NZ332754A - Microplate thermal shift assay which looks at thermal change - Google Patents

Microplate thermal shift assay which looks at thermal change

Info

Publication number
NZ332754A
NZ332754A NZ332754A NZ33275497A NZ332754A NZ 332754 A NZ332754 A NZ 332754A NZ 332754 A NZ332754 A NZ 332754A NZ 33275497 A NZ33275497 A NZ 33275497A NZ 332754 A NZ332754 A NZ 332754A
Authority
NZ
New Zealand
Prior art keywords
containers
samples
target molecule
thermal denaturation
thermal
Prior art date
Application number
NZ332754A
Other languages
English (en)
Inventor
Michael W Pantoliano
Alexander W Rhind
Francis R Salemme
Barry A Springer
Roger F Bone
Eugenio C Petrella
Original Assignee
Dimensional Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Publication of NZ332754A publication Critical patent/NZ332754A/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Clinical Laboratory Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
NZ332754A 1996-05-09 1997-05-09 Microplate thermal shift assay which looks at thermal change NZ332754A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1786096P 1996-05-09 1996-05-09
PCT/US1997/008154 WO1997042500A1 (en) 1996-05-09 1997-05-09 Microplate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization

Publications (1)

Publication Number Publication Date
NZ332754A true NZ332754A (en) 2000-07-28

Family

ID=21784935

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ332754A NZ332754A (en) 1996-05-09 1997-05-09 Microplate thermal shift assay which looks at thermal change

Country Status (9)

Country Link
US (12) US6036920A (hu)
EP (1) EP0914608A1 (hu)
JP (1) JP2000511629A (hu)
KR (1) KR20000011069A (hu)
AU (1) AU741049B2 (hu)
CA (1) CA2253587C (hu)
HU (1) HUP9902418A3 (hu)
NZ (1) NZ332754A (hu)
WO (1) WO1997042500A1 (hu)

Families Citing this family (189)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6337183B1 (en) 1995-09-08 2002-01-08 Scriptgen Pharmaceuticals, Inc. Screen for compounds with affinity for nucleic acids
CA2184195C (en) * 1995-10-25 2002-04-16 Andrew Pakula Screening method for identifying ligands for target proteins
US6063633A (en) * 1996-02-28 2000-05-16 The University Of Houston Catalyst testing process and apparatus
US6036920A (en) 1996-05-09 2000-03-14 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay apparatus for ligand development and multi-variable protein chemistry optimization
US6331392B1 (en) 1997-03-05 2001-12-18 Anadys Pharmaceutical, Inc. Screen employing fluorescence anisotropy to identify compounds with affinity for nucleic acids
CA2298629A1 (en) * 1997-08-01 1999-02-11 Novalon Pharmaceutical Corporation Method of identifying and developing drug leads
IL136046A0 (en) * 1997-11-12 2001-05-20 Dimensional Pharm Inc Methods for classifying proteins
US6555326B1 (en) * 1997-11-21 2003-04-29 Tularik Inc. Nuclear hormone receptor fluorescence polarization assay
US7101681B1 (en) * 1997-11-21 2006-09-05 Amgen, Inc. Nuclear hormone receptor drug screens
US6893877B2 (en) * 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6582962B1 (en) * 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
US6420109B1 (en) * 1998-09-11 2002-07-16 Genelabs Technologies, Inc. Nucleic acid ligand interaction assays
US6569631B1 (en) 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
FR2786787B1 (fr) * 1998-12-08 2002-04-19 Proteus Methode d'analyse in vitro d'un phenotype connu a partir d'un echantillon d'acides nucleiques
BR0009164A (pt) * 1999-03-19 2001-12-26 Genencor Int Placa de teste de múltiplos furos vazados paraseparação de alto desempenho
US7250305B2 (en) * 2001-07-30 2007-07-31 Uab Research Foundation Use of dye to distinguish salt and protein crystals under microcrystallization conditions
US20030022383A1 (en) * 1999-04-06 2003-01-30 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
ATE357656T1 (de) * 1999-04-06 2007-04-15 Univ Alabama Res Found Vorrichtung zum screening von kristallisierungsbedingungen in lösungen zur kristallzüchtung
US7247490B2 (en) * 1999-04-06 2007-07-24 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7214540B2 (en) * 1999-04-06 2007-05-08 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7244396B2 (en) * 1999-04-06 2007-07-17 Uab Research Foundation Method for preparation of microarrays for screening of crystal growth conditions
US6630006B2 (en) * 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US7057015B1 (en) * 1999-10-20 2006-06-06 The Salk Institute For Biological Studies Hormone receptor functional dimers and methods of their use
US6307372B1 (en) * 1999-11-02 2001-10-23 Glaxo Wellcome, Inc. Methods for high throughput chemical screening using magnetic resonance imaging
AU1591301A (en) 1999-11-09 2001-06-06 Sri International Workstation, apparatus, and methods for the high-throughput synthesis, screeningand characterization of combinatorial libraries
US7033840B1 (en) 1999-11-09 2006-04-25 Sri International Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
US6582907B1 (en) * 1999-12-09 2003-06-24 Pharmacia & Upjohn Company Use of fluorescence correlation spectroscopy to identify compounds that bind to target species under isothermal denaturing conditions
US6376180B1 (en) 1999-12-09 2002-04-23 Pharmacia & Upjohn Company Methods of identifying compounds that bind to target species under isothermal denaturing conditions
US20070020662A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computerized control of high-throughput experimental processing and digital analysis of comparative samples for a compound of interest
US20070021929A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computing methods for control of high-throughput experimental processing, digital analysis, and re-arraying comparative samples in computer-designed arrays
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
US6775567B2 (en) * 2000-02-25 2004-08-10 Xenogen Corporation Imaging apparatus
US20050196824A1 (en) * 2000-03-15 2005-09-08 Fisher Mark T. Chaperonin and osmolyte protein folding and related screening methods
DE60140553D1 (de) * 2000-09-14 2009-12-31 Caliper Life Sciences Inc MIKROFLUIDISCHE VORRICHTUNGEN UND METHODEN UM TEMPERATUR-VERMITTELTE REAKTIONEN DURCHZUFüHREN
US7182853B2 (en) * 2000-09-22 2007-02-27 University Of Dayton Redox control/monitoring platform for high throughput screening/drug discovery applications
US6985616B2 (en) * 2001-10-18 2006-01-10 Robodesign International, Inc. Automated verification and inspection device for sequentially inspecting microscopic crystals
DE10054059A1 (de) * 2000-10-31 2002-05-08 Max Delbrueck Centrum Verfahren zur Ermittlung von Faltungsbedingungen für rekombinante Proteine
US6724674B2 (en) * 2000-11-08 2004-04-20 International Business Machines Corporation Memory storage device with heating element
US20050202470A1 (en) * 2000-11-16 2005-09-15 Caliper Life Sciences, Inc. Binding assays using molecular melt curves
US7806980B2 (en) 2000-12-23 2010-10-05 Elan Pharmaceuticals, Inc. Method for crystallizing human beta secretase in complex with an inhibitor
US7601528B1 (en) 2000-12-23 2009-10-13 Elan Pharmaceuticals, Inc. Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease
US7217556B1 (en) 2000-12-23 2007-05-15 Pfizer Inc Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease
US20020164617A1 (en) * 2000-12-29 2002-11-07 Neogenesis Pharmaceuticals, Inc. Affinity selection-based screening of hydrophobic proteins
US20020132758A1 (en) * 2001-01-18 2002-09-19 Shell John W. Method for identifying compounds to treat medical pathologies associated with molecular crystallization
JP3745962B2 (ja) * 2001-01-24 2006-02-15 株式会社アドバンテスト インターリーブａｄ変換方式波形ディジタイザ装置、及び試験装置
GB0117706D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Automated semi-solid matrix assay and liquid handler apparatus for the same
US7670429B2 (en) * 2001-04-05 2010-03-02 The California Institute Of Technology High throughput screening of crystallization of materials
US7524668B1 (en) * 2001-05-10 2009-04-28 Elan Pharmaceuticals, Inc. Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof
US7384773B1 (en) * 2001-05-10 2008-06-10 Pfizer Inc Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof
US6563117B2 (en) * 2001-06-02 2003-05-13 Ilya Feygin Article comprising IR-reflective multi-well plates
US20030059807A1 (en) * 2001-06-07 2003-03-27 Proligo Llc Microcalorimetric detection of analytes and binding events
AU2002315157A1 (en) * 2001-06-14 2003-01-02 Anadys Pharmaceuticals, Inc. Methods of screening for ligands of target molecules
JP4347053B2 (ja) * 2001-08-03 2009-10-21 ナノスフェアー インコーポレイテッド ナノ粒子撮像システムおよび方法
US20030106492A1 (en) * 2001-09-07 2003-06-12 Douglas Levinson Apparatus and method for high-throughput preparation, visualization and screening of compositions
CA2460819A1 (en) * 2001-09-18 2003-03-27 Affinium Pharmaceuticals, Inc. Methods and apparatuses for purification
EP1438137A4 (en) * 2001-09-20 2010-07-07 Johnson & Johnson Pharm Res CONDUCTING MICROTITER PLATE
US20040033166A1 (en) * 2001-09-28 2004-02-19 Leonard Arnowitz Automated robotic device for dynamically controlled crystallization of proteins
KR20050034603A (ko) * 2001-10-09 2005-04-14 3-디멘져널 파마슈티칼즈 인코오포레이티드 치환된 디페닐옥사졸, 이의 합성 및 이의 형광프로브로서의 용도
US20060134683A1 (en) * 2001-10-23 2006-06-22 Michael Sogard Methods and devices for hybridization and binding assays using thermophoresis
GB0125436D0 (en) 2001-10-23 2001-12-12 Deltadot Ltd Analysis of temperature-dependent molecular configurations
WO2003035208A1 (en) * 2001-10-23 2003-05-01 Uab Research Foundation Method for preparation of microarrays for screening of crystal growth conditions
US7244611B2 (en) * 2001-10-23 2007-07-17 Nikon Research Corporation Of America Methods and devices for hybridization and binding assays using thermophoresis
DE10201075A1 (de) * 2002-01-14 2003-07-24 Basf Ag Verfahren und Vorrichtung zur Untersuchung des Weissanlaufens
WO2003062395A2 (en) * 2002-01-18 2003-07-31 Bristol-Myers Squibb Company Predictor sets for tyrosine kinase pathways
US6677151B2 (en) * 2002-01-30 2004-01-13 Applera Corporation Device and method for thermal cycling
WO2003071269A2 (en) * 2002-02-20 2003-08-28 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing stability of biological molecules
US20050079526A1 (en) * 2002-02-20 2005-04-14 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing refolding and aggregation of biological molecules
US7474399B2 (en) * 2002-02-22 2009-01-06 Xenogen Corporation Dual illumination system for an imaging apparatus and method
US7474398B2 (en) * 2002-02-22 2009-01-06 Xenogen Corporation Illumination system for an imaging apparatus with low profile output device
US6922246B2 (en) 2002-02-22 2005-07-26 Xenogen Corporation Bottom fluorescence illumination assembly for an imaging apparatus
WO2003076572A2 (en) 2002-03-04 2003-09-18 Bristol-Myers Squibb Company Novel nucleic acid molecules and polypeptides encoding baboon tafi
US20040005686A1 (en) * 2002-03-07 2004-01-08 Pharmacia Corporation Crystalline structure of human MAPKAP kinase-2
WO2003087834A2 (en) * 2002-04-08 2003-10-23 Affinium Pharmaceuticals, Inc. High throughput analysis of recombinant proteins in multi-well plates
US20040019432A1 (en) * 2002-04-10 2004-01-29 Sawafta Reyad I. System and method for integrated computer-aided molecular discovery
US7442537B1 (en) 2002-05-10 2008-10-28 Elan Pharmaceuticals, Inc. Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof
US20030219754A1 (en) * 2002-05-23 2003-11-27 Oleksy Jerome E. Fluorescence polarization detection of nucleic acids
US20070026528A1 (en) * 2002-05-30 2007-02-01 Delucas Lawrence J Method for screening crystallization conditions in solution crystal growth
GB0212764D0 (en) * 2002-05-31 2002-07-10 Deltadot Ltd Direct PCR quantification
AU2003256469A1 (en) * 2002-07-10 2004-01-23 Uab Research Foundation Method for distinguishing between biomolecule and non-biomolecule crystals
KR20050026505A (ko) * 2002-07-24 2005-03-15 3-디멘져널 파마슈티칼즈 인코오포레이티드 생체이물 제거의 조절을 결정하는 방법
JP2005534005A (ja) * 2002-07-24 2005-11-10 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド リガンドの同定法
US20040121445A1 (en) * 2002-07-31 2004-06-24 Fabien Marino Cell cultures
US8277753B2 (en) * 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
EP1539321A1 (de) * 2002-09-19 2005-06-15 MERCK PATENT GmbH Verfahren zum auffinden geeigneter chromatographiebedingungen zur trennung biologischer moleküle
US6905076B2 (en) * 2002-11-15 2005-06-14 Advanced Research And Technology Institute, Inc. High temperature incubation system and method for small volumes
US20050066276A1 (en) * 2002-12-13 2005-03-24 Moore Helen M. Methods for identifying, viewing, and analyzing syntenic and orthologous genomic regions between two or more species
US7648678B2 (en) * 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US7682565B2 (en) * 2002-12-20 2010-03-23 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US6966693B2 (en) * 2003-01-14 2005-11-22 Hewlett-Packard Development Company, L.P. Thermal characterization chip
WO2004065551A2 (en) * 2003-01-21 2004-08-05 Bristol-Myers Squibb Company Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (mgat3), and uses thereof
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
WO2004103288A2 (en) * 2003-05-13 2004-12-02 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Method of preventing recurrent miscarriages
DE10325300A1 (de) * 2003-06-04 2005-01-20 Siemens Ag Thermocycler
US20050038776A1 (en) * 2003-08-15 2005-02-17 Ramin Cyrus Information system for biological and life sciences research
JP2007504215A (ja) * 2003-09-03 2007-03-01 バイオフォームズ 生体分子を急速に結晶化するための方法及び装置
US20050226771A1 (en) * 2003-09-19 2005-10-13 Lehto Dennis A High speed microplate transfer
US20050225751A1 (en) * 2003-09-19 2005-10-13 Donald Sandell Two-piece high density plate
WO2005028629A2 (en) * 2003-09-19 2005-03-31 Applera Corporation Whole genome expression analysis system
US20070015289A1 (en) * 2003-09-19 2007-01-18 Kao H P Dispenser array spotting
US20050233472A1 (en) * 2003-09-19 2005-10-20 Kao H P Spotting high density plate using a banded format
US20050221357A1 (en) * 2003-09-19 2005-10-06 Mark Shannon Normalization of gene expression data
EP1670944A4 (en) * 2003-09-19 2012-12-05 Life Technologies Corp MICROPLATES SUITABLE FOR CARRYING OUT NUCLEOTIDE AMPLIFICATION WITH TEMPERATURE CYCLE
DE10348958B4 (de) * 2003-10-13 2008-04-17 Friedrich-Schiller-Universität Jena Verfahren zur Bestimmung der Temperatur von wässrigen Flüssigkeiten mit optischen Mitteln
US7332280B2 (en) * 2003-10-14 2008-02-19 Ronald Levy Classification of patients having diffuse large B-cell lymphoma based upon gene expression
US8697433B2 (en) * 2003-12-10 2014-04-15 Samsung Electronics Co., Ltd. Polymerase chain reaction (PCR) module and multiple PCR system using the same
US7767439B2 (en) * 2003-12-10 2010-08-03 Samsung Electronics Co., Ltd. Real-time PCR monitoring apparatus and method
EP1541237A3 (en) * 2003-12-10 2006-02-01 Samsung Electronics Co., Ltd. Polymerase chain reaction (pcr) module and multiple pcr system using the same
US7799557B2 (en) * 2003-12-10 2010-09-21 Samsung Electronics Co., Ltd. Polymerase chain reaction (PCR) module and multiple PCR system using the same
US7416710B1 (en) 2003-12-31 2008-08-26 Takeda San Diego, Inc. Method and system for performing crystallization trials
EP1735097B1 (en) 2004-03-12 2016-11-30 Life Technologies Corporation Nanoliter array loading
US7622296B2 (en) * 2004-05-28 2009-11-24 Wafergen, Inc. Apparatus and method for multiplex analysis
CN103884698B (zh) 2004-06-07 2017-04-12 先锋生物科技股份有限公司 用于微流体器件的光学透镜系统和方法
JPWO2006013832A1 (ja) * 2004-08-02 2008-05-01 古河電気工業株式会社 検体の光情報認識装置およびその認識方法
JP4577645B2 (ja) * 2004-09-30 2010-11-10 横河電機株式会社 スクリーニング装置
US7264206B2 (en) * 2004-09-30 2007-09-04 The Boeing Company Leading edge flap apparatuses and associated methods
US8809287B2 (en) * 2004-11-15 2014-08-19 Icahn School Of Medicine At Mount Sinai Compositions and methods for altering Wnt autocrine signaling
US20060111915A1 (en) * 2004-11-23 2006-05-25 Applera Corporation Hypothesis generation
CA2871777C (en) 2005-03-10 2015-07-28 Matthew J. Hayes System and methods for detecting multiple optical signals
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
US20070009396A1 (en) * 2005-07-05 2007-01-11 Hong Kong Ch Gene Ltd Multi-well plate guide protector and method for multi-well dispensing
NZ598031A (en) 2005-07-19 2013-11-29 Stemgen S P A Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps
US7835786B2 (en) * 2005-07-25 2010-11-16 Wisconsin Alumni Research Foundation Methods, systems, and computer program products for optimization of probes for spectroscopic measurement in turbid media
DE102005044021A1 (de) * 2005-09-14 2007-03-15 Eppendorf Ag Labortemperiereinrichtung mit Oberseite
JP2007225547A (ja) * 2006-02-27 2007-09-06 Fujifilm Corp 標的物質の疎水部位の検出方法
EP2001352A4 (en) * 2006-03-17 2010-04-07 Univ Duke MODEL OF FLUORESCENCE IN A DISORDER MEDIUM BASED ON THE MONTE CARLO METHOD AND SYSTEMS FOR USING THE SAME TO DETERMINE THE INTRINSIC FLUORESCENCE OF A DISORDER MEDIUM
EP2005173A4 (en) * 2006-03-30 2011-03-16 Univ Duke OPTICAL ANALYSIS SYSTEM FOR INTRA-OPERATIVE EVALUATION OF TUMOR MARGINS
DE602006012460D1 (de) 2006-06-07 2010-04-08 Nutrinova Gmbh Verfahren zum Screening von Substanzen die die Aktivität von Gpcrs modulieren
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
EP2061904A2 (en) 2006-09-06 2009-05-27 Ortho-McNeil Pharmaceutical, Inc. Biomarkers for assessing response to c-met treatment
US7807311B2 (en) * 2006-10-16 2010-10-05 Gm Global Technology Operations, Inc. Apparatus for hydrogen-air mixing in a fuel cell assembly and method
CA2677833C (en) 2007-01-22 2016-05-03 Wafergen, Inc. Apparatus for high throughput chemical reactions
JP5484041B2 (ja) * 2007-02-23 2014-05-07 学校法人関西学院 蛋白質結晶化剤および蛋白質結晶化剤を用いた蛋白質結晶化方法
WO2008103486A1 (en) * 2007-02-23 2008-08-28 Duke University Scaling method for fast monte carlo simulation of diffuse reflectance spectra
US9475051B2 (en) 2007-02-27 2016-10-25 Sony Corporation Nucleic acid amplifier
JP4458133B2 (ja) * 2007-02-27 2010-04-28 ソニー株式会社 核酸増幅装置
EP1965195A1 (en) * 2007-02-28 2008-09-03 Hitachi High-Technologies Corporation Luminescence measuring apparatus
US20080225265A1 (en) * 2007-03-17 2008-09-18 Mi Research, Inc. Method and apparatus for finding macromolecule crystallization conditions
US20090081639A1 (en) * 2007-05-31 2009-03-26 Phil Hill Assay for sensitivity to chemotherapeutic agents
GB2452057A (en) * 2007-08-23 2009-02-25 Shaw Stewart P D A microfluidic device for thermal assays
EP2194848A4 (en) * 2007-09-28 2013-08-14 Univ Duke SYSTEMS AND METHODS FOR SPECTRAL ANALYSIS OF A TISSUE MASS USING AN INSTRUMENT, AN OPTICAL PROBE AND A MONTE CARLO OR DIFFUSION ALGORITHM
WO2009055050A1 (en) * 2007-10-25 2009-04-30 Canon U.S. Life Sciences, Inc High-resolution melting analysis
US8993714B2 (en) * 2007-10-26 2015-03-31 Imiplex Llc Streptavidin macromolecular adaptor and complexes thereof
US20090155919A1 (en) * 2007-12-17 2009-06-18 Optix, Llp High throughput drug screening method
WO2010042249A2 (en) * 2008-04-24 2010-04-15 Duke University A diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering
US8093043B2 (en) * 2008-06-04 2012-01-10 New York University β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis
US8828730B2 (en) 2008-08-05 2014-09-09 Synapse B.V. Method and assembly for measuring thrombin generation in plasma
US9102526B2 (en) 2008-08-12 2015-08-11 Imiplex Llc Node polypeptides for nanostructure assembly
US9921154B2 (en) 2011-03-18 2018-03-20 Bio-Rad Laboratories, Inc. Multiplexed digital assays
US9156010B2 (en) * 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US20100233172A1 (en) * 2008-12-16 2010-09-16 Bristol-Myers Squibb Company Methods of inhibiting quiescent tumor proliferation
US9285363B2 (en) 2009-05-11 2016-03-15 Imiplex Llc Method of protein nanostructure fabrication
US8028843B2 (en) * 2009-05-15 2011-10-04 Hamilton Company Shift and scan test tube rack apparatus and method
US8476081B2 (en) * 2009-09-21 2013-07-02 Janssen Pharmaceutica Nv Assay for evaluating affinity and specificity of ligand-albumin binding
US9133343B2 (en) 2009-11-30 2015-09-15 Enzo Biochem, Inc. Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
US9091637B2 (en) 2009-12-04 2015-07-28 Duke University Smart fiber optic sensors systems and methods for quantitative optical spectroscopy
KR101368463B1 (ko) * 2010-04-23 2014-03-03 나노바이오시스 주식회사 2개의 열 블록을 포함하는 ｐｃｒ 장치
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
US8609040B2 (en) 2010-08-23 2013-12-17 Avia Biosystems, Llc System for creation of formulations and generation of denaturation graphs
CN102457333B (zh) * 2010-10-14 2014-06-04 华为技术有限公司 获取秩约束条件下优化变量的方法及设备
IT1403792B1 (it) * 2010-12-30 2013-10-31 St Microelectronics Srl Analizzatore per analisi biochimiche e metodo per la determinazione di concentrazioni di sostanze fluorescenti in una soluzione
US8718948B2 (en) 2011-02-24 2014-05-06 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
GB201106548D0 (en) * 2011-04-18 2011-06-01 Evitraproteoma Ab A method for determining ligand binding to a target protein using a thermal shift assahy
US9523693B2 (en) 2011-04-18 2016-12-20 Biotarget Engagement Interest Group Ab Methods for determining ligand binding to a target protein using a thermal shift assay
CN103797367B (zh) * 2011-09-06 2016-05-25 马克斯.普朗克促进科学协会 用于分析生物大分子复合物的方法及其用途
EP2605001A1 (en) * 2011-12-15 2013-06-19 Hain Lifescience GmbH A device and method for optically measuring fluorescence of nucleic acids in test samples and use of the device and method
TWI448919B (zh) * 2012-06-01 2014-08-11 Univ Southern Taiwan 以相對位能差預測蛋白質熱穩定之方法
US9970052B2 (en) 2012-08-23 2018-05-15 Bio-Rad Laboratories, Inc. Digital assays with a generic reporter
FR2995082A1 (fr) * 2012-08-30 2014-03-07 Univ Paris Diderot Paris 7 Methode de determination de l'energie de destabilisation de la conformation d'une proteine
EP3495428A1 (en) * 2013-03-15 2019-06-12 Life Technologies Corporation Methods for dye selection for protein melt temperature determinations
WO2014186508A1 (en) 2013-05-15 2014-11-20 University Of Rechester Human extensively self-renewing erythroblasts (esre)
US20140338860A1 (en) * 2013-05-17 2014-11-20 Anthony Walter Demsia Combination Vessel Holder for Heat Block Incubation
KR102266002B1 (ko) 2013-07-01 2021-06-16 일루미나, 인코포레이티드 촉매-무함유 표면 작용화 및 중합체 그라프팅
GB2524519B (en) * 2014-03-25 2019-11-06 Pelago Bioscience AB Methods for identifying a biomarker indicative of a reduced drug response using a thermal shift assay
US11569541B2 (en) 2014-06-30 2023-01-31 Black & Decker Inc. Battery pack for a cordless power tool
WO2016028804A1 (en) 2014-08-21 2016-02-25 Discoverx Corporation Homogenous thermal shift ligand binding assay
WO2016134342A1 (en) 2015-02-20 2016-08-25 Wafergen, Inc. Method for rapid accurate dispensing, visualization and analysis of single cells
JP6026628B1 (ja) * 2015-12-03 2016-11-16 株式会社東芝 鮮度マーカー及びこれを用いたセンシングシステム
US11460405B2 (en) 2016-07-21 2022-10-04 Takara Bio Usa, Inc. Multi-Z imaging and dispensing with multi-well devices
CA3017667A1 (en) 2017-09-18 2019-03-18 Ecolab Usa Inc. Adaptive range titration systems and methods
EP3697927B1 (en) 2017-10-19 2022-12-14 Bio-Rad Laboratories, Inc. Digital amplification assays with unconventional and/or inverse changes in photoluminescence
US11454619B2 (en) 2018-04-09 2022-09-27 Ecolab Usa Inc. Methods for colorimetric endpoint detection and multiple analyte titration systems
US11397170B2 (en) 2018-04-16 2022-07-26 Ecolab Usa Inc. Repetition time interval adjustment in adaptive range titration systems and methods
US11459604B2 (en) 2018-07-12 2022-10-04 Luminex Corporation Systems and methods for performing variable sample preparation and analysis processes
US11474109B2 (en) 2018-11-16 2022-10-18 Scintimetrics, Inc. Compositions and methods for controllably merging emulsion droplets and sample analysis
KR20220114026A (ko) 2019-12-12 2022-08-17 디엔에이 스크립트 폴리뉴클레오타이드의 주형-부재 효소 합성을 위한 키메라 말단 데옥시뉴클레오타이드 전달효소
AU2021347452A1 (en) 2020-09-22 2023-04-27 Dna Script Stabilized n-terminally truncated terminal deoxynucleotidyl transferase variants and uses thereof
US20230416708A1 (en) 2020-10-26 2023-12-28 Dna Script Novel Variants of Endonuclease V and Uses Thereof

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626684A (en) * 1983-07-13 1986-12-02 Landa Isaac J Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples
US4580895A (en) * 1983-10-28 1986-04-08 Dynatech Laboratories, Incorporated Sample-scanning photometer
US4628026A (en) * 1983-11-15 1986-12-09 Dietlind Gardell Method and apparatus for automated double fluorochromization analysis in lymphocytotoxicity testing
US5096807A (en) 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
JPS61241639A (ja) * 1985-04-19 1986-10-27 Hitachi Ltd 反応試料分析装置
EP0216026B1 (en) * 1985-06-26 1992-01-22 Japan Tectron Instruments Corporation Automatic analysis apparatus
US5260207A (en) * 1987-04-06 1993-11-09 Enzon Labs Inc. Engineering of electrostatic interactions at metal ion binding sites for the stabilization of proteins
JP2656564B2 (ja) * 1988-08-26 1997-09-24 株式会社日立製作所 免疫分析方法
DE4103216A1 (de) * 1991-02-02 1992-08-06 Hilti Ag Einrichtung zum auffinden magnetisierbaren materials in bauwerken
US5994056A (en) * 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
DE4123817C2 (de) * 1991-07-18 1994-06-09 Berthold Lab Prof Dr Strahlungsmeßgerät, insbesondere zur Messung der Lumineszenz
WO1993014781A1 (en) 1992-01-24 1993-08-05 The Regents Of The University Of California Novel peptides and method for altering the activity of allosteric proteins
WO1993018182A1 (en) * 1992-03-09 1993-09-16 Difco Laboratories Diagnostic microbiological testing apparatus and method
CA2093481A1 (en) * 1992-04-30 1993-10-31 Gottlieb Schacher Processing station for carrying out fluorescence polarization measurements in an analyzer
US5292513A (en) * 1992-05-18 1994-03-08 Anthony G. Gristina Method for nonspecific cellular immune stimulation
US5255976A (en) * 1992-07-10 1993-10-26 Vertex Pharmaceuticals Incorporated Temperature gradient calorimeter
US5314825A (en) * 1992-07-16 1994-05-24 Schiapparelli Biosystems, Inc. Chemical analyzer
US5585275A (en) * 1992-09-02 1996-12-17 Arris Pharmaceutical Corporation Pilot apparatus for peptide synthesis and screening
US5355215A (en) * 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
US5383023A (en) * 1993-03-01 1995-01-17 Walleczek; Jan Method and apparatus for performing dual-beam dual-wavelength fluorescence spectrophotometric evaluation of a biological specimen
US5679582A (en) * 1993-06-21 1997-10-21 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US5585277A (en) * 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
JP3598123B2 (ja) * 1993-07-15 2004-12-08 浜松ホトニクス株式会社 核酸の変性検出装置
US5436718A (en) * 1993-07-30 1995-07-25 Biolumin Corporation Mutli-functional photometer with movable linkage for routing optical fibers
CA2129787A1 (en) * 1993-08-27 1995-02-28 Russell G. Higuchi Monitoring multiple amplification reactions simultaneously and analyzing same
US5525300A (en) * 1993-10-20 1996-06-11 Stratagene Thermal cycler including a temperature gradient block
US5415839A (en) * 1993-10-21 1995-05-16 Abbott Laboratories Apparatus and method for amplifying and detecting target nucleic acids
US5631734A (en) * 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5557398A (en) * 1994-04-15 1996-09-17 Molecular Devices Corporation Photometric device
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US5631794A (en) * 1994-10-03 1997-05-20 Yang; Tai-Her Differential shunt-type protection circuit
US5589351A (en) * 1994-12-06 1996-12-31 Nps Pharmaceuticals, Inc. Fluorescence detection apparatus
US6337183B1 (en) * 1995-09-08 2002-01-08 Scriptgen Pharmaceuticals, Inc. Screen for compounds with affinity for nucleic acids
CA2184195C (en) * 1995-10-25 2002-04-16 Andrew Pakula Screening method for identifying ligands for target proteins
CA2236339A1 (en) * 1995-12-07 1997-06-12 Robert T. Sauer A fluorescence-based screening method for identifying ligands
US6036920A (en) * 1996-05-09 2000-03-14 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay apparatus for ligand development and multi-variable protein chemistry optimization
EP0934515B1 (en) * 1996-10-09 2006-03-08 Symyx Technologies, Inc. Infrared spectroscopy and imaging of libraries
US6331392B1 (en) * 1997-03-05 2001-12-18 Anadys Pharmaceutical, Inc. Screen employing fluorescence anisotropy to identify compounds with affinity for nucleic acids
US6569631B1 (en) * 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
US6242190B1 (en) * 1999-12-01 2001-06-05 John Hopkins University Method for high throughput thermodynamic screening of ligands

Also Published As

Publication number Publication date
HUP9902418A3 (en) 2001-10-29
US6849458B2 (en) 2005-02-01
US6036920A (en) 2000-03-14
US6214293B1 (en) 2001-04-10
EP0914608A1 (en) 1999-05-12
US20020114734A1 (en) 2002-08-22
US6020141A (en) 2000-02-01
KR20000011069A (ko) 2000-02-25
US6268158B1 (en) 2001-07-31
CA2253587C (en) 2008-01-29
US20040185504A1 (en) 2004-09-23
AU3205097A (en) 1997-11-26
WO1997042500A1 (en) 1997-11-13
US6268218B1 (en) 2001-07-31
US20030203497A1 (en) 2003-10-30
AU741049B2 (en) 2001-11-22
HUP9902418A2 (hu) 1999-11-29
US6291191B1 (en) 2001-09-18
CA2253587A1 (en) 1997-11-13
US6232085B1 (en) 2001-05-15
JP2000511629A (ja) 2000-09-05
US6303322B1 (en) 2001-10-16
US6291192B1 (en) 2001-09-18

Similar Documents

Publication Publication Date Title
NZ332754A (en) Microplate thermal shift assay which looks at thermal change
Wittwer et al. Rapid cycle DNA amplification
US6693709B2 (en) Photometric device
AU727296B2 (en) System and methods for monitoring for DNA amplification by fluorescence
CA2757783C (en) Instrument and method for the automated thermal treatment of liquid samples
US7817273B2 (en) Two-dimensional spectral imaging system
US7663750B2 (en) Two-dimensional spectral imaging system
US8427643B2 (en) Real-time PCR monitoring apparatus
JP2016512881A (ja) 試料アレイ内の試料を実質的に同時に監視するためのコンパクト光学システム
CN205329008U (zh) 一种实时荧光定量pcr仪
KR20000057407A (ko) 반응 용기
JP2008261842A (ja) 光線を放射及び検出するための装置
AU2003243288A1 (en) Fluorescence polarization detection of nucleic acids
WO2007011549A1 (en) Two-dimensional spectral imaging system
WO2002061127A3 (en) Arrayed polynucleotides and their use in genome analysis
US6383802B1 (en) Method and device for preparing samples for detecting a nucleotide sequence
WO2003019158A3 (de) Thermo-optisches analysesystem für biochemische reaktionen
AU3758501A (en) Reaction system for thermal cycling
Liquiers et al. The infrared and Raman spectra of the duplex of d (GGTATACC) in the crystal show bands due to both the A-form and the B-form of DNA
KR100479782B1 (ko) 생물학적공정모니터링방법및시스템
Goldman et al. Continuous fluorescence detection thermal cycling for DNA analysis using an array of LED light sources
PH12020050180A1 (en) An apparatus and method for conducting a nucleic acid amplification reaction based on a preset thermal profile
US20180104696A1 (en) Convective polymerase chain reaction apparatus and optical detecting method thereof
Knoll Molecular Beacons for the Detection of DNA-binding Proteins
GB2432906A (en) UV detection of nucleotide modification

Legal Events

Date Code Title Description
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
ASS Change of ownership

Owner name: LIFE TECHNOLOGIES CORPORATION, US

Free format text: OLD OWNER(S): 3-DIMENSIONAL PHARMACEUTICALS, INC.

EXPY Patent expired