NO963952L - Fremgangsmåte for fremstilling av immunglobuliner - Google Patents
Fremgangsmåte for fremstilling av immunglobulinerInfo
- Publication number
- NO963952L NO963952L NO963952A NO963952A NO963952L NO 963952 L NO963952 L NO 963952L NO 963952 A NO963952 A NO 963952A NO 963952 A NO963952 A NO 963952A NO 963952 L NO963952 L NO 963952L
- Authority
- NO
- Norway
- Prior art keywords
- plasma
- immunoglobulin
- preparing
- high titre
- fractionation
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 5
- 102000018358 immunoglobulin Human genes 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 229940072221 immunoglobulins Drugs 0.000 title abstract 2
- 210000002381 plasma Anatomy 0.000 abstract 4
- 238000005194 fractionation Methods 0.000 abstract 2
- 229940027941 immunoglobulin g Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 235000004252 protein component Nutrition 0.000 abstract 1
- 239000012460 protein solution Substances 0.000 abstract 1
- 238000003860 storage Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Virology (AREA)
- Analytical Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Fremgangsmåte for fremstilling av immunglobulinpreparater med høyt titer ved utførelse av de følgende trinn i rekkefølge: - fraksjonering av blodplasma fra et plasmaforråd, ved hvilken minst én industriell anvendelig fraksjon som vesentlig inneholder det polyklonale immunglobulin G, atskilles, hvorved det erholdes minst én restfraksjon, - fremstilling av en proteinløsning fra proteinkomponentene som er inneholdt i restfraksjonen fra trinn a) eller i underfraksjoner derav, og - minst én affinitetskromatografitrinn av den resulterende proteinløsning med immobiliserte ligander av minst én ligandtype, hvorved de bundne spesifikke plasmaproteiner frigjøres og overføres som aktive komponenter til et immunglobulinpreparat med høyt titer. De erholdte immunglobuliner kan bearbeides til et intravenøst forenlig lagringsstabilt produkt. Fremgangsmåten som fører til et verdifullt immunglobulinpreparat utnytter humane plasmafraksjoner som hittil ved konvensjonelle industrielle plasmafraksjoneringsfremgangsmåter er blitt kastet.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95810596A EP0764658B1 (de) | 1995-09-22 | 1995-09-22 | Verfahren zur Gewinnung von Immunglobulinen aus Fraktionen, die bei der Fraktionierung von menschlichem Blutplasma entstehen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO963952D0 NO963952D0 (no) | 1996-09-20 |
| NO963952L true NO963952L (no) | 1997-03-24 |
Family
ID=8221797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO963952A NO963952L (no) | 1995-09-22 | 1996-09-20 | Fremgangsmåte for fremstilling av immunglobuliner |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0764658B1 (no) |
| JP (1) | JP2952572B2 (no) |
| KR (1) | KR100236762B1 (no) |
| CN (1) | CN1089609C (no) |
| AT (1) | ATE211486T1 (no) |
| AU (1) | AU715427B2 (no) |
| BR (1) | BR9603826A (no) |
| CA (1) | CA2185617A1 (no) |
| CZ (1) | CZ286885B6 (no) |
| DE (1) | DE59509979D1 (no) |
| DK (1) | DK0764658T3 (no) |
| ES (1) | ES2170788T3 (no) |
| FI (1) | FI963719A (no) |
| HU (1) | HUP9602570A3 (no) |
| MX (1) | MX9604256A (no) |
| NO (1) | NO963952L (no) |
| NZ (1) | NZ299394A (no) |
| PL (1) | PL316126A1 (no) |
| PT (1) | PT764658E (no) |
| RO (1) | RO117921B1 (no) |
| RU (1) | RU2157240C2 (no) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1293119B1 (it) * | 1997-06-12 | 1999-02-11 | Mini Ricerca Scient Tecnolog | Processo per la separazione di immunoglobuline specifiche da plasma standard e loro utilizzo per trattamenti terapeutici |
| EP0911037B2 (en) | 1997-10-23 | 2007-06-13 | Mitsubishi Pharma Corporation | Room temperature storable immunoglobulin preparation for intravenous injection |
| BRPI0514435B8 (pt) * | 2004-08-20 | 2021-05-25 | American Nat Red Cross | isolamento sequêncial de proteínas e esquemas de purificação através de cromatografia por afinidade |
| EP2233499A1 (en) * | 2009-03-26 | 2010-09-29 | CSL Behring AG | Antibody composition with altered Fab sialylation |
| US20100322943A1 (en) * | 2009-06-17 | 2010-12-23 | Thomas Cantor | Therapeutic and diagnostic affinity purified specific polyclonal antibodies |
| ITRM20090558A1 (it) * | 2009-11-03 | 2011-05-04 | Michele Pitaro | Procedimento per la produzione di immunoglobuline estratte da plasma umano ad uso terapeutico neutralizzanti il virus di epstein barr e farmaco contenente dette immunoglobuline |
| GB201006753D0 (en) | 2010-04-22 | 2010-06-09 | Biotest Ag | Process for preparing an immunolobulin composition |
| SG187599A1 (en) * | 2010-07-23 | 2013-03-28 | Baxter Int | Manufacture of inter -alpha - inhibitor proteins (iaip) from plasma |
| ES2531459B1 (es) * | 2013-06-10 | 2015-12-28 | Antonio VILA SANJURJO | Método para la separación física de "traductomas" convolucionados |
| FR3018450B1 (fr) * | 2014-03-11 | 2016-04-15 | Lab Francais Du Fractionnement | Procede de preparation de proteines plasmatiques humaines |
| KR20150115639A (ko) * | 2014-04-04 | 2015-10-14 | 전숙영 | 치료용 면역글로불린 제제 제조에 사용되는 산성 완충액, 이를 이용한 치료용 면역글로불린 제제 제조방법 및 이 제조방법으로 제조된 치료용 면역글로불린 제제 |
| GB201413227D0 (en) | 2014-07-25 | 2014-09-10 | Bioproducts Lab Ltd | Process |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4232004A (en) * | 1977-09-21 | 1980-11-04 | American National Red Cross | Antibody-specific solid phase immunoadsorbent, preparation thereof, and antibody purification therewith |
| DE3516119A1 (de) * | 1985-05-04 | 1986-11-06 | Biotest Pharma GmbH, 6000 Frankfurt | Polyvalentes hyperimmunglobulin-praeparat |
| IL90281A (en) * | 1988-06-06 | 1994-10-07 | Miles Inc | Preparations containing MGI antibodies |
-
1995
- 1995-09-22 EP EP95810596A patent/EP0764658B1/de not_active Expired - Lifetime
- 1995-09-22 ES ES95810596T patent/ES2170788T3/es not_active Expired - Lifetime
- 1995-09-22 PT PT95810596T patent/PT764658E/pt unknown
- 1995-09-22 DE DE59509979T patent/DE59509979D1/de not_active Expired - Lifetime
- 1995-09-22 DK DK95810596T patent/DK0764658T3/da active
- 1995-09-22 AT AT95810596T patent/ATE211486T1/de not_active IP Right Cessation
-
1996
- 1996-09-16 CA CA002185617A patent/CA2185617A1/en not_active Abandoned
- 1996-09-16 NZ NZ299394A patent/NZ299394A/en unknown
- 1996-09-18 KR KR1019960040589A patent/KR100236762B1/ko not_active IP Right Cessation
- 1996-09-18 CZ CZ19962748A patent/CZ286885B6/cs not_active IP Right Cessation
- 1996-09-18 PL PL96316126A patent/PL316126A1/xx unknown
- 1996-09-19 AU AU65725/96A patent/AU715427B2/en not_active Ceased
- 1996-09-19 RO RO96-01839A patent/RO117921B1/ro unknown
- 1996-09-19 FI FI963719A patent/FI963719A/fi unknown
- 1996-09-19 HU HU9602570A patent/HUP9602570A3/hu unknown
- 1996-09-20 NO NO963952A patent/NO963952L/no unknown
- 1996-09-20 BR BR9603826A patent/BR9603826A/pt active Search and Examination
- 1996-09-21 CN CN96122771A patent/CN1089609C/zh not_active Expired - Fee Related
- 1996-09-23 RU RU96118916/14A patent/RU2157240C2/ru not_active IP Right Cessation
- 1996-09-23 MX MX9604256A patent/MX9604256A/es unknown
- 1996-09-24 JP JP8251895A patent/JP2952572B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2952572B2 (ja) | 1999-09-27 |
| CN1089609C (zh) | 2002-08-28 |
| ES2170788T3 (es) | 2002-08-16 |
| KR100236762B1 (ko) | 2000-01-15 |
| NO963952D0 (no) | 1996-09-20 |
| DE59509979D1 (de) | 2002-02-07 |
| CZ274896A3 (en) | 1997-04-16 |
| DK0764658T3 (da) | 2002-04-22 |
| HUP9602570A3 (en) | 1998-01-28 |
| CN1153063A (zh) | 1997-07-02 |
| ATE211486T1 (de) | 2002-01-15 |
| BR9603826A (pt) | 1998-06-02 |
| JPH09124508A (ja) | 1997-05-13 |
| RO117921B1 (ro) | 2002-09-30 |
| AU715427B2 (en) | 2000-02-03 |
| KR970015745A (ko) | 1997-04-28 |
| HU9602570D0 (en) | 1996-11-28 |
| CA2185617A1 (en) | 1997-03-23 |
| HUP9602570A2 (en) | 1997-08-28 |
| EP0764658B1 (de) | 2002-01-02 |
| EP0764658A1 (de) | 1997-03-26 |
| CZ286885B6 (en) | 2000-07-12 |
| NZ299394A (en) | 1997-12-19 |
| FI963719A (fi) | 1997-03-23 |
| PL316126A1 (en) | 1997-04-01 |
| AU6572596A (en) | 1997-04-10 |
| RU2157240C2 (ru) | 2000-10-10 |
| MX9604256A (es) | 1998-04-30 |
| FI963719A0 (fi) | 1996-09-19 |
| PT764658E (pt) | 2002-06-28 |
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