CO4970740A1 - PIRIDAZINONE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASA BIOSYNTHESIS - Google Patents
PIRIDAZINONE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASA BIOSYNTHESISInfo
- Publication number
- CO4970740A1 CO4970740A1 CO98047584A CO98047584A CO4970740A1 CO 4970740 A1 CO4970740 A1 CO 4970740A1 CO 98047584 A CO98047584 A CO 98047584A CO 98047584 A CO98047584 A CO 98047584A CO 4970740 A1 CO4970740 A1 CO 4970740A1
- Authority
- CO
- Colombia
- Prior art keywords
- heterocyclic
- alkyl
- group
- arylalkyl
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/18—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula I: en dondeX se selecciona del grupo conformadopor O, S, NR4 , N-ORa , y N-NRb Rc , en donde R4 se selecciona del grupo conformado por alquil, alquenil, cicloalquil, cicloalquenil, cicloalquilalquil, cicloalquenilalquil, aril, heterocíclico, heterocíclico alquil, y arilalquil; y Ra , Rb , y Rc se seleccionan independientemente del grupo conformado por alquil, cicloalquil, cicloalquilalquil, aril, y arilalquil; R se selecciona del grupo conformado por alquil, alquenil, alquinil, alquilcarbonilalquil, alquilsulfonilalquil, alquilsulfonilarilalquil, alcoxi, alcoxialquil, carboxi, carboxialquil, cianoalquil, haloalquil, haloalquenil, haloalquinil, hidroxialquil, cicloalquil, cicloalquilalquil, cicloalquenil, cicloalquenilalquil, aril, arilalquil, arilalquenil, arilalquinil, arilalcoxi, arilhaloalquil, arilhidroxialquil, ariloxi, ariloxihidroxialquil, ariloxihaloalquil, arilcarbonilalquil, haloalcoxihidroxialquil, heterocíclico, heterocíclico alquil, heterocíclico alcoxi, heterocíclico oxi, -C(O)R5 , -(CH2 )n C(O)R5 , -R6 -R7 , -(CH2 )n CH(OH)R5 , (CH2 )n CH(ORd )R5 , (CH2 )n C(NORd )R5 , (CH2 )n C(NRd )R5 , -(CH2 )n CH(NORd )R5 , -(CH2 )n CH(NRd Re )R5 , -(CH2 )n CºC-R7 , -(CH2 )n [CH(CX´3 )]m -(CH2 )n -CX´3 , -(CH2 )n (CX´2 )m -(CH2 )n -CX´3 , -(CH2 )n [CH(CX´3 )]m -(CH2 )n R8 , -(CH2 )n (CX´2 )m -(CH2 )n -R8 , (CH2 )n (CHX´)m -(CH2 )n -CX´3 , -(CH2 )n (CHX´)m -(CH2 )n -R8 y -(CH2 )n -R20 , en donde R5 se selecciona del grupo conformado por alquil, alquenil, alquinil, cicloalquil, cicloalquenil, aril, arilalquil, haloalquil, haloalquenil, haloalquinil, heterocíclico, y heterocíclico alquil; en donde R6 es alquileno ó alquenileno, alquileno sustituido con halo ó alquenileno sustituido con halo; ...A compound of formula I: where X is selected from the group consisting of O, S, NR4, N-ORa, and N-NRb Rc, where R4 is selected from the group consisting of alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, aryl, heterocyclic, heterocyclic alkyl, and arylalkyl; and Ra, Rb, and Rc are independently selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, aryl, and arylalkyl; R is selected from the group consisting of alkyl, alkenyl, alkynyl, alkylcarbonylalkyl, alquilsulfonilalquil, alquilsulfonilarilalquil, alkoxy, alkoxyalkyl, carboxy, carboxyalkyl, cyanoalkyl, haloalkyl, haloalkenyl, haloalkynyl, hydroxyalkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, arylalkyl, arylalkenyl , arylalkynyl, arylalkoxy, arylhaloalkyl, arylhydroxyalkyl, aryloxy, aryloxyhydroxyalkyl, aryloxyhaloalkyl, arylcarbonylalkyl, haloalkoxyhydroxyalkyl, heterocyclic, heterocyclic alkyl, heterocyclic alkoxy, heterocyclic oxy, -C () (C) -O () -R7, - (CH2) n CH (OH) R5, (CH2) n CH (ORd) R5, (CH2) n C (NORd) R5, (CH2) n C (NRd) R5, - (CH2) n CH (NORd) R5, - (CH2) n CH (NRd Re) R5, - (CH2) n CºC-R7, - (CH2) n [CH (CX´3)] m - (CH2) n -CX´3, - (CH2) n (CX´2) m - (CH2) n -CX´3, - (CH2) n [CH (CX´3)] m - (CH2) n R8, - (CH2) n (CX´ 2) m - (CH2) n -R8, (CH2) n (CHX´) m - (CH2) n -CX´3, - (CH2) n (CHX´) m - (CH2) n -R8 and - ( CH2 ) n -R20, where R5 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, haloalkyl, haloalkenyl, haloalquinyl, heterocyclic, and heterocyclic alkyl; wherein R6 is alkylene or alkenylene, halo-substituted alkylene, or halo-substituted alkenylene; ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91702397A | 1997-08-22 | 1997-08-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4970740A1 true CO4970740A1 (en) | 2000-11-07 |
Family
ID=25438243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO98047584A CO4970740A1 (en) | 1997-08-22 | 1998-08-20 | PIRIDAZINONE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASA BIOSYNTHESIS |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1007515A1 (en) |
BR (1) | BR9812127A (en) |
CA (1) | CA2299300C (en) |
CO (1) | CO4970740A1 (en) |
SA (1) | SA98190764B1 (en) |
TW (1) | TWI232216B (en) |
WO (1) | WO1999010331A1 (en) |
ZA (1) | ZA987555B (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6525053B1 (en) * | 1997-08-22 | 2003-02-25 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
US6307047B1 (en) * | 1997-08-22 | 2001-10-23 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
RU2209813C2 (en) | 1997-11-19 | 2003-08-10 | Кова Ко., Лтд. | Derivatives of pyridazine, medicinal agents based on thereof and method for treatment of arthritis |
TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
AU756275B2 (en) * | 1998-08-14 | 2003-01-09 | Nihon Nohyaku Co., Ltd. | Pyridazinone derivatives |
CN1279026C (en) * | 1998-10-27 | 2006-10-11 | 艾博特公司 | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
JP2000247959A (en) | 1999-02-26 | 2000-09-12 | Kowa Co | Pyridazin-3-one derivative, and drug containing the same |
CA2393724A1 (en) | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
US6664256B1 (en) | 2000-07-10 | 2003-12-16 | Kowa Co., Ltd. | Phenylpyridazine compounds and medicines containing the same |
ITMI20010733A1 (en) | 2001-04-05 | 2002-10-05 | Recordati Chem Pharm | USE OF ISOENZIN COX-2 INHIBITORS FOR THE TREATMENT OF URINARY INCONTINENCE |
CA2474239A1 (en) * | 2002-01-18 | 2003-07-24 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
WO2004083188A1 (en) | 2003-03-18 | 2004-09-30 | Kowa Co., Ltd. | Water-soluble phenylpyridazine derivative and medicine containing the same |
ES2275218T3 (en) | 2003-05-07 | 2007-06-01 | Osteologix A/S | HYDROSOLUBLE STRONTIUM SALTS FOR THE TREATMENT OF CARTILAGOS AND / OR BONE AFFECTIONS. |
WO2005007632A1 (en) * | 2003-07-18 | 2005-01-27 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
ES2324883T3 (en) | 2004-06-09 | 2009-08-18 | Sumitomo Chemical Company, Limited | PIRIDAZINE COMPOSITE AND ITS USE. |
WO2006001175A1 (en) | 2004-06-28 | 2006-01-05 | Sumitomo Chemical Company, Limited | Pyridazine compound and use thereof |
EP2591784B1 (en) | 2005-05-10 | 2016-09-14 | Intermune, Inc. | Pyridine-2-one-derivatives as modulators of stress-activated protein kinase system |
CA2623813A1 (en) * | 2005-10-03 | 2007-04-12 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compound and pharmaceutical application thereof |
EP1958948B1 (en) | 2005-12-07 | 2011-10-05 | Sumitomo Chemical Company, Limited | Pyridazine compound and use thereof |
AU2006322707B2 (en) | 2005-12-07 | 2011-09-15 | Sumitomo Chemical Company, Limited | Pyridazine compound and use thereof |
DE102007008843A1 (en) | 2007-02-23 | 2008-08-28 | Bayer Healthcare Ag | Process for the preparation of 4,5-dihalo-2-aryl-2H-pyridazin-3-ones |
DE102007008840A1 (en) * | 2007-02-23 | 2008-08-28 | Bayer Healthcare Ag | Novel polymorphic form of 2- (4-fluorophenyl) -4-3-hydroxy-3-methyl-1-butoxy) -5- [4-methylsulphonyl) phenyl] -3 (2H) -pyridazinone (FHMP) |
DE102007008839A1 (en) | 2007-02-23 | 2008-08-28 | Bayer Healthcare Ag | Process for the preparation of 4- (3-hydroxy-3-methylbutoxy) -5- [4- (methylsulfonyl) phenyl] -2-arylpyridazine-3 (2H) -ones |
DE102007020690A1 (en) * | 2007-05-03 | 2008-11-06 | Bayer Healthcare Ag | New amorphous form of 2- (4-fluorophenyl) -4-3-hydroxy-3-methyl-1-butoxy) -6 [4-methylsulfonyl) phenyl] -3 (2H) -pyridazinone (FHMP) |
DE102007020689A1 (en) * | 2007-05-03 | 2008-11-06 | Bayer Healthcare Ag | Novel polymorphic form of 2- (4-fluorophenyl) -4-3-hydroxy-3-methyl-1-butoxy-5- [4-methylsulfonyl) phenyl] 3 / 2H) -pyridazinone (FHMP) |
CA2726588C (en) | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
JO3115B1 (en) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | Pyridazinone Compounds and Their Use as DAAO Inhibitors |
JP6169492B2 (en) | 2011-11-15 | 2017-07-26 | 武田薬品工業株式会社 | Dihydroxy aromatic heterocyclic compounds |
AR092742A1 (en) | 2012-10-02 | 2015-04-29 | Intermune Inc | ANTIFIBROTIC PYRIDINONES |
EP3126362B1 (en) | 2014-04-02 | 2022-01-12 | Intermune, Inc. | Anti-fibrotic pyridinones |
US20240165148A1 (en) | 2021-03-15 | 2024-05-23 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988009675A1 (en) * | 1987-06-05 | 1988-12-15 | Medicis Corporation | Inhibition of arachidonic acid metabolism |
AU691673B2 (en) * | 1994-11-14 | 1998-05-21 | Dow Agrosciences Llc | Pyridazinones and their use as fungicides |
US5622948A (en) * | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
-
1998
- 1998-08-10 EP EP98938451A patent/EP1007515A1/en not_active Withdrawn
- 1998-08-10 WO PCT/US1998/016479 patent/WO1999010331A1/en active Application Filing
- 1998-08-10 CA CA002299300A patent/CA2299300C/en not_active Expired - Fee Related
- 1998-08-10 BR BR9812127-8A patent/BR9812127A/en not_active Application Discontinuation
- 1998-08-20 CO CO98047584A patent/CO4970740A1/en unknown
- 1998-08-20 ZA ZA987555A patent/ZA987555B/en unknown
- 1998-09-10 TW TW087113837A patent/TWI232216B/en not_active IP Right Cessation
- 1998-11-16 SA SA98190764A patent/SA98190764B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR9812127A (en) | 2000-07-18 |
EP1007515A1 (en) | 2000-06-14 |
CA2299300C (en) | 2007-04-17 |
SA98190764B1 (en) | 2006-08-06 |
WO1999010331A1 (en) | 1999-03-04 |
ZA987555B (en) | 1999-02-23 |
CA2299300A1 (en) | 1999-03-04 |
TWI232216B (en) | 2005-05-11 |
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