NZ541151A - Triazolopyridazines as protein kinase inhibitors - Google Patents
Triazolopyridazines as protein kinase inhibitorsInfo
- Publication number
- NZ541151A NZ541151A NZ541151A NZ54115103A NZ541151A NZ 541151 A NZ541151 A NZ 541151A NZ 541151 A NZ541151 A NZ 541151A NZ 54115103 A NZ54115103 A NZ 54115103A NZ 541151 A NZ541151 A NZ 541151A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- optionally substituted
- qrx
- zry
- occurrence
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/503—Pyridazines; Hydrogenated pyridazines spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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| WO2012151512A2 (en) | 2011-05-04 | 2012-11-08 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
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| CA2945263A1 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
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| CN108498512A (zh) * | 2018-04-22 | 2018-09-07 | 于志国 | 一种治疗心力衰竭的药物组合物及其制备方法和用途 |
| CN109045036B (zh) * | 2018-07-19 | 2020-10-02 | 中山大学 | [1,2,4]三唑并[4,3-b]哒嗪衍生物在制备抗肿瘤药物中的应用 |
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| DE2261693A1 (de) * | 1972-04-01 | 1974-06-20 | Boehringer Mannheim Gmbh | Nitroimidazolyl-triazolo-pyridazine und verfahren zu ihrer herstellung |
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| IL127911A0 (en) * | 1996-07-25 | 1999-11-30 | Merck Sharp & Dohme | Substituted triazolo-pyridazine derivatives as ligands for gaba receptors |
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| DE10038019A1 (de) * | 2000-08-04 | 2002-02-14 | Bayer Ag | Substituierte Triazolopyrid(az)ine |
| WO2002083139A1 (en) | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
| AU2002251266A1 (en) | 2001-04-10 | 2002-10-28 | Merck Sharp And Dohme Limited | Inhibitors of akt activity |
| JP4385620B2 (ja) * | 2002-03-01 | 2009-12-16 | アステラス製薬株式会社 | 含窒素複素環化合物 |
| CA2476757A1 (en) | 2002-03-01 | 2003-09-12 | Yamanouchi Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compound |
-
2003
- 2003-12-17 NZ NZ541151A patent/NZ541151A/en unknown
- 2003-12-17 US US10/738,956 patent/US7268136B2/en not_active Expired - Fee Related
- 2003-12-17 EP EP03814020A patent/EP1575959B1/en not_active Expired - Lifetime
- 2003-12-17 JP JP2004563592A patent/JP4817661B2/ja not_active Expired - Fee Related
- 2003-12-17 KR KR1020057011467A patent/KR101075812B1/ko not_active Expired - Fee Related
- 2003-12-17 CN CNB2003801091296A patent/CN100567296C/zh not_active Expired - Fee Related
- 2003-12-17 AT AT03814020T patent/ATE473980T1/de not_active IP Right Cessation
- 2003-12-17 RU RU2005122484/04A patent/RU2005122484A/ru not_active Application Discontinuation
- 2003-12-17 CA CA2510534A patent/CA2510534C/en not_active Expired - Fee Related
- 2003-12-17 AU AU2003297161A patent/AU2003297161B8/en not_active Ceased
- 2003-12-17 DE DE60333387T patent/DE60333387D1/de not_active Expired - Lifetime
- 2003-12-17 WO PCT/US2003/039990 patent/WO2004058769A2/en not_active Ceased
- 2003-12-17 MX MXPA05006478A patent/MXPA05006478A/es active IP Right Grant
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2005
- 2005-07-15 NO NO20053470A patent/NO20053470L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN100567296C (zh) | 2009-12-09 |
| RU2005122484A (ru) | 2006-01-20 |
| HK1087700A1 (zh) | 2006-10-20 |
| ATE473980T1 (de) | 2010-07-15 |
| NO20053470L (no) | 2005-09-02 |
| EP1575959A2 (en) | 2005-09-21 |
| AU2003297161B8 (en) | 2011-03-31 |
| KR20050084428A (ko) | 2005-08-26 |
| WO2004058769A2 (en) | 2004-07-15 |
| AU2003297161B2 (en) | 2011-03-10 |
| AU2003297161A1 (en) | 2004-07-22 |
| MXPA05006478A (es) | 2005-09-08 |
| US20040192696A1 (en) | 2004-09-30 |
| JP4817661B2 (ja) | 2011-11-16 |
| DE60333387D1 (de) | 2010-08-26 |
| EP1575959B1 (en) | 2010-07-14 |
| CN1742012A (zh) | 2006-03-01 |
| WO2004058769A3 (en) | 2004-09-30 |
| CA2510534A1 (en) | 2004-07-15 |
| JP2006513208A (ja) | 2006-04-20 |
| US7268136B2 (en) | 2007-09-11 |
| KR101075812B1 (ko) | 2011-10-25 |
| CA2510534C (en) | 2011-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| ERR | Error or correction |
Free format text: THE OWNER HAS BEEN CORRECTED TO 3155030, VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON, MASSACHUSETTS 02210, US Effective date: 20150127 |