AU2008301907B2 - Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide - Google Patents
Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide Download PDFInfo
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- AU2008301907B2 AU2008301907B2 AU2008301907A AU2008301907A AU2008301907B2 AU 2008301907 B2 AU2008301907 B2 AU 2008301907B2 AU 2008301907 A AU2008301907 A AU 2008301907A AU 2008301907 A AU2008301907 A AU 2008301907A AU 2008301907 B2 AU2008301907 B2 AU 2008301907B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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| RU2006111093A (ru) | 2003-09-06 | 2007-10-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы атр-связывающих кассетных транспортеров |
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| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
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| RU2569678C2 (ru) | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
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| US11384054B2 (en) | 2020-10-22 | 2022-07-12 | Scinopharm Taiwan, Ltd. | Crystalline form of ivacaftor and a process for preparing the same |
| US12324802B2 (en) | 2020-11-18 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| EP4259139A1 (en) | 2020-12-10 | 2023-10-18 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
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|---|---|---|---|---|
| WO2006002421A2 (en) * | 2004-06-24 | 2006-01-05 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| WO2007079139A2 (en) * | 2005-12-28 | 2007-07-12 | Vertex Pharmaceuticals, Inc. | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
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|---|---|---|---|---|
| SE0201669D0 (sv) * | 2002-06-03 | 2002-06-03 | Pharmacia Ab | New formulation and use thereof |
| BRPI0816345A2 (pt) * | 2007-09-14 | 2015-02-24 | Vertex Pharma | Formas sólidas de n-[2,4-bis-(1,1-dimetiletil)-5-hidroxifenil]-1,4-diidro-4-o xoquinolin-3-carboxamida |
| US20100256184A1 (en) * | 2008-08-13 | 2010-10-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US20100074949A1 (en) * | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| EP3330255B1 (en) * | 2009-03-20 | 2020-12-09 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
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- 2008-09-15 US US12/283,702 patent/US8163772B2/en active Active
- 2008-09-15 EP EP08832069A patent/EP2222304A2/en not_active Withdrawn
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- 2008-09-15 JP JP2010524884A patent/JP2010540417A/ja active Pending
- 2008-09-15 AU AU2008301907A patent/AU2008301907B2/en not_active Ceased
- 2008-09-15 CA CA2699292A patent/CA2699292A1/en not_active Abandoned
- 2008-09-15 MX MX2010002974A patent/MX2010002974A/es unknown
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006002421A2 (en) * | 2004-06-24 | 2006-01-05 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| WO2007079139A2 (en) * | 2005-12-28 | 2007-07-12 | Vertex Pharmaceuticals, Inc. | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
Also Published As
| Publication number | Publication date |
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| AU2008301907A1 (en) | 2009-03-26 |
| JP2010540417A (ja) | 2010-12-24 |
| MX2010002974A (es) | 2010-07-29 |
| CN101918366A (zh) | 2010-12-15 |
| US20090099230A1 (en) | 2009-04-16 |
| US8362253B2 (en) | 2013-01-29 |
| CA2699292A1 (en) | 2009-03-26 |
| US8623894B2 (en) | 2014-01-07 |
| NZ620027A (en) | 2015-05-29 |
| EP2222304A2 (en) | 2010-09-01 |
| BRPI0816345A2 (pt) | 2015-02-24 |
| US8163772B2 (en) | 2012-04-24 |
| RU2010114732A (ru) | 2011-10-20 |
| WO2009038683A3 (en) | 2010-08-26 |
| NZ600865A (en) | 2014-01-31 |
| NZ583848A (en) | 2012-07-27 |
| US20120165372A1 (en) | 2012-06-28 |
| WO2009038683A2 (en) | 2009-03-26 |
| US20130109717A1 (en) | 2013-05-02 |
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