NO983004L - Laktonderivater av 17<beta>-karboksy-karbotio- og amidandrostanderivater - Google Patents

Laktonderivater av 17<beta>-karboksy-karbotio- og amidandrostanderivater

Info

Publication number
NO983004L
NO983004L NO983004A NO983004A NO983004L NO 983004 L NO983004 L NO 983004L NO 983004 A NO983004 A NO 983004A NO 983004 A NO983004 A NO 983004A NO 983004 L NO983004 L NO 983004L
Authority
NO
Norway
Prior art keywords
derivatives
amidandrosteine
carbothio
carboxy
beta
Prior art date
Application number
NO983004A
Other languages
English (en)
Other versions
NO311022B1 (no
NO983004D0 (no
Inventor
Keith Biggadike
Panayiotis Alexandro Procopiou
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9526651.6A external-priority patent/GB9526651D0/en
Priority claimed from GBGB9613121.4A external-priority patent/GB9613121D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO983004D0 publication Critical patent/NO983004D0/no
Publication of NO983004L publication Critical patent/NO983004L/no
Publication of NO311022B1 publication Critical patent/NO311022B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO19983004A 1995-12-29 1998-06-26 Laktonderivater av 17<beta>-karboksy-karbotio- og amidandrostanderivater, anvendelse og fremstilling derav, samtfarmasoytiske preparater som inneholder dem NO311022B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9526651.6A GB9526651D0 (en) 1995-12-29 1995-12-29 Compounds
GBGB9613121.4A GB9613121D0 (en) 1996-06-21 1996-06-21 Compounds
PCT/GB1996/003140 WO1997024365A1 (en) 1995-12-29 1996-12-19 Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives

Publications (3)

Publication Number Publication Date
NO983004D0 NO983004D0 (no) 1998-06-26
NO983004L true NO983004L (no) 1998-08-26
NO311022B1 NO311022B1 (no) 2001-10-01

Family

ID=26308402

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19983004A NO311022B1 (no) 1995-12-29 1998-06-26 Laktonderivater av 17<beta>-karboksy-karbotio- og amidandrostanderivater, anvendelse og fremstilling derav, samtfarmasoytiske preparater som inneholder dem

Country Status (34)

Country Link
US (1) US6197761B1 (no)
EP (1) EP0876392B1 (no)
JP (1) JP2947944B2 (no)
KR (1) KR19990076859A (no)
CN (1) CN1133643C (no)
AP (1) AP9801274A0 (no)
AT (1) ATE194356T1 (no)
AU (1) AU721865B2 (no)
BG (1) BG102625A (no)
BR (1) BR9612309A (no)
CA (1) CA2241728A1 (no)
CZ (1) CZ207498A3 (no)
DE (1) DE69609199T2 (no)
DK (1) DK0876392T3 (no)
EA (1) EA001401B1 (no)
EE (1) EE9800227A (no)
ES (1) ES2150150T3 (no)
GR (1) GR3034564T3 (no)
HK (1) HK1012193A1 (no)
HU (1) HUP9903707A3 (no)
IL (1) IL124938A0 (no)
IS (1) IS4781A (no)
MX (1) MX9805181A (no)
NO (1) NO311022B1 (no)
NZ (1) NZ324373A (no)
OA (1) OA10701A (no)
PE (1) PE87598A1 (no)
PL (1) PL327629A1 (no)
PT (1) PT876392E (no)
SI (1) SI0876392T1 (no)
SK (1) SK89198A3 (no)
TR (1) TR199801247T2 (no)
TW (1) TW498072B (no)
WO (1) WO1997024365A1 (no)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE260931T1 (de) * 1997-06-30 2004-03-15 Glaxo Group Ltd Verfahren zur identifizierung von verbindungen mit verminderter systemischer aktivität
GB9909229D0 (en) * 1999-04-23 1999-06-16 Glaxo Group Ltd Enantiomers of mercapto lactones and processes for their synthesis
GB0017988D0 (en) * 2000-07-21 2000-09-13 Glaxo Group Ltd Novel process
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
AU2001275760B2 (en) * 2000-08-05 2005-03-17 Glaxo Group Limited 6.alpha., 9.alpha.-difluoro-17.alpha.-'(2-furanylcarboxyl) oxy!-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothioic acid S-fluoromethyl ester as an anti-inflammatory agent
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
ES2314052T3 (es) * 2001-04-30 2009-03-16 Glaxo Group Limited Derivados de ester de 17beta-carbotioato de androstano con un grupo ester ciclico en la posicion 17alfa.
US20040248867A1 (en) * 2001-06-12 2004-12-09 Keith Biggadike Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives
WO2003018575A1 (en) * 2001-08-24 2003-03-06 Wyeth Holdings Corporation 5-substituted-3(2h)-furanones useful for inhibition of farnesyl-protein transferase
GB0125259D0 (en) * 2001-10-20 2001-12-12 Glaxo Group Ltd Novel compounds
GB0127160D0 (en) * 2001-11-12 2002-01-02 Glaxo Group Ltd Novel compounds
WO2003042229A1 (en) * 2001-11-12 2003-05-22 Glaxo Group Limited Non-aromatic heterocyclic esters of furan-2-one-esters of 17.beta.-carboxyl or 17.beta.-carbothio glucocorticoids
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
CA2530680A1 (en) * 2003-04-04 2004-10-14 Alpharma Aps Process for the preparation of steroidal carbothioic acid derivatives and intermediates
EP1466920A1 (en) * 2003-04-04 2004-10-13 Alpharma APS Process for the preparation of steroidal 17 beta-carbothioates
PT103202B (pt) 2004-10-19 2011-01-27 Hovione Farmaciencia S A Processo para a esterificação de um ácido carbotiótico
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
AR059216A1 (es) * 2006-01-27 2008-03-19 Sun Pharmaceutical Ind Ltd 11b-hidroxiandrosta-4-eno-3-onas
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
CN103087137A (zh) * 2011-11-07 2013-05-08 天津金耀集团有限公司 一种21位为硫代烃基的糖皮质激素

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093721A (en) * 1974-08-30 1978-06-06 Glaxo Laboratories Limited Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
US5767113A (en) * 1995-05-10 1998-06-16 The Salk Institute For Biological Studies Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance

Also Published As

Publication number Publication date
PT876392E (pt) 2000-12-29
CA2241728A1 (en) 1997-07-10
JP2947944B2 (ja) 1999-09-13
IS4781A (is) 1998-06-23
CN1209135A (zh) 1999-02-24
DK0876392T3 (da) 2000-11-06
AU721865B2 (en) 2000-07-13
PL327629A1 (en) 1998-12-21
NO311022B1 (no) 2001-10-01
CN1133643C (zh) 2004-01-07
IL124938A0 (en) 1999-01-26
CZ207498A3 (cs) 1998-11-11
BG102625A (en) 1999-04-30
US6197761B1 (en) 2001-03-06
EE9800227A (et) 1998-12-15
KR19990076859A (ko) 1999-10-25
TR199801247T2 (xx) 1998-11-23
BR9612309A (pt) 1999-07-13
NZ324373A (en) 1999-10-28
ES2150150T3 (es) 2000-11-16
EP0876392A1 (en) 1998-11-11
WO1997024365A1 (en) 1997-07-10
HUP9903707A2 (hu) 2000-03-28
OA10701A (en) 2002-05-21
GR3034564T3 (en) 2001-01-31
MX9805181A (es) 1998-10-31
HK1012193A1 (en) 1999-07-30
HUP9903707A3 (en) 2000-04-28
AP9801274A0 (en) 1998-06-30
SK89198A3 (en) 1999-03-12
ATE194356T1 (de) 2000-07-15
JPH11501675A (ja) 1999-02-09
NO983004D0 (no) 1998-06-26
EA199800484A1 (ru) 1999-02-25
DE69609199D1 (de) 2000-08-10
EP0876392B1 (en) 2000-07-05
PE87598A1 (es) 1999-01-15
TW498072B (en) 2002-08-11
EA001401B1 (ru) 2001-02-26
SI0876392T1 (en) 2000-12-31
AU1140997A (en) 1997-07-28
DE69609199T2 (de) 2001-03-01

Similar Documents

Publication Publication Date Title
NO983004D0 (no) Laktonderivater av 17&lt;beta&gt;-karboksy-karbotio- og amidandrostanderivater
NO953244D0 (no) Derivater av cyklodepeptid PF 1022
FI973750A (fi) 2-metyylitienobentsodiatsepiinin valmistus ja kiteiset muodot
BR9611130A (pt) Derivados de 3-aril-5-halógeno-pirona
PL322277A1 (en) Derivatives of pyrazol-4-ylobenzoyl
PT1093815E (pt) Formulacao oral de 2-metil-tieno-benzodiazepina
BR9507179A (pt) Derivados de 3-aril-4-hidróxi-delta3-dihidrotiofena
PL324451A1 (en) Derivatives of diphenylmethylenepiperidine
HUP9901344A3 (en) Radicicol derivatives and pharmaceutical compositions thereof
NO962491D0 (no) Orale formuleringer av S(+)-etodolac
NO20005187D0 (no) n-sats syntese av 2-oksazolidinonderivater
BR9607427A (pt) Inibiçao de angiogêne usando interleucina 12
FI973124A0 (fi) D-vitamiinijohdannaisten dermatologinen käyttö
NO960699D0 (no) Antimigren 1,2,5-tiadiazolderivater av indolylalkylpyridinyl- og -pyrimidinylpiperaziner
PL330642A1 (en) Substituted derivatives of pyrazolyl-pyrazoles and their application as herbicides
DE69614038D1 (de) Alkenylcyclohexanderivate und flüssigkristalline Zusammensetzungen
FI944016A0 (fi) Makrolidien fluorisokerijohdannaiset
NO961404D0 (no) 4-indolylpiperazinyl-derivater
FI973500A0 (fi) 3-pyrrolidylideeni-2-oni-kefalosporiinien johdannaiset
BR9609723A (pt) Derivados da tricetona
FR2735476B1 (fr) Nouvelle application de derives du pyrrole
NO982855D0 (no) Sammensetning av overgangsmetall
NO974458D0 (no) Fremstilling av cis-4-O-beskyttede-2-cyklopentenolderivater
NO941809L (no) Asymmetrisk hydrogenering av furoimidazol-derivater
FI935609A (fi) Dihydrofuroimidatsolijohdannaisten asymmetrinen hydraus

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees