JP2010528050A5 - - Google Patents

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Publication number
JP2010528050A5
JP2010528050A5 JP2010509563A JP2010509563A JP2010528050A5 JP 2010528050 A5 JP2010528050 A5 JP 2010528050A5 JP 2010509563 A JP2010509563 A JP 2010509563A JP 2010509563 A JP2010509563 A JP 2010509563A JP 2010528050 A5 JP2010528050 A5 JP 2010528050A5
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JP
Japan
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formula
ring
compound
optionally substituted
hydrogen
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JP2010509563A
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English (en)
Japanese (ja)
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JP5686596B2 (ja
JP2010528050A (ja
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Priority claimed from PCT/US2008/064646 external-priority patent/WO2008147952A1/en
Publication of JP2010528050A publication Critical patent/JP2010528050A/ja
Publication of JP2010528050A5 publication Critical patent/JP2010528050A5/ja
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Publication of JP5686596B2 publication Critical patent/JP5686596B2/ja
Expired - Fee Related legal-status Critical Current
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JP2010509563A 2007-05-25 2008-05-23 嚢胞性線維症膜貫通コンダクタンス制御因子の調節因子 Expired - Fee Related JP5686596B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US93177507P 2007-05-25 2007-05-25
US60/931,775 2007-05-25
US96870407P 2007-08-29 2007-08-29
US60/968,704 2007-08-29
PCT/US2008/064646 WO2008147952A1 (en) 2007-05-25 2008-05-23 Modulators of cystic fibrosis transmembrane conductance regulator

Publications (3)

Publication Number Publication Date
JP2010528050A JP2010528050A (ja) 2010-08-19
JP2010528050A5 true JP2010528050A5 (enExample) 2012-07-05
JP5686596B2 JP5686596B2 (ja) 2015-03-18

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ID=39798146

Family Applications (1)

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JP2010509563A Expired - Fee Related JP5686596B2 (ja) 2007-05-25 2008-05-23 嚢胞性線維症膜貫通コンダクタンス制御因子の調節因子

Country Status (10)

Country Link
US (3) US8399479B2 (enExample)
EP (1) EP2170901B1 (enExample)
JP (1) JP5686596B2 (enExample)
CN (1) CN101687883B (enExample)
AU (1) AU2008256717B2 (enExample)
CA (1) CA2688004C (enExample)
ES (1) ES2548292T3 (enExample)
HU (1) HUE025553T2 (enExample)
NZ (1) NZ581419A (enExample)
WO (1) WO2008147952A1 (enExample)

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CA2635760C (en) 2005-12-28 2014-07-15 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
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US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
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AU2008335031B2 (en) 2007-12-13 2013-11-28 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
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WO2009123896A1 (en) 2008-03-31 2009-10-08 Vertex Pharmaceuticals Incorporated Pyridyl derivatives as cftr modulators
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
RU2011117177A (ru) 2008-09-29 2012-11-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) ДОЗИРОВАННЫЕ ЛЕКАРСТВЕННЫЕ ФОРМЫ 3-(6-(1-(2,2-ДИФТОРБЕНЗО[d][1,3]ДИОКСОЛ-5-ИЛ)ЦИКЛОПРОПАНКАРБОКСАМИДО)-3-МЕТИЛПИРИДИН-2-ИЛ)БЕНЗОЙНОЙ КИСЛОТЫ
CA2741718A1 (en) * 2008-10-23 2010-04-29 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
JP5699090B2 (ja) 2008-12-30 2015-04-08 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated 嚢胞性線維症膜コンダクタンス調節因子のモジュレーター
AU2010226400B2 (en) 2009-03-20 2016-07-14 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
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LT3150198T (lt) 2010-04-07 2021-12-10 Vertex Pharmaceuticals Incorporated 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiridin-2-il)benzoinės rūgšties farmacinė kompozicija ir jos įvedimas
ME02446B (me) 2010-04-07 2016-09-20 Vertex Pharma Čvrste forme 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksiamido)-3-metilpiridin-2-il)benzoeve kiseline
MX342288B (es) 2010-04-22 2016-09-23 Vertex Pharma Proceso para producir compuestos de cicloalquilcarboxamido-indol.
US8563593B2 (en) 2010-06-08 2013-10-22 Vertex Pharmaceuticals Incorporated Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
CA2852991C (en) 2011-11-08 2019-12-31 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
CA2865519C (en) 2012-02-27 2018-01-02 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl0-5-hydroxyphenyl-1]-1,4-dihydro-4-oxoquinolone-3-carboxamide for treating cystic fibrosis
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US9012496B2 (en) 2012-07-16 2015-04-21 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide and administration thereof
BR112015028173A2 (pt) 2013-05-10 2017-07-25 Nimbus Apollo Inc inibidores de acc e usos dos mesmos
JP6417403B2 (ja) 2013-05-10 2018-11-07 ギリアド アポロ, エルエルシー Acc阻害剤及びその使用
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BR112016010403A2 (pt) 2013-11-12 2017-08-08 Vertex Pharma Processo de preparação de composições farmacêuticas para o tratamento de doenças mediadas por cftr
KR102447581B1 (ko) 2014-04-15 2022-09-28 버텍스 파마슈티칼스 인코포레이티드 낭포성 섬유증 막전도 조절자 매개 질환 치료용 약제학적 조성물
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