NO963893L - Anvendelse av dimeticon som et transport- og bærersystem og/eller medikamentavleveringssystem - Google Patents
Anvendelse av dimeticon som et transport- og bærersystem og/eller medikamentavleveringssystemInfo
- Publication number
- NO963893L NO963893L NO963893A NO963893A NO963893L NO 963893 L NO963893 L NO 963893L NO 963893 A NO963893 A NO 963893A NO 963893 A NO963893 A NO 963893A NO 963893 L NO963893 L NO 963893L
- Authority
- NO
- Norway
- Prior art keywords
- pharmaceutical composition
- combination
- dimethylpolysiloxane
- contains dimethylpolysiloxane
- dimethicone
- Prior art date
Links
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 title claims description 39
- 238000012377 drug delivery Methods 0.000 title description 6
- 229960001275 dimeticone Drugs 0.000 title 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 title 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 38
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 38
- 239000008194 pharmaceutical composition Substances 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 12
- 239000004480 active ingredient Substances 0.000 claims description 9
- 229960002749 aminolevulinic acid Drugs 0.000 claims description 5
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 3
- 239000003504 photosensitizing agent Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 229940122957 Histamine H2 receptor antagonist Drugs 0.000 claims description 2
- 230000008512 biological response Effects 0.000 claims description 2
- 239000003193 general anesthetic agent Substances 0.000 claims description 2
- 230000002519 immonomodulatory effect Effects 0.000 claims description 2
- 230000003308 immunostimulating effect Effects 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000004899 motility Effects 0.000 claims description 2
- 239000003470 adrenal cortex hormone Substances 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000001741 anti-phlogistic effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000003435 antirheumatic agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 229910052797 bismuth Inorganic materials 0.000 claims 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 claims 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical group C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 claims 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 229940126409 proton pump inhibitor Drugs 0.000 claims 1
- 239000000612 proton pump inhibitor Substances 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 229940008099 dimethicone Drugs 0.000 description 23
- 230000002496 gastric effect Effects 0.000 description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 210000000748 cardiovascular system Anatomy 0.000 description 2
- 210000001198 duodenum Anatomy 0.000 description 2
- 206010016766 flatulence Diseases 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000001613 neoplastic effect Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000008180 pharmaceutical surfactant Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000006114 chemosensitizer Substances 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000000824 cytostatic agent Substances 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229940079905 intestinal adsorbents bismuth preparations Drugs 0.000 description 1
- 229960003174 lansoprazole Drugs 0.000 description 1
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000003750 lower gastrointestinal tract Anatomy 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960000381 omeprazole Drugs 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 238000002428 photodynamic therapy Methods 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
- 229960000620 ranitidine Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4409357A DE4409357C2 (de) | 1994-03-18 | 1994-03-18 | Verwendung von Dimeticon zur Eradikation von Heliobacter pylori |
| PCT/EP1995/000973 WO1995025545A1 (fr) | 1994-03-18 | 1995-03-15 | Utilisation de dimeticone en tant que systeme vehiculaire et/ou d'apport medicamenteux |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO963893D0 NO963893D0 (no) | 1996-09-17 |
| NO963893L true NO963893L (no) | 1996-11-04 |
Family
ID=6513210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO963893A NO963893L (no) | 1994-03-18 | 1996-09-17 | Anvendelse av dimeticon som et transport- og bærersystem og/eller medikamentavleveringssystem |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0804242A1 (fr) |
| JP (1) | JPH09510466A (fr) |
| CN (1) | CN1244129A (fr) |
| AU (1) | AU699199B2 (fr) |
| CA (1) | CA2185882A1 (fr) |
| CZ (1) | CZ300796A3 (fr) |
| DE (1) | DE4409357C2 (fr) |
| FI (1) | FI963682A (fr) |
| HU (1) | HU215595B (fr) |
| NO (1) | NO963893L (fr) |
| NZ (1) | NZ282805A (fr) |
| PL (1) | PL316307A1 (fr) |
| SK (1) | SK132496A3 (fr) |
| WO (1) | WO1995025545A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6100245A (en) * | 1999-09-07 | 2000-08-08 | Mcneil-Ppc, Inc. | Use of simethicone to treat ulcerative colitis |
| MXPA05012791A (es) * | 2003-05-25 | 2006-02-22 | Wang Yuwan | Formulacion sostenida que contiene dimeticona. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3848M (fr) * | 1964-05-04 | 1966-01-17 | Robert Schapiro | Associations thérapeutiques pour traitement de nombreux troubles digestifs organiques ou fonctionnels. |
| GB1357737A (en) * | 1970-10-09 | 1974-06-26 | Arpic Sa | Sustained release pharmaceutical compositions |
| NZ217844A (en) * | 1985-10-11 | 1989-10-27 | Sumitomo Pharma | A sustained release pharmaceutical composition containing silicone elastomer and an albumin |
| US4837029A (en) * | 1987-04-06 | 1989-06-06 | Carolina Medical Products, Inc. | Low foaming, aqueously homogenizable rifampin composition |
| US5446070A (en) * | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| HU206624B (en) * | 1989-01-19 | 1992-12-28 | Steigerwald Arzneimittelwerk | Process for producing pharmaceutical composition for treating illnesses of oesophagus and the gastro-intestinal system |
| IE903302A1 (en) * | 1989-09-15 | 1991-04-10 | Pehrom Pharmaceutical Corp | Topical preparation for treatment of aphthous ulcers and¹other lesions |
| IN171919B (fr) * | 1989-11-01 | 1993-02-06 | Mcneil Ppc Inc | |
| US5229137A (en) * | 1992-05-06 | 1993-07-20 | Brigham And Women's Hospital, Inc. | Methods and pharmaceutical compositions for treating episodic heartburn |
| WO1994003209A1 (fr) * | 1992-07-29 | 1994-02-17 | Merck & Co., Inc. | Combinaisons dexibuprofene/antacide/simethicone |
-
1994
- 1994-03-18 DE DE4409357A patent/DE4409357C2/de not_active Expired - Fee Related
-
1995
- 1995-03-15 PL PL95316307A patent/PL316307A1/xx unknown
- 1995-03-15 CN CN95192553A patent/CN1244129A/zh active Pending
- 1995-03-15 AU AU20713/95A patent/AU699199B2/en not_active Ceased
- 1995-03-15 CZ CZ963007A patent/CZ300796A3/cs unknown
- 1995-03-15 SK SK1324-96A patent/SK132496A3/sk unknown
- 1995-03-15 EP EP95913130A patent/EP0804242A1/fr not_active Withdrawn
- 1995-03-15 NZ NZ282805A patent/NZ282805A/en not_active IP Right Cessation
- 1995-03-15 WO PCT/EP1995/000973 patent/WO1995025545A1/fr not_active Application Discontinuation
- 1995-03-15 JP JP7524363A patent/JPH09510466A/ja not_active Withdrawn
- 1995-03-15 HU HU9602839A patent/HU215595B/hu not_active IP Right Cessation
- 1995-03-15 CA CA002185882A patent/CA2185882A1/fr not_active Abandoned
-
1996
- 1996-09-17 FI FI963682A patent/FI963682A/fi unknown
- 1996-09-17 NO NO963893A patent/NO963893L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HU215595B (hu) | 1999-01-28 |
| CA2185882A1 (fr) | 1995-09-28 |
| NO963893D0 (no) | 1996-09-17 |
| WO1995025545A1 (fr) | 1995-09-28 |
| DE4409357C2 (de) | 1996-10-17 |
| NZ282805A (en) | 1998-02-26 |
| AU699199B2 (en) | 1998-11-26 |
| PL316307A1 (en) | 1997-01-06 |
| FI963682A (fi) | 1996-11-13 |
| CZ300796A3 (en) | 1997-09-17 |
| CN1244129A (zh) | 2000-02-09 |
| EP0804242A1 (fr) | 1997-11-05 |
| AU2071395A (en) | 1995-10-09 |
| HU9602839D0 (en) | 1996-12-30 |
| HUT75711A (en) | 1997-05-28 |
| SK132496A3 (en) | 1997-06-04 |
| JPH09510466A (ja) | 1997-10-21 |
| FI963682A0 (fi) | 1996-09-17 |
| DE4409357A1 (de) | 1995-09-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5466006B2 (ja) | 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ | |
| CN101489985B (zh) | 具有快速皮肤穿透率的带正电荷的水溶性布洛芬前药 | |
| AU2018202185A1 (en) | Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses | |
| JPS6261917A (ja) | アリ−ルプロピオン酸誘導体の経皮的に吸収しうる含水製剤とその製造方法 | |
| ES2261655T3 (es) | Composicion farmaceutica solida que comprende 4'-ciano-trifluoro-3-(4-fluorofenilsulfonil)-2-hidroxi-2-metilpropiono-m-toluiduro y pvp. | |
| JP2004536799A5 (fr) | ||
| WO2002096406A1 (fr) | Compositions medicinales | |
| RU2227033C2 (ru) | Тауролидин и/или таурултам при лечении инфекционной язвенной болезни или инфекционного гастрита | |
| CN110612143B (zh) | 抗微生物化合物、组合物及其用途 | |
| JP2004510816A (ja) | モダフィニル化合物の製薬学的溶液 | |
| ES2604254T3 (es) | Combinaciones de flurbiprofeno de liberación controlada y relajante muscular | |
| US5834004A (en) | Enteral composition comprising dimethicone and a photosensitizer and a method of delivery | |
| JPH0710772B2 (ja) | 一定の放出性を保持した薬物粒子 | |
| JP2002534379A5 (fr) | ||
| NO963893L (no) | Anvendelse av dimeticon som et transport- og bærersystem og/eller medikamentavleveringssystem | |
| CZ20032488A3 (cs) | Gastroirezistentní soli ketokyselin a aminikyselin a jejich použití pro přípravu léků | |
| KR0175345B1 (ko) | 장점막 장애 예방 및 치료제 | |
| US20060141027A1 (en) | Sublingual administration of non-steroidal anti-inflammatory pharmacological substances | |
| JP6153264B2 (ja) | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 | |
| JP6621775B2 (ja) | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 | |
| JP7418502B2 (ja) | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 | |
| WO2023002338A1 (fr) | Compositions, procédés de fabrication et d'utilisation de celles-ci pour l'administration de médicaments ulcérogènes de celles-ci | |
| WO2002085347A1 (fr) | Agent prophylactique/therapeutique pour les maladies inflammatoires des muqueuses de la cavite buccale et autres | |
| KR20060123329A (ko) | 월경 곤란증의 예방 및/또는 치료제 | |
| TW202317195A (zh) | 一種傳遞生物活性化合物之可抗菌具溫感性的凝膠載劑組合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |