NO985711D0 - Farmas°ytikum for behandling av neurologiske og neuropsykiatriske mangler - Google Patents
Farmas°ytikum for behandling av neurologiske og neuropsykiatriske manglerInfo
- Publication number
- NO985711D0 NO985711D0 NO985711A NO985711A NO985711D0 NO 985711 D0 NO985711 D0 NO 985711D0 NO 985711 A NO985711 A NO 985711A NO 985711 A NO985711 A NO 985711A NO 985711 D0 NO985711 D0 NO 985711D0
- Authority
- NO
- Norway
- Prior art keywords
- neurological
- treatment
- neuropsychiatric
- pharmaceuticals
- deficiencies
- Prior art date
Links
- 230000000926 neurological effect Effects 0.000 title abstract 2
- 230000007812 deficiency Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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- C07D317/64—Oxygen atoms
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- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
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- C07C2603/02—Ortho- or ortho- and peri-condensed systems
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- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/86—Ring systems containing bridged rings containing four rings
- C07C2603/88—Ethanoanthracenes; Hydrogenated ethanoanthracenes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
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PCT/US1997/009450 WO1997045115A1 (en) | 1996-05-31 | 1997-05-29 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders |
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BR9909103A (pt) * | 1998-03-26 | 2001-10-16 | Univ Saskatchewan | ácidos alifático amino carboxìlico e amino fosfÈnico, amino nitrilas e amino tetrazóis como agentes de resgate celular |
ES2164040T3 (es) * | 1998-04-14 | 2008-02-01 | The General Hospital Corporation | Uso de d-serina o de d-alanina para el tratamiento de la esquizofrenia. |
TW555757B (en) | 1998-07-31 | 2003-10-01 | Akzo Nobel Nv | Aminomethylcarboxylic acid derivatives |
DE19840611A1 (de) * | 1998-09-05 | 2000-03-09 | Klaus Wanner | GABA-uptake-Inhibitoren mit Pyrrolidinstruktur |
AU6075400A (en) | 1999-07-06 | 2001-01-22 | Vertex Pharmaceuticals Incorporated | N-substituted glycine derivatives |
TWI243173B (en) | 1999-11-17 | 2005-11-11 | Akzo Nobel Nv | Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives |
DOP2001000189A (es) | 2000-06-30 | 2002-03-30 | Pfizer Prod Inc | Benzofenonas y sulfonas como inhibidores de la captación de glicina |
AU2001288896A1 (en) | 2000-09-08 | 2002-03-22 | Gliatech, Inc. | Substituted hydrazine derivatives |
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AR032653A1 (es) | 2001-02-09 | 2003-11-19 | Telik Inc | Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos. |
KR100900020B1 (ko) * | 2001-02-16 | 2009-06-01 | 알레릭스 뉴로사이언스, 인크. | Glyt-1 저해제로서의 티오펜 치환 아민 유도체 |
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GB0219153D0 (en) * | 2002-08-16 | 2002-09-25 | Pfizer Ltd | Substituted glycine derivatives for use as medicaments |
AU2003287023A1 (en) | 2002-11-05 | 2004-06-03 | Eli Lilly And Company | 3-aryloxy/ thio-2, 3-substituted propanamines and their use in inhibiting serotonin and norepinephrine reuptake |
JP2006524642A (ja) * | 2003-04-30 | 2006-11-02 | ハー・ルンドベック・アクチエゼルスカベット | 芳香族オキシフェニルおよび芳香族スルファニルフェニル誘導体 |
BRPI0413587A (pt) * | 2003-08-21 | 2006-10-17 | Lundbeck & Co As H | usos de um composto e de um inibidor de glyt-1, composição farmacêutica, kit, e, método para o tratamento de doença |
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MXPA06004279A (es) | 2003-10-14 | 2006-06-28 | Pfizer Prod Inc | Derivados biciclicos [3.1.0] como inhibidores del transportador de glicina. |
JP2007528879A (ja) * | 2004-03-12 | 2007-10-18 | ハー・ルンドベック・アクチエゼルスカベット | フェニルインダン誘導体 |
WO2005100301A1 (en) * | 2004-03-31 | 2005-10-27 | Eli Lilly And Company | 2-aryloxyethyl glycine derivatives and their use as glycine transport inhibitors |
AU2005311985A1 (en) | 2004-12-01 | 2006-06-08 | Kalypsys, Inc. | Inducible nitric oxide synthase dimerization inhibitors |
UA95788C2 (en) | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
EP2041088B1 (en) | 2006-06-28 | 2014-01-08 | Amgen Inc. | Glycine transporter-1 inhibitors |
JP5554319B2 (ja) | 2008-04-01 | 2014-07-23 | アボット ゲーエムベーハー ウント カンパニー カーゲー | テトラヒドロイソキノリン類、それを含む医薬組成物および治療におけるそれの使用 |
CN101613347B (zh) * | 2008-06-23 | 2012-07-04 | 中国人民解放军军事医学科学院毒物药物研究所 | 胺类化合物及其医药用途 |
AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
WO2013020930A1 (en) | 2011-08-05 | 2013-02-14 | Abbott Gmbh & Co. Kg | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9187439B2 (en) | 2011-09-21 | 2015-11-17 | Inception Orion, Inc. | Tricyclic compounds useful as neurogenic and neuroprotective agents |
EP2780328A1 (en) | 2011-11-18 | 2014-09-24 | Abbvie Deutschland GmbH & Co. KG | N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
AU2014336154A1 (en) | 2013-10-17 | 2016-04-28 | AbbVie Deutschland GmbH & Co. KG | Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
MX2016004936A (es) | 2013-10-17 | 2016-12-20 | Abbvie Deutschland | Derivados de aminocromano, aminotiocromano y amino-1,2,3,4-tetrahi droquinilina, composiciones farmaceuticas que los contienen, y su uso en terapia. |
CN105384651B (zh) * | 2014-07-28 | 2017-03-22 | 昆明学院 | 含芳环的胺类化合物及其制备方法和应用 |
US20200123115A1 (en) * | 2017-06-26 | 2020-04-23 | Esteve Pharmaceuticals, S.A. | Compounds having multimodal activity against pain |
WO2022187206A1 (en) * | 2021-03-01 | 2022-09-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dual-target mu opioid and dopamine d3 receptors ligands; preparation and use thereof |
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DE3050800C2 (es) * | 1979-03-22 | 1989-06-22 | Continental Pharma Inc., Bruessel/Bruxelles, Be | |
BE885303A (fr) * | 1980-09-19 | 1981-03-19 | Continental Pharma | Glycinamides |
JPH02129158A (ja) * | 1988-11-07 | 1990-05-17 | Nippon Steel Corp | 光学活性なグリシン誘導体及びその製造方法 |
ES2036926B1 (es) * | 1991-08-08 | 1994-01-16 | Uriach & Cia Sa J | "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina". |
AU678503B2 (en) * | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
DE4408528A1 (de) * | 1994-03-14 | 1995-09-28 | Hoechst Ag | Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung |
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1998
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SK285854B6 (sk) | 2007-09-06 |
SK170098A3 (en) | 2000-02-14 |
IL127244A (en) | 2005-11-20 |
NO985711L (no) | 1998-12-07 |
CA2619901A1 (en) | 1997-12-04 |
EP1014966A4 (en) | 2001-10-04 |
JP4424450B2 (ja) | 2010-03-03 |
ES2270462T3 (es) | 2007-04-01 |
AU730789B2 (en) | 2001-03-15 |
CZ294348B6 (cs) | 2004-12-15 |
HUP0100815A2 (hu) | 2001-08-28 |
IL127244A0 (en) | 1999-09-22 |
CA2254833A1 (en) | 1997-12-04 |
DK1014966T3 (da) | 2006-12-04 |
PT1014966E (pt) | 2006-12-29 |
DE69736441D1 (de) | 2006-09-14 |
HUP0100815A3 (en) | 2002-11-28 |
JP2002515037A (ja) | 2002-05-21 |
BR9709501A (pt) | 2000-11-07 |
CZ404298A3 (cs) | 1999-11-17 |
EP1014966B1 (en) | 2006-08-02 |
AU3153097A (en) | 1998-01-05 |
CA2254833C (en) | 2008-04-29 |
EP1014966A1 (en) | 2000-07-05 |
SI1014966T1 (sl) | 2006-10-31 |
ATE334668T1 (de) | 2006-08-15 |
DE69736441T2 (de) | 2007-07-19 |
CN1327383A (zh) | 2001-12-19 |
WO1997045115A1 (en) | 1997-12-04 |
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