NO982154L - Faktor VIII-hybrid med modifisert aktivitet - Google Patents

Faktor VIII-hybrid med modifisert aktivitet

Info

Publication number
NO982154L
NO982154L NO982154A NO982154A NO982154L NO 982154 L NO982154 L NO 982154L NO 982154 A NO982154 A NO 982154A NO 982154 A NO982154 A NO 982154A NO 982154 L NO982154 L NO 982154L
Authority
NO
Norway
Prior art keywords
factor viii
modified activity
hybrid
viii hybrid
activity
Prior art date
Application number
NO982154A
Other languages
English (en)
Norwegian (no)
Other versions
NO982154D0 (no
Inventor
Johannes J Voorberg
Original Assignee
Immuno Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immuno Ag filed Critical Immuno Ag
Publication of NO982154D0 publication Critical patent/NO982154D0/no
Publication of NO982154L publication Critical patent/NO982154L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/10—Factor VIII, AHF; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO982154A 1995-11-13 1998-05-12 Faktor VIII-hybrid med modifisert aktivitet NO982154L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/558,107 US5910481A (en) 1995-11-13 1995-11-13 Hybrid proteins with modified activity
PCT/EP1996/004977 WO1997018315A1 (en) 1995-11-13 1996-11-13 Hybrid factor viii with modified activity

Publications (2)

Publication Number Publication Date
NO982154D0 NO982154D0 (no) 1998-05-12
NO982154L true NO982154L (no) 1998-07-13

Family

ID=24228239

Family Applications (1)

Application Number Title Priority Date Filing Date
NO982154A NO982154L (no) 1995-11-13 1998-05-12 Faktor VIII-hybrid med modifisert aktivitet

Country Status (10)

Country Link
US (5) US5910481A (cs)
EP (1) EP0861326A1 (cs)
JP (1) JP2001501803A (cs)
AU (1) AU707410B2 (cs)
CA (1) CA2235628A1 (cs)
CZ (1) CZ140298A3 (cs)
HU (1) HUP9901161A3 (cs)
NO (1) NO982154L (cs)
PL (1) PL326673A1 (cs)
WO (1) WO1997018315A1 (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
US7560107B2 (en) * 1996-06-26 2009-07-14 Emory University Modified factor VIII
US20020019036A1 (en) * 1996-12-13 2002-02-14 Hans-Peter Schwarz Von willebrand factor derivatives and methods of isolating proteins that bind to von willebrand factor
EP1074842A1 (en) * 1999-07-21 2001-02-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Catalytic anti-factor VIII allo-antibodies
JP4361786B2 (ja) * 2001-06-14 2009-11-11 ザ スクリプス リサーチ インスティチュート 操作されたジスルフィド結合を有する安定化蛋白質
WO2006045503A1 (en) 2004-10-19 2006-05-04 Lonza Ag Method for solid phase peptide synthesis
ATE533789T1 (de) * 2006-12-15 2011-12-15 Inst Radiation Med Amms Pla Herstellung von mit geringen blutungen assoziiertem gerinnungshemmendem fusionsprotein und dessen verwendung
TWI492951B (zh) * 2007-12-31 2015-07-21 Baxter Int 表現人類凝血因子的基因轉殖非人類動物及其用途
JP2013500743A (ja) * 2009-08-04 2013-01-10 バクスター・インターナショナル・インコーポレイテッド Ｆｖｉｉｉおよびｖｗｆがノックアウトされた遺伝子導入マウス−血友病ａモデル
JP6174367B2 (ja) * 2013-04-26 2017-08-02 株式会社Ｌｓｉメディエンス トロンビン含有試薬及び測定方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985001961A1 (en) * 1983-10-28 1985-05-09 Genetics Institute Production of factor viii and related products
EP0146903A3 (en) * 1983-12-19 1987-07-22 Schering Corporation Production of a vector encoding a novel hybrid interferon species
JPH0826078B2 (ja) * 1984-01-12 1996-03-13 カイロン コーポレイション フアクタ−ｖ▲ｉｉｉ▼ｃ組成物
FI86885C (fi) * 1984-04-20 1992-10-26 Genentech Inc Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
WO1986006101A1 (en) * 1985-04-12 1986-10-23 Genetics Institute, Inc. Novel procoagulant proteins
IL83192A (en) * 1986-07-18 1992-11-15 Gist Brocades Nv Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies
EP0289586A4 (en) * 1986-11-17 1990-04-10 New England Medical Ct INCREASING GAMMA CARBOXYLATION OF RECOMBINANT, VITAMIN K-DEPENDENT PROTEINS.
NL8701021A (nl) * 1987-04-29 1988-11-16 Stichting Centraal Lab Humane t-pa(u-pa) substitutie-mutant eiwitten, daarvoor coderend recombinant dna, getransfecteerde gastheercellen, bereiding van de mutant eiwitten, en farmaceutische preparaten.
FI882746A7 (fi) * 1987-06-12 1988-12-13 Hoechst Japan Hybridiproteiini C ja menetelmä sen valmistamiseksi.
EP0294910B1 (en) * 1987-06-12 1996-09-11 Immuno Ag Novel proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them
PT88641B (pt) * 1987-10-02 1993-04-30 Genentech Inc Metodo para a preparacao de uma variante de adesao
DK176140B1 (da) * 1988-07-20 2006-09-25 Schering Ag Patentabteilung Flagermusspyt-plasminogenaktivatorer
FI914427A0 (fi) * 1989-03-21 1991-09-20 Vical Inc Expression av exogena polynukleotid- sekvenser i ett ryggradsdjur.
NL8902454A (nl) * 1989-10-03 1991-05-01 Stichting Centraal Lab Mutanten van de humane plasminogeen activator inhibitor 1 (pai-1), hun bereiding en toepassing, en recombinante polynucleotiden die voor deze mutanten coderende genetische informatie omvatten.
US5358932A (en) * 1989-12-29 1994-10-25 Zymogenetics, Inc. Hybrid protein C
DE69117545T2 (de) * 1990-01-25 1996-10-31 Univ Washington Faktor X-LACI-Hybridprotein
ZA909633B (en) * 1990-02-15 1991-10-30 Harvard College Covalent angiogenin/rnase hybrids
US5298422A (en) * 1991-11-06 1994-03-29 Baylor College Of Medicine Myogenic vector systems
US5364771A (en) * 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
US5563045A (en) * 1992-11-13 1996-10-08 Genetics Institute, Inc. Chimeric procoagulant proteins
WO1994011013A1 (en) * 1992-11-13 1994-05-26 Duke University Chimeric blood coagulation proteins
WO1995018829A1 (en) * 1994-01-07 1995-07-13 Novo Nordisk A/S Factor viii derivatives
WO1995018828A1 (en) * 1994-01-07 1995-07-13 Novo Nordisk A/S Factor viii derivatives
WO1995018827A1 (en) * 1994-01-07 1995-07-13 Novo Nordisk A/S Factor viii derivatives
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity

Also Published As

Publication number Publication date
CZ140298A3 (cs) 1998-08-12
US5869292A (en) 1999-02-09
HUP9901161A2 (hu) 1999-07-28
US6156888A (en) 2000-12-05
US5910481A (en) 1999-06-08
JP2001501803A (ja) 2001-02-13
US6051418A (en) 2000-04-18
US6130203A (en) 2000-10-10
CA2235628A1 (en) 1997-05-22
AU707410B2 (en) 1999-07-08
NO982154D0 (no) 1998-05-12
PL326673A1 (en) 1998-10-12
AU7624296A (en) 1997-06-05
EP0861326A1 (en) 1998-09-02
WO1997018315A1 (en) 1997-05-22
HUP9901161A3 (en) 2001-10-29

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