NO971349L - Anvendelse av aromatiske inhibitorer ved fremstilling av et legemiddel for behandling av en relativ androgenmangel hos menn - Google Patents
Anvendelse av aromatiske inhibitorer ved fremstilling av et legemiddel for behandling av en relativ androgenmangel hos mennInfo
- Publication number
- NO971349L NO971349L NO971349A NO971349A NO971349L NO 971349 L NO971349 L NO 971349L NO 971349 A NO971349 A NO 971349A NO 971349 A NO971349 A NO 971349A NO 971349 L NO971349 L NO 971349L
- Authority
- NO
- Norway
- Prior art keywords
- men
- pct
- androgen deficiency
- medicament
- manufacture
- Prior art date
Links
- 206010002261 Androgen deficiency Diseases 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000003098 androgen Substances 0.000 abstract 2
- 229940030486 androgens Drugs 0.000 abstract 2
- 230000009245 menopause Effects 0.000 abstract 2
- 239000003886 aromatase inhibitor Substances 0.000 abstract 1
- 229940046844 aromatase inhibitors Drugs 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 230000003054 hormonal effect Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4435368A DE4435368A1 (de) | 1994-09-22 | 1994-09-22 | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
| PCT/EP1995/003733 WO1996009057A1 (de) | 1994-09-22 | 1995-09-22 | Verwendung von aromatasehemmern zur herstellung eines arzneimittels zur behandlung eines relativen androgenmangels beim mann |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO971349D0 NO971349D0 (no) | 1997-03-21 |
| NO971349L true NO971349L (no) | 1997-05-16 |
Family
ID=6529877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO971349A NO971349L (no) | 1994-09-22 | 1997-03-21 | Anvendelse av aromatiske inhibitorer ved fremstilling av et legemiddel for behandling av en relativ androgenmangel hos menn |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5861389A (sv) |
| EP (1) | EP0782450B1 (sv) |
| JP (1) | JPH10505848A (sv) |
| KR (1) | KR100387345B1 (sv) |
| CN (1) | CN1104243C (sv) |
| AT (1) | ATE241989T1 (sv) |
| AU (1) | AU707997B2 (sv) |
| BR (1) | BR9509155A (sv) |
| CA (1) | CA2200195C (sv) |
| CZ (1) | CZ76097A3 (sv) |
| DE (2) | DE4435368A1 (sv) |
| DK (1) | DK0782450T3 (sv) |
| ES (1) | ES2199255T3 (sv) |
| FI (1) | FI971207A (sv) |
| HU (1) | HUT76981A (sv) |
| MX (1) | MX9702170A (sv) |
| NO (1) | NO971349L (sv) |
| PL (1) | PL182909B1 (sv) |
| PT (1) | PT782450E (sv) |
| SK (1) | SK36397A3 (sv) |
| WO (1) | WO1996009057A1 (sv) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19610645A1 (de) * | 1996-03-06 | 1997-09-11 | Schering Ag | Kombination von Dehydroepiandrosteron und Aromatasehemmern und Verwendung dieser Kombination zur Herstellung eines Arzeimittels zur Behandlung eines relativen und absoluten Androgenmangels beim Mann |
| US5972921A (en) | 1997-12-12 | 1999-10-26 | Hormos Medical Oy Ltd. | Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men |
| CA2409647C (en) | 2000-05-26 | 2012-07-03 | Harry Fisch | Methods of treating androgen deficiency in men using selective antiestrogens |
| US7067557B2 (en) * | 2000-05-26 | 2006-06-27 | Harry Fisch | Methods of treating androgen deficiency in men using selective antiestrogens |
| US6607755B2 (en) | 2001-06-21 | 2003-08-19 | Michael Donald Farley | Anti-aromatase pharmaceutical composition for controlling testosterone/estrone ratios |
| US7737185B2 (en) * | 2001-07-09 | 2010-06-15 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene |
| US7173064B2 (en) * | 2001-07-09 | 2007-02-06 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy |
| ATE406153T1 (de) * | 2001-07-09 | 2008-09-15 | Repros Therapeutics Inc | Verfahren und materialien für die behandlung des testosteron-mangels bei männern |
| AU2002364949C1 (en) * | 2001-12-06 | 2008-05-29 | University Of Tennessee Research Foundation | Treating muscle wasting with selective androgen receptor modulators |
| US6586417B1 (en) | 2002-04-22 | 2003-07-01 | Nutrisport Pharmacal, Inc. | Ester and ether derivatives of 4-hydroxy 4-androstene-3,17-dione and a method for the regulation of athletic function in humans |
| AU2003203010A1 (en) * | 2003-01-13 | 2004-08-13 | Michael Donald Farley | Improvements in or relating to anti-aromatase composition |
| WO2004064814A1 (en) * | 2003-01-13 | 2004-08-05 | Michael Donald Farley | Improvements in or relating to anti-aromatase composition |
| US20040248989A1 (en) | 2003-06-05 | 2004-12-09 | Risto Santti | Method for the treatment or prevention of lower urinary tract symptoms |
| WO2006019916A1 (en) * | 2004-07-14 | 2006-02-23 | Repros Therapeutics Inc. | Trans-clomiphene for the treatment of benign prostate hypertrophy, prostate cancer, hypogonadism, elevated triglycerides and high cholesterol |
| EP1848416A4 (en) * | 2005-02-04 | 2008-09-24 | Repros Therapeutics Inc | METHOD AND MATERIALS USING TRANS-CLOMIPHES FOR TREATING MALE INACCURIBILITY |
| PL383444A1 (pl) * | 2005-03-22 | 2008-03-17 | Repros Therapeutics Inc. | Sposoby dawkowania trans-klomifenu |
| MX2008014825A (es) | 2006-05-22 | 2008-12-01 | Hormos Medical Ltd | Moduladores selectivos del receptor de estrogeno o inhibidores de aromatasa para tratar prostatitis cronica no bacteriana. |
| ME00996B (me) | 2007-10-16 | 2012-10-20 | Repros Therapeutics Inc | Trans-klomifen za liječenje metaboličkog sindroma |
| US20100255127A1 (en) * | 2007-11-21 | 2010-10-07 | Kracie Pharma, Ltd. | Aromatase inhibitor |
| US20090215738A1 (en) * | 2008-02-26 | 2009-08-27 | Michael Charles Scally | Prevention and treatment of an increase in cardiovascular risk, adverse cardiovascular events, infertility, and adverse psychological effects after androgen or gnrh analogue intake |
| WO2011016814A1 (en) * | 2009-08-07 | 2011-02-10 | Kneller Bruce W | 5α-ANDROSTANE-3,6,17-TRIONE (KNELLER'S TRIONE) AND METHODS OF USE THEREFOR |
| US20090306031A1 (en) * | 2009-08-07 | 2009-12-10 | Kneller Bruce W | 5alpha-ANDROSTANE-3,6,17-TRIONE (KNELLER'S TRIONE) AND METHODS OF USE THEREFOR |
| UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| US20140235601A1 (en) * | 2011-08-09 | 2014-08-21 | Kenneth W. Adams | Use of Aromatase Inhibitor Or Estrogen Blocker For Increasing Spermatogenesis Or Testosterone Levels In Males |
| PT2753312T (pt) * | 2011-09-08 | 2017-02-03 | Mereo Biopharma 2 Ltd | Utilização de um inibidor da aromatase para o tratamento de hipogonadismo e doenças relacionadas |
| CN102641502A (zh) * | 2012-04-25 | 2012-08-22 | 中国农业大学 | 芳香酶抑制剂的新用途 |
| WO2014070523A1 (en) | 2012-11-02 | 2014-05-08 | Repros Therapeutics Inc. | Trans-clomiphene for use in cancer therapy |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4322416A (en) * | 1980-06-27 | 1982-03-30 | Merrell Dow Pharmaceuticals Inc. | 10-Alkynyl steroids |
| US4289762A (en) * | 1980-06-27 | 1981-09-15 | Merrell Dow Pharmaceuticals Inc. | 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors |
| DE3362176D1 (en) * | 1982-07-14 | 1986-03-27 | Akzo Nv | Novel 19-thio-androstane derivatives |
| DE3322285A1 (de) * | 1983-06-18 | 1984-12-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| DE3539244A1 (de) * | 1985-11-01 | 1987-05-07 | Schering Ag | 1-methyl-15(alpha)-alkyl-androsta- 1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| GB8531745D0 (en) * | 1985-12-24 | 1986-02-05 | Erba Farmitalia | 10beta-alkynyl-4-9(11)-estradiene derivatives |
| GB8615092D0 (en) * | 1986-06-20 | 1986-07-23 | Erba Farmitalia | Androst-4-ene-317-diones |
| DE3705990A1 (de) * | 1987-02-20 | 1988-09-01 | Schering Ag | 1-methyl-15(alpha)-(1-oxyalkyl)-androsta-1,4-dien- 3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| DE3926365A1 (de) * | 1989-08-04 | 1991-02-07 | Schering Ag | Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln |
| GB9226620D0 (en) * | 1992-12-21 | 1993-02-17 | Fujisawa Pharmaceutical Co | A new compound fr 901537,production thereof and use thereof |
-
1994
- 1994-09-22 DE DE4435368A patent/DE4435368A1/de not_active Withdrawn
-
1995
- 1995-09-22 US US08/809,582 patent/US5861389A/en not_active Expired - Fee Related
- 1995-09-22 CA CA002200195A patent/CA2200195C/en not_active Expired - Fee Related
- 1995-09-22 DE DE59510714T patent/DE59510714D1/de not_active Expired - Fee Related
- 1995-09-22 EP EP95934094A patent/EP0782450B1/de not_active Expired - Lifetime
- 1995-09-22 AT AT95934094T patent/ATE241989T1/de not_active IP Right Cessation
- 1995-09-22 PL PL95319299A patent/PL182909B1/pl not_active IP Right Cessation
- 1995-09-22 MX MX9702170A patent/MX9702170A/es not_active IP Right Cessation
- 1995-09-22 CN CN95195216A patent/CN1104243C/zh not_active Expired - Fee Related
- 1995-09-22 DK DK95934094T patent/DK0782450T3/da active
- 1995-09-22 CZ CZ97760A patent/CZ76097A3/cs unknown
- 1995-09-22 KR KR1019970701850A patent/KR100387345B1/ko not_active IP Right Cessation
- 1995-09-22 AU AU36518/95A patent/AU707997B2/en not_active Ceased
- 1995-09-22 ES ES95934094T patent/ES2199255T3/es not_active Expired - Lifetime
- 1995-09-22 PT PT95934094T patent/PT782450E/pt unknown
- 1995-09-22 BR BR9509155A patent/BR9509155A/pt not_active Application Discontinuation
- 1995-09-22 JP JP8510608A patent/JPH10505848A/ja active Pending
- 1995-09-22 SK SK363-97A patent/SK36397A3/sk unknown
- 1995-09-22 WO PCT/EP1995/003733 patent/WO1996009057A1/de not_active Application Discontinuation
- 1995-09-22 HU HU9701697A patent/HUT76981A/hu unknown
-
1997
- 1997-03-21 NO NO971349A patent/NO971349L/no unknown
- 1997-03-21 FI FI971207A patent/FI971207A/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100387345B1 (ko) | 2003-08-30 |
| DE59510714D1 (de) | 2003-07-10 |
| PL319299A1 (en) | 1997-08-04 |
| PL182909B1 (pl) | 2002-04-30 |
| ES2199255T3 (es) | 2004-02-16 |
| BR9509155A (pt) | 1997-10-14 |
| EP0782450A1 (de) | 1997-07-09 |
| AU707997B2 (en) | 1999-07-29 |
| CZ76097A3 (en) | 1997-07-16 |
| CA2200195A1 (en) | 1996-03-28 |
| AU3651895A (en) | 1996-04-09 |
| HUT76981A (hu) | 1998-01-28 |
| DE4435368A1 (de) | 1996-03-28 |
| US5861389A (en) | 1999-01-19 |
| EP0782450B1 (de) | 2003-06-04 |
| NO971349D0 (no) | 1997-03-21 |
| FI971207A0 (sv) | 1997-03-21 |
| CN1158570A (zh) | 1997-09-03 |
| FI971207A (sv) | 1997-03-21 |
| WO1996009057A1 (de) | 1996-03-28 |
| KR970706002A (ko) | 1997-11-03 |
| SK36397A3 (en) | 1997-08-06 |
| ATE241989T1 (de) | 2003-06-15 |
| JPH10505848A (ja) | 1998-06-09 |
| MX9702170A (es) | 1998-04-30 |
| PT782450E (pt) | 2003-09-30 |
| CN1104243C (zh) | 2003-04-02 |
| DK0782450T3 (da) | 2003-08-18 |
| CA2200195C (en) | 2008-04-22 |
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