HUP0401153A3 - Combinations comprising epothilones and pharmaceutical uses thereof - Google Patents
Combinations comprising epothilones and pharmaceutical uses thereofInfo
- Publication number
- HUP0401153A3 HUP0401153A3 HU0401153A HUP0401153A HUP0401153A3 HU P0401153 A3 HUP0401153 A3 HU P0401153A3 HU 0401153 A HU0401153 A HU 0401153A HU P0401153 A HUP0401153 A HU P0401153A HU P0401153 A3 HUP0401153 A3 HU P0401153A3
- Authority
- HU
- Hungary
- Prior art keywords
- epothilones
- combinations
- pharmaceutical uses
- pharmaceutical
- Prior art date
Links
- 229930013356 epothilone Natural products 0.000 title 1
- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30655901P | 2001-07-19 | 2001-07-19 | |
| US30656001P | 2001-07-19 | 2001-07-19 | |
| US30657101P | 2001-07-19 | 2001-07-19 | |
| PCT/EP2002/008020 WO2003007924A2 (en) | 2001-07-19 | 2002-07-18 | Combinations comprising epothilones and pharmaceutical uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401153A2 HUP0401153A2 (hu) | 2004-10-28 |
| HUP0401153A3 true HUP0401153A3 (en) | 2008-01-28 |
Family
ID=27405180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401153A HUP0401153A3 (en) | 2001-07-19 | 2002-07-18 | Combinations comprising epothilones and pharmaceutical uses thereof |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20040235796A1 (hu) |
| EP (2) | EP2210643A3 (hu) |
| JP (2) | JP2005501825A (hu) |
| KR (2) | KR20090040925A (hu) |
| CN (2) | CN1283248C (hu) |
| AU (2) | AU2002328921B2 (hu) |
| BR (1) | BR0211271A (hu) |
| CA (1) | CA2453108A1 (hu) |
| CO (1) | CO5560565A2 (hu) |
| EC (2) | ECSP084948A (hu) |
| HU (1) | HUP0401153A3 (hu) |
| IL (2) | IL159517A0 (hu) |
| MX (1) | MXPA04000567A (hu) |
| NO (1) | NO20040214L (hu) |
| NZ (2) | NZ530572A (hu) |
| PL (1) | PL365030A1 (hu) |
| RU (1) | RU2375058C2 (hu) |
| TW (1) | TWI315982B (hu) |
| WO (1) | WO2003007924A2 (hu) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| WO1999001124A1 (en) | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US7312237B2 (en) | 2001-03-14 | 2007-12-25 | Bristol-Myers Squibb Co. | Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases |
| TWI315982B (en) * | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| SI1686997T1 (sl) | 2003-11-18 | 2009-08-31 | Novartis Ag | Inhibitorji mutantne oblike KIT |
| US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
| EP1640004A1 (en) * | 2004-09-24 | 2006-03-29 | Schering Aktiengesellschaft | Use of epothilones in the treatment of bone metastases and bone tumors or cancers |
| US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
| MX2007013741A (es) | 2005-05-02 | 2008-01-21 | Novartis Ag | Uso de derivados de pirimidilaminobenzamida para el tratamiento de mastocitosis sistemica. |
| CN100384419C (zh) * | 2005-12-02 | 2008-04-30 | 菏泽睿鹰制药集团有限公司 | 一种埃坡霉素缓释植入组合物及应用 |
| CA2799202C (en) | 2010-05-18 | 2016-07-05 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
| RU2478407C1 (ru) * | 2011-09-05 | 2013-04-10 | Федеральное государственное бюджетное учреждение Министерства здравоохранения и социального развития Российской Федерации "Медицинский радиологический научный центр" (ФГБУ МРНЦ Минздравсоцразвития России) | Способ комбинированного лечения местно-распространенного рака желудка |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2409754A (en) * | 1946-10-22 | Method for obtaining hydantoins | ||
| US3475486A (en) * | 1966-09-12 | 1969-10-28 | Monsanto Co | Process for preparing phosphonic acids |
| FR2182943A1 (en) | 1972-04-10 | 1973-12-14 | Rustenburg Platinum Mines Ltd | Cis-dihalo-bis(ethyleneimine) platinum (ii) derivs - anti-cancer agents |
| CH588505A5 (hu) | 1972-06-08 | 1977-06-15 | Research Corp | |
| DE2405254C2 (de) * | 1974-02-04 | 1982-05-27 | Henkel KGaA, 4000 Düsseldorf | Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper |
| FR2531088B1 (fr) * | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| IT1187828B (it) * | 1985-05-24 | 1987-12-23 | Gentili Ist Spa | Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| FR2694558B1 (fr) * | 1992-08-05 | 1994-10-28 | Sanofi Elf | Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant. |
| DE69233803D1 (de) | 1992-10-28 | 2011-03-31 | Genentech Inc | Verwendung von vaskulären Endothelwachstumsfaktor-Antagonisten |
| AU5953894A (en) | 1992-12-23 | 1994-07-19 | Merck & Co., Inc. | Bisphosphonate/estrogen therapy for treating and preventing bone loss |
| WO1996004904A1 (fr) | 1994-08-08 | 1996-02-22 | Debiopharm S.A. | Preparation pharmaceutiquement stable d'oxaliplatine |
| DK0833643T3 (da) * | 1995-06-06 | 2005-05-30 | Merck & Co Inc | Formuleringer af vandfrit mononatriumsalt af alendronat og deres anvendelse til behandling af knoglesygdomme |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| JP4183099B2 (ja) * | 1995-11-17 | 2008-11-19 | ゲゼルシャフト・フュア・ビオテヒノロジッシェ・フォルシュング・ミット・ベシュレンクテル・ハフツング（ゲー・ベー・エフ） | エポチロンｃおよびｄ、製造法ならびに組成物 |
| JP2001500851A (ja) | 1996-08-30 | 2001-01-23 | ノバルティス アクチエンゲゼルシャフト | エポシロンの製造法および製造過程中に得られる中間生産物 |
| DE19638745C2 (de) | 1996-09-11 | 2001-05-10 | Schering Ag | Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR) |
| CN100344627C (zh) | 1996-11-18 | 2007-10-24 | 生物技术研究有限公司(Gbf) | 埃坡霉素c、其制备方法以及作为细胞抑制剂和植物保护剂的应用 |
| WO1999001124A1 (en) * | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| AR017979A1 (es) * | 1998-02-05 | 2001-10-24 | Novartis Ag | Formulaciones farmaceuticas de epotilonas, metodo para su preparacion y el uso de los mismos para la manufactura de un medicamento |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| IL138113A0 (en) | 1998-02-25 | 2001-10-31 | Sloan Kettering Inst Cancer | Synthesis of epothilones, intermediates thereto and analogues thereof |
| FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
| US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
| WO2000000485A1 (de) * | 1998-06-30 | 2000-01-06 | Schering Aktiengesellschaft | Epothilon-derivate, verfahren zu deren herstellung, zwischenprodukte und ihre pharmazeutische verwendung |
| ES2342240T3 (es) | 1998-08-11 | 2010-07-02 | Novartis Ag | Derivados de isoquinolina con actividad que inhibe la angiogenia. |
| DE19845798A1 (de) * | 1998-09-29 | 2000-04-13 | Schering Ag | Verwendung von Neoangiogenese-Markern für Diagnose und Therapie von Tumoren, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung |
| UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| KR100716272B1 (ko) | 1998-11-20 | 2007-05-09 | 코산 바이오사이언시즈, 인코포레이티드 | 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질 |
| EP1140173B2 (en) | 1998-12-22 | 2013-04-03 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists and uses thereof |
| DK1156823T3 (da) | 1999-02-12 | 2009-01-19 | Scripps Research Inst | Fremgangsmåder til behandling af tumorer og metastaser ved anvendelse af en kombination af anti-angiogene terapier og immunoterapier |
| DE19908760A1 (de) * | 1999-02-18 | 2000-08-24 | Schering Ag | Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
| BR0009507A (pt) | 1999-03-30 | 2002-01-15 | Novartis Ag | Derivados de ftalazina para o tratamento de doenças inflamatórias |
| GB9907908D0 (en) * | 1999-04-07 | 1999-06-02 | Bataille Regis | Organic compounds |
| WO2000071104A2 (en) * | 1999-05-21 | 2000-11-30 | Novartis Ag | Use of bisphosphonic acids for treating angiogenesis |
| JP2003519183A (ja) * | 2000-01-04 | 2003-06-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 心臓および動脈の石灰化を抑制する低用量ビスホスホネートの使用 |
| GB0001930D0 (en) | 2000-01-27 | 2000-03-22 | Novartis Ag | Organic compounds |
| US6706731B2 (en) | 2000-02-09 | 2004-03-16 | Novartis Ag | Pyridine derivatives inhibiting angiogenesis and/or VEGF receptor tyrosine kinase |
| US7312237B2 (en) | 2001-03-14 | 2007-12-25 | Bristol-Myers Squibb Co. | Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases |
| TWI315982B (en) * | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
-
2002
- 2002-07-17 TW TW091115929A patent/TWI315982B/zh not_active IP Right Cessation
- 2002-07-18 CN CNB028144147A patent/CN1283248C/zh not_active Expired - Fee Related
- 2002-07-18 HU HU0401153A patent/HUP0401153A3/hu unknown
- 2002-07-18 RU RU2004105144/15A patent/RU2375058C2/ru not_active IP Right Cessation
- 2002-07-18 KR KR1020097006647A patent/KR20090040925A/ko not_active Application Discontinuation
- 2002-07-18 CN CN200910168406A patent/CN101791308A/zh active Pending
- 2002-07-18 KR KR10-2004-7000700A patent/KR20040030808A/ko not_active Application Discontinuation
- 2002-07-18 US US10/484,482 patent/US20040235796A1/en not_active Abandoned
- 2002-07-18 NZ NZ530572A patent/NZ530572A/en not_active IP Right Cessation
- 2002-07-18 PL PL02365030A patent/PL365030A1/xx not_active IP Right Cessation
- 2002-07-18 JP JP2003513533A patent/JP2005501825A/ja not_active Withdrawn
- 2002-07-18 AU AU2002328921A patent/AU2002328921B2/en not_active Ceased
- 2002-07-18 EP EP10157876A patent/EP2210643A3/en not_active Withdrawn
- 2002-07-18 WO PCT/EP2002/008020 patent/WO2003007924A2/en active Application Filing
- 2002-07-18 EP EP02764726A patent/EP1412029A2/en not_active Withdrawn
- 2002-07-18 BR BR0211271-0A patent/BR0211271A/pt not_active Application Discontinuation
- 2002-07-18 NZ NZ550174A patent/NZ550174A/en not_active IP Right Cessation
- 2002-07-18 IL IL15951702A patent/IL159517A0/xx unknown
- 2002-07-18 CA CA002453108A patent/CA2453108A1/en not_active Abandoned
- 2002-07-18 MX MXPA04000567A patent/MXPA04000567A/es active IP Right Grant
-
2003
- 2003-12-22 IL IL159517A patent/IL159517A/en not_active IP Right Cessation
-
2004
- 2004-01-16 NO NO20040214A patent/NO20040214L/no not_active Application Discontinuation
- 2004-02-11 CO CO04011525A patent/CO5560565A2/es not_active Application Discontinuation
-
2005
- 2005-12-20 AU AU2005246964A patent/AU2005246964B2/en not_active Ceased
-
2008
- 2008-01-24 US US12/019,294 patent/US7612052B2/en not_active Expired - Fee Related
- 2008-07-04 EC EC2008004948A patent/ECSP084948A/es unknown
-
2009
- 2009-08-28 US US12/549,947 patent/US8008330B2/en not_active Expired - Fee Related
- 2009-11-19 EC EC2009004948A patent/ECSP094948A/es unknown
-
2010
- 2010-03-01 JP JP2010044000A patent/JP2010159271A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1463742A4 (en) | NEW PYRAZOLO AND PYRROLO PYRIMIDINES AND THEIR USES | |
| HK1084883A1 (en) | 2-cyanopyrrolopyrimidines and pharmaceutical uses thereof | |
| EP1367060A4 (en) | GLUCOPYRANOSYLOXYBENZYLBENZENE DERIVATIVES AND THEIR MEDICAL USE | |
| EP1364957A4 (en) | GLYCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND THEIR MEDICAL USE | |
| EP1364958A4 (en) | GLYCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND MEDICINAL USE THEREOF | |
| IL158523A0 (en) | Epothilone derivatives and pharmaceutical compositions containing the same | |
| EP1408978A4 (en) | NOVEL PHENYLAMINO-PYRIMIDINES AND THEIR USE | |
| PL366510A1 (en) | Pharmaceutical combinations | |
| IL154553A0 (en) | Urocortin-iii and uses thereof | |
| HK1069385A1 (en) | Heterocyclic compound and medicinal use thereof | |
| GB0108470D0 (en) | Pharmaceutical compositions and their use | |
| TWI315982B (en) | Combinations comprising epothilones and pharmaceutical uses thereof | |
| AU2003296369A8 (en) | Imminoamines and preparation thereof | |
| GB0126889D0 (en) | Compounds and their uses | |
| EP1379228A4 (en) | (Z) -STYRYLBENZYLSULPONES AND THEIR PHARMACEUTICAL APPLICATIONS | |
| EP1392317A4 (en) | SUBSTITUTED 1-BENZAZEPINE AND DERIVATIVES THEREOF | |
| EP1408985A4 (en) | NEW PYRIDOPYRIMIDONE AND ITS USES | |
| IL153176A (en) | Phenylpiperazines and pharmaceutical compositions comprising them | |
| GB0129872D0 (en) | Novel pharmaceutical | |
| AUPR548601A0 (en) | Pyrazolopyrazinecompound and pharmaceutical use thereof | |
| EP1367123A4 (en) | NEUROTONIN AND ITS USE | |
| GB0128138D0 (en) | Pharmaceutical use | |
| GB0102447D0 (en) | Protein variants and uses thereof | |
| GB0129876D0 (en) | Novel pharmaceutical | |
| GB0130509D0 (en) | Novel pharmaceutical |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |