NO993646L - Tiazolbenzensulfonamider som <beta>3-agonister for behandling av diabetes og fedme - Google Patents

Tiazolbenzensulfonamider som <beta>3-agonister for behandling av diabetes og fedme

Info

Publication number
NO993646L
NO993646L NO993646A NO993646A NO993646L NO 993646 L NO993646 L NO 993646L NO 993646 A NO993646 A NO 993646A NO 993646 A NO993646 A NO 993646A NO 993646 L NO993646 L NO 993646L
Authority
NO
Norway
Prior art keywords
compounds
levels
obesity
diabetes
treatment
Prior art date
Application number
NO993646A
Other languages
English (en)
Other versions
NO993646D0 (no
Inventor
Robert J Mathvink
Emma R Parmee
Samuel Tolman
Ann E Weber
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9705041.3A external-priority patent/GB9705041D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO993646D0 publication Critical patent/NO993646D0/no
Publication of NO993646L publication Critical patent/NO993646L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Tiazolsubstituerte benzen- sulfonamider er p3-adrenerge reseptor- agonister med meget liten pj- og P,- adrenerg reseptoraktivitet og forbind- elsene er som sådanne i stand til å øke lipolysen og energiforbruket i celler. Forbindelsene har således kraftig akti- vitet ved behandling av type II-diabet- BS og fedme. Forbindelsene kan også an- vendes for å nedsette triglyseridnivåer og kolesterolnivåer eller heve høy- densitetslipoproteinnivåer eller for å nedsette tarmmotilitet. I tillegg kan forbindelsene anvendes for å redusere neurogenisk inflammasjon eller som antidepressive midler. Forbindelsene fremstilles ved kopling av et amino- alkylfenylsulfonamid med et hensikts- messig substituert epoksid. Preparater og metoder for anvendelse av forbind- elsene ved behandling av diabetes og fedme og for nedsettelse av triglyse- ridnivåer og kolesterolnivåer, eller for heving av høydensitetslipoprotein- nivåer eller for redusering av tarm- motilitet, er også beskrevet.
NO993646A 1997-01-28 1999-07-27 Tiazolbenzensulfonamider som <beta>3-agonister for behandling av diabetes og fedme NO993646L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3676097P 1997-01-28 1997-01-28
GBGB9705041.3A GB9705041D0 (en) 1997-03-12 1997-03-12 Thiazole benzenesulfonamides as selective B3 agonists for the treatment of diabetes and obesity
PCT/US1998/001317 WO1998032753A1 (en) 1997-01-28 1998-01-23 THIAZOLE BENZENESULFONAMIDES AS β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY

Publications (2)

Publication Number Publication Date
NO993646D0 NO993646D0 (no) 1999-07-27
NO993646L true NO993646L (no) 1999-09-27

Family

ID=26311166

Family Applications (1)

Application Number Title Priority Date Filing Date
NO993646A NO993646L (no) 1997-01-28 1999-07-27 Tiazolbenzensulfonamider som <beta>3-agonister for behandling av diabetes og fedme

Country Status (22)

Country Link
EP (1) EP0968209A1 (no)
JP (1) JP2001509166A (no)
KR (1) KR20000070568A (no)
CN (1) CN1251099A (no)
AR (1) AR011092A1 (no)
AU (1) AU728812B2 (no)
BG (1) BG103686A (no)
BR (1) BR9807096A (no)
CA (1) CA2278739A1 (no)
EA (1) EA199900692A1 (no)
EE (1) EE9900328A (no)
HR (1) HRP980044A2 (no)
HU (1) HUP0002053A3 (no)
ID (1) ID22273A (no)
IL (1) IL131130A0 (no)
IS (1) IS5131A (no)
NO (1) NO993646L (no)
PE (1) PE52299A1 (no)
PL (1) PL334833A1 (no)
SK (1) SK100099A3 (no)
TR (1) TR199902442T2 (no)
WO (1) WO1998032753A1 (no)

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AR035858A1 (es) 2001-04-23 2004-07-21 Bayer Corp Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
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DE60211199T2 (de) 2001-08-14 2007-02-01 Eli Lilly And Co., Indianapolis 3-substituierte oxindol-beta-3-agonisten
ES2272749T3 (es) 2001-08-14 2007-05-01 Eli Lilly And Company Derivados de indol como agonistas beta-3 adrenergicos para el tratamiento de diabetes tipo 2.
CA2463441A1 (en) * 2001-10-12 2003-05-08 Bayer Pharmaceuticals Corporation Phenyl substituted 5-membered nitrogen containing heterocycles for the treatment of obesity
JP2005518357A (ja) 2001-11-20 2005-06-23 イーライ・リリー・アンド・カンパニー ベータ３アドレナリンアゴニスト
ATE297925T1 (de) 2001-11-20 2005-07-15 Lilly Co Eli 3-substituierte oxindol beta 3 agonisten
US7009060B2 (en) 2002-01-11 2006-03-07 Eli Lilly And Company 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as β3 agonists
US6872724B2 (en) 2002-07-24 2005-03-29 Merck & Co., Inc. Polymorphs with tyrosine kinase activity
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WO2006132196A1 (ja) * 2005-06-08 2006-12-14 Asahi Kasei Pharma Corporation β３作動薬を含有する新規な医薬
PE20070458A1 (es) 2005-09-14 2007-07-05 Takeda Pharmaceutical Composicion farmaceutica que comprende 2-[[6-(3r)-3-amino-1-piperidinil]-3,4-dihidro-3-metil-2,4-dioxo-1(2h)-pirimidinil]metil]-benzonitrilo como inhibidor de dipeptidil peptidasa
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Also Published As

Publication number Publication date
BR9807096A (pt) 2000-04-18
WO1998032753A1 (en) 1998-07-30
IS5131A (is) 1999-07-23
HUP0002053A2 (hu) 2001-08-28
ID22273A (id) 1999-09-23
EE9900328A (et) 2000-02-15
PE52299A1 (es) 1999-05-26
TR199902442T2 (xx) 2000-07-21
CA2278739A1 (en) 1998-07-30
AR011092A1 (es) 2000-08-02
PL334833A1 (en) 2000-03-27
EA199900692A1 (ru) 2000-02-28
HRP980044A2 (en) 1998-10-31
HUP0002053A3 (en) 2001-09-28
JP2001509166A (ja) 2001-07-10
AU6038498A (en) 1998-08-18
BG103686A (bg) 2000-06-30
NO993646D0 (no) 1999-07-27
AU728812B2 (en) 2001-01-18
EP0968209A1 (en) 2000-01-05
CN1251099A (zh) 2000-04-19
IL131130A0 (en) 2001-01-28
KR20000070568A (ko) 2000-11-25
SK100099A3 (en) 2000-05-16

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