NZ530123A - Particles comprising DPPC, insulin, sodium citrate and optionally an amino acid in a composition for inhalation that has rapid release properties - Google Patents
Particles comprising DPPC, insulin, sodium citrate and optionally an amino acid in a composition for inhalation that has rapid release propertiesInfo
- Publication number
- NZ530123A NZ530123A NZ530123A NZ53012302A NZ530123A NZ 530123 A NZ530123 A NZ 530123A NZ 530123 A NZ530123 A NZ 530123A NZ 53012302 A NZ53012302 A NZ 53012302A NZ 530123 A NZ530123 A NZ 530123A
- Authority
- NZ
- New Zealand
- Prior art keywords
- particles
- insulin
- dppc
- sodium citrate
- weight
- Prior art date
Links
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 238000011321 prophylaxis Methods 0.000 description 1
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- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
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- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
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- NJGWOFRZMQRKHT-UHFFFAOYSA-N surfactin Natural products CC(C)CCCCCCCCCC1CC(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O1 NJGWOFRZMQRKHT-UHFFFAOYSA-N 0.000 description 1
- NJGWOFRZMQRKHT-WGVNQGGSSA-N surfactin C Chemical compound CC(C)CCCCCCCCC[C@@H]1CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O1 NJGWOFRZMQRKHT-WGVNQGGSSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Electric Propulsion And Braking For Vehicles (AREA)
- Charge And Discharge Circuits For Batteries Or The Like (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/888,126 US20020141946A1 (en) | 2000-12-29 | 2001-06-22 | Particles for inhalation having rapid release properties |
| PCT/US2002/020280 WO2003000202A2 (en) | 2001-06-22 | 2002-06-24 | Particles for inhalation having rapid release properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ530123A true NZ530123A (en) | 2007-01-26 |
Family
ID=25392579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ530123A NZ530123A (en) | 2001-06-22 | 2002-06-24 | Particles comprising DPPC, insulin, sodium citrate and optionally an amino acid in a composition for inhalation that has rapid release properties |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20020141946A1 (enExample) |
| EP (1) | EP1404299A2 (enExample) |
| JP (1) | JP4067047B2 (enExample) |
| CN (1) | CN1518441A (enExample) |
| CA (1) | CA2449439A1 (enExample) |
| IL (1) | IL158987A0 (enExample) |
| MX (1) | MXPA03011861A (enExample) |
| NZ (1) | NZ530123A (enExample) |
| PL (1) | PL367399A1 (enExample) |
| WO (1) | WO2003000202A2 (enExample) |
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| US9119778B2 (en) | 2009-03-26 | 2015-09-01 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| US9433576B2 (en) | 2010-09-29 | 2016-09-06 | Pulmatrix, Inc. | Cationic dry powders |
| US9642798B2 (en) | 2010-09-29 | 2017-05-09 | Pulmatrix, Inc. | Monovalent metal cation dry powders for inhalation |
| US9737518B2 (en) | 2013-04-01 | 2017-08-22 | Pulmatrix Operating Company, Inc. | Tiotropium dry powders |
| US10589039B2 (en) | 2012-02-29 | 2020-03-17 | Pulmatric Operating Company, Inc. | Methods for producing respirable dry powders |
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| US20060171899A1 (en) * | 1998-12-10 | 2006-08-03 | Akwete Adjei | Water-stabilized aerosol formulation system and method of making |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| US7575761B2 (en) | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
| JP2005507881A (ja) * | 2001-09-17 | 2005-03-24 | グラクソ グループ リミテッド | 乾燥粉末医薬製剤 |
| EP1446104B2 (en) | 2001-11-01 | 2011-08-03 | Novartis AG | Spray drying methods |
| US6923175B2 (en) | 2002-03-20 | 2005-08-02 | Mannkind Corporation | Inhalation apparatus |
| US7008644B2 (en) | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
| US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
| KR20120080243A (ko) * | 2003-05-28 | 2012-07-16 | 노바르티스 아게 | 아미노산 및/또는 인지질로 부분 또는 완전 코팅된 수불용성 활성제 미립자의 제조를 위한 알코올성 수용액의 분무 건조법 |
| JP2007517771A (ja) * | 2003-10-01 | 2007-07-05 | モメンタ ファーマシューティカルズ インコーポレイテッド | 活性物質を肺送達するための多糖 |
| JP2007523319A (ja) * | 2003-10-03 | 2007-08-16 | アルザ コーポレイション | リポソーム組成物中の二重層−薬物相互作用の評価のためのスクリーニング方法 |
| EP1718277A1 (en) * | 2004-02-10 | 2006-11-08 | Advanced Inhalation Research, Inc. | Particles for inhalation rapid release properties |
| CN101010305B (zh) | 2004-08-20 | 2010-08-11 | 曼金德公司 | 二酮哌嗪合成的催化反应 |
| BR122019022692B1 (pt) | 2004-08-23 | 2023-01-10 | Mannkind Corporation | Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo |
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| FR3020947B1 (fr) | 2014-05-14 | 2018-08-31 | Adocia | Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations |
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- 2002-06-24 NZ NZ530123A patent/NZ530123A/en unknown
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2007
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2009
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| US9238005B2 (en) | 2009-03-26 | 2016-01-19 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
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| US9233158B2 (en) | 2010-08-30 | 2016-01-12 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
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| US10376465B2 (en) | 2010-09-29 | 2019-08-13 | Pulmatrix Operating Company, Inc. | Monovalent metal cation dry powders for inhalation |
| US10589039B2 (en) | 2012-02-29 | 2020-03-17 | Pulmatric Operating Company, Inc. | Methods for producing respirable dry powders |
| US10806871B2 (en) | 2012-02-29 | 2020-10-20 | Pulmatrix Operating Company, Inc. | Inhalable dry powders |
| US11235112B2 (en) | 2012-02-29 | 2022-02-01 | Pulmatrix Operating Company, Inc. | Inhalable dry powders |
| US9737518B2 (en) | 2013-04-01 | 2017-08-22 | Pulmatrix Operating Company, Inc. | Tiotropium dry powders |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03011861A (es) | 2004-03-26 |
| US20080227690A1 (en) | 2008-09-18 |
| JP2005500309A (ja) | 2005-01-06 |
| CN1518441A (zh) | 2004-08-04 |
| IL158987A0 (en) | 2004-05-12 |
| WO2003000202A2 (en) | 2003-01-03 |
| JP4067047B2 (ja) | 2008-03-26 |
| US20100026235A1 (en) | 2010-02-04 |
| WO2003000202A3 (en) | 2003-08-14 |
| EP1404299A2 (en) | 2004-04-07 |
| PL367399A1 (en) | 2005-02-21 |
| CA2449439A1 (en) | 2003-01-03 |
| US20020141946A1 (en) | 2002-10-03 |
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| Date | Code | Title | Description |
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| RENW | Renewal (renewal fees accepted) | ||
| PSEA | Patent sealed |