NZ501808A - Arylpyridazinones and their use as prostaglandin endoperoxide H synthase biosynthesis inhibitors - Google Patents
Arylpyridazinones and their use as prostaglandin endoperoxide H synthase biosynthesis inhibitorsInfo
- Publication number
- NZ501808A NZ501808A NZ501808A NZ50180898A NZ501808A NZ 501808 A NZ501808 A NZ 501808A NZ 501808 A NZ501808 A NZ 501808A NZ 50180898 A NZ50180898 A NZ 50180898A NZ 501808 A NZ501808 A NZ 501808A
- Authority
- NZ
- New Zealand
- Prior art keywords
- heterocyclic
- alkyl
- alkoxy
- amino
- formula
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 150000003180 prostaglandins Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- -1 cycloalkenylalkyl Chemical group 0.000 abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 3
- 125000005015 aryl alkynyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004104 aryloxy group Chemical group 0.000 abstract 3
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 3
- 125000005343 heterocyclic alkyl group Chemical group 0.000 abstract 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 2
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000003368 amide group Chemical group 0.000 abstract 2
- 125000002431 aminoalkoxy group Chemical group 0.000 abstract 2
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 abstract 2
- 125000001691 aryl alkyl amino group Chemical group 0.000 abstract 2
- 125000004659 aryl alkyl thio group Chemical group 0.000 abstract 2
- 125000001769 aryl amino group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 2
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000004986 diarylamino group Chemical group 0.000 abstract 2
- 125000005291 haloalkenyloxy group Chemical group 0.000 abstract 2
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 2
- 125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- 125000005093 alkyl carbonyl alkyl group Chemical group 0.000 abstract 1
- 125000004688 alkyl sulfonyl alkyl group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000006213 aryl hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
- 125000005164 aryl thioalkyl group Chemical group 0.000 abstract 1
- 125000006212 aryloxy hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 1
- 125000000232 haloalkynyl group Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/18—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91702397A | 1997-08-22 | 1997-08-22 | |
| US12957098A | 1998-08-05 | 1998-08-05 | |
| PCT/US1998/016479 WO1999010331A1 (en) | 1997-08-22 | 1998-08-10 | Arylpyridazinones as prostaglandin endoperoxide h synthase biosynthesis inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ501808A true NZ501808A (en) | 2002-12-20 |
Family
ID=26827711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ501808A NZ501808A (en) | 1997-08-22 | 1998-08-10 | Arylpyridazinones and their use as prostaglandin endoperoxide H synthase biosynthesis inhibitors |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JP2003516925A (cs) |
| KR (1) | KR100675028B1 (cs) |
| CN (1) | CN1167687C (cs) |
| AR (1) | AR015422A1 (cs) |
| AU (1) | AU741317B2 (cs) |
| BG (1) | BG64675B1 (cs) |
| CZ (1) | CZ300847B6 (cs) |
| HU (1) | HUP0400909A3 (cs) |
| IL (1) | IL133552A (cs) |
| NO (1) | NO315423B1 (cs) |
| NZ (1) | NZ501808A (cs) |
| PL (1) | PL194175B1 (cs) |
| SK (1) | SK286972B6 (cs) |
| TR (1) | TR200000478T2 (cs) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1041876B (en) * | 1998-10-27 | 2006-06-23 | Abbott Laboratories | Prostaglandin endoperoxide h synthase biosynthesis inhibitors |
| FR2969606B1 (fr) * | 2010-12-22 | 2013-01-11 | Pf Medicament | Derives de diarylpyridazinones, leur preparation et leur application en therapeutique humaine |
| CN107334767B (zh) * | 2017-06-08 | 2019-03-05 | 中国医学科学院医药生物技术研究所 | 一种哒嗪酮类化合物在肿瘤治疗中的应用 |
| JP7147444B2 (ja) * | 2018-10-03 | 2022-10-05 | 株式会社島津製作所 | 試料注入装置および試料注入システム |
| CN114560814B (zh) * | 2022-03-02 | 2023-10-20 | 天津理工大学 | 一种取代2,3-二氮杂萘酮类化合物的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4238490A (en) * | 1979-02-12 | 1980-12-09 | Diamond Shamrock Corporation | Antihypertensive pyridazin(2H)-3-ones |
| BR8108745A (pt) * | 1980-08-07 | 1982-07-06 | Diamond Shamrock Corp | Difenilpiridazinonas herbicidas e reguladores do crescimento da planta |
| US4404203A (en) * | 1981-05-14 | 1983-09-13 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| WO1988009675A1 (en) * | 1987-06-05 | 1988-12-15 | Medicis Corporation | Inhibition of arachidonic acid metabolism |
| IL115889A0 (en) * | 1994-11-14 | 1996-01-31 | Rohm & Haas | Pyridazinones and their use as fungicides |
| US5622948A (en) * | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
| CA2224563A1 (en) * | 1995-06-12 | 1996-12-27 | G.D. Searle & Co. | Combination of a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist for the treatment of inflammations |
| ES2224366T3 (es) * | 1997-03-14 | 2005-03-01 | MERCK FROSST CANADA & CO. | Piridazinonas como inhibidores de ciclooxigenasa-2. |
-
1998
- 1998-08-10 HU HU0400909A patent/HUP0400909A3/hu unknown
- 1998-08-10 JP JP2000507660A patent/JP2003516925A/ja active Pending
- 1998-08-10 SK SK231-2000A patent/SK286972B6/sk not_active IP Right Cessation
- 1998-08-10 CN CNB988083221A patent/CN1167687C/zh not_active Expired - Fee Related
- 1998-08-10 CZ CZ20000446A patent/CZ300847B6/cs not_active IP Right Cessation
- 1998-08-10 AU AU86976/98A patent/AU741317B2/en not_active Ceased
- 1998-08-10 NZ NZ501808A patent/NZ501808A/xx unknown
- 1998-08-10 KR KR1020007001824A patent/KR100675028B1/ko not_active Expired - Fee Related
- 1998-08-10 PL PL98355418A patent/PL194175B1/pl not_active IP Right Cessation
- 1998-08-10 IL IL13355298A patent/IL133552A/xx not_active IP Right Cessation
- 1998-08-10 TR TR2000/00478T patent/TR200000478T2/xx unknown
- 1998-08-24 AR ARP980104193A patent/AR015422A1/es active IP Right Grant
-
2000
- 2000-02-22 NO NO20000863A patent/NO315423B1/no not_active IP Right Cessation
- 2000-03-15 BG BG104241A patent/BG64675B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR015422A1 (es) | 2001-05-02 |
| PL194175B1 (pl) | 2007-05-31 |
| CN1167687C (zh) | 2004-09-22 |
| IL133552A0 (en) | 2001-04-30 |
| SK2312000A3 (en) | 2001-02-12 |
| CZ300847B6 (cs) | 2009-08-26 |
| AU8697698A (en) | 1999-03-16 |
| BG64675B1 (bg) | 2005-11-30 |
| NO315423B1 (no) | 2003-09-01 |
| JP2003516925A (ja) | 2003-05-20 |
| HUP0400909A3 (en) | 2004-10-28 |
| IL133552A (en) | 2005-12-18 |
| KR100675028B1 (ko) | 2007-01-29 |
| NO20000863D0 (no) | 2000-02-22 |
| SK286972B6 (sk) | 2009-08-06 |
| BG104241A (en) | 2000-10-31 |
| KR20010023196A (ko) | 2001-03-26 |
| CZ2000446A3 (cs) | 2000-05-17 |
| NO20000863L (no) | 2000-02-22 |
| PL355418A1 (en) | 2004-04-19 |
| TR200000478T2 (tr) | 2002-04-22 |
| AU741317B2 (en) | 2001-11-29 |
| CN1277605A (zh) | 2000-12-20 |
| HUP0400909A2 (hu) | 2004-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO4970740A1 (es) | Inhibidores piridazinona de la biosintesis de la prostaglandina endoperoxido h sintasa | |
| EP1070710A3 (en) | Dithiolan derivatives, their preparation and their therapeutic effect | |
| UA72946C2 (uk) | Похідні хіназоліну як інгібітори васкулярного ендотеліального фактора росту (vegf) | |
| KR970701722A (ko) | 포스폰산 디에스테르 유도체(phosphonic diester derivative) | |
| HUT64336A (en) | Methods for producing new thiazole-benzofurane derivatives and pharmaceutical preparatives containing them | |
| ATE250622T1 (de) | 4'-c-ethynyl-pyrimidine nukleoside | |
| HU9203002D0 (en) | Method for producing tricyclic heterocyclic compounds | |
| HU9401006D0 (en) | Proces for producing benzodiazepine derivatives and pharmaceutical compositions containing them | |
| NZ314003A (en) | Medicaments for treating osteoporosis containing thiazolidine compounds | |
| KR900004693A (ko) | 피리딘 화합물 및 그의 약제학적 용도 | |
| NZ501808A (en) | Arylpyridazinones and their use as prostaglandin endoperoxide H synthase biosynthesis inhibitors | |
| GR3006780T3 (cs) | ||
| KR960706476A (ko) | 인터류킨-1 활성 억제제로서의 신규한 벤젠설포닐아민 유도체(Novel benzen-esulfonylimine derivatives as inhibitors of lL-1 action) | |
| CA2212893A1 (en) | Prokinetic oxadiazoles | |
| HUP0102522A2 (hu) | 3',3'-N-bisz-helyettesített makrolid LHRH antagonista vegyületek és alkalmazásuk, eljárás előállításukra, valamint e vegyületeket tartalmazó gyógyászati készítmények | |
| NZ228803A (en) | Sulphonanilides and anti-hypertensive compositions | |
| BR9608929A (pt) | Derivados de hidroxilamina anti-isquêmicos e composições farmacêuticas | |
| IE820455L (en) | Trifluoromethylphenyltetrahydropyridines having anorectic¹activity | |
| EP0798304A4 (en) | DRUGS AGAINST TRHOMBOCYTOPENIA | |
| WO2000008006A3 (en) | Piperidine and piperazine derivatives, process for their preparation and pharmaceutical compounds containing them | |
| HUT58717A (en) | Process for producing n,n,n'-trisubstituted 5-bisaminomethylene-1,3-dioxane-4,6-dione derivatives and pharmaceutical compositions containing them | |
| HUP9700104A2 (hu) | 1,3,4-Tiadiazol-származékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények, és eljárás a hatóanyag előállítására | |
| HUP9700105A2 (hu) | 5-Fenil-1,3,4-tiadiazol-származékok, eljárás az előállításukra, és ilyen hatóanyagot tartalmazó gyógyászati készítmények | |
| MX9707911A (es) | Derivados de amina 1-[w-(3,4-dihidro-2-naftalenil)alquil]- ciclica, proceso para su preparacion y composiciones farmaceuticas que contienen los mismos. | |
| HUP9902666A2 (hu) | Nitronvegyületek, valamint ezeket a vegyületeket tartalmazó szemgyulladás kezelésére alkalmas gyógyszerkészítmények |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |