RU2010114732A - Твердые формы n-[2,4-бис(1,1-диметилэтил)-5-гидроксифенил]-1,4-дигидро-4-оксохинолин-3-карбоксамида - Google Patents

Твердые формы n-[2,4-бис(1,1-диметилэтил)-5-гидроксифенил]-1,4-дигидро-4-оксохинолин-3-карбоксамида Download PDF

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RU2010114732A
RU2010114732A RU2010114732/04A RU2010114732A RU2010114732A RU 2010114732 A RU2010114732 A RU 2010114732A RU 2010114732/04 A RU2010114732/04 A RU 2010114732/04A RU 2010114732 A RU2010114732 A RU 2010114732A RU 2010114732 A RU2010114732 A RU 2010114732A
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Russia
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degrees
compound
angstroms
crystalline form
besylate
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RU2010114732/04A
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Russian (ru)
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Джон ДЕМАТТЕИ (US)
Джон ДЕМАТТЕИ
Юйши ФЭН (US)
Юйши ФЭН
Кристиан ХАРРИСОН (US)
Кристиан ХАРРИСОН
Адам ЛУКЕР (US)
Адам ЛУКЕР
Правин МУДУНУРИ (US)
Правин МУДУНУРИ
Штефани РЕПЕР (US)
Штефани РЕПЕР
Юэган ЧЖАН (US)
Юэган Чжан
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Вертекс Фармасьютикалз Инкорпорейтед (Us)
Вертекс Фармасьютикалз Инкорпорейтед
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Publication of RU2010114732A publication Critical patent/RU2010114732A/ru

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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  • Quinoline Compounds (AREA)
RU2010114732/04A 2007-09-14 2008-09-15 Твердые формы n-[2,4-бис(1,1-диметилэтил)-5-гидроксифенил]-1,4-дигидро-4-оксохинолин-3-карбоксамида RU2010114732A (ru)

Applications Claiming Priority (2)

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US97260507P 2007-09-14 2007-09-14
US60/972,605 2007-09-14

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RU2010114732A true RU2010114732A (ru) 2011-10-20

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RU2010114732/04A RU2010114732A (ru) 2007-09-14 2008-09-15 Твердые формы n-[2,4-бис(1,1-диметилэтил)-5-гидроксифенил]-1,4-дигидро-4-оксохинолин-3-карбоксамида

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US (3) US8163772B2 (enExample)
EP (1) EP2222304A2 (enExample)
JP (1) JP2010540417A (enExample)
CN (1) CN101918366A (enExample)
AU (1) AU2008301907B2 (enExample)
BR (1) BRPI0816345A2 (enExample)
CA (1) CA2699292A1 (enExample)
MX (1) MX2010002974A (enExample)
NZ (3) NZ583848A (enExample)
RU (1) RU2010114732A (enExample)
WO (1) WO2009038683A2 (enExample)

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RU2749213C2 (ru) * 2014-10-07 2021-06-07 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе

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ES2578735T3 (es) 2007-08-24 2016-07-29 Vertex Pharmaceuticals Incorporated Isotiazolopiridinonas útiles para el tratamiento de (entre otros) fibrosis quística
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US20100036130A1 (en) 2007-12-07 2010-02-11 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
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JP5523352B2 (ja) * 2008-02-28 2014-06-18 バーテックス ファーマシューティカルズ インコーポレイテッド Ｃｆｔｒ修飾因子としてのへテロアリール誘導体
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