KR900004693A - 피리딘 화합물 및 그의 약제학적 용도 - Google Patents

피리딘 화합물 및 그의 약제학적 용도 Download PDF

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KR900004693A
KR900004693A KR1019890013304A KR890013304A KR900004693A KR 900004693 A KR900004693 A KR 900004693A KR 1019890013304 A KR1019890013304 A KR 1019890013304A KR 890013304 A KR890013304 A KR 890013304A KR 900004693 A KR900004693 A KR 900004693A
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다까노리 우에
유지 오노
가즈유끼 가와사끼
도오루 나까지마
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하기하라 후미오
요시또미 세이야꾸 가부시끼가이샤
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Abstract

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Description

피리딘 화합물 및 그의 약제학적 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 일반식(Ⅰ)의 피리딘 화합물 또는 그들의 염
    [식에서, R1및 R2는 같거나 다르며, 각각 수소, 할로겐, 알킬, 알콕시, 또는 임의 치환된 페닐이며; Ar은 임의 치환된 아릴 또는 헤테로 아릴을 의미하고; Y는 단일결합 또는 사슬에 이중결합(들)을 가질 수도 있는 알킬렌을 의미하며; W은 하기 일반식(Ⅱ)의 기를 나타낸다:
    (식에서 R3및 R4는 같거나 다르며, 각각 수소, 할로겐, 알킬, 알콕시 또는 임의 치환된 페닐을 의미하고, X는 -O-, -S- 또는 -N(R5)-(식에서 R5는 수소, 알킬 또는 아실을 의미함)또는 -CON(R7)-(식에서 R7는 수소, 알킬 또는 아실을 의미함)를 의미하고, Z는 단일결합, -O-, -S- 또는 -N(R5)-(식에서 R6는 수소, 알킬 또는 아실을 의미함)를 의미하고, A는 알킬렌을 의미하고, B는 알콕시 카르보닐, 카르복실, 히드록실기, -N(R8)(R9) (식에서 R8및 R9는 같거나 다르며, 각각 수소, 알킬, 히드록시 알킬, 아실 또는 임의 치환된 아랄킬 또는 헤테로 아랄킬을 의미하거나, 또는 결합하여 이웃하는 질소와 함께 헤테로시클릭기를 형성하는 기를 의미한다), 또는 -CON(R10)(R11), (식에서 R10및 R11은 같거나 다르며, 각각 수소, 알킬, 히드록시알킬, 아실 또는 임의 치환된 아랄킬 또는 헤테로 아랄킬을 의미하거나, 또는 결합하여 이웃하는 질소와 함께 헤테로시클릭기를 형성하는 기를 의미함), 일반식(Ⅲ)의 기:
    (식에서 R12및 R13는 같거나 다르며, 각각 수소, 알킬, 히드록시알킬, 아실, 임의 치환된 페닐 또는 임의 치환된 아랄킬 또는 헤테로아랄킬을 나타내거나, 또는 결합하여 이웃하는 질소 원자와 함께 헤테로시클릭기를 형성하는 기를 의미하며, p는 -O-, -S(O)p- (식에서 p는 0 내지 2의 정수를 의미함), -N(R14)- (식에서 R14는 수소, 알킬 또는 아실을 의미함) 또는 -N(R15)CO- (식에서 R15는 수소, 알킬 또는 아실을 의미함)를 나타내고, Q는 탄소원자수 5이상의 알킬렌, 시클릭알킬렌, 삽입된 산소 또는 황을 그중에 가지는 탄소원자수 4이상의 알킬렌 또는 말단에 카르보닐기를 가지는 탄소원자수 5이상의 알킬렌을 의미하며, 단p가 -N(R15)CO-)일때 Q는 탄소원자수 3이상의 알킬렌을 읨함) 또는 하기 일반식(Ⅳ)의 기를 의미한다.
    (식에서 n은 3 내지 5의 정수를 의미한다.)
  2. 제1항에 있어서, 상술된 화합물이 2-[2-(3-디메틸아미노프로필)-1-메틸에틸티오]-3-(2-테노일)피리딘, 2-(6-디메틸아미노헥실티오)-3-(2-테노일)피리딘, 2-(7-디메틸아미노헵틸티오)-3-(2-테노일)피리딘, 2-[2-(3-디메틸아미노프로필)에틸티오]-3-(2-테노일)피리딘, 2-2-(6-디메틸아미노헥실티오)에틸티오-3-(2-테노일)피리딘, 2-[2-(6-디메틸아미노헥실티오)-1-메틸에틸티오]-3-(2-테노일)피리딘, 2-[2-(6-디메틸아미노헥실티오)-1,1-메틸에틸티오]-3-(2-테노일)피리딘, 2-(7-디메틸아미노-1-메틸헵틸티오)-3-(2-테노일)피리딘, 2-(6-디메틸아미노헥실티오)-6-메틸-3-(2-테노일)피리딘, 2-(6-디메틸아미노헥실티오)-6-이소프로필-3-(2-테노일)피리딘, 3-벤조일-2[2-(3-디메틸아미노노프로필티오)-1-메틸에틸티오]-6-메틸피리딘, 2-(6-디메틸아미노헥실티오)-6-이소프로필-3-(5-메틸-2-테노일)피리딘, 2-[6-(N-벤질-N-메틸아미노)헥실티오]-3-(2-테노일)-6-이소프로필피리딘, 2-(6-벤질아미노헥실티오)-3-(2-테노일)-6-이소프로필피리딘, 2-[6-(N-(3,4-[메톡시벤질)-N-메틸아미노)헥실티오]-3-(2-테노일)-6-이소프로필피리딘, 2-(6-에틸아미노헥실티오)-3-(2-테노일)-6-이소프로필피리딘, 2-[6-(4-벤질피페리디노)헥실티오]-3-(2-테노일)-6-이소프로필피리딘, 2-[6-(4-디메틸아미노피페리디노)헥실티오]-3-(2-테노일)-6-이소프로필피리딘, 2-[6-(2-페닐에틸아미노)헥실티오]-3-(2-테노일)-6-이소프로필피리딘 및 2-[6-(N-(2-디메틸아미노에틸)-N-메틸아미노)헥실티오]-3-(2-테노일)-6-이소프로필피리딘 그들의 약제학적으로 허용되는 염들인 화합물.
  3. 제1 또는 2항에서 청구된 피리딘 화합물의 치료학적 유효량을 약제학적으로 허용되는 첨가제와 함께 함유하는 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890013304A 1988-09-14 1989-09-12 피리딘 화합물 및 그의 약제학적 용도 KR910003586B1 (ko)

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US5565413A (en) * 1994-12-06 1996-10-15 Zeneca Limited Substituted pyridyl phenyl ketone herbicides
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ZA9756B (en) * 1996-01-16 1997-07-17 Warner Lambert Co Process for preparing 4,6-disubstituted pyrido[3,4-d]-pyrimidines
US6297198B1 (en) 1996-05-14 2001-10-02 Syngenta Participations Ag Isoxazole derivatives and their use as herbicides
ATE496032T1 (de) 1999-02-24 2011-02-15 Hoffmann La Roche 4-phenylpyridinderivate und deren verwendung als nk-1 rezeptorantagonisten
CA2479744A1 (en) 2002-03-28 2003-10-09 Paul E. Finke Substituted 2,3-diphenyl pyridines
AR040456A1 (es) * 2002-06-27 2005-04-06 Bristol Myers Squibb Co Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana
TWI280239B (en) 2003-07-15 2007-05-01 Hoffmann La Roche Process for preparation of pyridine derivatives
EP1824846A2 (en) 2003-11-03 2007-08-29 Probiodrug AG Novel compounds for the treatment of neurological disorders
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NZ578744A (en) 2007-01-31 2012-02-24 Vertex Pharma 2-aminopyridine derivatives useful as kinase inhibitors
JP5631310B2 (ja) 2008-07-23 2014-11-26 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 三環式ピラゾロピリジンキナーゼ阻害剤
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
CA2731451A1 (en) 2008-07-23 2010-01-28 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
AU2009279611A1 (en) 2008-08-06 2010-02-11 Vertex Pharmaceuticals Incorporated Aminopyridine kinase inhibitors
AU2010245914A1 (en) 2009-05-06 2011-12-15 Vertex Pharmaceuticals Incorporated Pyrazolopyridines
CA2787363A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyrimidine kinase inhibitors
CA2787079A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyrazine kinase inhibitors
EP2528917B1 (en) 2010-01-27 2016-10-19 Vertex Pharmaceuticals Incorporated Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases
US9750728B2 (en) 2012-09-29 2017-09-05 Targeted Therapeutics, Llc Method and pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway
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