NO984120L - Triarylforbindelser - Google Patents
TriarylforbindelserInfo
- Publication number
- NO984120L NO984120L NO984120A NO984120A NO984120L NO 984120 L NO984120 L NO 984120L NO 984120 A NO984120 A NO 984120A NO 984120 A NO984120 A NO 984120A NO 984120 L NO984120 L NO 984120L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- biphenylpyridines
- biphenylbenzamides
- azaryl
- phenylcarboxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
(4-oksy-3-(aryl)fenyl)-azaryl eller -arylkarbonyloksyforbindelse, i fri form eller syreaddisjonssaltform er nyttig som farmasøytiske midler for behandling og profylakse av inflammasjon, særlig inflammatorisk eller obstruktive sykdommer i luftveiene, f.eks. for astmaterapi. Foretrukkede forbindelser er nye bifenylpyridiner, bifenylbenzamider og bifenyl fenylkarboksyforbindelser. Forbindelsene er selektive hemmere av ODE 4 isoenzymaktivitet og virker også i å nedregulere eller hemme TNF-a-frigjøring.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9604926.7A GB9604926D0 (en) | 1996-03-08 | 1996-03-08 | Organic compounds |
PCT/EP1997/001157 WO1997032853A1 (en) | 1996-03-08 | 1997-03-07 | Triaryl compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
NO984120D0 NO984120D0 (no) | 1998-09-07 |
NO984120L true NO984120L (no) | 1998-11-09 |
Family
ID=10790065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO984120A NO984120L (no) | 1996-03-08 | 1998-09-07 | Triarylforbindelser |
Country Status (24)
Country | Link |
---|---|
US (4) | US6090817A (no) |
EP (1) | EP0885193A1 (no) |
JP (1) | JP2001501582A (no) |
KR (1) | KR19990087592A (no) |
CN (1) | CN1216980A (no) |
AR (1) | AR006122A1 (no) |
AU (1) | AU721783B2 (no) |
BR (1) | BR9708011A (no) |
CA (1) | CA2249546A1 (no) |
CO (1) | CO4780025A1 (no) |
CZ (1) | CZ285098A3 (no) |
GB (1) | GB9604926D0 (no) |
HU (1) | HUP9902103A3 (no) |
ID (1) | ID16152A (no) |
IL (1) | IL125716A0 (no) |
NO (1) | NO984120L (no) |
NZ (1) | NZ331310A (no) |
PE (1) | PE55498A1 (no) |
PL (1) | PL328488A1 (no) |
RU (1) | RU2194035C2 (no) |
SK (1) | SK121698A3 (no) |
TR (1) | TR199801777T2 (no) |
WO (1) | WO1997032853A1 (no) |
ZA (1) | ZA972007B (no) |
Families Citing this family (66)
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US7772432B2 (en) | 1991-09-19 | 2010-08-10 | Astrazeneca Ab | Amidobenzamide derivatives which are useful as cytokine inhibitors |
GB9816837D0 (en) | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
KR20010024175A (ko) | 1997-09-23 | 2001-03-26 | 돈 리사 로얄 | 시토킨에 의해 매개되는 질환 치료용 아미드 유도체 |
JPH11209350A (ja) | 1998-01-26 | 1999-08-03 | Eisai Co Ltd | 含窒素複素環誘導体およびその医薬 |
CA2328927C (en) | 1998-05-15 | 2008-02-19 | Astrazeneca Ab | Benzamide derivatives for the treatment of diseases mediated by cytokines |
SK286247B6 (sk) | 1998-05-15 | 2008-06-06 | Astrazeneca Ab | Benzamidové deriváty, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú a ich použitie pri príprave liečiva na liečbu chorobných stavov sprostredkovaných cytokínmi |
IL141183A0 (en) | 1998-08-04 | 2002-02-10 | Astrazeneca Ab | Amide derivatives useful as inhibitors of the production of cytokines |
GB9817845D0 (en) * | 1998-08-17 | 1998-10-14 | Glaxo Group Ltd | Chemical compounds |
RU2219171C2 (ru) | 1998-09-25 | 2003-12-20 | Астразенека Аб | Производные амида, способ их получения и фармацевтическая композиция на их основе |
WO2000020402A1 (en) | 1998-10-01 | 2000-04-13 | Astrazeneca Ab | Chemical compounds |
CN1178932C (zh) | 1999-03-17 | 2004-12-08 | 阿斯特拉曾尼卡有限公司 | 酰胺衍生物 |
JP5038568B2 (ja) | 1999-08-21 | 2012-10-03 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 協力剤の組合せ物 |
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JP2004521928A (ja) * | 2001-02-12 | 2004-07-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 4型ホスホジエステラーゼ阻害剤の心筋疾患における使用 |
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GB0324790D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
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KR101337045B1 (ko) | 2005-02-16 | 2013-12-05 | 아나코르 파마슈티칼스 인코포레이티드 | 보론함유 소분자 |
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Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1237895B (de) * | 1963-10-03 | 1967-03-30 | Adox Fotowerke Dr C Schleussne | Spektral sensibilisierte fotografische Silberhalogenidemulsion |
AU644016B2 (en) * | 1990-09-28 | 1993-12-02 | Smith Kline & French Laboratories Limited | Phenylpyridinol derivatives as medicaments |
DE4221583A1 (de) | 1991-11-12 | 1993-05-13 | Bayer Ag | Substituierte biphenylpyridone |
GB9222253D0 (en) * | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
JP3802581B2 (ja) * | 1995-03-01 | 2006-07-26 | 富山化学工業株式会社 | 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤 |
FR2767525B1 (fr) * | 1997-08-21 | 1999-11-12 | Cird Galderma | Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant |
WO1999061410A1 (en) * | 1998-05-12 | 1999-12-02 | American Home Products Corporation | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia |
-
1996
- 1996-03-08 GB GBGB9604926.7A patent/GB9604926D0/en active Pending
-
1997
- 1997-03-06 PE PE1997000161A patent/PE55498A1/es not_active Application Discontinuation
- 1997-03-06 CO CO97012275A patent/CO4780025A1/es unknown
- 1997-03-06 AR ARP970100891A patent/AR006122A1/es not_active Application Discontinuation
- 1997-03-07 JP JP09531477A patent/JP2001501582A/ja active Pending
- 1997-03-07 PL PL97328488A patent/PL328488A1/xx unknown
- 1997-03-07 IL IL12571697A patent/IL125716A0/xx unknown
- 1997-03-07 CA CA002249546A patent/CA2249546A1/en not_active Abandoned
- 1997-03-07 WO PCT/EP1997/001157 patent/WO1997032853A1/en not_active Application Discontinuation
- 1997-03-07 KR KR1019980707034A patent/KR19990087592A/ko not_active Application Discontinuation
- 1997-03-07 BR BR9708011A patent/BR9708011A/pt not_active Application Discontinuation
- 1997-03-07 SK SK1216-98A patent/SK121698A3/sk unknown
- 1997-03-07 CZ CZ982850A patent/CZ285098A3/cs unknown
- 1997-03-07 HU HU9902103A patent/HUP9902103A3/hu unknown
- 1997-03-07 EP EP97908195A patent/EP0885193A1/en not_active Withdrawn
- 1997-03-07 NZ NZ331310A patent/NZ331310A/en unknown
- 1997-03-07 TR TR1998/01777T patent/TR199801777T2/xx unknown
- 1997-03-07 CN CN97192856A patent/CN1216980A/zh active Pending
- 1997-03-07 AU AU20254/97A patent/AU721783B2/en not_active Ceased
- 1997-03-07 ZA ZA972007A patent/ZA972007B/xx unknown
- 1997-03-07 RU RU98118568/04A patent/RU2194035C2/ru active
- 1997-03-07 US US09/142,099 patent/US6090817A/en not_active Expired - Fee Related
- 1997-03-10 ID IDP970748A patent/ID16152A/id unknown
-
1998
- 1998-09-07 NO NO984120A patent/NO984120L/no unknown
-
2000
- 2000-04-27 US US09/559,520 patent/US6258843B1/en not_active Expired - Fee Related
- 2000-09-06 US US09/655,668 patent/US6288092B1/en not_active Expired - Fee Related
-
2001
- 2001-07-25 US US09/915,047 patent/US6410547B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6288092B1 (en) | 2001-09-11 |
WO1997032853A1 (en) | 1997-09-12 |
CA2249546A1 (en) | 1997-09-12 |
ID16152A (id) | 1997-09-04 |
US20020028831A1 (en) | 2002-03-07 |
JP2001501582A (ja) | 2001-02-06 |
SK121698A3 (en) | 1998-12-02 |
NZ331310A (en) | 2001-03-30 |
HUP9902103A3 (en) | 2000-06-28 |
AR006122A1 (es) | 1999-08-11 |
AU2025497A (en) | 1997-09-22 |
US6090817A (en) | 2000-07-18 |
GB9604926D0 (en) | 1996-05-08 |
PE55498A1 (es) | 1998-10-10 |
TR199801777T2 (xx) | 1998-11-23 |
PL328488A1 (en) | 1999-02-01 |
US6410547B1 (en) | 2002-06-25 |
RU2194035C2 (ru) | 2002-12-10 |
US6258843B1 (en) | 2001-07-10 |
EP0885193A1 (en) | 1998-12-23 |
AU721783B2 (en) | 2000-07-13 |
CN1216980A (zh) | 1999-05-19 |
CZ285098A3 (cs) | 1999-01-13 |
MX9807247A (es) | 1998-12-31 |
HUP9902103A2 (hu) | 1999-10-28 |
BR9708011A (pt) | 1999-07-27 |
KR19990087592A (ko) | 1999-12-27 |
CO4780025A1 (es) | 1999-05-26 |
IL125716A0 (en) | 1999-04-11 |
NO984120D0 (no) | 1998-09-07 |
ZA972007B (en) | 1998-09-07 |
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