NZ583848A - Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide - Google Patents
Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamideInfo
- Publication number
- NZ583848A NZ583848A NZ583848A NZ58384808A NZ583848A NZ 583848 A NZ583848 A NZ 583848A NZ 583848 A NZ583848 A NZ 583848A NZ 58384808 A NZ58384808 A NZ 58384808A NZ 583848 A NZ583848 A NZ 583848A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- degrees
- peak
- benzene sulfonate
- crystalline compound
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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| US7973169B2 (en) | 2003-09-06 | 2011-07-05 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
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| CN101395147B (zh) | 2005-12-28 | 2013-05-29 | 弗特克斯药品有限公司 | 作为atp-结合盒转运蛋白调节剂用于治疗囊性纤维化的1-(苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(苯基)环丙烷-甲酰胺衍生物及相关化合物 |
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| KR101985044B1 (ko) | 2011-11-08 | 2019-05-31 | 버텍스 파마슈티칼스 인코포레이티드 | Atp-결합 카세트 수송체의 조절제 |
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| AR118555A1 (es) | 2019-04-03 | 2021-10-20 | Vertex Pharma | Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| US12303502B2 (en) | 2019-04-18 | 2025-05-20 | Kinedexe UK Limited | Oral liquid composition comprising ivacaftor |
| TWI867024B (zh) | 2019-08-14 | 2024-12-21 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
| CA3150162A1 (en) | 2019-08-14 | 2021-02-18 | Vertex Pharmaceuticals Incorporated | Crystalline forms of cftr modulators |
| TWI899097B (zh) | 2019-08-14 | 2025-10-01 | 美商維泰克斯製藥公司 | 製備cftr調節劑之方法 |
| CR20230120A (es) | 2020-08-07 | 2023-09-01 | Vertex Pharma | Moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| US11384054B2 (en) | 2020-10-22 | 2022-07-12 | Scinopharm Taiwan, Ltd. | Crystalline form of ivacaftor and a process for preparing the same |
| US12324802B2 (en) | 2020-11-18 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| KR20230118123A (ko) | 2020-12-10 | 2023-08-10 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 치료 방법 |
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| SE0201669D0 (sv) * | 2002-06-03 | 2002-06-03 | Pharmacia Ab | New formulation and use thereof |
| PL2502911T3 (pl) * | 2004-06-24 | 2017-09-29 | Vertex Pharma | Modulatory transporterów kasety wiążącej ATP |
| WO2007079139A2 (en) | 2005-12-28 | 2007-07-12 | Vertex Pharmaceuticals, Inc. | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| CN101918366A (zh) * | 2007-09-14 | 2010-12-15 | 弗特克斯药品有限公司 | N-[2,4-双(1,1-二甲基乙基)-5-羟基苯基]-1,4-二氢-4-氧代喹啉-3-甲酰胺的固体形式 |
| US20100256184A1 (en) * | 2008-08-13 | 2010-10-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US20100074949A1 (en) * | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| CA3071058C (en) * | 2009-03-20 | 2023-01-24 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
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- 2008-09-15 US US12/283,702 patent/US8163772B2/en active Active
- 2008-09-15 RU RU2010114732/04A patent/RU2010114732A/ru not_active Application Discontinuation
- 2008-09-15 JP JP2010524884A patent/JP2010540417A/ja active Pending
- 2008-09-15 EP EP08832069A patent/EP2222304A2/en not_active Withdrawn
- 2008-09-15 MX MX2010002974A patent/MX2010002974A/es unknown
- 2008-09-15 WO PCT/US2008/010728 patent/WO2009038683A2/en not_active Ceased
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- 2008-09-15 AU AU2008301907A patent/AU2008301907B2/en not_active Ceased
- 2008-09-15 CA CA2699292A patent/CA2699292A1/en not_active Abandoned
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| RU2010114732A (ru) | 2011-10-20 |
| EP2222304A2 (en) | 2010-09-01 |
| NZ600865A (en) | 2014-01-31 |
| US8163772B2 (en) | 2012-04-24 |
| US20090099230A1 (en) | 2009-04-16 |
| AU2008301907B2 (en) | 2014-02-20 |
| CA2699292A1 (en) | 2009-03-26 |
| US20120165372A1 (en) | 2012-06-28 |
| MX2010002974A (es) | 2010-07-29 |
| US8362253B2 (en) | 2013-01-29 |
| CN101918366A (zh) | 2010-12-15 |
| WO2009038683A2 (en) | 2009-03-26 |
| WO2009038683A3 (en) | 2010-08-26 |
| JP2010540417A (ja) | 2010-12-24 |
| BRPI0816345A2 (pt) | 2015-02-24 |
| US20130109717A1 (en) | 2013-05-02 |
| NZ620027A (en) | 2015-05-29 |
| AU2008301907A1 (en) | 2009-03-26 |
| US8623894B2 (en) | 2014-01-07 |
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