NZ569949A - Sublingual fentanyl spray - Google Patents
Sublingual fentanyl sprayInfo
- Publication number
- NZ569949A NZ569949A NZ569949A NZ56994907A NZ569949A NZ 569949 A NZ569949 A NZ 569949A NZ 569949 A NZ569949 A NZ 569949A NZ 56994907 A NZ56994907 A NZ 56994907A NZ 569949 A NZ569949 A NZ 569949A
- Authority
- NZ
- New Zealand
- Prior art keywords
- fentanyl
- formulation
- sublingual
- dose
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76205706P | 2006-01-25 | 2006-01-25 | |
| PCT/US2007/002163 WO2007087431A2 (en) | 2006-01-25 | 2007-01-25 | Sublingual fentanyl spray |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ569949A true NZ569949A (en) | 2011-10-28 |
Family
ID=38309867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ569949A NZ569949A (en) | 2006-01-25 | 2007-01-25 | Sublingual fentanyl spray |
Country Status (16)
| Country | Link |
|---|---|
| US (6) | US8486972B2 (enExample) |
| EP (2) | EP2641595A1 (enExample) |
| JP (3) | JP5241514B2 (enExample) |
| CN (1) | CN101378735B (enExample) |
| AU (1) | AU2007208229B2 (enExample) |
| BR (1) | BRPI0707235B8 (enExample) |
| CA (1) | CA2637672C (enExample) |
| DK (1) | DK1976521T3 (enExample) |
| ES (1) | ES2535233T3 (enExample) |
| MX (3) | MX374396B (enExample) |
| NZ (1) | NZ569949A (enExample) |
| PL (1) | PL1976521T3 (enExample) |
| PT (1) | PT1976521E (enExample) |
| RU (1) | RU2432950C2 (enExample) |
| SI (1) | SI1976521T1 (enExample) |
| WO (1) | WO2007087431A2 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE388705T1 (de) | 2000-07-31 | 2008-03-15 | Nycomed Danmark Aps | Fentanyl zusammensetzung zur nasalen anwendung |
| RU2432950C2 (ru) | 2006-01-25 | 2011-11-10 | Инсис Терапьютикс Инк. | Подъязычный спрей на основе фентанила |
| US8210167B2 (en) * | 2007-03-02 | 2012-07-03 | Corbco, Inc. | Manually operated monodose nasal sprayer |
| US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
| ES2668366T3 (es) * | 2007-08-02 | 2018-05-17 | Insys Development Company, Inc. | Pulverización sublingual de fentanilo |
| GB0720967D0 (en) * | 2007-10-25 | 2007-12-05 | Protophama Ltd | Anti-material pharmaceutical composition |
| WO2009094459A1 (en) * | 2008-01-22 | 2009-07-30 | The Board Of Regents Of The University Of Texas System | Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief |
| US20090286832A1 (en) * | 2008-05-15 | 2009-11-19 | Kiichiro Nabeta | Narcotic emulsion formulations for treatment of surgical pain |
| KR101564058B1 (ko) | 2009-02-26 | 2015-10-29 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 암 통증 치료용 마취 유상액 제제 |
| GB2469792A (en) * | 2009-04-23 | 2010-11-03 | Calvin John Ross | Oil-based pharmaceutical formulation for sublingual delivery |
| JP2012524771A (ja) * | 2009-04-23 | 2012-10-18 | ロンドンファーマ リミテッド | 中性油を含む舌下用の医薬組成物 |
| AU2010248776B2 (en) * | 2009-05-15 | 2013-06-06 | Baudax Bio, Inc. | Sublingual dexmedetomidine compositions and methods of use thereof |
| US20120214874A1 (en) * | 2009-08-26 | 2012-08-23 | Nuvo Research Inc. | Pharmaceutical formulations and methods of use |
| US20130202654A1 (en) * | 2009-11-23 | 2013-08-08 | Cipla Limited | Topical Foam Composition |
| US20120295893A1 (en) * | 2009-12-14 | 2012-11-22 | Coeruleus Ltd. | Compositions and methods of counteracting residual sedative effects of sleep/ hypnotic drugs |
| GB2481728B (en) * | 2010-06-30 | 2012-05-23 | Londonpharma Ltd | Formulations and delivery devices for the sublingual administration of opioids |
| US8627816B2 (en) | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| GB2487007B (en) * | 2012-03-19 | 2013-06-05 | Londonpharma Ltd | COC containers and delivery devices for the sublingual administration of opioids |
| US9867818B2 (en) | 2013-09-10 | 2018-01-16 | Insys Development Company, Inc. | Sublingual buprenorphine spray |
| US9918981B2 (en) | 2013-09-10 | 2018-03-20 | Insys Development Company, Inc. | Liquid buprenorphine formulations |
| WO2015038327A1 (en) | 2013-09-10 | 2015-03-19 | Insys Pharma, Inc. | Sublingual buprenorphine spray |
| US9839611B2 (en) | 2013-09-10 | 2017-12-12 | Insys Development Company, Inc. | Sublingual buprenorphine spray |
| US9956166B2 (en) | 2013-09-18 | 2018-05-01 | Sorrento Therapeutics, Inc. | Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin |
| US9566233B2 (en) | 2013-11-14 | 2017-02-14 | Insys Development Company, Inc. | Ondansetron sublingual spray formulation |
| US10441538B2 (en) * | 2014-07-08 | 2019-10-15 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
| US10617686B2 (en) * | 2014-07-08 | 2020-04-14 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
| US10722510B2 (en) * | 2014-07-08 | 2020-07-28 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
| US9855234B2 (en) * | 2014-07-08 | 2018-01-02 | Insys Development Company, Inc. | Diclofenac sublingual spray |
| US20160199294A1 (en) * | 2014-07-08 | 2016-07-14 | Insys Development Company, Inc. | Sublingual naloxone spray |
| US11135155B2 (en) | 2014-07-08 | 2021-10-05 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
| JP2017519803A (ja) * | 2014-07-08 | 2017-07-20 | インシス・ファーマ・インコーポレーテッド | 舌下ナロキソンスプレー |
| US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
| US10172833B2 (en) | 2015-08-11 | 2019-01-08 | Insys Development Company, Inc. | Sublingual ondansetron spray |
| CN120114438A (zh) * | 2016-04-13 | 2025-06-10 | 内布拉斯加大学董事会 | 施用树脂毒素的方法和用树脂毒素治疗心血管疾病的方法 |
| US20170340557A1 (en) * | 2016-05-27 | 2017-11-30 | Insys Development Company, Inc. | Sublingual fentanyl formulations containing a permeation enhancer |
| US9650338B1 (en) | 2016-07-29 | 2017-05-16 | VDM Biochemicals, Inc. | Opioid antagonist compounds and methods of making and using |
| AU2021217164A1 (en) * | 2020-02-05 | 2022-08-25 | Summit Biosciences Inc. | Drug products for intranasal administration and uses thereof |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4244478A (en) | 1979-06-27 | 1981-01-13 | Mpl, Inc. | Closure assembly for unit dose vial |
| GB8900267D0 (en) | 1989-01-06 | 1989-03-08 | Riker Laboratories Inc | Narcotic analgesic formulations and apparatus containing same |
| US5219083A (en) | 1992-04-02 | 1993-06-15 | Sterling Winthrop Inc. | Stopper for reduction of particulate matter |
| ATE173396T1 (de) * | 1993-08-10 | 1998-12-15 | Boots Co Plc | Spruehformulierung mit kuehleffekt |
| ATE223202T1 (de) | 1994-09-30 | 2002-09-15 | Mika Pharma Ges Fuer Die Entwi | Pharmazeutische zusammensetzung |
| US20030095925A1 (en) | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders |
| US20050180923A1 (en) | 1997-10-01 | 2005-08-18 | Dugger Harry A.Iii | Buccal, polar and non-polar spray containing testosterone |
| US20050287075A1 (en) | 1997-10-01 | 2005-12-29 | Dugger Harry A Iii | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
| US20030095927A1 (en) | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders |
| US20030077229A1 (en) | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs |
| US20030185761A1 (en) | 1997-10-01 | 2003-10-02 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
| WO1999016417A1 (en) | 1997-10-01 | 1999-04-08 | Flemington Pharmaceutical Corporation | Buccal, polar and non-polar spray or capsule |
| US20030077228A1 (en) | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating endocrine disorders |
| US20050281752A1 (en) | 1997-10-01 | 2005-12-22 | Dugger Harry A Iii | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
| US20030095926A1 (en) | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract |
| US20030082107A1 (en) | 1997-10-01 | 2003-05-01 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer |
| US20030077227A1 (en) | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
| US20050163719A1 (en) | 1997-10-01 | 2005-07-28 | Dugger Harry A.Iii | Buccal, polar and non-polar spray containing diazepam |
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| US20040136913A1 (en) | 1997-10-01 | 2004-07-15 | Dugger Harry A. | Buccal, polar and non-polar spray containing sumatriptan |
| US20040141923A1 (en) | 1997-10-01 | 2004-07-22 | Dugger Harry A. | Buccal, polar and non-polar spray containing alprazolam |
| US20030190286A1 (en) | 1997-10-01 | 2003-10-09 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating allergies or asthma |
| US20040136914A1 (en) | 1997-10-01 | 2004-07-15 | Dugger Harry A. | Buccal, polar and non-polar spray containing ondansetron |
| US20040136915A1 (en) | 1997-10-01 | 2004-07-15 | Dugger Harry A. | Buccal, polar and non-polar spray containing atropine |
| US20090162300A1 (en) | 1997-10-01 | 2009-06-25 | Dugger Iii Harry A | Buccal, polar and non-polar spray containing alprazolam |
| SE9803239D0 (sv) | 1998-09-24 | 1998-09-24 | Diabact Ab | Composition for the treatment of acute pain |
| SE9803240D0 (sv) * | 1998-09-24 | 1998-09-24 | Diabact Ab | A pharmaceutical composition having a rapid action |
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| RU2432950C2 (ru) | 2006-01-25 | 2011-11-10 | Инсис Терапьютикс Инк. | Подъязычный спрей на основе фентанила |
| ES2668366T3 (es) * | 2007-08-02 | 2018-05-17 | Insys Development Company, Inc. | Pulverización sublingual de fentanilo |
-
2007
- 2007-01-25 RU RU2008130763/15A patent/RU2432950C2/ru not_active Application Discontinuation
- 2007-01-25 US US11/698,739 patent/US8486972B2/en not_active Expired - Fee Related
- 2007-01-25 DK DK07762549T patent/DK1976521T3/en active
- 2007-01-25 CN CN200780003555XA patent/CN101378735B/zh active Active
- 2007-01-25 AU AU2007208229A patent/AU2007208229B2/en not_active Ceased
- 2007-01-25 CA CA2637672A patent/CA2637672C/en not_active Expired - Fee Related
- 2007-01-25 EP EP13172985.7A patent/EP2641595A1/en not_active Withdrawn
- 2007-01-25 PL PL07762549T patent/PL1976521T3/pl unknown
- 2007-01-25 EP EP07762549.9A patent/EP1976521B1/en not_active Not-in-force
- 2007-01-25 MX MX2015000710A patent/MX374396B/es unknown
- 2007-01-25 ES ES07762549.9T patent/ES2535233T3/es active Active
- 2007-01-25 MX MX2008009522A patent/MX2008009522A/es active IP Right Grant
- 2007-01-25 PT PT77625499T patent/PT1976521E/pt unknown
- 2007-01-25 SI SI200731630T patent/SI1976521T1/sl unknown
- 2007-01-25 JP JP2008552436A patent/JP5241514B2/ja active Active
- 2007-01-25 BR BRPI0707235A patent/BRPI0707235B8/pt not_active IP Right Cessation
- 2007-01-25 WO PCT/US2007/002163 patent/WO2007087431A2/en not_active Ceased
- 2007-01-25 NZ NZ569949A patent/NZ569949A/en not_active IP Right Cessation
-
2008
- 2008-07-24 MX MX2020008616A patent/MX2020008616A/es unknown
-
2012
- 2012-11-22 JP JP2012256454A patent/JP5630877B2/ja active Active
-
2013
- 2013-03-22 JP JP2013059447A patent/JP2013127003A/ja active Pending
- 2013-05-15 US US13/895,124 patent/US8835460B2/en not_active Expired - Fee Related
-
2014
- 2014-07-31 US US14/448,720 patent/US9289387B2/en not_active Expired - Fee Related
-
2016
- 2016-02-12 US US15/042,999 patent/US9642797B2/en not_active Expired - Fee Related
-
2017
- 2017-04-04 US US15/478,430 patent/US10016403B2/en not_active Expired - Fee Related
-
2018
- 2018-06-27 US US16/019,941 patent/US20180303813A1/en not_active Abandoned
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 25 JAN 2017 BY COMPUTER PACKAGES INC Effective date: 20140128 |
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