KR970706002A - 남성의 상대적 안드로겐 결핍증 치료를 위한 약제의 제조에 있어서 아로마타제 억제제의 용도(Use of Aromatase Inhibitors in the Preparation of a Drug for Treating a Relative Androgen Deficiency in Men) - Google Patents

남성의 상대적 안드로겐 결핍증 치료를 위한 약제의 제조에 있어서 아로마타제 억제제의 용도(Use of Aromatase Inhibitors in the Preparation of a Drug for Treating a Relative Androgen Deficiency in Men)

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Publication number
KR970706002A
KR970706002A KR1019970701850A KR19970701850A KR970706002A KR 970706002 A KR970706002 A KR 970706002A KR 1019970701850 A KR1019970701850 A KR 1019970701850A KR 19970701850 A KR19970701850 A KR 19970701850A KR 970706002 A KR970706002 A KR 970706002A
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KR
South Korea
Prior art keywords
preparation
androgen deficiency
relative androgen
medicament
male
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KR1019970701850A
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English (en)
Other versions
KR100387345B1 (ko
Inventor
알버트 라들마이어
울술라-프리데릭 하벤니히트
프리드문트 노이만
Original Assignee
클로제, 울리히
쉐링 악티엔게젤샤프트
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Application filed by 클로제, 울리히, 쉐링 악티엔게젤샤프트 filed Critical 클로제, 울리히
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Abstract

본 발명은 남성의 상대적 안드로겐 결핍증을 치료하기 위한 약제의 제조에 있어서 아로마타제 억제제의 용도에 관한 것이다. 선택적 아로마타제 억제제는, 예를들어, 아타메스탄, 포르메스탄, 펜트로졸, 아리미덱스, 파드로졸, CGS 20267 및(또는) 보로졸이 있고, 바람직하게는 본 발명에 따른 약제의 제조를 위해 사용된다.

Description

남성의 상대적 안드로겐 결핍증 치료를 위한 약제의 제조에 있어서 아로마타제 억제제의 용도(Use of Aromatase Inhibitors in the Preparation of a Drug for Treating a Relative Androgen Deficiency in Men)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 남성의 상대적 안드로겐 결핍증을 치료하기 위한 약제의 제조에 있어서 1종 이상의 아로마타제 억제제의 용도.
  2. 제1항에 있어서, 선택적 아로마타제 억제제의 용도.
  3. 제2항에 있어서, 아타메스탄, 포르메스탄, 펜트로졸, 아리미덱스, 파드로졸, CGS 20267 보로졸의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970701850A 1994-09-22 1995-09-22 남성의상대적안드로겐결핍증치료를위한약제제조용아로마타제억제제의용도 KR100387345B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4435368A DE4435368A1 (de) 1994-09-22 1994-09-22 Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann
DEP4435368.5 1994-09-22

Publications (2)

Publication Number Publication Date
KR970706002A true KR970706002A (ko) 1997-11-03
KR100387345B1 KR100387345B1 (ko) 2003-08-30

Family

ID=6529877

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970701850A KR100387345B1 (ko) 1994-09-22 1995-09-22 남성의상대적안드로겐결핍증치료를위한약제제조용아로마타제억제제의용도

Country Status (21)

Country Link
US (1) US5861389A (ko)
EP (1) EP0782450B1 (ko)
JP (1) JPH10505848A (ko)
KR (1) KR100387345B1 (ko)
CN (1) CN1104243C (ko)
AT (1) ATE241989T1 (ko)
AU (1) AU707997B2 (ko)
BR (1) BR9509155A (ko)
CA (1) CA2200195C (ko)
CZ (1) CZ76097A3 (ko)
DE (2) DE4435368A1 (ko)
DK (1) DK0782450T3 (ko)
ES (1) ES2199255T3 (ko)
FI (1) FI971207A (ko)
HU (1) HUT76981A (ko)
MX (1) MX9702170A (ko)
NO (1) NO971349L (ko)
PL (1) PL182909B1 (ko)
PT (1) PT782450E (ko)
SK (1) SK36397A3 (ko)
WO (1) WO1996009057A1 (ko)

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DE19610645A1 (de) 1996-03-06 1997-09-11 Schering Ag Kombination von Dehydroepiandrosteron und Aromatasehemmern und Verwendung dieser Kombination zur Herstellung eines Arzeimittels zur Behandlung eines relativen und absoluten Androgenmangels beim Mann
US5972921A (en) 1997-12-12 1999-10-26 Hormos Medical Oy Ltd. Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men
US7067557B2 (en) * 2000-05-26 2006-06-27 Harry Fisch Methods of treating androgen deficiency in men using selective antiestrogens
US6391920B1 (en) 2000-05-26 2002-05-21 Harry Fisch Methods of treating androgen deficiency in men using selective antiestrogens
US6607755B2 (en) * 2001-06-21 2003-08-19 Michael Donald Farley Anti-aromatase pharmaceutical composition for controlling testosterone/estrone ratios
PL211339B1 (pl) * 2001-07-09 2012-05-31 Zonagen Zastosowanie kompozycji do wytwarzania leku do leczenia niedoboru testosteronu u samców ssaków
US7173064B2 (en) * 2001-07-09 2007-02-06 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy
US7737185B2 (en) * 2001-07-09 2010-06-15 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene
CN1617715B (zh) * 2001-12-06 2010-05-12 Gtx公司 用雄激素受体选择性调节剂治疗肌消耗
US6586417B1 (en) 2002-04-22 2003-07-01 Nutrisport Pharmacal, Inc. Ester and ether derivatives of 4-hydroxy 4-androstene-3,17-dione and a method for the regulation of athletic function in humans
WO2004064813A1 (en) * 2003-01-13 2004-08-05 Michael Donald Farley Improvements in or relating to anti-aromatase composition
WO2004064814A1 (en) * 2003-01-13 2004-08-05 Michael Donald Farley Improvements in or relating to anti-aromatase composition
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PL219509B1 (pl) * 2005-02-04 2015-05-29 Repros Therapeutics Inc Zastosowanie kompozycji zawierającej trans-klomifen
RU2413508C2 (ru) * 2005-03-22 2011-03-10 Репрос Терапьютикс Инк. Режимы дозирования транс-кломифена
CA2652783C (en) * 2006-05-22 2015-07-14 Hormos Medical Ltd. Selective estrogen receptor modulators or aromatase inhibitors for treating chronic nonbacterial prostatitis
UA96076C2 (en) 2007-10-16 2011-09-26 Репрос Терапьютикс Инк. Use of trans-clomiphene
JPWO2009066712A1 (ja) * 2007-11-21 2011-04-07 クラシエ製薬株式会社 アロマターゼ阻害剤
US20090215738A1 (en) * 2008-02-26 2009-08-27 Michael Charles Scally Prevention and treatment of an increase in cardiovascular risk, adverse cardiovascular events, infertility, and adverse psychological effects after androgen or gnrh analogue intake
CA2673461C (en) * 2009-08-07 2011-07-26 Bruce W. Kneller 5.alpha.-androstane-3,6,17-trione (kneller's trione) and methods of use therefor
US20090306031A1 (en) * 2009-08-07 2009-12-10 Kneller Bruce W 5alpha-ANDROSTANE-3,6,17-TRIONE (KNELLER'S TRIONE) AND METHODS OF USE THEREFOR
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
CA2881604C (en) * 2011-08-09 2021-09-14 Kenneth W. Adams Use of aromatase inhibitor or estrogen blocker for increasing spermatogenesis or testosterone levels in males
ES2613667T3 (es) * 2011-09-08 2017-05-25 Mereo Biopharma 2 Limited Composiciones farmacéuticas que comprenden un inhibidor de aromatasa
CN102641502A (zh) * 2012-04-25 2012-08-22 中国农业大学 芳香酶抑制剂的新用途
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Also Published As

Publication number Publication date
ATE241989T1 (de) 2003-06-15
CN1158570A (zh) 1997-09-03
NO971349D0 (no) 1997-03-21
DK0782450T3 (da) 2003-08-18
DE59510714D1 (de) 2003-07-10
CA2200195C (en) 2008-04-22
ES2199255T3 (es) 2004-02-16
SK36397A3 (en) 1997-08-06
CN1104243C (zh) 2003-04-02
HUT76981A (hu) 1998-01-28
CA2200195A1 (en) 1996-03-28
KR100387345B1 (ko) 2003-08-30
EP0782450A1 (de) 1997-07-09
WO1996009057A1 (de) 1996-03-28
AU3651895A (en) 1996-04-09
PL319299A1 (en) 1997-08-04
AU707997B2 (en) 1999-07-29
FI971207A0 (fi) 1997-03-21
BR9509155A (pt) 1997-10-14
PT782450E (pt) 2003-09-30
NO971349L (no) 1997-05-16
JPH10505848A (ja) 1998-06-09
MX9702170A (es) 1998-04-30
PL182909B1 (pl) 2002-04-30
CZ76097A3 (en) 1997-07-16
FI971207A (fi) 1997-03-21
EP0782450B1 (de) 2003-06-04
US5861389A (en) 1999-01-19
DE4435368A1 (de) 1996-03-28

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