CN1518441A - 具有快速释放性质的吸入式微粒 - Google Patents

具有快速释放性质的吸入式微粒 Download PDF

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Publication number
CN1518441A
CN1518441A CNA028125665A CN02812566A CN1518441A CN 1518441 A CN1518441 A CN 1518441A CN A028125665 A CNA028125665 A CN A028125665A CN 02812566 A CN02812566 A CN 02812566A CN 1518441 A CN1518441 A CN 1518441A
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China
Prior art keywords
microparticles
insulin
weight
dppc
sodium citrate
Prior art date
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Pending
Application number
CNA028125665A
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English (en)
Chinese (zh)
Inventor
ղ�ݸ���L��ʩ���ؿ�
詹妮弗·L·施米特克
P����̩
陈东浩
A���»���
理查德·P·巴泰基
��S���տ���
戴维·A·爱德华兹
杰弗里·S·赫凯奇
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Advanced Inhalation Research Inc
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Advanced Inhalation Research Inc
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Application filed by Advanced Inhalation Research Inc filed Critical Advanced Inhalation Research Inc
Publication of CN1518441A publication Critical patent/CN1518441A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Charge And Discharge Circuits For Batteries Or The Like (AREA)
  • Electric Propulsion And Braking For Vehicles (AREA)
CNA028125665A 2001-06-22 2002-06-24 具有快速释放性质的吸入式微粒 Pending CN1518441A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/888,126 US20020141946A1 (en) 2000-12-29 2001-06-22 Particles for inhalation having rapid release properties
US09/888,126 2001-06-22

Publications (1)

Publication Number Publication Date
CN1518441A true CN1518441A (zh) 2004-08-04

Family

ID=25392579

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028125665A Pending CN1518441A (zh) 2001-06-22 2002-06-24 具有快速释放性质的吸入式微粒

Country Status (10)

Country Link
US (3) US20020141946A1 (enExample)
EP (1) EP1404299A2 (enExample)
JP (1) JP4067047B2 (enExample)
CN (1) CN1518441A (enExample)
CA (1) CA2449439A1 (enExample)
IL (1) IL158987A0 (enExample)
MX (1) MXPA03011861A (enExample)
NZ (1) NZ530123A (enExample)
PL (1) PL367399A1 (enExample)
WO (1) WO2003000202A2 (enExample)

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CN107041949A (zh) * 2008-08-15 2017-08-15 阿索尔达治疗公司 在cns神经性损伤后非‑急性期间处理的组合物及方法
CN107596518A (zh) * 2012-02-29 2018-01-19 普马特里克斯营业公司 可吸入干粉剂
CN108434126A (zh) * 2009-03-26 2018-08-24 普马特里克斯营业公司 治疗肺病的干粉配方与方法

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US20100026235A1 (en) 2010-02-04
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JP2005500309A (ja) 2005-01-06
US20020141946A1 (en) 2002-10-03
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US20080227690A1 (en) 2008-09-18

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