NO992381L - N-(aryl/heteroaryl/alkylacetyl/aminosyreamider, farmasöytiske sammensetninger omfattende disse og fremgangsmåter til inhibering av <beta>-amyloidpeptidfrigivning og/eller dets syntese ved anvendelse av slike forbindelser - Google Patents

N-(aryl/heteroaryl/alkylacetyl/aminosyreamider, farmasöytiske sammensetninger omfattende disse og fremgangsmåter til inhibering av <beta>-amyloidpeptidfrigivning og/eller dets syntese ved anvendelse av slike forbindelser

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Publication number
NO992381L
NO992381L NO992381A NO992381A NO992381L NO 992381 L NO992381 L NO 992381L NO 992381 A NO992381 A NO 992381A NO 992381 A NO992381 A NO 992381A NO 992381 L NO992381 L NO 992381L
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Norway
Prior art keywords
group
heteroaryl
aryl
synthesis
compounds
Prior art date
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NO992381A
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English (en)
Norwegian (no)
Other versions
NO992381D0 (no
Inventor
Jing Wu
Jay S Tung
Jeffrey S Nissen
Thomas E Mabry
Lee H Latimer
Clark Norman Eid
James E Audia
Original Assignee
Elan Pharm Inc
Lilly Co Eli
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Application filed by Elan Pharm Inc, Lilly Co Eli filed Critical Elan Pharm Inc
Publication of NO992381D0 publication Critical patent/NO992381D0/no
Publication of NO992381L publication Critical patent/NO992381L/no

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/37—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
NO992381A 1996-11-22 1999-05-18 N-(aryl/heteroaryl/alkylacetyl/aminosyreamider, farmasöytiske sammensetninger omfattende disse og fremgangsmåter til inhibering av <beta>-amyloidpeptidfrigivning og/eller dets syntese ved anvendelse av slike forbindelser NO992381L (no)

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PCT/US1997/022231 WO1998022433A1 (en) 1996-11-22 1997-11-21 N-(ARYL/HETEROARYL/ALKYLACETYL) AMINO ACID AMIDES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS

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AU729133B2 (en) 2001-01-25
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TR199901603T2 (xx) 2000-02-21
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JP2001504498A (ja) 2001-04-03
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IL129504A0 (en) 2000-02-29
NO992381D0 (no) 1999-05-18
PL334516A1 (en) 2000-02-28
EP0946499A1 (en) 1999-10-06
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WO1998022433A1 (en) 1998-05-28
AU5267798A (en) 1998-06-10
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