NZ580888A - Compositions of eltrombopag olamine substantially free from coordinating metals or reducing sugars - Google Patents

Compositions of eltrombopag olamine substantially free from coordinating metals or reducing sugars

Info

Publication number
NZ580888A
NZ580888A NZ580888A NZ58088807A NZ580888A NZ 580888 A NZ580888 A NZ 580888A NZ 580888 A NZ580888 A NZ 580888A NZ 58088807 A NZ58088807 A NZ 58088807A NZ 580888 A NZ580888 A NZ 580888A
Authority
NZ
New Zealand
Prior art keywords
tablet
pharmaceutical
amount
micron
diluent
Prior art date
Application number
NZ580888A
Other languages
English (en)
Inventor
Shivakumar G Kapsi
Francis X Muller
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39343460&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ580888(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of NZ580888A publication Critical patent/NZ580888A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NZ580888A 2007-05-03 2007-08-01 Compositions of eltrombopag olamine substantially free from coordinating metals or reducing sugars NZ580888A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91576107P 2007-05-03 2007-05-03
US94773107P 2007-07-03 2007-07-03
PCT/US2007/074918 WO2008136843A1 (en) 2007-05-03 2007-08-01 Novel pharmaceutical composition

Publications (1)

Publication Number Publication Date
NZ580888A true NZ580888A (en) 2012-03-30

Family

ID=39343460

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ580888A NZ580888A (en) 2007-05-03 2007-08-01 Compositions of eltrombopag olamine substantially free from coordinating metals or reducing sugars

Country Status (35)

Country Link
US (15) US20100129352A1 (enExample)
EP (5) EP4218732B1 (enExample)
JP (10) JP5419866B2 (enExample)
KR (3) KR101632851B1 (enExample)
CN (3) CN101686930A (enExample)
AR (1) AR059656A1 (enExample)
AU (1) AU2007352608C1 (enExample)
BR (1) BRPI0721651B8 (enExample)
CA (1) CA2685831C (enExample)
CL (1) CL2007002242A1 (enExample)
CO (1) CO6260058A2 (enExample)
CR (1) CR11143A (enExample)
CY (1) CY1117284T1 (enExample)
DK (3) DK2152237T3 (enExample)
DO (1) DOP2009000253A (enExample)
EA (2) EA020883B1 (enExample)
EC (1) ECSP077628A (enExample)
ES (4) ES2565179T3 (enExample)
FI (3) FI4218732T3 (enExample)
HR (4) HRP20250383T3 (enExample)
HU (3) HUE067736T2 (enExample)
IL (3) IL238840B2 (enExample)
JO (1) JO3643B1 (enExample)
LT (3) LT3090730T (enExample)
MA (1) MA30236B1 (enExample)
MX (1) MX2009011881A (enExample)
MY (1) MY158072A (enExample)
NZ (1) NZ580888A (enExample)
PE (3) PE20151953A1 (enExample)
PL (4) PL3090730T3 (enExample)
PT (4) PT3090730T (enExample)
SI (4) SI3090730T1 (enExample)
TW (2) TWI538674B (enExample)
WO (1) WO2008136843A1 (enExample)
ZA (1) ZA200907710B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107913411A (zh) * 2016-10-11 2018-04-17 广东东阳光药业有限公司 艾曲泊帕包合物及其制剂和制备方法

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ECSP077628A (es) 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
WO2010045310A1 (en) * 2008-10-16 2010-04-22 Glaxosmithkline Llc Method of treating thrombocytopenia
US7956048B2 (en) 2009-04-01 2011-06-07 Pliva Hrvatska D.O.O. Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof
EP2434894B1 (en) * 2009-05-29 2016-08-31 Novartis AG Methods of administration of thrombopoietin agonist compounds
TWI505828B (zh) 2010-12-20 2015-11-01 葛蘭素史克智慧財產（第二）有限公司 新穎醫藥組成物
WO2012121958A2 (en) * 2011-03-08 2012-09-13 Glaxosmithkline Llc Combination
US20150306099A1 (en) * 2012-11-27 2015-10-29 Glaxosmithkline Llc Combination
US9770437B2 (en) * 2013-09-02 2017-09-26 Hetero Research Foundation Compositions of eltrombopag
KR101545268B1 (ko) 2015-02-05 2015-08-20 보령제약 주식회사 정제 및 이의 제조방법
WO2016126012A1 (en) * 2015-02-05 2016-08-11 Boryung Pharmaceutical Co., Ltd Tablet and method of preparing the same
WO2017042839A1 (en) 2015-09-08 2017-03-16 Actavis Group Ptc Ehf. Novel eltrombopag salt and preparation thereof
EP3375442A4 (en) * 2016-01-22 2018-12-26 Jiangsu Hengrui Medicine Co., Ltd. Pharmaceutical composition comprising bicyclo-substituted pyrazolon azo derivative or salt thereof and preparation method thereof
CN106361719A (zh) * 2016-08-25 2017-02-01 浙江万晟药业有限公司 一种艾曲泊帕液体胶囊及其制备方法
WO2018078644A1 (en) * 2016-10-24 2018-05-03 Hetero Labs Limited Orally disintegrating tablets of eltrombopag
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
US20180280861A1 (en) * 2017-03-30 2018-10-04 JMAC Resources, Inc. Mixer Truck Water Spray Bar
EP3395331B1 (en) 2017-04-26 2019-08-21 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising eltrombopag olamine
CN107468662A (zh) * 2017-10-10 2017-12-15 甘宜玲 一种治疗消化不良的药物片剂及其制备方法
CN107898784B (zh) * 2017-11-01 2020-09-18 天津国际生物医药联合研究院 艾曲波帕乙醇胺在抗结核分枝杆菌感染中的应用
CN109893503A (zh) * 2017-12-11 2019-06-18 武汉武药科技有限公司 一种艾曲泊帕口服混悬液及其制备方法
EP3409272B1 (en) 2018-03-07 2020-06-24 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical composition comprising eltrombopag olamine, reducing sugar, and polymeric binder
WO2020055364A2 (en) 2018-08-02 2020-03-19 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi A pharmaceutical composition comprising eltrombopag olamine
CN110327330A (zh) * 2019-08-08 2019-10-15 上海中医药大学 艾曲波帕在制备抗癌血管生成药物及抗癌药物组合物中的应用
WO2021055820A1 (en) 2019-09-20 2021-03-25 Novartis Ag 3'-[(2z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid and its salts formulation
TR201917244A1 (tr) 2019-11-07 2021-05-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Eltrombopag olami̇n i̇çeren kapsül
WO2021110942A1 (en) 2019-12-06 2021-06-10 Synthon B.V. Pharmaceutical composition comprising eltrombopag bis(monoethanolamine)
CA3160779A1 (en) * 2019-12-06 2021-06-10 Synthon B.V. Pharmaceutical composition comprising eltrombopag bis(monoethanolamine)
JP2023507432A (ja) 2019-12-20 2023-02-22 インスティル バイオ （ユーケイ） リミテッド 腫瘍浸潤リンパ球を単離するためのデバイスおよび方法ならびにそれらの使用
CN114053421A (zh) * 2020-07-31 2022-02-18 广东东阳光药业有限公司 一种血小板生成素受体激动剂的组合物及其制备方法
WO2022056346A1 (en) * 2020-09-14 2022-03-17 Actavis Laboratories Fl, Inc. Eltrombopag choline dosage forms
TR202014694A1 (tr) * 2020-09-16 2022-03-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Eltrombopag olami̇n i̇çeren bi̇r kati oral farmasöri̇k formülasyon
EP4014970A1 (en) 2020-12-21 2022-06-22 Genepharm S.A. A solid oral composition of eltrombopag olamine
WO2022195545A1 (en) 2021-03-18 2022-09-22 Novartis Ag Novel pharmaceutical formulations
WO2022201087A1 (en) 2021-03-25 2022-09-29 Novartis Ag 3'-[(2z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid and its salts formulation
JP2023051897A (ja) * 2021-09-30 2023-04-11 日本ジェネリック株式会社 溶出性に優れ、変色を防止したエルトロンボパグオラミンを含む錠剤
EP4436554A1 (en) 2021-12-15 2024-10-02 Galenicum Health SLU Pharmaceutical compositions comprising eltrombopag
US20250381143A1 (en) * 2021-12-30 2025-12-18 Adlai Nortye Biopharma Co., Ltd. A solid pharmaceutical composition
CN115919789A (zh) * 2022-12-08 2023-04-07 山东新时代药业有限公司 一种艾曲泊帕乙醇胺片及其制备方法

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE193350C (enExample)
US851444A (en) * 1905-11-13 1907-04-23 Agfa Ag Amido-oxy-sulfonic acid of phenylnaphthimidazol and process of making same.
GB779880A (en) 1953-02-27 1957-07-24 Ciba Ltd Functional derivatives of azo-dyestuffs containing sulphonic acid groups and processfor making them
US2809963A (en) * 1954-10-26 1957-10-15 Ciba Ltd Azo-dyestuffs
DE1046220B (de) 1956-04-21 1958-12-11 Bayer Ag Verfahren zur Herstellung von Monoazofarbstoffen und deren Metallkomplexverbindungen
GB826207A (en) 1956-07-23 1959-12-31 Bayer Ag ú´-ú´-dihydroxy-monoazo dyestuffs containing pyrrolidonyl residues and their metal complex compounds
US2950273A (en) * 1956-11-20 1960-08-23 Agfa Ag Process for the production of symmetrical and unsymmetrical azo compounds
US3366619A (en) * 1965-04-09 1968-01-30 Interchem Corp Disazo pyrazolone pigments
US4435417A (en) * 1981-02-20 1984-03-06 Gruppo Lepetit S.P.A. Antiinflammatory 3H-naphtho[1,2-d]imidazoles
ES523609A0 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
FR2559483B1 (fr) * 1984-02-10 1986-12-05 Sandoz Sa Composes heterocycliques contenant des groupes basiques et/ou cationiques, leur preparation et leur utilisation comme colorants
US4582831A (en) * 1984-11-16 1986-04-15 Pfizer Inc. Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor
FI91869C (fi) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
US4880788A (en) * 1987-10-30 1989-11-14 Baylor College Of Medicine Method for preventing and treating thrombosis
CA2044951C (en) * 1990-06-21 1996-01-16 Shinya Takenaka Automatic gain control circuit
WO1993017681A1 (en) 1992-03-02 1993-09-16 Abbott Laboratories Angiotensin ii receptor antagonists
JPH069382A (ja) 1992-04-17 1994-01-18 Takeda Chem Ind Ltd 安定化された固型製剤およびその製造方法
US5214813A (en) * 1992-05-29 1993-06-01 Gastle Thomas H Patient support device
US5238442A (en) * 1992-06-26 1993-08-24 Townsend Engineering Company Method and means for applying liquid to the interior of a casing on a sausage encasing machine
US5358941A (en) 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
IL109570A0 (en) 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
EP0638617A1 (de) 1993-08-13 1995-02-15 Ciba-Geigy Ag Pigmentsalze
EP0661170B1 (en) * 1993-12-28 1998-09-02 Dai Nippon Printing Co., Ltd. Thermal transfer sheet
US5482546A (en) * 1994-03-30 1996-01-09 Canon Kabushiki Kaisha Dye, ink containing the same, and ink-jet recording method and instrument using the ink
US5760038A (en) * 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5746821A (en) * 1995-02-13 1998-05-05 Engelhard Corporation Pigment compositions
CN1966520B (zh) 1995-06-07 2012-07-11 葛兰素集团有限公司 结合血小板生成素受体的肽和化合物
US5622818A (en) * 1995-11-29 1997-04-22 Eastman Kodak Company Color photographic elements containing yellow colored magenta dye forming masking couplers
US5669967A (en) * 1996-05-30 1997-09-23 Engelhard Corporation Pigment compositions
US5932546A (en) * 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
TW522014B (en) 1997-02-07 2003-03-01 Sepracor Inc Lactose-free, non-hygroscopic and anhydrous pharmaceutical unit dosage form containing descarboethoxyloratadine
SE9701398D0 (sv) 1997-04-15 1997-04-15 Astra Pharma Prod Novel compounds
GB9715830D0 (en) * 1997-07-25 1997-10-01 Basf Ag Reactive dyes containing piperazine
WO1999011262A1 (en) 1997-09-02 1999-03-11 Roche Diagnostics Gmbh Mpl-receptor ligands, process for their preparation, medicaments containing them and their use for the treatment and prevention of thrombocytopaenia and anaemia
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US20010016568A1 (en) * 1997-10-31 2001-08-23 Juan I. Luengo Novel metal complexes
DE19851389A1 (de) * 1998-11-07 2000-05-11 Dystar Textilfarben Gmbh & Co Gelbe Farbstoffmischungen von wasserlöslichen faserreaktiven Azofarbstoffen und ihre Verwendung
GC0000177A (en) 1998-12-17 2006-03-29 Smithkline Beecham Thrombopoietin mimetics
CO5210907A1 (es) 1999-05-12 2002-10-30 Novartis Ag Solvatos de pometrozina, insecticidamente activos, composiciones que contienen estos compuestos y metodos tanto para producir dichos compuestos y composiciones como para controlar plagas animales con estas composiciones
KR20020069183A (ko) 1999-07-26 2002-08-29 시오노기세이야쿠가부시키가이샤 트롬보포이에틴 작동성을 나타내는 의약 조성물
AU770564B2 (en) 1999-09-10 2004-02-26 Smithkline Beecham Corporation Thrombopoietin mimetics
AU771460B2 (en) 1999-09-24 2004-03-25 Smithkline Beecham Corporation Thrombopoietin mimetics
JP2003513965A (ja) 1999-11-05 2003-04-15 スミスクライン・ビーチャム・コーポレイション セミカルバゾン誘導体およびそれらのトロンボポエチン模倣物としての使用
EP1104674A1 (de) 1999-11-10 2001-06-06 Curacyte AG O,o'-Dihydroxyazofarbstoffe als Bestandteile von Arzneimitteln mit TPO-Agonistischer oder -Synergetischer Wirkung
WO2001047498A2 (en) * 1999-12-23 2001-07-05 Pfizer Products Inc. Hydrogel-driven layered drug dosage form comprising sertraline
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
HUP0001417A2 (hu) 2000-04-07 2002-12-28 Sanofi-Synthelabo Gyógyászatilag alkalmazható új sók, eljárás előállításukra és azokat tartalmazó gyógyászati készítmények
US6214813B1 (en) * 2000-04-07 2001-04-10 Kinetek Pharmaceuticals, Inc. Pyrazole compounds
US6436915B1 (en) 2000-04-07 2002-08-20 Kinetek Pharmaceuticals, Inc. Pyrazole compounds
US6428871B1 (en) * 2000-05-05 2002-08-06 Michael Cozzolino Method of manufacturing decorative wood products from engineered wood products
CY2010012I2 (el) 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
JP2004520302A (ja) 2000-12-19 2004-07-08 スミスクライン・ビーチャム・コーポレイション トロンボポエチン模倣物
JP2004532614A (ja) 2000-12-21 2004-10-28 スミスクライン・ビーチャム・コーポレイション 金属キレート化アゴニストによる細胞膜受容体の活性化の調節
MXPA03006510A (es) * 2001-01-26 2003-10-15 Shionogi & Co Compuestos halogenados que muestran agonismo del receptor de trombopoyetina.
WO2002059099A1 (en) 2001-01-26 2002-08-01 Shionogi & Co., Ltd. Cyclic compounds having thrombopoietin receptor agonism
EP1370252A4 (en) 2001-03-01 2006-04-05 Smithkline Beecham Corp Thrombopoietin mimetics
JP3927001B2 (ja) 2001-06-15 2007-06-06 三菱化学株式会社 色素セット、インクセット並びに記録方法
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
JP2005519878A (ja) 2001-11-30 2005-07-07 キネテク ファーマシューティカルズ，インコーポレーテッド ヒドラゾノピラゾール誘導体および治療剤としてのその使用
AU2003213673A1 (en) 2002-03-01 2003-09-16 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof
SI2630954T1 (sl) * 2002-03-20 2017-02-28 Civitas Therapeutics, Inc. Pulmonalno dovajanje za levodopo
AUPS245302A0 (en) 2002-05-21 2002-06-13 Cuskelly, John Ventilation control device
MY142390A (en) * 2002-05-22 2010-11-30 Glaxosmithkline Llc 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US7414040B2 (en) 2002-06-06 2008-08-19 Smithkline Beecham Corporation Thrombopoietin mimetics
US20060084682A1 (en) 2002-12-13 2006-04-20 Heerding Dirk A Thrombopoietin mimetics
US20090048318A1 (en) * 2003-04-29 2009-02-19 Connie Erickson-Miller Methods for treating degenerative diseases/injuries
US20090143453A1 (en) * 2003-04-29 2009-06-04 Connie Erickson-Miller Methods for treating degenerative diseases/injuries
EP1622609A4 (en) 2003-04-29 2008-09-03 Smithkline Beecham Corp METHODS OF TREATING DEGENERATIVE DISEASES / LESIONS
US20090298179A1 (en) * 2003-04-29 2009-12-03 Connie Erickson-Miller Methods For Treating Degenerative Diseases/Injuries
TW200526638A (en) 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
CN101132776A (zh) * 2004-11-17 2008-02-27 生物马林药物股份有限公司 稳定的四氢生物喋呤片剂制剂
WO2007044982A2 (en) * 2005-10-13 2007-04-19 Smithkline Beecham Corporation Methods for the preservation of platelet efficacy during storage
JP4226002B2 (ja) 2005-12-27 2009-02-18 ルビコン株式会社 積層形フィルムコンデンサの製造方法
US20080055395A1 (en) 2006-08-29 2008-03-06 Motorola, Inc. Creating a dynamic group call through similarity between images
UY30915A1 (es) 2007-02-16 2008-09-02 Smithkline Beecham Corp Método de tratamiento de canceres
ECSP077628A (es) * 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
GB0719235D0 (en) 2007-10-02 2007-11-14 Glaxo Group Ltd Novel compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107913411A (zh) * 2016-10-11 2018-04-17 广东东阳光药业有限公司 艾曲泊帕包合物及其制剂和制备方法
CN107913411B (zh) * 2016-10-11 2023-08-25 广东东阳光药业股份有限公司 艾曲泊帕包合物及其制剂和制备方法

Also Published As

Publication number Publication date
DK4218732T3 (da) 2025-06-16
LT4400104T (lt) 2026-06-25
BRPI0721651A2 (pt) 2014-04-01
SI4400104T1 (sl) 2026-07-31
ES2565179T3 (es) 2016-04-01
TWI538674B (zh) 2016-06-21
EP4400104A2 (en) 2024-07-17
PL4218732T3 (pl) 2025-07-21
US20100047346A1 (en) 2010-02-25
BRPI0721651B1 (pt) 2019-10-29
JP7642148B2 (ja) 2025-03-07
EP4400104A3 (en) 2024-10-09
EA034294B1 (ru) 2020-01-27
EP3090730A1 (en) 2016-11-09
CN102688207A (zh) 2012-09-26
CL2007002242A1 (es) 2008-02-08
US20100040684A1 (en) 2010-02-18
DOP2009000253A (es) 2009-12-15
DK2152237T3 (en) 2016-03-14
JP2014005302A (ja) 2014-01-16
PT4400104T (pt) 2026-06-03
JP7642149B2 (ja) 2025-03-07
JP2017137343A (ja) 2017-08-10
IL274602A (en) 2020-06-30
US20100047347A1 (en) 2010-02-25
KR101537200B1 (ko) 2015-07-15
TW200843742A (en) 2008-11-16
ES2981985T3 (es) 2024-10-14
JP2025081605A (ja) 2025-05-27
HK1136968A1 (en) 2010-07-16
CO6260058A2 (es) 2011-03-22
US20190209479A1 (en) 2019-07-11
LT3090730T (lt) 2024-06-25
KR101475971B1 (ko) 2014-12-23
JP2025020368A (ja) 2025-02-12
TW201410240A (zh) 2014-03-16
US20100047348A1 (en) 2010-02-25
EA200971018A1 (ru) 2010-04-30
MY158072A (en) 2016-08-30
HRP20260766T3 (hr) 2026-08-14
HRP20250383T1 (hr) 2025-07-18
FI4218732T3 (fi) 2025-07-04
HRP20160206T1 (hr) 2016-04-08
US20160199353A1 (en) 2016-07-14
EP4218732A1 (en) 2023-08-02
PE20080773A1 (es) 2008-08-23
FI3090730T3 (fi) 2024-05-20
HUE027209T2 (en) 2016-10-28
SI4218732T1 (sl) 2025-07-31
AR059656A1 (es) 2008-04-23
EP3090730B1 (en) 2024-04-10
US20100040683A1 (en) 2010-02-18
HRP20250383T3 (hr) 2025-07-18
US20140341991A1 (en) 2014-11-20
US8062665B2 (en) 2011-11-22
ZA200907710B (en) 2014-03-26
IL238840B2 (en) 2024-11-01
PT2152237E (pt) 2016-03-28
US8052993B2 (en) 2011-11-08
PE20121407A1 (es) 2012-11-15
JP2010526140A (ja) 2010-07-29
US20160031822A1 (en) 2016-02-04
PT3090730T (pt) 2024-06-06
US20170112771A1 (en) 2017-04-27
US20120093927A1 (en) 2012-04-19
JO3643B1 (ar) 2020-08-27
HUE067736T2 (hu) 2024-11-28
IL274602B (en) 2021-10-31
CA2685831A1 (en) 2008-11-13
CN102697745A (zh) 2012-10-03
AU2007352608C1 (en) 2024-11-21
TWI439267B (zh) 2014-06-01
AU2007352608B2 (en) 2011-12-08
WO2008136843A1 (en) 2008-11-13
MA30236B1 (fr) 2009-03-02
EP4218732B1 (en) 2025-03-26
PL4400104T3 (pl) 2026-07-20
JP6144713B2 (ja) 2017-06-07
US8052995B2 (en) 2011-11-08
LT4218732T (lt) 2025-06-25
FI4400104T3 (fi) 2026-06-15
KR20150008513A (ko) 2015-01-22
JP2019123747A (ja) 2019-07-25
US20100129352A1 (en) 2010-05-27
EP2152237A1 (en) 2010-02-17
EP2152237A4 (en) 2012-02-08
KR20140049086A (ko) 2014-04-24
DK3090730T3 (da) 2024-07-15
EA201400387A1 (ru) 2014-07-30
US8071129B2 (en) 2011-12-06
IL238840A0 (en) 2015-06-30
EP2152237B1 (en) 2015-12-30
US8052994B2 (en) 2011-11-08
IL238840B (en) 2020-05-31
JP5419866B2 (ja) 2014-02-19
PT4218732T (pt) 2025-06-11
ECSP077628A (es) 2008-12-30
EA020883B1 (ru) 2015-02-27
CA2685831C (en) 2013-11-26
KR101632851B1 (ko) 2016-06-22
BRPI0721651B8 (pt) 2021-05-25
CN101686930A (zh) 2010-03-31
PL3090730T3 (pl) 2024-08-26
SI2152237T1 (sl) 2016-04-29
MX2009011881A (es) 2009-12-16
SI3090730T1 (sl) 2024-07-31
KR20100020456A (ko) 2010-02-22
US20180338926A1 (en) 2018-11-29
JP2015129195A (ja) 2015-07-16
IL201891A0 (en) 2010-06-16
HUE072202T2 (hu) 2025-10-28
JP6560289B2 (ja) 2019-08-14
IL274602B2 (en) 2024-12-01
JP2023011888A (ja) 2023-01-24
US20170296512A1 (en) 2017-10-19
US8828430B2 (en) 2014-09-09
JP5735078B2 (ja) 2015-06-17
EP4400104B1 (en) 2026-04-22
EP3090730B9 (en) 2024-07-03
CY1117284T1 (el) 2017-04-26
JP2025020367A (ja) 2025-02-12
PL2152237T3 (pl) 2016-06-30
PE20151953A1 (es) 2016-01-14
JP2021100968A (ja) 2021-07-08
EP4218733A1 (en) 2023-08-02
BRPI0721651A8 (pt) 2017-09-19
ES3073615T3 (en) 2026-07-14
AU2007352608A1 (en) 2008-11-13
US20180117009A1 (en) 2018-05-03
HRP20240595T3 (hr) 2024-09-13
ES3032244T3 (en) 2025-07-16
CR11143A (es) 2010-03-22
IL201891A (en) 2016-02-29

Similar Documents

Publication Publication Date Title
CA2685831C (en) Novel pharmaceutical composition
AU2016202063C1 (en) Novel pharmaceutical composition
AU2012201288C1 (en) Novel pharmaceutical composition
HK1227719A1 (en) Tablets comprising eltrombopag olamine
HK40105753A (en) Tablets comprising eltrombopag olamine
HK40093816A (en) Tablets comprising eltrombopag olamine
HK1136968B (en) Novel pharmaceutical composition

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 01 AUG 2017 BY THOMSON REUTERS

Effective date: 20140619

ASS Change of ownership

Owner name: NOVARTIS AG, CH

Effective date: 20151126

ERR Error or correction

Free format text: THE AGENT HAS BEEN REMOVED; THE CONTACT HAS BEEN REMOVED

Effective date: 20151126

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 AUG 2018 BY CPA GLOBAL

Effective date: 20170720

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 AUG 2019 BY CPA GLOBAL

Effective date: 20180719

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 AUG 2020 BY CPA GLOBAL

Effective date: 20190718

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 AUG 2021 BY CPA GLOBAL

Effective date: 20200716

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 AUG 2022 BY CPA GLOBAL

Effective date: 20210722

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 AUG 2023 BY CPA GLOBAL

Effective date: 20220721

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 AUG 2024 BY CPA GLOBAL

Effective date: 20230720

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 AUG 2025 BY ABHISHEK KUMAR - CPA-PTO PAYMENTS

Effective date: 20240718

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 AUG 2026 BY ABHISHEK KUMAR - CPA-PTO PAYMENTS

Effective date: 20250717