WO2003032961A3 - Methods for preventing and treating bone loss with steroid compounds - Google Patents

Methods for preventing and treating bone loss with steroid compounds Download PDF

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Publication number
WO2003032961A3
WO2003032961A3 PCT/EP2002/011123 EP0211123W WO03032961A3 WO 2003032961 A3 WO2003032961 A3 WO 2003032961A3 EP 0211123 W EP0211123 W EP 0211123W WO 03032961 A3 WO03032961 A3 WO 03032961A3
Authority
WO
WIPO (PCT)
Prior art keywords
preventing
methods
bone loss
treating bone
steroid compounds
Prior art date
Application number
PCT/EP2002/011123
Other languages
French (fr)
Other versions
WO2003032961A2 (en
Inventor
Salle Enrico Di
Giorgio Massimini
Colin Lowery
Paul Edward Goss
Original Assignee
Pharmacia Italia Spa
Upjohn Co
Salle Enrico Di
Giorgio Massimini
Colin Lowery
Paul Edward Goss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa, Upjohn Co, Salle Enrico Di, Giorgio Massimini, Colin Lowery, Paul Edward Goss filed Critical Pharmacia Italia Spa
Priority to MXPA04003405A priority Critical patent/MXPA04003405A/en
Priority to EP02801313A priority patent/EP1435967A2/en
Priority to CA002463142A priority patent/CA2463142A1/en
Priority to IL16116202A priority patent/IL161162A0/en
Priority to BR0213162-5A priority patent/BR0213162A/en
Priority to NZ532064A priority patent/NZ532064A/en
Priority to JP2003535765A priority patent/JP2005508958A/en
Publication of WO2003032961A2 publication Critical patent/WO2003032961A2/en
Publication of WO2003032961A3 publication Critical patent/WO2003032961A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method of preventing and treating abnormal metabolic bone disorders in a postmenopausal or oophorectomized woman is disclosed, which comprises administering to said an effective amount of exemestane or 17-hydro-exemestane, alone or in combination with additional therapeutic agents.
PCT/EP2002/011123 2001-10-10 2002-09-30 Methods for preventing and treating bone loss with steroid compounds WO2003032961A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
MXPA04003405A MXPA04003405A (en) 2001-10-10 2002-09-30 Methods for preventing and treating bone loss with steroid compounds.
EP02801313A EP1435967A2 (en) 2001-10-10 2002-09-30 Methods for preventing and treating bone loss with steroid compounds
CA002463142A CA2463142A1 (en) 2001-10-10 2002-09-30 Methods for preventing and treating bone loss with steroid compounds
IL16116202A IL161162A0 (en) 2001-10-10 2002-09-30 Methods for preventing and treating bone loss with steroid compounds
BR0213162-5A BR0213162A (en) 2001-10-10 2002-09-30 Methods for the prevention and treatment of bone loss with steroid compounds.
NZ532064A NZ532064A (en) 2001-10-10 2002-09-30 Methods for preventing and treating bone loss with steroid compounds
JP2003535765A JP2005508958A (en) 2001-10-10 2002-09-30 Methods for preventing and treating bone loss with steroid compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32820901P 2001-10-10 2001-10-10
US60/328,209 2001-10-10

Publications (2)

Publication Number Publication Date
WO2003032961A2 WO2003032961A2 (en) 2003-04-24
WO2003032961A3 true WO2003032961A3 (en) 2003-09-04

Family

ID=23279989

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/011123 WO2003032961A2 (en) 2001-10-10 2002-09-30 Methods for preventing and treating bone loss with steroid compounds

Country Status (12)

Country Link
EP (1) EP1435967A2 (en)
JP (1) JP2005508958A (en)
KR (1) KR20050032507A (en)
CN (1) CN1713915A (en)
BR (1) BR0213162A (en)
CA (1) CA2463142A1 (en)
IL (1) IL161162A0 (en)
MX (1) MXPA04003405A (en)
NZ (1) NZ532064A (en)
PL (1) PL370080A1 (en)
WO (1) WO2003032961A2 (en)
ZA (1) ZA200402734B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040053900A1 (en) * 1998-12-23 2004-03-18 Pharmacia Corporation Method of using a COX-2 inhibitor and an aromatase inhibitor as a combination therapy
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US7332482B2 (en) 2003-09-24 2008-02-19 Bioxell S.P.A. Method for treating benign prostatic hyperplasia
EP1937251A2 (en) * 2005-04-25 2008-07-02 Pfizer Products Inc. Pharmaceutical compositions and methods comprising a combination of a selective estrogen receptor modulator and an aromatase inhibitor
ES2627692T3 (en) 2010-06-10 2017-07-31 Aragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
WO2013090829A1 (en) 2011-12-14 2013-06-20 Aragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
PT3929196T (en) 2013-09-24 2023-09-11 Fujifilm Corp Novel nitrogen-containing compound or salt thereof, or metal complex thereof
SG11201805387RA (en) 2015-12-30 2018-07-30 Univ Saint Louis Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307135A1 (en) * 1987-09-11 1989-03-15 FARMITALIA CARLO ERBA S.r.l. 17-substituted androsta-1,4-dien-3-one derivatives
US5663195A (en) * 1994-10-19 1997-09-02 Merck & Co., Inc. Method of preventing bone loss
WO1998033919A2 (en) * 1997-01-30 1998-08-06 Ixsys, Incorporated Anti-alpha-v beta-3 recombinant humanized antibodies, nucleic acids encoding same and methods of use
WO2000002553A1 (en) * 1998-07-08 2000-01-20 Lipogenics, Inc. Compositions and methods for treating and preventing bone diseases using tocotrienols
WO2001012206A2 (en) * 1999-08-13 2001-02-22 Heinrich Wieland Soy-glycine extracts and aromatase inhibitors for positively influencing collagen

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307135A1 (en) * 1987-09-11 1989-03-15 FARMITALIA CARLO ERBA S.r.l. 17-substituted androsta-1,4-dien-3-one derivatives
US5663195A (en) * 1994-10-19 1997-09-02 Merck & Co., Inc. Method of preventing bone loss
WO1998033919A2 (en) * 1997-01-30 1998-08-06 Ixsys, Incorporated Anti-alpha-v beta-3 recombinant humanized antibodies, nucleic acids encoding same and methods of use
WO2000002553A1 (en) * 1998-07-08 2000-01-20 Lipogenics, Inc. Compositions and methods for treating and preventing bone diseases using tocotrienols
WO2001012206A2 (en) * 1999-08-13 2001-02-22 Heinrich Wieland Soy-glycine extracts and aromatase inhibitors for positively influencing collagen

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GOSS P ET AL: "The effects of exemestane on bone and lipids in the ovariectomized rat.", BREAST CANCER RESEARCH AND TREATMENT, vol. 69, no. 3, October 2001 (2001-10-01), 24th Annual San Antonio Breast Cancer Symposium;San Antonio, Texas, USA; December 10-13, 2001, October, 2001, pages 224, XP008012823, ISSN: 0167-6806 *
GOSS PAUL: "Anti-aromatase agents in the treatment and prevention of breast cancer.", CANCER CONTROL, (2002 MAR-APR) 9 (2 SUPPL) 2-8. REF: 28, XP001133770 *
PYTLIK M ET AL: "Effects of formestane on development of osteopenia caused by ovariectomy in rats.", CALCIFIED TISSUE INTERNATIONAL, vol. 64, no. SUPPL. 1, 1999, XXVIth European Symposium on Calcified Tissues;Maastricht, Netherlands; May 7-11, 1999, pages S68, XP008012825, ISSN: 0171-967X *
ZILEMBO N ET AL: "Markers of bone turnover in metastatic breast cancer (MBC) patients having progressed on tamoxifen: Short term effect of further treatment with either exemestane (EXE) or megestrol acetate (MA).", EUROPEAN JOURNAL OF CANCER, vol. 37, no. Supplement 6, 23 October 2001 (2001-10-23), 11th European Cancer Conference;Lisbon, Portugal; October 21-25, 2001, October, 2001, pages S193 - S194, XP001133767, ISSN: 0959-8049 *

Also Published As

Publication number Publication date
JP2005508958A (en) 2005-04-07
KR20050032507A (en) 2005-04-07
PL370080A1 (en) 2005-05-16
CN1713915A (en) 2005-12-28
ZA200402734B (en) 2005-01-13
WO2003032961A2 (en) 2003-04-24
EP1435967A2 (en) 2004-07-14
BR0213162A (en) 2004-09-14
CA2463142A1 (en) 2003-04-24
MXPA04003405A (en) 2004-06-18
IL161162A0 (en) 2004-08-31
NZ532064A (en) 2006-04-28

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