KR20040030808A - 에포틸론 포함 조합물 및 그의 제약 용도 - Google Patents

에포틸론 포함 조합물 및 그의 제약 용도 Download PDF

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Publication number
KR20040030808A
KR20040030808A KR10-2004-7000700A KR20047000700A KR20040030808A KR 20040030808 A KR20040030808 A KR 20040030808A KR 20047000700 A KR20047000700 A KR 20047000700A KR 20040030808 A KR20040030808 A KR 20040030808A
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KR
South Korea
Prior art keywords
combination
formula
hydrogen
lower alkyl
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR10-2004-7000700A
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English (en)
Korean (ko)
Inventor
티안링 첸
다이앤 그릴레이
존 데이비드 로터멜
마르쿠스 와르트만
지넷 마저리 우드
Original Assignee
노파르티스 아게
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Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20040030808A publication Critical patent/KR20040030808A/ko
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/502Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR10-2004-7000700A 2001-07-19 2002-07-18 에포틸론 포함 조합물 및 그의 제약 용도 Ceased KR20040030808A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US30657101P 2001-07-19 2001-07-19
US30656001P 2001-07-19 2001-07-19
US30655901P 2001-07-19 2001-07-19
US60/306,560 2001-07-19
US60/306,571 2001-07-19
US60/306,559 2001-07-19
PCT/EP2002/008020 WO2003007924A2 (en) 2001-07-19 2002-07-18 Combinations comprising epothilones and pharmaceutical uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020097006647A Division KR20090040925A (ko) 2001-07-19 2002-07-18 에포틸론 포함 조합물 및 그의 제약 용도

Publications (1)

Publication Number Publication Date
KR20040030808A true KR20040030808A (ko) 2004-04-09

Family

ID=27405180

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020097006647A Ceased KR20090040925A (ko) 2001-07-19 2002-07-18 에포틸론 포함 조합물 및 그의 제약 용도
KR10-2004-7000700A Ceased KR20040030808A (ko) 2001-07-19 2002-07-18 에포틸론 포함 조합물 및 그의 제약 용도

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020097006647A Ceased KR20090040925A (ko) 2001-07-19 2002-07-18 에포틸론 포함 조합물 및 그의 제약 용도

Country Status (19)

Country Link
US (3) US20040235796A1 (enExample)
EP (2) EP2210643A3 (enExample)
JP (2) JP2005501825A (enExample)
KR (2) KR20090040925A (enExample)
CN (2) CN101791308A (enExample)
AU (2) AU2002328921B2 (enExample)
BR (1) BR0211271A (enExample)
CA (1) CA2453108A1 (enExample)
CO (1) CO5560565A2 (enExample)
EC (2) ECSP084948A (enExample)
HU (1) HUP0401153A3 (enExample)
IL (2) IL159517A0 (enExample)
MX (1) MXPA04000567A (enExample)
NO (1) NO20040214L (enExample)
NZ (2) NZ530572A (enExample)
PL (1) PL365030A1 (enExample)
RU (1) RU2375058C2 (enExample)
TW (1) TWI315982B (enExample)
WO (1) WO2003007924A2 (enExample)

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US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP0977563B1 (en) 1996-12-03 2005-10-12 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
WO2002072085A1 (en) 2001-03-14 2002-09-19 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
TWI315982B (en) * 2001-07-19 2009-10-21 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US20050171167A1 (en) * 2003-11-04 2005-08-04 Haby Thomas A. Process and formulation containing epothilones and analogs thereof
JP4762150B2 (ja) 2003-11-18 2011-08-31 ノバルティス アーゲー Kitの変異体の阻害剤
US20050215604A1 (en) * 2004-03-26 2005-09-29 Kosan Biosciences, Inc. Combination therapies with epothilones and carboplatin
EP1640004A1 (en) * 2004-09-24 2006-03-29 Schering Aktiengesellschaft Use of epothilones in the treatment of bone metastases and bone tumors or cancers
US20060121511A1 (en) 2004-11-30 2006-06-08 Hyerim Lee Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
PL1879585T3 (pl) 2005-05-02 2013-08-30 Novartis Ag Zastosowanie pochodnych pirymidyloaminobenzamidowych do leczenia mastocytozy układowej
CN100384419C (zh) * 2005-12-02 2008-04-30 菏泽睿鹰制药集团有限公司 一种埃坡霉素缓释植入组合物及应用
CA2799202C (en) 2010-05-18 2016-07-05 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
RU2478407C1 (ru) * 2011-09-05 2013-04-10 Федеральное государственное бюджетное учреждение Министерства здравоохранения и социального развития Российской Федерации "Медицинский радиологический научный центр" (ФГБУ МРНЦ Минздравсоцразвития России) Способ комбинированного лечения местно-распространенного рака желудка

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TWI315982B (en) * 2001-07-19 2009-10-21 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof

Also Published As

Publication number Publication date
KR20090040925A (ko) 2009-04-27
WO2003007924A3 (en) 2003-09-25
TWI315982B (en) 2009-10-21
ECSP084948A (es) 2008-08-29
IL159517A0 (en) 2004-06-01
RU2004105144A (ru) 2005-04-20
BR0211271A (pt) 2004-08-03
RU2375058C2 (ru) 2009-12-10
US20040235796A1 (en) 2004-11-25
US7612052B2 (en) 2009-11-03
HUP0401153A2 (hu) 2004-10-28
US8008330B2 (en) 2011-08-30
JP2005501825A (ja) 2005-01-20
PL365030A1 (en) 2004-12-27
AU2005246964A1 (en) 2006-01-12
NZ550174A (en) 2008-04-30
CN101791308A (zh) 2010-08-04
NZ530572A (en) 2006-11-30
CO5560565A2 (es) 2005-09-30
AU2005246964B2 (en) 2008-04-24
ECSP094948A (es) 2009-12-28
CN1283248C (zh) 2006-11-08
CA2453108A1 (en) 2003-01-30
WO2003007924A2 (en) 2003-01-30
US20090318390A1 (en) 2009-12-24
HUP0401153A3 (en) 2008-01-28
US20080119529A1 (en) 2008-05-22
EP1412029A2 (en) 2004-04-28
EP2210643A2 (en) 2010-07-28
JP2010159271A (ja) 2010-07-22
MXPA04000567A (es) 2004-04-20
CN1533293A (zh) 2004-09-29
AU2002328921B2 (en) 2006-11-02
IL159517A (en) 2012-04-30
EP2210643A3 (en) 2010-11-24
NO20040214L (no) 2004-03-18

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