NO983511L - Difenylstilbener som pro-legemidler til COX-2-inhibitorer - Google Patents
Difenylstilbener som pro-legemidler til COX-2-inhibitorerInfo
- Publication number
- NO983511L NO983511L NO983511A NO983511A NO983511L NO 983511 L NO983511 L NO 983511L NO 983511 A NO983511 A NO 983511A NO 983511 A NO983511 A NO 983511A NO 983511 L NO983511 L NO 983511L
- Authority
- NO
- Norway
- Prior art keywords
- diphenylstilbenes
- cox
- prodrugs
- inhibitors
- cyclooxygenase
- Prior art date
Links
- 229940111134 coxibs Drugs 0.000 title 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- JLZUZNKTTIRERF-UHFFFAOYSA-N tetraphenylethylene Chemical class C1=CC=CC=C1C(C=1C=CC=CC=1)=C(C=1C=CC=CC=1)C1=CC=CC=C1 JLZUZNKTTIRERF-UHFFFAOYSA-N 0.000 title 1
- 102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 2
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1095096P | 1996-02-01 | 1996-02-01 | |
| GBGB9605647.8A GB9605647D0 (en) | 1996-03-18 | 1996-03-18 | Diphenyl stilbenes as prodrugs to cox-2 inhibitors |
| PCT/CA1997/000063 WO1997028120A1 (en) | 1996-02-01 | 1997-01-29 | Diphenyl stilbenes as prodrugs to cox-2 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO983511D0 NO983511D0 (no) | 1998-07-30 |
| NO983511L true NO983511L (no) | 1998-09-30 |
Family
ID=26308949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO983511A NO983511L (no) | 1996-02-01 | 1998-07-30 | Difenylstilbener som pro-legemidler til COX-2-inhibitorer |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0882015B1 (ja) |
| JP (1) | JP3662936B2 (ja) |
| KR (1) | KR19990082260A (ja) |
| CN (1) | CN1214677A (ja) |
| AT (1) | ATE198323T1 (ja) |
| AU (1) | AU707199B2 (ja) |
| CA (1) | CA2244134C (ja) |
| CZ (1) | CZ241698A3 (ja) |
| DE (1) | DE69703791T2 (ja) |
| EA (1) | EA199800675A1 (ja) |
| EE (1) | EE9800230A (ja) |
| ES (1) | ES2152648T3 (ja) |
| HU (1) | HUP9902119A3 (ja) |
| IL (1) | IL125441A0 (ja) |
| NO (1) | NO983511L (ja) |
| NZ (1) | NZ326283A (ja) |
| PL (1) | PL328225A1 (ja) |
| SK (1) | SK102698A3 (ja) |
| WO (1) | WO1997028120A1 (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635417B1 (en) | 1996-07-31 | 2003-10-21 | California Institute Of Technology | Complex formation between DSDNA and oligomer of cyclic heterocycles |
| US5998140A (en) * | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
| EP1246621A4 (en) | 1999-12-23 | 2004-11-24 | Nitromed Inc | NITROSED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS FOR THEIR USE |
| AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| US7199154B2 (en) | 2002-07-26 | 2007-04-03 | Merck Frosst Company | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors |
| AU2003261281A1 (en) | 2002-07-29 | 2004-02-16 | Nicox S.A. | Cyclooxygenase- 2 selective inhibitors, compositions and methods of use |
| AR043444A1 (es) * | 2003-03-05 | 2005-07-27 | Merck Frosst Canada Inc | Profarmacos de diaril-2- 5h -furanonas que liberan oxido nitrico como inhibidores de la ciclooxigenasa-2 |
| CN1914151A (zh) * | 2004-01-27 | 2007-02-14 | 默克弗罗斯特公司 | 作为环氧合酶－2抑制剂的二芳基－2(5h)－呋喃酮类的释放一氧化氮的前药 |
| US7622501B2 (en) | 2004-01-27 | 2009-11-24 | Merck Frosst Canada & Co. | Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors |
| WO2006029436A1 (de) * | 2004-09-17 | 2006-03-23 | Universität Wien | Cox-ii-inhibitorverbindungen |
| WO2022195579A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990012786A1 (fr) * | 1989-04-24 | 1990-11-01 | Otsuka Pharmaceutical Factory, Inc. | Derive de 3-halogeno-2,3-diphenylacrylaldehyde, son procede de fabrication et agent de traitement de l'hyperlipidemie |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5393790A (en) * | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
-
1997
- 1997-01-29 KR KR1019980705989A patent/KR19990082260A/ko not_active Application Discontinuation
- 1997-01-29 EE EE9800230A patent/EE9800230A/xx unknown
- 1997-01-29 EA EA199800675A patent/EA199800675A1/ru unknown
- 1997-01-29 EP EP97900915A patent/EP0882015B1/en not_active Expired - Lifetime
- 1997-01-29 PL PL97328225A patent/PL328225A1/xx unknown
- 1997-01-29 SK SK1026-98A patent/SK102698A3/sk unknown
- 1997-01-29 AU AU14346/97A patent/AU707199B2/en not_active Ceased
- 1997-01-29 HU HU9902119A patent/HUP9902119A3/hu unknown
- 1997-01-29 WO PCT/CA1997/000063 patent/WO1997028120A1/en not_active Application Discontinuation
- 1997-01-29 CZ CZ982416A patent/CZ241698A3/cs unknown
- 1997-01-29 CA CA002244134A patent/CA2244134C/en not_active Expired - Fee Related
- 1997-01-29 NZ NZ326283A patent/NZ326283A/xx unknown
- 1997-01-29 AT AT97900915T patent/ATE198323T1/de not_active IP Right Cessation
- 1997-01-29 CN CN97193332A patent/CN1214677A/zh active Pending
- 1997-01-29 ES ES97900915T patent/ES2152648T3/es not_active Expired - Lifetime
- 1997-01-29 DE DE69703791T patent/DE69703791T2/de not_active Expired - Fee Related
- 1997-01-29 JP JP52720397A patent/JP3662936B2/ja not_active Expired - Fee Related
- 1997-01-29 IL IL12544197A patent/IL125441A0/xx unknown
-
1998
- 1998-07-30 NO NO983511A patent/NO983511L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK102698A3 (en) | 1999-04-13 |
| EE9800230A (et) | 1998-12-15 |
| AU1434697A (en) | 1997-08-22 |
| PL328225A1 (en) | 1999-01-18 |
| NO983511D0 (no) | 1998-07-30 |
| DE69703791T2 (de) | 2001-06-21 |
| MX9806213A (es) | 1998-12-31 |
| CA2244134A1 (en) | 1997-08-07 |
| JP3662936B2 (ja) | 2005-06-22 |
| WO1997028120A1 (en) | 1997-08-07 |
| HUP9902119A2 (hu) | 2001-04-28 |
| CN1214677A (zh) | 1999-04-21 |
| EP0882015B1 (en) | 2000-12-27 |
| JP2000504332A (ja) | 2000-04-11 |
| DE69703791D1 (de) | 2001-02-01 |
| HUP9902119A3 (en) | 2001-08-28 |
| ES2152648T3 (es) | 2001-02-01 |
| AU707199B2 (en) | 1999-07-08 |
| CZ241698A3 (cs) | 1998-12-16 |
| IL125441A0 (en) | 1999-03-12 |
| EA199800675A1 (ru) | 1999-02-25 |
| ATE198323T1 (de) | 2001-01-15 |
| KR19990082260A (ko) | 1999-11-25 |
| CA2244134C (en) | 2005-04-26 |
| NZ326283A (en) | 1998-12-23 |
| EP0882015A1 (en) | 1998-12-09 |
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