NO984298D0 - Isolert dimer av fiberoblast-aktivitetsprotein <alfa>, og anvendelse derav - Google Patents

Isolert dimer av fiberoblast-aktivitetsprotein <alfa>, og anvendelse derav

Info

Publication number
NO984298D0
NO984298D0 NO984298A NO984298A NO984298D0 NO 984298 D0 NO984298 D0 NO 984298D0 NO 984298 A NO984298 A NO 984298A NO 984298 A NO984298 A NO 984298A NO 984298 D0 NO984298 D0 NO 984298D0
Authority
NO
Norway
Prior art keywords
fiberoblast
alfa
activity protein
isolated dimer
dimer
Prior art date
Application number
NO984298A
Other languages
English (en)
Norwegian (no)
Other versions
NO984298L (no
Inventor
Rainer Zimmerman
John E Park
Wolfgang Rettig
Lloyd J Old
Original Assignee
Ludwig Inst Cancer Res
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Inst Cancer Res, Boehringer Ingelheim Int filed Critical Ludwig Inst Cancer Res
Publication of NO984298L publication Critical patent/NO984298L/no
Publication of NO984298D0 publication Critical patent/NO984298D0/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70517CD8
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/06Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
NO984298A 1996-03-18 1998-09-17 Isolert dimer av fiberoblast-aktivitetsprotein <alfa>, og anvendelse derav NO984298D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/619,280 US5767242A (en) 1994-04-20 1996-03-18 Isolated dimeric fibroblast activation protein alpha, and uses thereof
PCT/US1997/004215 WO1997034927A1 (en) 1996-03-18 1997-03-12 Isolated dimeric fibroblast activation protein alpha, and uses thereof

Publications (2)

Publication Number Publication Date
NO984298L NO984298L (no) 1998-09-17
NO984298D0 true NO984298D0 (no) 1998-09-17

Family

ID=24481231

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984298A NO984298D0 (no) 1996-03-18 1998-09-17 Isolert dimer av fiberoblast-aktivitetsprotein <alfa>, og anvendelse derav

Country Status (23)

Country Link
US (2) US5767242A (es)
EP (1) EP0960127B1 (es)
JP (1) JP4102441B2 (es)
KR (1) KR20000064655A (es)
CN (1) CN1214052A (es)
AT (1) ATE449106T1 (es)
AU (1) AU729369B2 (es)
BG (1) BG102781A (es)
BR (1) BR9708100A (es)
CA (1) CA2242342C (es)
CZ (1) CZ299698A3 (es)
DE (1) DE69739665D1 (es)
DK (1) DK0960127T3 (es)
EE (1) EE03693B1 (es)
ES (1) ES2334183T3 (es)
HU (1) HUP0104468A3 (es)
IL (1) IL125124A0 (es)
NO (1) NO984298D0 (es)
NZ (2) NZ331758A (es)
PL (1) PL328947A1 (es)
SK (1) SK126798A3 (es)
TR (1) TR199801845T2 (es)
WO (1) WO1997034927A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455677B1 (en) 1998-04-30 2002-09-24 Boehringer Ingelheim International Gmbh FAPα-specific antibody with improved producibility
US6979697B1 (en) * 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
EP1806138A1 (en) * 1999-05-25 2007-07-11 Point Therapeutics, Inc. Anti-tumor agents comprising boroproline compounds
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
JP2003500360A (ja) * 1999-05-25 2003-01-07 ポイント セラピューティクス, インコーポレイテッド ボロプロリン化合物類を含む抗癌剤
US20030092890A1 (en) * 1999-07-28 2003-05-15 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2002076499A2 (en) * 2001-03-23 2002-10-03 Aphton Corporation Combination treatment of pancreatic cancer
US20090191232A1 (en) * 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
US20030021786A1 (en) * 2001-07-09 2003-01-30 Gevas Philip C. Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
JP2005531540A (ja) 2002-04-30 2005-10-20 トラスティーズ・オブ・タフツ・カレッジ セリンプロテアーゼ阻害剤のスマートプロドラッグ
JP2006506442A (ja) * 2002-07-09 2006-02-23 ポイント セラピューティクス, インコーポレイテッド ボロプロリン化合物併用療法
US20080057491A1 (en) * 2003-02-07 2008-03-06 Mckee Patrick A Substrates and inhibitors of antiplasmin cleaving enzyme and methods of use
US7309774B2 (en) 2003-02-07 2007-12-18 The Board Of Regents Of The University Of Oklahoma Antiplasmin cleaving enzyme
WO2004088326A2 (en) * 2003-03-28 2004-10-14 Aphton Corporation Gastrin hormone immunoassays
WO2005071073A1 (en) * 2004-01-09 2005-08-04 Point Therapeutics, Inc. Fap compositions and the use thereof for immunomodulation
EP1730193A2 (en) * 2004-03-29 2006-12-13 Receptor Biologix, Inc. Monoclonal antibodies to gastrin hormone
US20090010919A1 (en) * 2004-07-29 2009-01-08 Bayer Healthcare Ag Diagnostics and Therapeutics for Diseases Associated With Fibroblast Activation Protein (Fap)
WO2006032980A1 (en) * 2004-09-22 2006-03-30 Receptor Biologix, Inc. Monoclonal antibolies to progastrin
EP1812458A2 (en) * 2004-10-27 2007-08-01 Wen-Tien Chen Methods and compositions for seprase inactivation
ES2812629T3 (es) 2004-11-24 2021-03-17 Techlab Inc Dispositivo para la detección de analitos
EP1963537A4 (en) 2005-12-14 2009-11-11 Ludwig Inst For Cancer Res Ltd METHOD FOR DIAGNOSING RHEUMATOID ARTHRITIS BY DETERMINING FIBROBLASTIC SYNOVIOCYTES FOR FIBROBLAST ACTIVATION PROTEIN
US8933201B2 (en) 2006-06-07 2015-01-13 The Board Of Regents Of The University Of Oklahoma Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use
CN101506381B (zh) * 2006-06-21 2012-09-05 斯克里普斯研究学院 针对肿瘤基质抗原fap的dna组合物及其使用方法
US8513187B2 (en) 2009-02-27 2013-08-20 Trustees Of Tufts College Soft protease inhibitors, and pro-soft forms thereof
PL2938360T3 (pl) * 2012-12-28 2020-05-18 Cobiores Nv Minimalnie toksyczne proleki
CN103267852B (zh) * 2013-05-15 2015-03-25 中国医学科学院北京协和医院 成纤维激活蛋白α在制备胰腺癌预后试剂盒中的用途
EP4299134A3 (en) 2014-06-13 2024-03-27 Bach Biosciences, LLC Fap-activated therapeutic agents, and uses related thereto
CN105859866B (zh) * 2016-05-27 2019-08-13 郑州大学 Fap来源的抗肿瘤ctl表位肽p265及其应用
ES2972577T3 (es) 2016-12-14 2024-06-13 Purdue Research Foundation Formación de imágenes y terapia dirigidas a la proteína de activación de fibroblastos (FAP)
CA3066756A1 (en) 2017-06-15 2018-12-20 Cancer Advances Inc. Compositions and methods for inducing humoral and cellular immunities against tumors and cancer
AU2021405744A1 (en) 2020-12-22 2023-08-03 Cobiores Nv Compounds comprising a tetrapeptidic moiety
WO2022167664A1 (en) 2021-02-07 2022-08-11 Cobiores Nv Compounds comprising a tetrapeptidic moiety

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1320734C (en) * 1986-02-04 1993-07-27 Suntory Limited Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
US5587299A (en) * 1994-04-20 1996-12-24 Memorial Sloan-Kettering Cancer Center Isolated nucleic acid molecule coding for fibroblast activation protein alpha and uses thereof

Also Published As

Publication number Publication date
HUP0104468A2 (hu) 2002-04-29
CA2242342C (en) 2013-05-14
IL125124A0 (en) 1999-01-26
HUP0104468A3 (en) 2004-10-28
CN1214052A (zh) 1999-04-14
JP4102441B2 (ja) 2008-06-18
AU2330297A (en) 1997-10-10
TR199801845T2 (xx) 1998-12-21
NZ331758A (en) 2000-01-28
BG102781A (en) 1999-09-30
ATE449106T1 (de) 2009-12-15
EP0960127A4 (en) 2004-09-08
US5965373A (en) 1999-10-12
NZ335543A (en) 2001-03-30
EE9800306A (et) 1999-02-15
CA2242342A1 (en) 1997-09-25
AU729369B2 (en) 2001-02-01
PL328947A1 (en) 1999-03-01
KR20000064655A (ko) 2000-11-06
ES2334183T3 (es) 2010-03-05
JP2000507100A (ja) 2000-06-13
EP0960127B1 (en) 2009-11-18
NO984298L (no) 1998-09-17
BR9708100A (pt) 2000-01-04
WO1997034927A1 (en) 1997-09-25
EP0960127A1 (en) 1999-12-01
DK0960127T3 (da) 2010-03-29
DE69739665D1 (de) 2009-12-31
SK126798A3 (en) 1999-05-07
CZ299698A3 (cs) 1999-01-13
EE03693B1 (et) 2002-04-15
US5767242A (en) 1998-06-16

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