NZ331126A - Camptothecin derivatives and the use thereof as antitumor agents - Google Patents

Camptothecin derivatives and the use thereof as antitumor agents

Info

Publication number
NZ331126A
NZ331126A NZ331126A NZ33112697A NZ331126A NZ 331126 A NZ331126 A NZ 331126A NZ 331126 A NZ331126 A NZ 331126A NZ 33112697 A NZ33112697 A NZ 33112697A NZ 331126 A NZ331126 A NZ 331126A
Authority
NZ
New Zealand
Prior art keywords
compound
formula
hydrogen
alkyl
compounds
Prior art date
Application number
NZ331126A
Other languages
English (en)
Inventor
Lucio Merlini
Sergio Penco
Franco Zunino
Original Assignee
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11373368&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ331126(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ist Naz Stud Cura Dei Tumori filed Critical Ist Naz Stud Cura Dei Tumori
Publication of NZ331126A publication Critical patent/NZ331126A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NZ331126A 1996-02-23 1997-02-19 Camptothecin derivatives and the use thereof as antitumor agents NZ331126A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI000338A IT1282673B1 (it) 1996-02-23 1996-02-23 Derivati della camptotecina e loro uso come agenti antitumorali
PCT/EP1997/000786 WO1997031003A1 (en) 1996-02-23 1997-02-19 Camptothecin derivatives and the use thereof as antitumor agents

Publications (1)

Publication Number Publication Date
NZ331126A true NZ331126A (en) 2000-02-28

Family

ID=11373368

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ331126A NZ331126A (en) 1996-02-23 1997-02-19 Camptothecin derivatives and the use thereof as antitumor agents

Country Status (22)

Country Link
US (2) US6130227A (ref)
EP (1) EP0885230B1 (ref)
JP (1) JP4171527B2 (ref)
KR (1) KR100497906B1 (ref)
CN (1) CN1107677C (ref)
AT (1) ATE221071T1 (ref)
AU (1) AU718361B2 (ref)
BR (1) BR9707622B1 (ref)
CZ (1) CZ289268B6 (ref)
DE (1) DE69714220T2 (ref)
DK (1) DK0885230T3 (ref)
EE (1) EE03529B1 (ref)
ES (1) ES2180932T3 (ref)
HU (1) HUP9900987A3 (ref)
IL (1) IL125856A (ref)
IT (1) IT1282673B1 (ref)
NZ (1) NZ331126A (ref)
PT (1) PT885230E (ref)
RU (1) RU2165935C2 (ref)
SK (1) SK283217B6 (ref)
UA (1) UA49005C2 (ref)
WO (1) WO1997031003A1 (ref)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE211931T1 (de) * 1998-06-26 2002-02-15 Quanam Medical Corp Topoisomerase inhibitoren zur restenose- prevention
US7105492B2 (en) 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
SI1044977T1 (en) * 1999-03-09 2002-08-31 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
AR025587A1 (es) 1999-09-13 2002-12-04 Hoffmann La Roche Formulaciones en dispersion que contienen inhibidores de lipasa
AU2002258787A1 (en) * 2001-04-11 2002-10-28 Emerald Biostructures, Inc. Screening methods for identifying ligands
RU2319482C2 (ru) * 2001-11-23 2008-03-20 Чугаи Сейяку Кабусики Кайся Способ идентификации противоопухолевых целевых ферментов
ES2287495T3 (es) * 2002-03-01 2007-12-16 Pfizer Italia S.R.L. Forma polimorfa cristalina de clorhidrato de irinotecan.
TW200306314A (en) * 2002-04-16 2003-11-16 Tanabe Seiyaku Co Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
TWI333492B (en) * 2003-11-12 2010-11-21 Smithkline Beecham Cork Ltd Crystalline topotecan hydrochloride product and preparation thereof
CN101340910B (zh) 2005-12-21 2012-12-12 希格马托制药工业公司 抗药性肿瘤的治疗
WO2007095389A2 (en) * 2006-02-17 2007-08-23 Novacea, Inc. Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs
CN101033230B (zh) 2006-03-10 2010-12-08 中国科学院上海药物研究所 一类喜树碱衍生物及其应用
ITMI20061474A1 (it) * 2006-07-26 2008-01-27 Indena Spa Derivati della camptotecina ad attivita antitumorale
CN102731516B (zh) * 2011-04-07 2014-07-02 宁波天衡药业股份有限公司 一类具有抗肿瘤活性的喜树碱衍生物
CN104774209B (zh) * 2014-01-15 2018-06-19 上海海和药物研究开发有限公司 一种9-烯丙基喜树碱衍生物的合成方法
CN117940432B (zh) * 2021-09-01 2025-12-23 上海弼领生物技术有限公司 一种喜树碱类化合物、其制备方法和用途
CN120554369A (zh) * 2024-05-24 2025-08-29 深圳微芯生物科技股份有限公司 喜树碱类似物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
JPS58154582A (ja) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
US5459269A (en) * 1992-06-18 1995-10-17 North Carolina State University 14-halo-camptothecins
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
CN1107678C (zh) * 1996-08-19 2003-05-07 比奥纽默里克药物公司 高亲脂性喜树碱衍生物，其制备方法及其用途

Also Published As

Publication number Publication date
CN1211987A (zh) 1999-03-24
AU718361B2 (en) 2000-04-13
US6130227A (en) 2000-10-10
EE9800259A (et) 1999-02-15
BR9707622A (pt) 1999-07-27
KR19990087110A (ko) 1999-12-15
HUP9900987A2 (hu) 1999-08-30
CZ289268B6 (cs) 2001-12-12
ITMI960338A0 (ref) 1996-02-23
IL125856A0 (en) 1999-04-11
DE69714220D1 (de) 2002-08-29
WO1997031003A1 (en) 1997-08-28
DK0885230T3 (da) 2002-11-18
KR100497906B1 (ko) 2006-03-09
BR9707622B1 (pt) 2010-08-10
IL125856A (en) 2001-08-26
EP0885230B1 (en) 2002-07-24
ES2180932T3 (es) 2003-02-16
RU2165935C2 (ru) 2001-04-27
ATE221071T1 (de) 2002-08-15
CZ265298A3 (cs) 1999-01-13
US6306868B1 (en) 2001-10-23
SK112798A3 (en) 1999-01-11
SK283217B6 (sk) 2003-03-04
JP2000505448A (ja) 2000-05-09
EE03529B1 (et) 2001-10-15
CN1107677C (zh) 2003-05-07
JP4171527B2 (ja) 2008-10-22
AU1875397A (en) 1997-09-10
UA49005C2 (uk) 2002-09-16
HUP9900987A3 (en) 2000-01-28
ITMI960338A1 (it) 1997-08-23
EP0885230A1 (en) 1998-12-23
DE69714220T2 (de) 2002-11-14
IT1282673B1 (it) 1998-03-31
PT885230E (pt) 2002-12-31

Similar Documents

Publication Publication Date Title
NZ331126A (en) Camptothecin derivatives and the use thereof as antitumor agents
US5910491A (en) Highly lipophilic camptothecin derivatives
KR100191193B1 (ko) 6환 화합물
AU681941B2 (en) Water-soluble camptothecin derivatives, process for their preparation and their use as antitumor agents
TW202345836A (zh) 可用作ＮＬＲＰ３衍生物之吡啶并－〔３，４－ｄ〕噠嗪胺衍生物
WO2022121981A1 (zh) 新型喜树碱衍生物、含其的组合物和其用途
JP2025526425A (ja) 抗体薬物複合体に適した毒素分子
JP4990620B2 (ja) ７−置換カンプトテシンおよびカンプトテシン類似体ならびにそれらの調製方法
KR20010053119A (ko) 다양한 라멜라린 화합물 및 유사체의 합성 방법
EP0644877A1 (en) Substituted-hexahydrobenzo a]phenanthridines
CN116102557A (zh) 苯二氮卓类化合物及其制备方法和在医药上的用途
TW200404806A (en) Camptothecins with a modified lactone ring
CN118834221B (zh) 一种软海绵素b类似物
ES2309340T3 (es) Abridor del canal de k activado por calcio de alta conductancia.
WO2025153047A1 (zh) 喜树碱衍生物及其制备方法和应用
KR102473019B1 (ko) 트립톨라이드 유도체 및 이의 제조방법과 응용
CA2247513C (en) Camptothecin derivatives and the use thereof as antitumor agents
KR20260006000A (ko) 중수소화 캄토테신 화합물 및 이의 제조 방법과 용도
WO2022083679A1 (en) Prodrugs for sustained releasing therapeutic agents and uses thereof
WO2016087596A1 (en) Securinine derivatives useful in the treatment of cancer
CN120757535A (zh) 含氧代吡啶并氧代脂肪环结构的化合物及其医药用途
HU226377B1 (en) 8h-thieno[2,3-b]pyrrolizin-8-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them
AU2005247032A1 (en) New benzo [b]pyrano[3,2-h]acridin-7-one cinnamate compounds, a process for their preparation and pharmaceutical compositions containing them
JPH09227559A (ja) スピロ置換三環性複素環式化合物
GB2402129A (en) Novel furan derivatives and their use as antiproliferative agents

Legal Events

Date Code Title Description
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
EXPY Patent expired