HUP9902103A2 - Triarilvegyületek - Google Patents
TriarilvegyületekInfo
- Publication number
- HUP9902103A2 HUP9902103A2 HU9902103A HUP9902103A HUP9902103A2 HU P9902103 A2 HUP9902103 A2 HU P9902103A2 HU 9902103 A HU9902103 A HU 9902103A HU P9902103 A HUP9902103 A HU P9902103A HU P9902103 A2 HUP9902103 A2 HU P9902103A2
- Authority
- HU
- Hungary
- Prior art keywords
- oxy
- aryl
- compounds
- inflammatory
- phenylbiphenylcarboxylic
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 1
- UKJFDHQIVVKJTE-UHFFFAOYSA-N 2,6-diphenylbenzoic acid Chemical class OC(=O)C1=C(C=2C=CC=CC=2)C=CC=C1C1=CC=CC=C1 UKJFDHQIVVKJTE-UHFFFAOYSA-N 0.000 abstract 1
- KQNQGPDKRIUXPS-UHFFFAOYSA-N 2-(2-phenylphenyl)benzamide Chemical class NC(=O)C1=CC=CC=C1C1=CC=CC=C1C1=CC=CC=C1 KQNQGPDKRIUXPS-UHFFFAOYSA-N 0.000 abstract 1
- 101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000000414 obstructive effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgyát szabad bázis vagy gyógyászatilag elfőgadhatósavaddíciós só főrmájú (4-őxi-3-aril-fenil)-azaril- vagy -aril-karbőnil-őxi-származékők képezik, amelyek gyógyszerként használhatókgyűlladásős kezelésére és megelőzésére, különösen a légúti gyűlladásősvagy őbstrűktív betegségek, példáűl asztma kezelésére. A találmányszerinti vegyületek közül előnyösek az új befenilpiridinek, bifenil-benzamidők és fenil-bifenil-karbőnsavak. A találmány szerintivegyületek a PDE 4 izőenzim-aktivitás szelektív inhibitőrai, és a TNF-a felszabadűlását csökkentik vagy inhibiálják. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9604926.7A GB9604926D0 (en) | 1996-03-08 | 1996-03-08 | Organic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9902103A2 true HUP9902103A2 (hu) | 1999-10-28 |
HUP9902103A3 HUP9902103A3 (en) | 2000-06-28 |
Family
ID=10790065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9902103A HUP9902103A3 (en) | 1996-03-08 | 1997-03-07 | Triaryl compounds |
Country Status (24)
Country | Link |
---|---|
US (4) | US6090817A (hu) |
EP (1) | EP0885193A1 (hu) |
JP (1) | JP2001501582A (hu) |
KR (1) | KR19990087592A (hu) |
CN (1) | CN1216980A (hu) |
AR (1) | AR006122A1 (hu) |
AU (1) | AU721783B2 (hu) |
BR (1) | BR9708011A (hu) |
CA (1) | CA2249546A1 (hu) |
CO (1) | CO4780025A1 (hu) |
CZ (1) | CZ285098A3 (hu) |
GB (1) | GB9604926D0 (hu) |
HU (1) | HUP9902103A3 (hu) |
ID (1) | ID16152A (hu) |
IL (1) | IL125716A0 (hu) |
NO (1) | NO984120L (hu) |
NZ (1) | NZ331310A (hu) |
PE (1) | PE55498A1 (hu) |
PL (1) | PL328488A1 (hu) |
RU (1) | RU2194035C2 (hu) |
SK (1) | SK121698A3 (hu) |
TR (1) | TR199801777T2 (hu) |
WO (1) | WO1997032853A1 (hu) |
ZA (1) | ZA972007B (hu) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7772432B2 (en) | 1991-09-19 | 2010-08-10 | Astrazeneca Ab | Amidobenzamide derivatives which are useful as cytokine inhibitors |
GB9816837D0 (en) | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
AU739066B2 (en) | 1997-09-23 | 2001-10-04 | Astrazeneca Ab | Amide derivatives for the treatment of diseases mediated by cytokines |
JPH11209350A (ja) * | 1998-01-26 | 1999-08-03 | Eisai Co Ltd | 含窒素複素環誘導体およびその医薬 |
CA2328699A1 (en) | 1998-05-15 | 1999-11-25 | Dearg Sutherland Brown | Benzamide derivatives for the treatment of diseases mediated by cytokines |
BR9910474A (pt) | 1998-05-15 | 2001-01-02 | Astrazeneca Ab | Composto derivado de amida, processo para preparação do mesmo, composição farmacêutica, e, uso de um composto derivado de amida |
IL141183A0 (en) | 1998-08-04 | 2002-02-10 | Astrazeneca Ab | Amide derivatives useful as inhibitors of the production of cytokines |
GB9817845D0 (en) * | 1998-08-17 | 1998-10-14 | Glaxo Group Ltd | Chemical compounds |
ES2211172T3 (es) * | 1998-09-25 | 2004-07-01 | Astrazeneca Ab | Derivados de benzamida y su utilizacion como inhibidores de citoquinas. |
US6593333B1 (en) | 1998-10-01 | 2003-07-15 | Astrazeneca Ab | Substituted anilino-quinazoline (or quinoline) compounds and use thereof |
SK287238B6 (sk) | 1999-03-17 | 2010-04-07 | Astrazeneca Ab | Amidové deriváty, spôsob ich prípravy, farmaceutická kompozícia, ktorá ich obsahuje, a ich použitie |
AU777012B2 (en) | 1999-08-21 | 2004-09-30 | Takeda Gmbh | Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist |
US6436971B2 (en) * | 2000-02-09 | 2002-08-20 | Smithkline Beecham Corporation | Use of PDE 4-specific inhibitors to reduce the severity of a bacterial infection after a respiratory viral infection |
US20040005995A1 (en) * | 2001-07-26 | 2004-01-08 | Edelson Jeffrey D | Method for reducing exacerbations associated with copd |
US20050070529A1 (en) * | 2001-02-12 | 2005-03-31 | Merk Pantent Gmbh | Use of type 4 phosphodiesterase inhibitors in myocardial diseases |
CN100348569C (zh) | 2001-11-30 | 2007-11-14 | 伯哈姆学院 | 癌细胞中编程性细胞死亡的诱导 |
US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
US20040175382A1 (en) * | 2003-03-06 | 2004-09-09 | Schafer Peter H. | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system |
FR2856064B1 (fr) * | 2003-06-13 | 2005-08-19 | Servier Lab | Nouveaux derives de benzothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
GB0324790D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
EP1699436A2 (en) * | 2003-12-12 | 2006-09-13 | Myogen, Inc. | Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure |
CA2560528A1 (en) * | 2004-03-22 | 2005-10-06 | Myogen, Inc. | (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
WO2005092333A1 (en) * | 2004-03-22 | 2005-10-06 | Myogen, Inc. | (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
EP1758873A1 (en) * | 2004-06-22 | 2007-03-07 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
CA2572179A1 (en) * | 2004-06-23 | 2006-01-19 | Myogen, Inc. | Enoximone formulations and their use in the treatment of pde-iii mediated diseases |
MX2007007696A (es) * | 2004-12-23 | 2007-08-17 | Galderma Res & Dev | Compuestos ligandos moduladores de los receptores nucleares del acido retinoico(rars) y uso en medicina humana y en cosmeticos. |
AU2006214247C1 (en) | 2005-02-16 | 2012-11-08 | Anacor Pharmaceuticals, Llc | Boron-containing small molecules |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
RU2452729C2 (ru) * | 2005-09-16 | 2012-06-10 | Арроу Терапьютикс Лимитед | Бифенильные производные и их применение при лечении гепатита с |
JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
EP1976536A4 (en) | 2005-12-30 | 2011-03-02 | Anacor Pharmaceuticals Inc | SMALL MOLECULES CONTAINING BORON |
RS54108B1 (en) | 2006-02-16 | 2015-12-31 | Anacor Pharmaceuticals Inc. | SMALL MOLECULES CONTAINING BORON AS AGENTS FOR INFLAMMATION |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
AU2007249435A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
KR20090064418A (ko) | 2006-09-08 | 2009-06-18 | 브레인셀즈 인코퍼레이션 | 4-아실아미노피리딘 유도체 포함 조합물 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
AU2008326381B2 (en) * | 2007-11-21 | 2014-10-23 | Decode Genetics Ehf | Biaryl PDE4 inhibitors for treating inflammation |
EP2222639A1 (en) * | 2007-11-21 | 2010-09-01 | Decode Genetics EHF | Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders |
EP3246034A1 (en) | 2008-03-06 | 2017-11-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
EP2285384A4 (en) * | 2008-05-12 | 2012-04-25 | Anacor Pharmaceuticals Inc | BORN SMALL MOLECULES |
US8461336B2 (en) | 2008-09-04 | 2013-06-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
WO2010027975A1 (en) * | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
US9493489B2 (en) * | 2008-10-15 | 2016-11-15 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
EA201190034A1 (ru) * | 2008-12-17 | 2012-02-28 | Анакор Фармасьютикалс, Инк. | Полиморфы (s)-3-аминометил-7-(3-гидроксипропокси)-3н-бензо[c][1,2]оксаборол-1-ола |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
JP2013500974A (ja) * | 2009-07-28 | 2013-01-10 | アナコール ファーマシューティカルズ,インコーポレイテッド | 三置換ホウ素含有分子 |
WO2011019618A1 (en) | 2009-08-14 | 2011-02-17 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
WO2011037731A1 (en) * | 2009-09-25 | 2011-03-31 | Anacor Pharmaceuticals, Inc. | Boron containing small molecules |
WO2011049971A1 (en) | 2009-10-20 | 2011-04-28 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
WO2011060199A1 (en) * | 2009-11-11 | 2011-05-19 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
US8716478B2 (en) | 2010-01-27 | 2014-05-06 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
US8623911B2 (en) | 2010-03-19 | 2014-01-07 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agent |
KR102152901B1 (ko) | 2010-09-07 | 2020-09-07 | 아나코르 파마슈티칼스 인코포레이티드 | 세균 감염을 치료하기 위한 벤족사보롤 유도체 |
US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
US11447506B2 (en) | 2016-05-09 | 2022-09-20 | Anacor Pharmaceuticals, Inc. | Crystal forms of crisaborole in free form and preparation method and use thereof |
WO2018081814A1 (en) * | 2016-10-31 | 2018-05-03 | University Of Kansas | Grp94 selective inhibitors and uses thereof |
MA51232A (fr) | 2018-02-22 | 2020-10-07 | Chemocentryx Inc | Indane-amines utiles en tant qu'antagonistes de pd-l1 |
CN109776445B (zh) * | 2019-03-28 | 2022-12-06 | 中国药科大学 | 苯并噁二唑类化合物及其制备方法和医药用途 |
AU2020276277A1 (en) | 2019-05-15 | 2021-12-09 | Chemocentryx, Inc. | Triaryl compounds for treatment of PD-L1 diseases |
CN112010882B (zh) * | 2019-05-31 | 2021-09-14 | 武汉大学 | 立体选择性制备3,5-双取代环己烯类化合物的方法及应用 |
CN114555080A (zh) | 2019-10-16 | 2022-05-27 | 凯莫森特里克斯股份有限公司 | 用于治疗pd-l1疾病的杂芳基联苯胺 |
CN111499566A (zh) * | 2020-04-30 | 2020-08-07 | 南京工业大学 | 一种吡啶衍生物化合物及其制备方法 |
CN115466195B (zh) * | 2022-09-15 | 2024-04-19 | 中国科学院成都生物研究所 | 一类联苯类酰胺化合物及其制备方法和应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1237895B (de) * | 1963-10-03 | 1967-03-30 | Adox Fotowerke Dr C Schleussne | Spektral sensibilisierte fotografische Silberhalogenidemulsion |
EP0550576A1 (en) * | 1990-09-28 | 1993-07-14 | Smith Kline & French Laboratories Limited | Phenylpyridinol derivatives as medicaments |
DE4221583A1 (de) | 1991-11-12 | 1993-05-13 | Bayer Ag | Substituierte biphenylpyridone |
GB9222253D0 (en) * | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
JP3802581B2 (ja) * | 1995-03-01 | 2006-07-26 | 富山化学工業株式会社 | 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤 |
FR2767525B1 (fr) * | 1997-08-21 | 1999-11-12 | Cird Galderma | Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant |
CA2331056A1 (en) * | 1998-05-12 | 1999-12-02 | Wyeth | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia |
-
1996
- 1996-03-08 GB GBGB9604926.7A patent/GB9604926D0/en active Pending
-
1997
- 1997-03-06 CO CO97012275A patent/CO4780025A1/es unknown
- 1997-03-06 AR ARP970100891A patent/AR006122A1/es not_active Application Discontinuation
- 1997-03-06 PE PE1997000161A patent/PE55498A1/es not_active Application Discontinuation
- 1997-03-07 IL IL12571697A patent/IL125716A0/xx unknown
- 1997-03-07 EP EP97908195A patent/EP0885193A1/en not_active Withdrawn
- 1997-03-07 AU AU20254/97A patent/AU721783B2/en not_active Ceased
- 1997-03-07 KR KR1019980707034A patent/KR19990087592A/ko not_active Application Discontinuation
- 1997-03-07 CZ CZ982850A patent/CZ285098A3/cs unknown
- 1997-03-07 CN CN97192856A patent/CN1216980A/zh active Pending
- 1997-03-07 RU RU98118568/04A patent/RU2194035C2/ru active
- 1997-03-07 BR BR9708011A patent/BR9708011A/pt not_active Application Discontinuation
- 1997-03-07 HU HU9902103A patent/HUP9902103A3/hu unknown
- 1997-03-07 NZ NZ331310A patent/NZ331310A/en unknown
- 1997-03-07 CA CA002249546A patent/CA2249546A1/en not_active Abandoned
- 1997-03-07 TR TR1998/01777T patent/TR199801777T2/xx unknown
- 1997-03-07 PL PL97328488A patent/PL328488A1/xx unknown
- 1997-03-07 WO PCT/EP1997/001157 patent/WO1997032853A1/en not_active Application Discontinuation
- 1997-03-07 US US09/142,099 patent/US6090817A/en not_active Expired - Fee Related
- 1997-03-07 ZA ZA972007A patent/ZA972007B/xx unknown
- 1997-03-07 JP JP09531477A patent/JP2001501582A/ja active Pending
- 1997-03-07 SK SK1216-98A patent/SK121698A3/sk unknown
- 1997-03-10 ID IDP970748A patent/ID16152A/id unknown
-
1998
- 1998-09-07 NO NO984120A patent/NO984120L/no unknown
-
2000
- 2000-04-27 US US09/559,520 patent/US6258843B1/en not_active Expired - Fee Related
- 2000-09-06 US US09/655,668 patent/US6288092B1/en not_active Expired - Fee Related
-
2001
- 2001-07-25 US US09/915,047 patent/US6410547B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PE55498A1 (es) | 1998-10-10 |
NZ331310A (en) | 2001-03-30 |
CA2249546A1 (en) | 1997-09-12 |
NO984120D0 (no) | 1998-09-07 |
JP2001501582A (ja) | 2001-02-06 |
EP0885193A1 (en) | 1998-12-23 |
CZ285098A3 (cs) | 1999-01-13 |
US6258843B1 (en) | 2001-07-10 |
GB9604926D0 (en) | 1996-05-08 |
ID16152A (id) | 1997-09-04 |
US6090817A (en) | 2000-07-18 |
US20020028831A1 (en) | 2002-03-07 |
BR9708011A (pt) | 1999-07-27 |
KR19990087592A (ko) | 1999-12-27 |
US6288092B1 (en) | 2001-09-11 |
NO984120L (no) | 1998-11-09 |
AU721783B2 (en) | 2000-07-13 |
RU2194035C2 (ru) | 2002-12-10 |
PL328488A1 (en) | 1999-02-01 |
AU2025497A (en) | 1997-09-22 |
CO4780025A1 (es) | 1999-05-26 |
SK121698A3 (en) | 1998-12-02 |
CN1216980A (zh) | 1999-05-19 |
US6410547B1 (en) | 2002-06-25 |
ZA972007B (en) | 1998-09-07 |
IL125716A0 (en) | 1999-04-11 |
WO1997032853A1 (en) | 1997-09-12 |
TR199801777T2 (xx) | 1998-11-23 |
AR006122A1 (es) | 1999-08-11 |
HUP9902103A3 (en) | 2000-06-28 |
MX9807247A (es) | 1998-12-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP9902103A2 (hu) | Triarilvegyületek | |
HK1057899A1 (en) | Arylmethylamine derivatives for use as tryptase inhibitors | |
HK1087702A1 (en) | Arylmethylamine derivatives for use as tryptase inhibitors | |
TW262461B (hu) | ||
MXPA04005790A (es) | Compuestos y usos de los mismos para reducir la actividad de la lipasa sensible a la hormona. | |
DE69920757D1 (de) | Immunsuppressive wirkungen von pteridinderivaten | |
GB2303629B (en) | Hydroxamic acids and their use as metalloproteinase inhibitors | |
FI953515A (fi) | Fluoksetiinin farmaseuttiset formulaatiot | |
BR9917038A (pt) | Composto, composição farmacêutica, método de modulação da atividade receptora de quimocinas, método de tratamento ou prevenção de doenças inflamatórias, método de tratamento ou prevenção de asma e método de tratamento ou prevenção de disfunções inflamatórias | |
NO963499L (no) | Hydroksaminsyre- og karboksylsyrederivater, fremgangsmåte for deres fremstilling og anvendelse derav | |
BR9712085A (pt) | Inibidores de metaloprotease heterocìclicos | |
HUP0401867A2 (hu) | A valproinsav-amid és a 2-valproénsav-amid származékainak használata a fájdalommal és a fejfájással járó betegségek kezelésére vagy megelőzésére | |
AU2002363182A1 (en) | Smad7 inhibitors for the treatment of cns diseases | |
RU95111308A (ru) | Производные 2-амино-4-фенил-4-оксомасляной кислоты, способы получения, фармацевтическая композиция | |
IL143594A0 (en) | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases | |
RU95113437A (ru) | (h±)-сложный этиловый эфир транс-2-диметиламино-1-фенил-3-циклогексентранс-1-карбоновой кислоты в виде первичного ортофосфата и твердая фармацевтическая композиция с обезболивающей активностью | |
HUP9903892A2 (hu) | Hidroxámsavszármazékok | |
HUP9701284A2 (hu) | 2,3-Benzodiazepin-származékok felhasználása az endogén opioid rendszerrel összefüggő betegségek és állapotok kezelésére, és megelőzésére alkalmas gyógyászati készítmények előállítására | |
DE60141898D1 (de) | VERBINDUNG, ZUSAMMENSETZUNG UND VERFAHREN ZUR BEHANDLUNG VON ENTZüNDLICHEN UND ENTZüNDUNGS-VERWANDTEN ERKRANKUNGEN | |
HU896587D0 (en) | 2-amino-carbonic acid derivatives, and medical preparations containing them as active agents, and process for the production of the active agents and the preparation | |
DE60305018D1 (de) | Citalopram zur behandlung von bluthochdruck | |
HUP0200129A2 (hu) | N-(3'4'-dimetoxi-cinnamoil)-antranilsav alkalmazása szívkoszorúér-műtéttel kapcsolatos cardiovascularis események megelőzésére vagy mérséklésére | |
GB9828845D0 (en) | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases |