NZ535578A - Methods of inducing terminal differentiation - Google Patents

Methods of inducing terminal differentiation

Info

Publication number
NZ535578A
NZ535578A NZ535578A NZ53557803A NZ535578A NZ 535578 A NZ535578 A NZ 535578A NZ 535578 A NZ535578 A NZ 535578A NZ 53557803 A NZ53557803 A NZ 53557803A NZ 535578 A NZ535578 A NZ 535578A
Authority
NZ
New Zealand
Prior art keywords
saha
pharmaceutically acceptable
hydrate
acceptable salt
hydroxamic acid
Prior art date
Application number
NZ535578A
Other languages
English (en)
Inventor
Victora M Richon
Thomas A Miller
Judy Chiao
W Kevin Kelly
Original Assignee
Merck Hdac Res Llc
Sloan Kettering Inst Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27805074&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ535578(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Hdac Res Llc, Sloan Kettering Inst Cancer filed Critical Merck Hdac Res Llc
Publication of NZ535578A publication Critical patent/NZ535578A/en

Links

Classifications

    • AHUMAN NECESSITIES
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    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/164Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
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    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
NZ535578A 2002-03-04 2003-03-04 Methods of inducing terminal differentiation NZ535578A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36175902P 2002-03-04 2002-03-04
PCT/US2003/006451 WO2003075839A2 (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation

Publications (1)

Publication Number Publication Date
NZ535578A true NZ535578A (en) 2008-03-28

Family

ID=27805074

Family Applications (3)

Application Number Title Priority Date Filing Date
NZ55018503A NZ550185A (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation Methods of inducing terminal differentiation
NZ535578A NZ535578A (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation
NZ567758A NZ567758A (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation using suberoylanilide hydrozmic acid (SAHA)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NZ55018503A NZ550185A (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation Methods of inducing terminal differentiation

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ567758A NZ567758A (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation using suberoylanilide hydrozmic acid (SAHA)

Country Status (18)

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US (7) US20040072735A1 (US20040072735A1-20040415-C00087.png)
EP (4) EP2266552A3 (US20040072735A1-20040415-C00087.png)
JP (4) JP4732693B2 (US20040072735A1-20040415-C00087.png)
KR (2) KR100892016B1 (US20040072735A1-20040415-C00087.png)
CN (3) CN101259120B (US20040072735A1-20040415-C00087.png)
AU (1) AU2003213684C1 (US20040072735A1-20040415-C00087.png)
BR (1) BR0308250A (US20040072735A1-20040415-C00087.png)
CA (3) CA2478094C (US20040072735A1-20040415-C00087.png)
ES (1) ES2532607T3 (US20040072735A1-20040415-C00087.png)
HK (1) HK1072362A1 (US20040072735A1-20040415-C00087.png)
IL (3) IL163909A0 (US20040072735A1-20040415-C00087.png)
MX (1) MXPA04008577A (US20040072735A1-20040415-C00087.png)
NO (2) NO329984B1 (US20040072735A1-20040415-C00087.png)
NZ (3) NZ550185A (US20040072735A1-20040415-C00087.png)
PL (1) PL372239A1 (US20040072735A1-20040415-C00087.png)
RU (3) RU2394022C2 (US20040072735A1-20040415-C00087.png)
WO (1) WO2003075839A2 (US20040072735A1-20040415-C00087.png)
ZA (2) ZA200407942B (US20040072735A1-20040415-C00087.png)

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US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
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US7148257B2 (en) 2002-03-04 2006-12-12 Merck Hdac Research, Llc Methods of treating mesothelioma with suberoylanilide hydroxamic acid
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