NO986103L - Substituerte indazol-derivater og deres anvendelse som fosfodiesterase (PDE)type IV - og tumornekrose-faktor (TNF)inhibitorer - Google Patents

Substituerte indazol-derivater og deres anvendelse som fosfodiesterase (PDE)type IV - og tumornekrose-faktor (TNF)inhibitorer

Info

Publication number
NO986103L
NO986103L NO986103A NO986103A NO986103L NO 986103 L NO986103 L NO 986103L NO 986103 A NO986103 A NO 986103A NO 986103 A NO986103 A NO 986103A NO 986103 L NO986103 L NO 986103L
Authority
NO
Norway
Prior art keywords
pde
phosphodiesterase
tnf
inhibitors
type
Prior art date
Application number
NO986103A
Other languages
English (en)
Norwegian (no)
Other versions
NO986103D0 (no
Inventor
Anthony Marfat
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO986103L publication Critical patent/NO986103L/no
Publication of NO986103D0 publication Critical patent/NO986103D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO986103A 1996-06-25 1998-12-23 Substituerte indazol-derivater og deres anvendelse som fosfodiesterase (PDE NO986103D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2038596P 1996-06-25 1996-06-25
PCT/IB1997/000630 WO1997049702A1 (en) 1996-06-25 1997-06-02 Substituted indazole derivatives and their use as phosphodiesterase (pde) type iv and tumor necrosis factor (tnf) inhibitors

Publications (2)

Publication Number Publication Date
NO986103L true NO986103L (no) 1998-12-23
NO986103D0 NO986103D0 (no) 1998-12-23

Family

ID=21798354

Family Applications (1)

Application Number Title Priority Date Filing Date
NO986103A NO986103D0 (no) 1996-06-25 1998-12-23 Substituerte indazol-derivater og deres anvendelse som fosfodiesterase (PDE

Country Status (43)

Country Link
US (1) US6040329A (id)
EP (1) EP0912558B1 (id)
JP (1) JP3152940B2 (id)
KR (1) KR20000022516A (id)
CN (1) CN1080260C (id)
AP (1) AP1025A (id)
AR (1) AR007456A1 (id)
AT (1) ATE244713T1 (id)
AU (1) AU716376B2 (id)
BG (1) BG64052B1 (id)
BR (1) BR9712782A (id)
CA (1) CA2258285C (id)
CO (1) CO4900056A1 (id)
CZ (1) CZ423398A3 (id)
DE (1) DE69723447T2 (id)
DK (1) DK0912558T3 (id)
DZ (1) DZ2254A1 (id)
EA (1) EA002274B1 (id)
ES (1) ES2201299T3 (id)
GT (1) GT199700075A (id)
HK (1) HK1018700A1 (id)
HN (1) HN1997000079A (id)
HR (1) HRP970350B1 (id)
HU (1) HUP9903009A3 (id)
ID (1) ID18579A (id)
IL (1) IL127036A (id)
IS (1) IS4910A (id)
MA (1) MA24225A1 (id)
MY (1) MY116915A (id)
NO (1) NO986103D0 (id)
NZ (1) NZ332752A (id)
OA (1) OA10934A (id)
PA (1) PA8432301A1 (id)
PL (1) PL330974A1 (id)
PT (1) PT912558E (id)
SI (1) SI0912558T1 (id)
SK (1) SK176598A3 (id)
TN (1) TNSN97108A1 (id)
TR (1) TR199802685T2 (id)
TW (1) TW434237B (id)
WO (1) WO1997049702A1 (id)
YU (1) YU60198A (id)
ZA (1) ZA975581B (id)

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US6248746B1 (en) 1998-01-07 2001-06-19 Euro-Celtique S.A. 3-(arylalkyl) xanthines
PL340799A1 (en) * 1997-11-04 2001-02-26 Pfizer Prod Inc Therapeutically active compounds based on a substitution of indazole bioisoster for cathechol in pde 4 inhibitors
ES2239063T3 (es) * 1999-12-23 2005-09-16 Icos Corporation Inhibidores de la fosfodiesterasa ciclica especifica de amp.
US6362213B1 (en) 1999-12-23 2002-03-26 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US6953774B2 (en) 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
US7153871B2 (en) 2001-01-22 2006-12-26 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
US7205320B2 (en) 2001-01-22 2007-04-17 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
JP4535680B2 (ja) * 2001-04-16 2010-09-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規１ｈ−インダゾール化合物
EP1908463B1 (en) 2001-12-14 2011-09-28 Merck Serono SA Methods of inducing ovulation using a non-polypeptide camp level modulator
JP2006504656A (ja) 2002-07-19 2006-02-09 メモリー・ファーマシューティカルズ・コーポレイション Ｎ−置換されたアニリン及びジフェニルアミンアナログを含むホスホジエステラーゼ４インヒビター
CN100381425C (zh) * 2002-07-19 2008-04-16 记忆药物公司 作为磷酸二酯酶4抑制剂的6-氨基-1h-吲唑及其药物组合物和用途
US7087625B2 (en) * 2002-11-19 2006-08-08 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
US7226930B2 (en) 2003-04-18 2007-06-05 Memory Pharmaceutical Corporation Phosphodiesterase 4 inhibitors
US20090048255A1 (en) * 2003-07-21 2009-02-19 Schumacher Richard A Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs
MY141255A (en) * 2003-12-11 2010-03-31 Memory Pharm Corp Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
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WO2006129158A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited 3 - indazolyl - isoxazoline derivatives as inhibitors of phosphodiesterase type - i
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
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US7781460B2 (en) 2005-09-05 2010-08-24 Ranbaxy Laboratories Limited Substituted indazoles as inhibitors of phosphodiesterase type-IV
US7915286B2 (en) 2005-09-16 2011-03-29 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
KR101568884B1 (ko) 2007-03-14 2015-11-12 랜박시 래보러터리스 리미티드 포스포디에스테라제 저해제로서 피라졸로 (３,４-ｂ) 피리딘 유도체
US20100029689A1 (en) * 2008-07-02 2010-02-04 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN102596961B (zh) * 2009-10-30 2015-12-02 詹森药业有限公司 咪唑并[1，2-b]哒嗪衍生物及其作为PDE10抑制剂的用途
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US20150125438A1 (en) * 2012-07-20 2015-05-07 Sang Jae Kim Anti-Inflammatory Peptides and Composition Comprising the Same
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KR20220167804A (ko) * 2021-06-11 2022-12-22 주식회사 메타센테라퓨틱스 인돌 유도체를 포함하는 최종당화산물 관련 질환의 치료용 조성물

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Also Published As

Publication number Publication date
ZA975581B (en) 1998-12-24
EA199801047A1 (ru) 1999-06-24
CO4900056A1 (es) 2000-03-27
TNSN97108A1 (fr) 2005-03-15
CN1223651A (zh) 1999-07-21
US6040329A (en) 2000-03-21
WO1997049702A1 (en) 1997-12-31
MY116915A (en) 2004-04-30
HRP970350A2 (en) 1998-06-30
YU60198A (sh) 1999-09-27
HRP970350B1 (en) 2003-04-30
CN1080260C (zh) 2002-03-06
GT199700075A (es) 1998-12-04
PA8432301A1 (es) 1999-12-27
HUP9903009A2 (hu) 2000-05-28
HUP9903009A3 (en) 2002-01-28
MA24225A1 (fr) 1997-12-31
EA002274B1 (ru) 2002-02-28
DK0912558T3 (da) 2003-08-18
BG64052B1 (bg) 2003-11-28
CA2258285A1 (en) 1997-12-31
DE69723447D1 (de) 2003-08-14
PT912558E (pt) 2003-11-28
BG103056A (en) 1999-10-29
TW434237B (en) 2001-05-16
SI0912558T1 (en) 2003-10-31
JPH11514668A (ja) 1999-12-14
AU2785797A (en) 1998-01-14
ES2201299T3 (es) 2004-03-16
EP0912558A1 (en) 1999-05-06
BR9712782A (pt) 1999-12-07
NZ332752A (en) 2001-04-27
JP3152940B2 (ja) 2001-04-03
HK1018700A1 (en) 1999-12-30
PL330974A1 (en) 1999-06-21
CZ423398A3 (cs) 1999-12-15
TR199802685T2 (xx) 1999-03-22
NO986103D0 (no) 1998-12-23
KR20000022516A (ko) 2000-04-25
AP1025A (en) 2001-11-19
ATE244713T1 (de) 2003-07-15
ID18579A (id) 1998-04-23
DE69723447T2 (de) 2003-12-24
OA10934A (en) 2002-02-18
EP0912558B1 (en) 2003-07-09
AP9701020A0 (en) 1997-07-31
IL127036A0 (en) 1999-09-22
SK176598A3 (en) 2000-06-12
AR007456A1 (es) 1999-10-27
DZ2254A1 (fr) 2002-12-18
IS4910A (is) 1998-11-27
HN1997000079A (es) 1997-12-26
IL127036A (en) 2001-06-14
CA2258285C (en) 2002-11-26
AU716376B2 (en) 2000-02-24

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