NZ573286A - (1-Benzyl-3-{ [2-(1-cyclopentyl-piperidin-4-ylamino)-benzothiazole-6-sulfonyl]-isobutyl-amino} -2-hydroxy-propyl)-carbamic acid hexahydrofuro[2,3-b]furan-3-yl ester and analogues thereof - Google Patents
(1-Benzyl-3-{ [2-(1-cyclopentyl-piperidin-4-ylamino)-benzothiazole-6-sulfonyl]-isobutyl-amino} -2-hydroxy-propyl)-carbamic acid hexahydrofuro[2,3-b]furan-3-yl ester and analogues thereofInfo
- Publication number
- NZ573286A NZ573286A NZ573286A NZ57328607A NZ573286A NZ 573286 A NZ573286 A NZ 573286A NZ 573286 A NZ573286 A NZ 573286A NZ 57328607 A NZ57328607 A NZ 57328607A NZ 573286 A NZ573286 A NZ 573286A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- compounds
- alkyl
- formula
- amino
- Prior art date
Links
- JQUNFHFWXCXPRK-UHFFFAOYSA-N 2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl n-[4-[[2-[(1-cyclopentylpiperidin-4-yl)amino]-1,3-benzothiazol-6-yl]sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate Chemical compound C=1C=C2N=C(NC3CCN(CC3)C3CCCC3)SC2=CC=1S(=O)(=O)N(CC(C)C)CC(O)C(NC(=O)OC1C2CCOC2OC1)CC1=CC=CC=C1 JQUNFHFWXCXPRK-UHFFFAOYSA-N 0.000 title claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 158
- 239000003814 drug Substances 0.000 claims abstract description 32
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229940079593 drug Drugs 0.000 claims abstract description 20
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims abstract description 17
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- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical group N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 claims description 29
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 22
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- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- CUUIMBADMOHKFR-UHFFFAOYSA-N 2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl n-[4-[1,3-benzothiazol-6-ylsulfonyl(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate Chemical class C=1C=C2N=CSC2=CC=1S(=O)(=O)N(CC(C)C)CC(O)C(NC(=O)OC1C2CCOC2OC1)CC1=CC=CC=C1 CUUIMBADMOHKFR-UHFFFAOYSA-N 0.000 abstract 1
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- 239000002600 sunflower oil Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 125000001302 tertiary amino group Chemical group 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000014599 transmission of virus Effects 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06116003 | 2006-06-23 | ||
| PCT/EP2007/056235 WO2007147884A1 (en) | 2006-06-23 | 2007-06-22 | 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ573286A true NZ573286A (en) | 2011-09-30 |
Family
ID=37596252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ573286A NZ573286A (en) | 2006-06-23 | 2007-06-22 | (1-Benzyl-3-{ [2-(1-cyclopentyl-piperidin-4-ylamino)-benzothiazole-6-sulfonyl]-isobutyl-amino} -2-hydroxy-propyl)-carbamic acid hexahydrofuro[2,3-b]furan-3-yl ester and analogues thereof |
Country Status (31)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3090B1 (ar) * | 2009-12-11 | 2017-03-15 | Janssen Sciences Ireland Uc | 5- امينو-4- هيدروكسي-بنتويل اميدات |
| JP5984218B2 (ja) | 2010-07-02 | 2016-09-06 | ギリアード サイエンシーズ， インコーポレイテッド | Ａｉｄｓを処置するためのナフト−２−イル酢酸誘導体 |
| WO2012003498A1 (en) | 2010-07-02 | 2012-01-05 | Gilead Sciences, Inc. | 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds |
| US9024038B2 (en) | 2010-12-27 | 2015-05-05 | Purdue Research Foundation | Compunds and methods for treating HIV |
| KR20140027295A (ko) * | 2011-04-21 | 2014-03-06 | 길리애드 사이언시즈, 인코포레이티드 | 벤조티아졸 화합물 및 이들의 약학적 용도 |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| WO2013103724A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids |
| PE20141558A1 (es) | 2012-04-20 | 2014-11-06 | Gilead Sciences Inc | Derivados de acido benzotiazol-6-il acetico y su uso para tratar una infeccion por vih |
| WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100369904C (zh) * | 2001-02-14 | 2008-02-20 | 泰博特克药品有限公司 | 2-(取代-氨基)-苯并噻唑磺酰胺hiv蛋白酶抑制剂 |
| TWI286476B (en) * | 2001-12-12 | 2007-09-11 | Tibotec Pharm Ltd | Combination of cytochrome P450 dependent protease inhibitors |
| AP1878A (en) * | 2002-08-02 | 2008-08-13 | Tibotec Pharm Ltd | Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors. |
| EP1670448B1 (en) * | 2003-09-30 | 2007-11-21 | Tibotec Pharmaceuticals Ltd. | Hcv inhibiting sulfonamides |
-
2007
- 2007-06-04 JO JO2007212A patent/JO2841B1/en active
- 2007-06-15 UY UY30416A patent/UY30416A1/es not_active Application Discontinuation
- 2007-06-21 CL CL2007001826A patent/CL2007001826A1/es unknown
- 2007-06-22 CN CN2007800236807A patent/CN101479275B/zh active Active
- 2007-06-22 DK DK07765554.6T patent/DK2035432T3/da active
- 2007-06-22 MX MX2009000160A patent/MX2009000160A/es active IP Right Grant
- 2007-06-22 ES ES07765554T patent/ES2381129T3/es active Active
- 2007-06-22 CA CA2653233A patent/CA2653233C/en active Active
- 2007-06-22 BR BRPI0713487-8A patent/BRPI0713487B1/pt not_active IP Right Cessation
- 2007-06-22 AT AT07765554T patent/ATE544769T1/de active
- 2007-06-22 US US12/304,990 patent/US8202887B2/en not_active Expired - Fee Related
- 2007-06-22 KR KR1020097000754A patent/KR101419320B1/ko active IP Right Grant
- 2007-06-22 PE PE2007000802A patent/PE20080342A1/es active IP Right Grant
- 2007-06-22 PT PT07765554T patent/PT2035432E/pt unknown
- 2007-06-22 JP JP2009515891A patent/JP5232776B2/ja active Active
- 2007-06-22 SI SI200730904T patent/SI2035432T1/sl unknown
- 2007-06-22 EP EP07765554A patent/EP2035432B1/en active Active
- 2007-06-22 TW TW096122406A patent/TWI415851B/zh not_active IP Right Cessation
- 2007-06-22 AR ARP070102776A patent/AR061619A1/es active IP Right Grant
- 2007-06-22 MY MYPI20085209A patent/MY146805A/en unknown
- 2007-06-22 AP AP2008004679A patent/AP2069A/en active
- 2007-06-22 AU AU2007262943A patent/AU2007262943B2/en not_active Ceased
- 2007-06-22 WO PCT/EP2007/056235 patent/WO2007147884A1/en active Application Filing
- 2007-06-22 NZ NZ573286A patent/NZ573286A/en not_active IP Right Cessation
- 2007-06-22 UA UAA200813950A patent/UA96445C2/ru unknown
- 2007-06-22 EA EA200970052A patent/EA016387B1/ru not_active IP Right Cessation
- 2007-06-22 PL PL07765554T patent/PL2035432T3/pl unknown
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2008
- 2008-11-19 IL IL195381A patent/IL195381A/en active IP Right Grant
- 2008-12-05 ZA ZA200810350A patent/ZA200810350B/xx unknown
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2009
- 2009-04-30 HK HK09104046.7A patent/HK1125633A1/xx not_active IP Right Cessation
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2012
- 2012-05-08 CY CY20121100429T patent/CY1112971T1/el unknown
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