CO4970740A1 - Inhibidores piridazinona de la biosintesis de la prostaglandina endoperoxido h sintasa - Google Patents

Inhibidores piridazinona de la biosintesis de la prostaglandina endoperoxido h sintasa

Info

Publication number
CO4970740A1
CO4970740A1 CO98047584A CO98047584A CO4970740A1 CO 4970740 A1 CO4970740 A1 CO 4970740A1 CO 98047584 A CO98047584 A CO 98047584A CO 98047584 A CO98047584 A CO 98047584A CO 4970740 A1 CO4970740 A1 CO 4970740A1
Authority
CO
Colombia
Prior art keywords
heterocyclic
alkyl
group
arylalkyl
cycloalkyl
Prior art date
Application number
CO98047584A
Other languages
English (en)
Inventor
Lawrence A Black
Basha Anwer
Kolosa Teodozyj
Michael E Kort
Liu Huaqing
Carty Catherine M Mc
V Patel Meena
Jeffrey J Rohde
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of CO4970740A1 publication Critical patent/CO4970740A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/18—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de fórmula I: en dondeX se selecciona del grupo conformadopor O, S, NR4 , N-ORa , y N-NRb Rc , en donde R4 se selecciona del grupo conformado por alquil, alquenil, cicloalquil, cicloalquenil, cicloalquilalquil, cicloalquenilalquil, aril, heterocíclico, heterocíclico alquil, y arilalquil; y Ra , Rb , y Rc se seleccionan independientemente del grupo conformado por alquil, cicloalquil, cicloalquilalquil, aril, y arilalquil; R se selecciona del grupo conformado por alquil, alquenil, alquinil, alquilcarbonilalquil, alquilsulfonilalquil, alquilsulfonilarilalquil, alcoxi, alcoxialquil, carboxi, carboxialquil, cianoalquil, haloalquil, haloalquenil, haloalquinil, hidroxialquil, cicloalquil, cicloalquilalquil, cicloalquenil, cicloalquenilalquil, aril, arilalquil, arilalquenil, arilalquinil, arilalcoxi, arilhaloalquil, arilhidroxialquil, ariloxi, ariloxihidroxialquil, ariloxihaloalquil, arilcarbonilalquil, haloalcoxihidroxialquil, heterocíclico, heterocíclico alquil, heterocíclico alcoxi, heterocíclico oxi, -C(O)R5 , -(CH2 )n C(O)R5 , -R6 -R7 , -(CH2 )n CH(OH)R5 , (CH2 )n CH(ORd )R5 , (CH2 )n C(NORd )R5 , (CH2 )n C(NRd )R5 , -(CH2 )n CH(NORd )R5 , -(CH2 )n CH(NRd Re )R5 , -(CH2 )n CºC-R7 , -(CH2 )n [CH(CX´3 )]m -(CH2 )n -CX´3 , -(CH2 )n (CX´2 )m -(CH2 )n -CX´3 , -(CH2 )n [CH(CX´3 )]m -(CH2 )n R8 , -(CH2 )n (CX´2 )m -(CH2 )n -R8 , (CH2 )n (CHX´)m -(CH2 )n -CX´3 , -(CH2 )n (CHX´)m -(CH2 )n -R8 y -(CH2 )n -R20 , en donde R5 se selecciona del grupo conformado por alquil, alquenil, alquinil, cicloalquil, cicloalquenil, aril, arilalquil, haloalquil, haloalquenil, haloalquinil, heterocíclico, y heterocíclico alquil; en donde R6 es alquileno ó alquenileno, alquileno sustituido con halo ó alquenileno sustituido con halo; ...
CO98047584A 1997-08-22 1998-08-20 Inhibidores piridazinona de la biosintesis de la prostaglandina endoperoxido h sintasa CO4970740A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91702397A 1997-08-22 1997-08-22

Publications (1)

Publication Number Publication Date
CO4970740A1 true CO4970740A1 (es) 2000-11-07

Family

ID=25438243

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98047584A CO4970740A1 (es) 1997-08-22 1998-08-20 Inhibidores piridazinona de la biosintesis de la prostaglandina endoperoxido h sintasa

Country Status (8)

Country Link
EP (1) EP1007515A1 (es)
BR (1) BR9812127A (es)
CA (1) CA2299300C (es)
CO (1) CO4970740A1 (es)
SA (1) SA98190764B1 (es)
TW (1) TWI232216B (es)
WO (1) WO1999010331A1 (es)
ZA (1) ZA987555B (es)

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Publication number Priority date Publication date Assignee Title
US6307047B1 (en) * 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6525053B1 (en) * 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
CA2307111C (en) 1997-11-19 2009-06-30 Kowa Co., Ltd. Novel pyridazine derivatives and drugs containing the same as the active ingredient
TWI241295B (en) 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
AU756275B2 (en) * 1998-08-14 2003-01-09 Nihon Nohyaku Co., Ltd. Pyridazinone derivatives
TR200101765T2 (tr) * 1998-10-27 2002-02-21 Abbott Laboratories Prostaglandin endoperoksit H sentaz biyosentez inhibitörleri
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
JP2000247959A (ja) 1999-02-26 2000-09-12 Kowa Co ピリダジン−３−オン誘導体及びこれを含有する医薬
US6649629B2 (en) 1999-12-23 2003-11-18 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
US6664256B1 (en) 2000-07-10 2003-12-16 Kowa Co., Ltd. Phenylpyridazine compounds and medicines containing the same
ITMI20010733A1 (it) 2001-04-05 2002-10-05 Recordati Chem Pharm Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria
JP2005519895A (ja) * 2002-01-18 2005-07-07 ファルマシア・コーポレーション Ｐ３８阻害剤としての置換ピリダジノン
US7211577B2 (en) 2003-03-18 2007-05-01 Kowa Co., Ltd. Water-soluble phenylpyridazine derivative and medicine containing the same
PL1745791T3 (pl) 2003-05-07 2013-11-29 Osteologix As Leczenie chorób chrząstki/kości za pomocą rozpuszczalnych w wodzie soli strontu
WO2005007632A1 (en) * 2003-07-18 2005-01-27 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
PL1767529T3 (pl) 2004-06-09 2009-10-30 Sumitomo Chemical Co Pirydazynowy związek oraz jego zastosowanie
ES2354219T3 (es) 2004-06-28 2011-03-11 Sumitomo Chemical Company, Limited Compuesto de piridazina y utilización del mismo.
ES2524922T3 (es) 2005-05-10 2014-12-15 Intermune, Inc. Derivados de piridona para modular el sistema de proteína cinasa activada por estrés
US7968572B2 (en) 2005-10-03 2011-06-28 Ono Pharmaceuticals Co., Ltd. Nitrogen-containing heterocyclic compound and pharmaceutical application thereof
KR20080081914A (ko) 2005-12-07 2008-09-10 스미또모 가가꾸 가부시끼가이샤 피리다진 화합물 및 이의 용도
DK1958948T3 (da) 2005-12-07 2011-10-31 Sumitomo Chemical Co Pyridazinforbindelse og anvendelse deraf
DE102007008840A1 (de) 2007-02-23 2008-08-28 Bayer Healthcare Ag Neue polymorphe Form von 2-(4-Fluorophenyl)-4-3-hydroxy-3-methyl-1-butoxy)-5-[4-methylsulfonyl)phenyl]-3(2H)-pyridazinon (FHMP)
DE102007008843A1 (de) 2007-02-23 2008-08-28 Bayer Healthcare Ag Verfahren zur Herstellung von 4,5-Dihalogen-2-aryl-2H-pyridazin-3-onen
DE102007008839A1 (de) 2007-02-23 2008-08-28 Bayer Healthcare Ag Verfahren zur Herstellung von 4-(3-Hydroxy-3-methyl-butoxy)-5-[4-(methylsulfonyl)phenyl]-2-arylpyridazin-3(2H)-onen
DE102007020689A1 (de) * 2007-05-03 2008-11-06 Bayer Healthcare Ag Neue polymorphe Form von 2-(4-Fluorophenyl)-4-3-hydroxy-3-methyl-1-butoxy-5-[4-methylsulfonyl)phenyl]3/2H)-pyridazinon (FHMP)
DE102007020690A1 (de) * 2007-05-03 2008-11-06 Bayer Healthcare Ag Neue amorphe Form von 2-(4-Fluorophenyl)-4-3-hydroxy-3-mehtyl-1-butoxy)-6[4-methylsulfonyl)phenyl]-3(2H)-pyridazinon (FHMP)
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
JO3115B1 (ar) 2011-08-22 2017-09-20 Takeda Pharmaceuticals Co مركبات بيريدازينون واستخدامها كمثبطات daao
PE20141361A1 (es) 2011-11-15 2014-10-13 Takeda Pharmaceutical Compuesto heterociclico dihidroxi aromatico
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CA2943363A1 (en) 2014-04-02 2015-10-08 Intermune, Inc. Anti-fibrotic pyridinones
CA3209491A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease

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Also Published As

Publication number Publication date
WO1999010331A1 (en) 1999-03-04
TWI232216B (en) 2005-05-11
CA2299300A1 (en) 1999-03-04
SA98190764B1 (ar) 2006-08-06
EP1007515A1 (en) 2000-06-14
CA2299300C (en) 2007-04-17
BR9812127A (pt) 2000-07-18
ZA987555B (en) 1999-02-23

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