 |
| CN1698879B (zh) * | 2005-06-21 | 2010-08-11 | 蔺益民 | 具有解酒护肝功能的产品及制备方法和用途 |
| PL1909600T3 (pl) * | 2005-07-29 | 2012-09-28 | Tima Found | Kompozycja spowalniająca metabolizm alkoholu i ograniczająca ryzyko chorób wywołanych alkoholem |
-
2009
- 2009-01-23 MY MYPI2010003500A patent/MY160074A/en unknown
- 2009-01-23 EP EP09704632A patent/EP2254569B1/en not_active Not-in-force
- 2009-01-23 CA CA2713104A patent/CA2713104C/en not_active Expired - Fee Related
- 2009-01-23 WO PCT/US2009/000431 patent/WO2009094177A1/en not_active Ceased
- 2009-01-23 DK DK09704632.0T patent/DK2254569T3/da active
- 2009-01-23 NZ NZ587134A patent/NZ587134A/en not_active IP Right Cessation
- 2009-01-23 KR KR1020167010378A patent/KR20160048228A/ko not_active Withdrawn
- 2009-01-23 CN CN2009801101030A patent/CN101977600B/zh not_active Expired - Fee Related
- 2009-01-23 AU AU2009206753A patent/AU2009206753B2/en not_active Ceased
- 2009-01-23 TW TW098103157A patent/TWI440463B/zh not_active IP Right Cessation
- 2009-01-23 US US12/863,979 patent/US8440632B2/en not_active Expired - Fee Related
- 2009-01-23 KR KR1020107018644A patent/KR101648987B1/ko not_active Expired - Fee Related
- 2009-01-23 JP JP2010544334A patent/JP5523348B2/ja not_active Expired - Fee Related
- 2009-01-23 ES ES09704632T patent/ES2400491T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009206753A1 (en) | 2009-07-30 |
| AU2009206753B2 (en) | 2014-07-03 |
| CN101977600B (zh) | 2013-02-27 |
| KR101648987B1 (ko) | 2016-08-17 |
| US8440632B2 (en) | 2013-05-14 |
| CA2713104A1 (en) | 2009-07-30 |
| TW200936144A (en) | 2009-09-01 |
| ES2400491T3 (es) | 2013-04-10 |
| HK1144772A1 (en) | 2011-03-11 |
| WO2009094177A1 (en) | 2009-07-30 |
| TWI440463B (zh) | 2014-06-11 |
| KR20160048228A (ko) | 2016-05-03 |
| CN101977600A (zh) | 2011-02-16 |
| KR20100111300A (ko) | 2010-10-14 |
| JP5523348B2 (ja) | 2014-06-18 |
| JP2011510075A (ja) | 2011-03-31 |
| EP2254569B1 (en) | 2012-11-28 |
| US20110065659A1 (en) | 2011-03-17 |
| MY160074A (en) | 2017-02-15 |
| CA2713104C (en) | 2016-07-12 |
| EP2254569A1 (en) | 2010-12-01 |
| NZ587134A (en) | 2012-04-27 |
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