NZ550174A - Combinations comprising a vasculostatic compound such as vatalanib and epothilones, and pharmaceutical uses thereof - Google Patents
Combinations comprising a vasculostatic compound such as vatalanib and epothilones, and pharmaceutical uses thereofInfo
- Publication number
- NZ550174A NZ550174A NZ550174A NZ55017402A NZ550174A NZ 550174 A NZ550174 A NZ 550174A NZ 550174 A NZ550174 A NZ 550174A NZ 55017402 A NZ55017402 A NZ 55017402A NZ 550174 A NZ550174 A NZ 550174A
- Authority
- NZ
- New Zealand
- Prior art keywords
- combination
- epothilone
- treatment
- lower alkyl
- hydrogen
- Prior art date
Links
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- 229950000578 vatalanib Drugs 0.000 title claims description 15
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Landscapes
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| NZ530572A NZ530572A (en) | 2001-07-19 | 2002-07-18 | Combinations comprising bisphosphonate and epothilones, and pharmaceutical uses thereof |
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| NZ530572A NZ530572A (en) | 2001-07-19 | 2002-07-18 | Combinations comprising bisphosphonate and epothilones, and pharmaceutical uses thereof |
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| EP (2) | EP2210643A3 (enExample) |
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| HU (1) | HUP0401153A3 (enExample) |
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| EP1386922B1 (en) | 1996-12-03 | 2012-04-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereof, analogues and uses thereof |
| US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| ATE554756T1 (de) | 2001-03-14 | 2012-05-15 | Bristol Myers Squibb Co | Kombination aus epothilon-analog und chemotherapeutika zur behandlung von proliferativen erkrankungen |
| TWI315982B (en) * | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| SI1686997T1 (sl) | 2003-11-18 | 2009-08-31 | Novartis Ag | Inhibitorji mutantne oblike KIT |
| US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
| EP1640004A1 (en) * | 2004-09-24 | 2006-03-29 | Schering Aktiengesellschaft | Use of epothilones in the treatment of bone metastases and bone tumors or cancers |
| US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
| CN103638028A (zh) | 2005-05-02 | 2014-03-19 | 诺瓦提斯公司 | 嘧啶基氨基苯甲酰胺衍生物用于治疗全身性肥大细胞增多症的应用 |
| CN100384419C (zh) * | 2005-12-02 | 2008-04-30 | 菏泽睿鹰制药集团有限公司 | 一种埃坡霉素缓释植入组合物及应用 |
| CA2927832C (en) | 2010-05-18 | 2021-03-23 | Cerulean Pharma Inc. | Cyclodextrin-containing polymer-therapeutic agent conjugates and their use |
| RU2478407C1 (ru) * | 2011-09-05 | 2013-04-10 | Федеральное государственное бюджетное учреждение Министерства здравоохранения и социального развития Российской Федерации "Медицинский радиологический научный центр" (ФГБУ МРНЦ Минздравсоцразвития России) | Способ комбинированного лечения местно-распространенного рака желудка |
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| US2409754A (en) * | 1946-10-22 | Method for obtaining hydantoins | ||
| US3475486A (en) * | 1966-09-12 | 1969-10-28 | Monsanto Co | Process for preparing phosphonic acids |
| FR2182943A1 (en) | 1972-04-10 | 1973-12-14 | Rustenburg Platinum Mines Ltd | Cis-dihalo-bis(ethyleneimine) platinum (ii) derivs - anti-cancer agents |
| CH605550A5 (enExample) | 1972-06-08 | 1978-09-29 | Research Corp | |
| DE2405254C2 (de) * | 1974-02-04 | 1982-05-27 | Henkel KGaA, 4000 Düsseldorf | Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper |
| FR2531088B1 (fr) * | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| IT1187828B (it) * | 1985-05-24 | 1987-12-23 | Gentili Ist Spa | Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| FR2694558B1 (fr) * | 1992-08-05 | 1994-10-28 | Sanofi Elf | Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant. |
| KR100335584B1 (ko) | 1992-10-28 | 2002-11-29 | 제넨테크, 인코포레이티드 | 혈관내피세포성장인자에대한길항제 |
| EP0675723A4 (en) | 1992-12-23 | 1998-08-05 | Merck & Co Inc | THERAPY USING BISPHOSPHONATES AND STROGENS TO TREAT AND PREVENT BONE RESORPTION. |
| AU2989695A (en) | 1994-08-08 | 2000-03-07 | Debiopharm S.A. | Pharmaceutically stable oxaliplatinum preparation |
| WO1996039149A1 (en) * | 1995-06-06 | 1996-12-12 | Merck & Co., Inc. | Anhydrous alendronate monosodium salt formulations |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| DE59609305D1 (de) * | 1995-11-17 | 2002-07-11 | Biotechnolog Forschung Gmbh | Epothilon-Derivate und deren Herstellung |
| AU716610B2 (en) | 1996-08-30 | 2000-03-02 | Novartis Ag | Method for producing epothilones, and intermediate products obtained during the production process |
| DE19638745C2 (de) | 1996-09-11 | 2001-05-10 | Schering Ag | Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR) |
| ATE267197T1 (de) | 1996-11-18 | 2004-06-15 | Biotechnolog Forschung Gmbh | Epothilon d, dessen herstellung und dessen verwendung als cytostatisches mittel bzw. als pflanzenschutzmittel |
| EP1386922B1 (en) * | 1996-12-03 | 2012-04-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereof, analogues and uses thereof |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| KR20080016756A (ko) | 1998-02-05 | 2008-02-21 | 노파르티스 아게 | 유기화합물 함유 조성물 |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
| CA2322157C (en) | 1998-02-25 | 2012-05-29 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
| AU5036999A (en) * | 1998-06-30 | 2000-01-17 | Schering Aktiengesellschaft | Epothilon derivatives, their preparation process, intermediate products and their pharmaceutical use |
| ES2342240T3 (es) | 1998-08-11 | 2010-07-02 | Novartis Ag | Derivados de isoquinolina con actividad que inhibe la angiogenia. |
| DE19845798A1 (de) * | 1998-09-29 | 2000-04-13 | Schering Ag | Verwendung von Neoangiogenese-Markern für Diagnose und Therapie von Tumoren, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung |
| UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| CN100381566C (zh) | 1998-11-20 | 2008-04-16 | 科森生物科学公司 | 产生环氧噻酮及其衍生物的重组方法和材料 |
| EP1579871A1 (en) | 1998-12-22 | 2005-09-28 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists and uses thereof |
| RU2236251C2 (ru) | 1999-02-12 | 2004-09-20 | Дзе Скриппс Рисерч Инститьют | Способы лечения опухолей и метастазов с использованием комбинации антиангиогенной терапии и иммунотерапии |
| DE19908760A1 (de) * | 1999-02-18 | 2000-08-24 | Schering Ag | Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
| ATE329596T1 (de) | 1999-03-30 | 2006-07-15 | Novartis Pharma Gmbh | Phthalazinderivate zur behandlung von entzündlicher erkrankungen |
| GB9907908D0 (en) * | 1999-04-07 | 1999-06-02 | Bataille Regis | Organic compounds |
| EP1178810B8 (en) * | 1999-05-21 | 2005-07-27 | Novartis AG | Use of bisphosphonic acids for treating angiogenesis |
| JP2003519183A (ja) * | 2000-01-04 | 2003-06-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 心臓および動脈の石灰化を抑制する低用量ビスホスホネートの使用 |
| GB0001930D0 (en) | 2000-01-27 | 2000-03-22 | Novartis Ag | Organic compounds |
| WO2001058899A1 (en) | 2000-02-09 | 2001-08-16 | Novartis Ag | Pyridine derivatives inhibiting angiogenesis and/or vegf receptor tyrosine kinase |
| ATE554756T1 (de) | 2001-03-14 | 2012-05-15 | Bristol Myers Squibb Co | Kombination aus epothilon-analog und chemotherapeutika zur behandlung von proliferativen erkrankungen |
| TWI315982B (en) * | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
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2002
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- 2002-07-18 NZ NZ550174A patent/NZ550174A/en not_active IP Right Cessation
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- 2002-07-18 CN CN200910168406A patent/CN101791308A/zh active Pending
- 2002-07-18 KR KR10-2004-7000700A patent/KR20040030808A/ko not_active Ceased
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- 2002-07-18 JP JP2003513533A patent/JP2005501825A/ja not_active Withdrawn
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- 2002-07-18 PL PL02365030A patent/PL365030A1/xx not_active IP Right Cessation
- 2002-07-18 EP EP02764726A patent/EP1412029A2/en not_active Withdrawn
- 2002-07-18 KR KR1020097006647A patent/KR20090040925A/ko not_active Ceased
- 2002-07-18 MX MXPA04000567A patent/MXPA04000567A/es active IP Right Grant
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- 2002-07-18 IL IL15951702A patent/IL159517A0/xx unknown
- 2002-07-18 HU HU0401153A patent/HUP0401153A3/hu unknown
- 2002-07-18 US US10/484,482 patent/US20040235796A1/en not_active Abandoned
- 2002-07-18 CN CNB028144147A patent/CN1283248C/zh not_active Expired - Fee Related
- 2002-07-18 BR BR0211271-0A patent/BR0211271A/pt not_active Application Discontinuation
- 2002-07-18 CA CA002453108A patent/CA2453108A1/en not_active Abandoned
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2003
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2004
- 2004-01-16 NO NO20040214A patent/NO20040214L/no not_active Application Discontinuation
- 2004-02-11 CO CO04011525A patent/CO5560565A2/es not_active Application Discontinuation
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2005
- 2005-12-20 AU AU2005246964A patent/AU2005246964B2/en not_active Ceased
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2008
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- 2008-07-04 EC EC2008004948A patent/ECSP084948A/es unknown
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2009
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2010
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