|
GB9004483D0
(en)
*
|
1990-02-28 |
1990-04-25 |
Erba Carlo Spa |
New aryl-and heteroarylethenylene derivatives and process for their preparation
|
|
US5587385A
(en)
*
|
1991-12-24 |
1996-12-24 |
Farmitalia Carlo Erba S.R.L. |
Arylidene-heterocyclic derivatives and process for their preparation
|
|
US5792771A
(en)
*
|
1992-11-13 |
1998-08-11 |
Sugen, Inc. |
Quinazoline compounds and compositions thereof for the treatment of disease
|
|
US5712395A
(en)
*
|
1992-11-13 |
1998-01-27 |
Yissum Research Development Corp. |
Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
|
|
US5981569A
(en)
*
|
1992-11-13 |
1999-11-09 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease
|
|
US5763441A
(en)
*
|
1992-11-13 |
1998-06-09 |
Sugen, Inc. |
Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
|
|
GB9326136D0
(en)
*
|
1993-12-22 |
1994-02-23 |
Erba Carlo Spa |
Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents
|
|
GB9406137D0
(en)
*
|
1994-03-28 |
1994-05-18 |
Erba Carlo Spa |
N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation
|
|
GB9412719D0
(en)
*
|
1994-06-24 |
1994-08-17 |
Erba Carlo Spa |
Substituted azaindolylidene compounds and process for their preparation
|
|
GB9423997D0
(en)
*
|
1994-11-28 |
1995-01-11 |
Erba Carlo Spa |
Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation
|
|
AU5645196A
(en)
*
|
1995-04-11 |
1996-10-30 |
Lonza A.G. |
Process for preparing azaindoles with an activated copper ch romite catalyst by catalytic dehydrocyclisation of alkylpyri dylamines (pyridopyridines)
|
|
US5650415A
(en)
*
|
1995-06-07 |
1997-07-22 |
Sugen, Inc. |
Quinoline compounds
|
|
US5880141A
(en)
*
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
US6316635B1
(en)
|
1995-06-07 |
2001-11-13 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
JPH11507052A
(ja)
*
|
1995-06-07 |
1999-06-22 |
スージェン・インコーポレーテッド |
キナゾリンおよび医薬組成物
|
|
US5773459A
(en)
*
|
1995-06-07 |
1998-06-30 |
Sugen, Inc. |
Urea- and thiourea-type compounds
|
|
US6147106A
(en)
|
1997-08-20 |
2000-11-14 |
Sugen, Inc. |
Indolinone combinatorial libraries and related products and methods for the treatment of disease
|
|
US6906093B2
(en)
|
1995-06-07 |
2005-06-14 |
Sugen, Inc. |
Indolinone combinatorial libraries and related products and methods for the treatment of disease
|
|
AU6112896A
(en)
*
|
1995-06-07 |
1996-12-30 |
Sugen, Inc. |
Tyrphostin-like compounds for the treatment of cell prolifer ative disorders or cell differentiation disorders
|
|
US5710173A
(en)
*
|
1995-06-07 |
1998-01-20 |
Sugen, Inc. |
Thienyl compounds for inhibition of cell proliferative disorders
|
|
US5763470A
(en)
*
|
1995-06-07 |
1998-06-09 |
Sugen Inc. |
Benzopyran compounds and methods for their use
|
|
US7119174B2
(en)
|
1995-12-18 |
2006-10-10 |
Sugen, Inc. |
Diagnosis and treatment of AUR1 and/or AUR2 related disorders
|
|
US6716575B2
(en)
|
1995-12-18 |
2004-04-06 |
Sugen, Inc. |
Diagnosis and treatment of AUR1 and/or AUR2 related disorders
|
|
US6696448B2
(en)
|
1996-06-05 |
2004-02-24 |
Sugen, Inc. |
3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
|
|
US6682921B1
(en)
|
1996-08-21 |
2004-01-27 |
New York University |
Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases
|
|
US6818440B2
(en)
|
1997-04-28 |
2004-11-16 |
Sugen, Inc. |
Diagnosis and treatment of alk-7 related disorders
|
|
AR012634A1
(es)
|
1997-05-02 |
2000-11-08 |
Sugen Inc |
Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
|
|
EP0984930B1
(en)
*
|
1997-05-07 |
2005-04-06 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
US6316429B1
(en)
|
1997-05-07 |
2001-11-13 |
Sugen, Inc. |
Bicyclic protein kinase inhibitors
|
|
US6486185B1
(en)
|
1997-05-07 |
2002-11-26 |
Sugen, Inc. |
3-heteroarylidene-2-indolinone protein kinase inhibitors
|
|
US6228641B1
(en)
|
1997-05-20 |
2001-05-08 |
Sugen, Inc. |
Diagnosis and treatment of PTP04 related disorders
|
|
US6342593B1
(en)
|
1997-06-11 |
2002-01-29 |
Sugen, Inc. |
Diagnosis and treatment of ALP related disorders
|
|
US7115710B2
(en)
|
1997-06-11 |
2006-10-03 |
Sugen, Inc. |
Diagnosis and treatment of PTP related disorders
|
|
US6987113B2
(en)
|
1997-06-11 |
2006-01-17 |
Sugen, Inc. |
Tyrosine kinase inhibitors
|
|
US6388063B1
(en)
|
1997-06-18 |
2002-05-14 |
Sugen, Inc. |
Diagnosis and treatment of SAD related disorders
|
|
US6313158B1
(en)
|
1997-06-20 |
2001-11-06 |
Sugen, Inc. |
Bioavailability of 3-heteroarylidenyl-2-indolinones active as protein tyrosine kinase inhibitors
|
|
US6114371A
(en)
*
|
1997-06-20 |
2000-09-05 |
Sugen, Inc. |
3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors
|
|
US6130238A
(en)
*
|
1997-06-20 |
2000-10-10 |
Sugen, Inc. |
3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors
|
|
US6051593A
(en)
*
|
1997-06-20 |
2000-04-18 |
Sugen, Inc. |
3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
|
|
US6235769B1
(en)
|
1997-07-03 |
2001-05-22 |
Sugen, Inc. |
Methods of preventing and treating neurological disorders with compounds that modulate the function of the C-RET receptor protein tyrosine kinase
|
|
WO1999007701A1
(en)
|
1997-08-05 |
1999-02-18 |
Sugen, Inc. |
Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors
|
|
US20040067531A1
(en)
*
|
1997-08-20 |
2004-04-08 |
Sugen, Inc. |
Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
|
|
SK285357B6
(sk)
*
|
1997-09-26 |
2006-11-03 |
Zentaris Gmbh |
Zlúčeniny na báze azabenzimidazolu modulujúce funkciu serínovej/treonínovej proteínkinázy
|
|
US6133305A
(en)
|
1997-09-26 |
2000-10-17 |
Sugen, Inc. |
3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity
|
|
UA71555C2
(en)
|
1997-10-06 |
2004-12-15 |
Zentaris Gmbh |
Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives
|
|
US6225346B1
(en)
|
1997-10-24 |
2001-05-01 |
Sugen, Inc. |
Tyrphostin like compounds
|
|
US5935626A
(en)
*
|
1997-11-24 |
1999-08-10 |
Moorman Manufacturing Company |
Weather resistant mineral feeds and methods of making same
|
|
US6495353B1
(en)
|
1998-01-21 |
2002-12-17 |
Sugen, Inc. |
Human orthologues of wart
|
|
US6531502B1
(en)
|
1998-01-21 |
2003-03-11 |
Sugen, Inc. |
3-Methylidenyl-2-indolinone modulators of protein kinase
|
|
EP1066257A2
(en)
*
|
1998-03-26 |
2001-01-10 |
Sugen, Inc. |
Heterocylic classes of compounds for the modulating tyrosine protein kinase
|
|
ATE302269T1
(de)
|
1998-04-14 |
2005-09-15 |
Sugen Inc |
Ste20-verwandte proteinkinasen
|
|
US6569868B2
(en)
|
1998-04-16 |
2003-05-27 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
DK2020408T3
(da)
|
1998-05-29 |
2013-09-30 |
Sugen Inc |
Pyrrol-substitueret 2-indolinon som proteinkinaseinhibitor
|
|
CA2342222A1
(en)
|
1998-08-31 |
2000-03-09 |
Sugen, Inc. |
Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity
|
|
US6680335B2
(en)
|
1998-09-28 |
2004-01-20 |
Sugen, Inc. |
Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
|
|
WO2000035909A1
(en)
|
1998-12-17 |
2000-06-22 |
F. Hoffmann-La Roche Ag |
4-aryloxindoles as inhibitors of jnk protein kinases
|
|
WO2000035908A1
(en)
*
|
1998-12-17 |
2000-06-22 |
F. Hoffmann-La Roche Ag |
4-alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinases, in particular cdk2
|
|
JP2002532503A
(ja)
|
1998-12-17 |
2002-10-02 |
エフ.ホフマン−ラ ロシュ アーゲー |
プロテインキナーゼ阻害剤としての4,5−ピラジノオキシンドール
|
|
US6153634A
(en)
*
|
1998-12-17 |
2000-11-28 |
Hoffmann-La Roche Inc. |
4,5-azolo-oxindoles
|
|
EP1630559A3
(en)
*
|
1998-12-30 |
2006-06-07 |
Sugen, Inc. |
PYK2 (RAFTK) and inflammation
|
|
US6689806B1
(en)
|
1999-03-24 |
2004-02-10 |
Sugen, Inc. |
Indolinone compounds as kinase inhibitors
|
|
EP1165513A1
(en)
*
|
1999-03-24 |
2002-01-02 |
Sugen, Inc. |
Indolinone compounds as kinase inhibitors
|
|
CN1368970A
(zh)
*
|
1999-04-06 |
2002-09-11 |
克诺尔股份有限公司 |
作为酪氨酸激酶抑制剂的取代的1,4-二氢茚并[1,2-c]吡唑
|
|
US6297238B1
(en)
|
1999-04-06 |
2001-10-02 |
Basf Aktiengesellschaft |
Therapeutic agents
|
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
|
EP1222273A2
(en)
|
1999-10-22 |
2002-07-17 |
PHARMACIA & UPJOHN COMPANY |
Drosophila g protein coupled receptors, nucleic acids, and methods related to the same
|
|
US6878733B1
(en)
|
1999-11-24 |
2005-04-12 |
Sugen, Inc. |
Formulations for pharmaceutical agents ionizable as free acids or free bases
|
|
US20020002169A1
(en)
|
1999-12-08 |
2002-01-03 |
Griffin John H. |
Protein kinase inhibitors
|
|
US6313310B1
(en)
|
1999-12-15 |
2001-11-06 |
Hoffmann-La Roche Inc. |
4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
|
|
NZ519697A
(en)
|
1999-12-22 |
2004-08-27 |
Sugen Inc |
Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds
|
|
DE60030164T2
(de)
*
|
1999-12-30 |
2007-08-30 |
Sugen, Inc., San Francisco |
3-Heteroarylidenyl-2-Indolinon Derivate für die Modulierung der Aktivität einer Proteinkinase und für die Verwendung bei der Chemotherapie von Krebs
|
|
SK12712002A3
(sk)
|
2000-02-07 |
2003-02-04 |
Abbott Gmbh & Co. Kg |
Deriváty 2-benzotiazolylmočoviny a ich použitie ako inhibítorov proteínkináz
|
|
PT1255752E
(pt)
|
2000-02-15 |
2007-10-17 |
Pharmacia & Upjohn Co Llc |
Inibidores de proteína quinases: 2-indolinonas substituídas com pirrolo
|
|
DE60111358T2
(de)
|
2000-02-28 |
2006-05-11 |
Sugen, Inc., San Diego |
3-(pyrolyllacton)-2-indolinon verbindungen zur verwendung als kinase-hemmstoffe
|
|
MY128450A
(en)
|
2000-05-24 |
2007-02-28 |
Upjohn Co |
1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
|
|
EP1294688A2
(en)
|
2000-06-02 |
2003-03-26 |
Sugen, Inc. |
Indolinone derivatives as protein kinase/phosphatase inhibitors
|
|
US6335342B1
(en)
*
|
2000-06-19 |
2002-01-01 |
Pharmacia & Upjohn S.P.A. |
Azaindole derivatives, process for their preparation, and their use as antitumor agents
|
|
US6726918B1
(en)
|
2000-07-05 |
2004-04-27 |
Oculex Pharmaceuticals, Inc. |
Methods for treating inflammation-mediated conditions of the eye
|
|
AU3649502A
(en)
|
2000-11-29 |
2002-06-11 |
Oculex Pharm Inc |
Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
|
|
US6582919B2
(en)
|
2001-06-11 |
2003-06-24 |
Response Genetics, Inc. |
Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates
|
|
AR042586A1
(es)
|
2001-02-15 |
2005-06-29 |
Sugen Inc |
3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
|
|
MXPA03008560A
(es)
|
2001-03-22 |
2004-06-30 |
Abbot Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos.
|
|
US6599902B2
(en)
|
2001-05-30 |
2003-07-29 |
Sugen, Inc. |
5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
|
|
JP2005500034A
(ja)
|
2001-06-20 |
2005-01-06 |
プロション バイオテク リミテッド |
受容体型タンパク質チロシンキナーゼ活性化を遮断する抗体、そのスクリーニング方法、及びその使用
|
|
AR038957A1
(es)
*
|
2001-08-15 |
2005-02-02 |
Pharmacia Corp |
Terapia de combinacion para el tratamiento del cancer
|
|
CA2461812C
(en)
|
2001-09-27 |
2011-09-20 |
Allergan, Inc. |
3-(arylamino)methylene-1,3-dihydro-2h-indol-2-ones as kinase inhibitors
|
|
US7005444B2
(en)
|
2001-09-27 |
2006-02-28 |
Allergan, Inc. |
3-(heteroarylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors
|
|
EP1434774A1
(en)
|
2001-10-10 |
2004-07-07 |
Sugen, Inc. |
3-(4-substituted heterocyclyl)-pyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors
|
|
CA2479205A1
(en)
*
|
2002-03-28 |
2003-10-09 |
Eisai Co., Ltd. |
Azaindoles as inhibitors of c-jun n-terminal kinases
|
|
US6541504B1
(en)
|
2002-04-03 |
2003-04-01 |
Allergan Sales, Llc |
(3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
|
|
WO2003084951A1
(en)
*
|
2002-04-03 |
2003-10-16 |
Allergan, Inc. |
(3z) -3-(3-hydro-isobenzofuran-1-ylidene)-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
|
|
WO2003103581A2
(en)
|
2002-06-05 |
2003-12-18 |
Genentech, Inc. |
Compositions and methods for liver growth and liver protection
|
|
US8450302B2
(en)
|
2002-08-02 |
2013-05-28 |
Ab Science |
2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
|
|
CA2494695C
(en)
|
2002-08-02 |
2011-04-05 |
Ab Science |
2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
|
|
US6747025B1
(en)
|
2002-11-27 |
2004-06-08 |
Allergan, Inc. |
Kinase inhibitors for the treatment of disease
|
|
US6699863B1
(en)
|
2002-11-27 |
2004-03-02 |
Allergan, Inc. |
Kinase inhibitors for the treatment of disease
|
|
US20050048099A1
(en)
|
2003-01-09 |
2005-03-03 |
Allergan, Inc. |
Ocular implant made by a double extrusion process
|
|
ES2502490T3
(es)
|
2003-02-26 |
2014-10-03 |
Sugen, Inc. |
Compuestos aminoheteroarílicos como inhibidores de proteín quinasas
|
|
US7157577B2
(en)
|
2003-03-07 |
2007-01-02 |
Sugen Inc. |
5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
|
|
BRPI0413281A
(pt)
|
2003-08-06 |
2006-10-10 |
Sugen Inc |
3-ciclopentilideno-1,3,dihidroindol-2-onas geometricamente restringidas como potentes inibidores de proteìna cinase
|
|
ATE525377T1
(de)
*
|
2003-10-15 |
2011-10-15 |
Osi Pharm Inc |
Imidazoä1,5-aüpyrazine als inhibitoren von tyrosinkinase
|
|
DK1684750T3
(da)
|
2003-10-23 |
2010-08-09 |
Ab Science |
2-aminoaryloxazol-forbindelser som tyrosinkinase-inhibitorer
|
|
US7504509B2
(en)
|
2003-12-19 |
2009-03-17 |
Plexxikon, Inc. |
Compounds and methods for development of Ret modulators
|
|
EP2168968B1
(en)
|
2004-04-02 |
2017-08-23 |
OSI Pharmaceuticals, LLC |
6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
|
|
US20050244469A1
(en)
|
2004-04-30 |
2005-11-03 |
Allergan, Inc. |
Extended therapeutic effect ocular implant treatments
|
|
US8685435B2
(en)
|
2004-04-30 |
2014-04-01 |
Allergan, Inc. |
Extended release biodegradable ocular implants
|
|
WO2005113561A1
(en)
*
|
2004-05-20 |
2005-12-01 |
Sugen, Inc. |
Cyclicsulfonate pyrrole indolinones as kinase inhibitors
|
|
US20060058339A1
(en)
*
|
2004-06-17 |
2006-03-16 |
Ibrahim Prabha N |
Compounds modulating c-kit activity and uses therefor
|
|
US7498342B2
(en)
|
2004-06-17 |
2009-03-03 |
Plexxikon, Inc. |
Compounds modulating c-kit activity
|
|
AR053090A1
(es)
|
2004-07-20 |
2007-04-25 |
Osi Pharm Inc |
Imidazotriazinas como inhibidores de proteina quinasas y su uso para la preparacion de medicamentos
|
|
KR20080019578A
(ko)
|
2005-04-04 |
2008-03-04 |
에이비 사이언스 |
치환된 옥사졸 유도체 및 이의 티로신 키나제 억제제로서의용도
|
|
WO2007013896A2
(en)
*
|
2005-05-17 |
2007-02-01 |
Plexxikon, Inc. |
Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
|
|
US7566721B2
(en)
*
|
2005-08-08 |
2009-07-28 |
Osi Pharmaceuticals, Inc. |
Substituted thienol[2,3-d]pyrimidines as kinase inhibitors
|
|
CN100519524C
(zh)
*
|
2005-09-29 |
2009-07-29 |
中国人民解放军军事医学科学院毒物药物研究所 |
吲哚丙烯酸衍生物及其用于制备免疫抑制剂的用途
|
|
US7371862B2
(en)
*
|
2005-11-11 |
2008-05-13 |
Pfizer Italia S.R.L. |
Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
|
AR057960A1
(es)
|
2005-12-02 |
2007-12-26 |
Osi Pharm Inc |
Inhibidores de proteina quinasa biciclicos
|
|
US8575164B2
(en)
*
|
2005-12-19 |
2013-11-05 |
OSI Pharmaceuticals, LLC |
Combination cancer therapy
|
|
JP2009521490A
(ja)
*
|
2005-12-22 |
2009-06-04 |
スミスクライン ビーチャム コーポレーション |
化合物
|
|
WO2007087419A2
(en)
|
2006-01-24 |
2007-08-02 |
Allergan, Inc. |
Substituted 3-(5-membered unsaturated heterocyclyl) -1, 3-dihydro-indol-2-one derivatives as tyrosine kinase inhibitors for the treatment of cancer
|
|
US7977351B2
(en)
|
2006-03-22 |
2011-07-12 |
Allergan, Inc. |
Heteroaryl dihydroindolones as kinase inhibitors
|
|
CL2007002617A1
(es)
*
|
2006-09-11 |
2008-05-16 |
Sanofi Aventis |
Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
|
|
DK2529622T3
(en)
|
2006-09-22 |
2018-05-07 |
Pharmacyclics Llc |
INHIBITORS OF BRUTON-TYROSINKINASE
|
|
US8558002B2
(en)
|
2006-11-16 |
2013-10-15 |
Allergan, Inc. |
Sulfoximines as kinase inhibitors
|
|
AU2007319151B2
(en)
|
2006-11-16 |
2013-05-23 |
Allergan, Inc. |
Sulfoximines as kinase inhibitors
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
US20120101114A1
(en)
|
2007-03-28 |
2012-04-26 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
NZ579911A
(en)
*
|
2007-03-28 |
2012-05-25 |
Pharmacyclics Inc |
Inhibitors of bruton's tyrosine kinase
|
|
JP2010523652A
(ja)
|
2007-04-13 |
2010-07-15 |
エージェンシー フォー サイエンス,テクノロジー アンド リサーチ |
腫瘍発生を制御する方法および腫瘍発生のリスクを診断する方法
|
|
US8231892B2
(en)
|
2007-05-24 |
2012-07-31 |
Allergan, Inc. |
Biodegradable drug delivery system
|
|
SG183036A1
(en)
|
2007-07-17 |
2012-08-30 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
CN101909630A
(zh)
|
2007-11-02 |
2010-12-08 |
新加坡科技研究局 |
预防和治疗肿瘤的方法和化合物
|
|
EP2250173A1
(en)
*
|
2008-01-18 |
2010-11-17 |
OSI Pharmaceuticals, Inc. |
Imidazopyrazinol derivatives for the treatment of cancers
|
|
ES2396613T3
(es)
*
|
2008-05-19 |
2013-02-22 |
OSI Pharmaceuticals, LLC |
Imidazopirazinas e imidazotriazinas sustituidas
|
|
US20090301928A1
(en)
*
|
2008-06-05 |
2009-12-10 |
United Comb & Novelty Corporation |
Packaging For Lipped Containers
|
|
US20110224235A1
(en)
|
2008-07-16 |
2011-09-15 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
|
|
AU2010232670B2
(en)
|
2009-04-03 |
2015-07-09 |
F. Hoffmann-La Roche Ag |
Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof
|
|
US8513415B2
(en)
|
2009-04-20 |
2013-08-20 |
OSI Pharmaceuticals, LLC |
Preparation of C-pyrazine-methylamines
|
|
WO2010129740A1
(en)
*
|
2009-05-07 |
2010-11-11 |
Osi Pharmaceuticals, Inc. |
Use of osi-906 for treating adrenocortical carcinoma
|
|
US9340555B2
(en)
|
2009-09-03 |
2016-05-17 |
Allergan, Inc. |
Compounds as tyrosine kinase modulators
|
|
RU2012109233A
(ru)
|
2009-09-03 |
2013-10-10 |
Аллерган, Инк. |
Соединения как модуляторы тирозинкиназы
|
|
MX2012005284A
(es)
|
2009-11-06 |
2012-06-28 |
Plexxikon Inc |
Compuestos y metodos para la modulacion de cinasas. e indicaciones para ello.
|
|
MX2012005678A
(es)
|
2009-11-16 |
2012-09-07 |
Univ California |
Enhibidores de cinasas.
|
|
WO2011153049A1
(en)
|
2010-06-02 |
2011-12-08 |
The Trustees Of The University Of Pennsylvania |
Methods and use of compounds that bind to her2/neu receptor complex
|
|
WO2011153050A1
(en)
|
2010-06-02 |
2011-12-08 |
The Trustees Of The University Of Pennsylvania |
Methods and use of compounds that bind to her2/neu receptor complex
|
|
KR101580714B1
(ko)
|
2010-06-03 |
2016-01-04 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 인산화효소(btk)의 억제제의 용도
|
|
EP2580320B1
(en)
|
2010-06-14 |
2018-08-01 |
The Scripps Research Institute |
Reprogramming of cells to a new fate
|
|
KR101911972B1
(ko)
|
2011-02-07 |
2018-10-25 |
플렉시콘 인코퍼레이티드 |
키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증
|
|
TWI558702B
(zh)
|
2011-02-21 |
2016-11-21 |
普雷辛肯公司 |
醫藥活性物質的固態形式
|
|
EA201490265A1
(ru)
|
2011-07-13 |
2014-12-30 |
Фармасайкликс, Инк. |
Ингибиторы тирозинкиназы брутона
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
KR20250151610A
(ko)
|
2012-06-04 |
2025-10-21 |
파마싸이클릭스 엘엘씨 |
브루톤 타이로신 키나아제 저해제의 결정 형태
|
|
BR112015001690A2
(pt)
|
2012-07-24 |
2017-11-07 |
Pharmacyclics Inc |
mutações associadas com a resistência a inibidores da tirosina quinase de bruton (btk)
|
|
US9637523B2
(en)
|
2012-08-31 |
2017-05-02 |
Westfaelische Wilhelms-Universitaet Muenster |
Methods and peptides for preventing and treating a BCR-ABL and a C-ABL associated disease
|
|
WO2014078578A1
(en)
|
2012-11-15 |
2014-05-22 |
Pharmacyclics, Inc. |
Pyrrolopyrimidine compounds as kinase inhibitors
|
|
US9468681B2
(en)
|
2013-03-01 |
2016-10-18 |
California Institute Of Technology |
Targeted nanoparticles
|
|
JP6800750B2
(ja)
|
2013-08-02 |
2020-12-16 |
ファーマサイクリックス エルエルシー |
固形腫瘍の処置方法
|
|
WO2015023703A1
(en)
|
2013-08-12 |
2015-02-19 |
Pharmacyclics, Inc. |
Methods for the treatment of her2 amplified cancer
|
|
JP2016531941A
(ja)
|
2013-09-30 |
2016-10-13 |
ファーマサイクリックス エルエルシー |
ブルトン型チロシンキナーゼの阻害剤
|
|
JP2017509336A
(ja)
|
2014-03-20 |
2017-04-06 |
ファーマサイクリックス エルエルシー |
ホスホリパーゼcガンマ2及び耐性に関連した変異
|
|
US9533991B2
(en)
|
2014-08-01 |
2017-01-03 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
CA2955747A1
(en)
|
2014-08-07 |
2016-02-11 |
Pharmacyclics Llc |
Novel formulations of a bruton's tyrosine kinase inhibitor
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
US10287401B2
(en)
|
2015-07-01 |
2019-05-14 |
California Institute Of Technology |
Cationic mucic acid polymer-based delivery systems
|
|
AU2018294351B2
(en)
*
|
2017-06-30 |
2022-12-22 |
The Regents Of The University Of California |
Compositions and methods for modulating hair growth
|
|
WO2019241327A1
(en)
|
2018-06-13 |
2019-12-19 |
California Institute Of Technology |
Nanoparticles for crossing the blood brain barrier and methods of treatment using the same
|