NO962265L - Medikamentbærer for törrpulver-inhalator - Google Patents

Medikamentbærer for törrpulver-inhalator

Info

Publication number
NO962265L
NO962265L NO962265A NO962265A NO962265L NO 962265 L NO962265 L NO 962265L NO 962265 A NO962265 A NO 962265A NO 962265 A NO962265 A NO 962265A NO 962265 L NO962265 L NO 962265L
Authority
NO
Norway
Prior art keywords
carrier
medicament
dose
inhaled
impregnated
Prior art date
Application number
NO962265A
Other languages
English (en)
Norwegian (no)
Other versions
NO962265D0 (no
Inventor
Paul Mulhauser
Jeffrey Karg
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Publication of NO962265D0 publication Critical patent/NO962265D0/no
Publication of NO962265L publication Critical patent/NO962265L/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)
NO962265A 1993-12-02 1996-05-31 Medikamentbærer for törrpulver-inhalator NO962265L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/161,230 US5388573A (en) 1993-12-02 1993-12-02 Dry powder inhalator medicament carrier
PCT/US1994/010664 WO1995015190A1 (en) 1993-12-02 1994-09-21 Dry powder inhalator medicament carrier

Publications (2)

Publication Number Publication Date
NO962265D0 NO962265D0 (no) 1996-05-31
NO962265L true NO962265L (no) 1996-07-31

Family

ID=22580378

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962265A NO962265L (no) 1993-12-02 1996-05-31 Medikamentbærer for törrpulver-inhalator

Country Status (15)

Country Link
US (1) US5388573A (de)
EP (1) EP0792175B1 (de)
JP (1) JP3573212B2 (de)
KR (1) KR960706360A (de)
CN (1) CN1143915A (de)
AT (1) ATE209516T1 (de)
AU (1) AU687101B2 (de)
BR (1) BR9408206A (de)
CA (1) CA2177703A1 (de)
DE (1) DE69429286T2 (de)
FI (1) FI962272A0 (de)
HU (1) HU216507B (de)
NO (1) NO962265L (de)
NZ (1) NZ274378A (de)
WO (1) WO1995015190A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048857A (en) * 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
DE4142238A1 (de) * 1991-12-20 1993-06-24 Boehringer Ingelheim Kg Pulverinhalator mit pulvertraeger aus regelmaessigen mikrostrukturen
CN1119833A (zh) * 1993-03-03 1996-04-03 泰纳克斯公司 干粉吸入器的药粉载盘
US5647347A (en) * 1994-10-21 1997-07-15 Glaxo Wellcome Inc. Medicament carrier for dry powder inhalator
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US5699789A (en) * 1996-03-11 1997-12-23 Hendricks; Mark R. Dry powder inhaler
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
GB9610821D0 (en) * 1996-05-23 1996-07-31 Glaxo Wellcome Inc Metering apparatus
US5871010A (en) * 1996-06-10 1999-02-16 Sarnoff Corporation Inhaler apparatus with modified surfaces for enhanced release of dry powders
US5794613A (en) * 1997-01-09 1998-08-18 Sepracor, Inc. Multiple-dose dispenser for dry powder inhalers
US6006747A (en) 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
JP4221859B2 (ja) * 1999-02-12 2009-02-12 株式会社デンソー 半導体装置の製造方法
SE524957C2 (sv) * 2002-04-12 2004-11-02 Microdrug Ag Förfarande för uppdelning och fördelning i luft av torrt pulvermedikament
SE525027C2 (sv) * 2002-04-12 2004-11-16 Microdrug Ag Anordning utgörande en pulverlufthyvel
SE524990C2 (sv) * 2002-04-12 2004-11-09 Microdrug Ag Preparation av terapeutiskt torrt pulver samt förfarande för uppdelning och spridning i luft av medicinskt pulver
US8037880B2 (en) * 2006-04-07 2011-10-18 The University Of Western Ontario Dry powder inhaler
US8251060B2 (en) * 2006-11-15 2012-08-28 Perfetti and Perfetti, LLC Device and method for delivering an aerosol drug
USD635246S1 (en) * 2010-03-26 2011-03-29 Oriel Therapeutics, Inc. Dose disk for dry powder inhalers
US9351924B2 (en) 2011-03-11 2016-05-31 Snu R&Db Foundation Drug delivery system including laminated structure
US9016274B1 (en) 2013-10-14 2015-04-28 Jackie L. White Devices for vaporizing and delivering an aerosol agent
US10179215B2 (en) 2015-03-19 2019-01-15 Altria Client Services Llc Vaporizer for vaporizing a constituent of a plant material
US10765821B2 (en) * 2015-03-19 2020-09-08 Altria Client Services Llc Vaporizer for vaporizing a constituent of a plant material
US10292431B2 (en) 2016-07-18 2019-05-21 Jackie L. White Pellet substrates for vaporizing and delivering an aerosol
US10624386B2 (en) 2017-07-18 2020-04-21 Jackie L. White Pellet substrates for vaporizing and delivering an aerosol
US11458262B2 (en) 2019-06-25 2022-10-04 Altria Client Services Llc Capsules, heat-not-burn (HNB) aerosol-generating devices, and methods of generating an aerosol
USD916361S1 (en) 2019-06-25 2021-04-13 Altria Client Services Llc Aerosol-generating capsule
US12053022B2 (en) 2021-01-04 2024-08-06 Altria Client Services Llc Capsules with integrated mouthpieces, heat-not-burn (HNB) aerosol-generating devices, and methods of generating an aerosol
US12011034B2 (en) 2021-01-18 2024-06-18 Altria Client Services Llc Capsules including embedded heaters and heat-not-burn (HNB) aerosol-generating devices
US11789476B2 (en) 2021-01-18 2023-10-17 Altria Client Services Llc Heat-not-burn (HNB) aerosol-generating devices including intra-draw heater control, and methods of controlling a heater
US11910826B2 (en) 2021-01-18 2024-02-27 Altria Client Services Llc Heat-not-burn (HNB) aerosol-generating devices and capsules
US11510870B1 (en) 2021-08-31 2022-11-29 Jackie L. White Substrates for vaporizing and delivering an aerosol

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2603216A (en) * 1952-07-15 Powder inhaler
US2592369A (en) * 1948-10-15 1952-04-08 Abbott Lab Powder inhaler
US2503732A (en) * 1949-01-28 1950-04-11 Wyeth Corp Inhalator
US2470298A (en) * 1949-02-07 1949-05-17 Abbott Lab Powdered medicine dispenser
US2603215A (en) * 1949-02-12 1952-07-15 American Cyanamid Co Drug inhalator
US2569720A (en) * 1949-03-22 1951-10-02 Package Devices Inc Medicinal inhaler
US2722935A (en) * 1949-03-22 1955-11-08 Robert E Thompson Powder dispenser
US2517482A (en) * 1949-04-09 1950-08-01 Sharp & Dohme Inc Inhaler
US2549303A (en) * 1949-04-20 1951-04-17 Bristol Lab Inc Inhaler for crystalline pencilllin or the like
US2604094A (en) * 1949-06-25 1952-07-22 Schenley Ind Inc Inhaler
US2579280A (en) * 1949-06-25 1951-12-18 Macgregor Instr Company Inhaler
US2573918A (en) * 1949-11-05 1951-11-06 Vick Chemical Company Device for dispensing medicaments
US2581182A (en) * 1950-03-14 1952-01-01 Abbott Lab Inhaler
GB705404A (en) * 1950-05-19 1954-03-10 A M Bickford & Sons Ltd An inhaler for medicinal substances
US2946332A (en) * 1957-12-23 1960-07-26 Nysco Lab Inc Insufflator
US2992645A (en) * 1958-05-06 1961-07-18 Benger Lab Ltd Disperser for powders
US3669113A (en) * 1966-03-07 1972-06-13 Fisons Ltd Inhalation device
GB1182779A (en) * 1966-09-17 1970-03-04 Fisons Pharmaceuticals Ltd Inhalation Device
US3809084A (en) * 1970-02-16 1974-05-07 American Cyanamid Co Pressurized portable dispenser
US3949751A (en) * 1970-03-03 1976-04-13 Fisons Limited Method and device for dispensing medicament to the body
IT941426B (it) * 1971-07-17 1973-03-01 Isf Spa Inalatore a camera di turbinio per sostanze medicamentose polveriformi
US3888253A (en) * 1972-08-04 1975-06-10 Beecham Group Ltd Device for administration of medicines
GB1392945A (en) * 1972-08-23 1975-05-07 Fisons Ltd Inhalation device
US3795244A (en) * 1973-02-02 1974-03-05 Syntex Corp Inhalation device
GB1459426A (en) * 1973-02-26 1976-12-22 Allen & Hanburys Ltd Inhalation devices
FR2224175B1 (de) * 1973-04-04 1978-04-14 Isf Spa
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
GB1387954A (en) * 1973-05-08 1975-03-19 Miles Lab Insufflator
US3895111A (en) * 1973-06-27 1975-07-15 American Cyanamid Co Asthma treatment by inhalation of micronized N,N-diethyl-4-methyl-1-piperazinecarboxamide pamoate
US3980074A (en) * 1973-07-18 1976-09-14 Beecham Group Limited Device for the administration of powders
GB1479283A (en) * 1973-07-23 1977-07-13 Bespak Industries Ltd Inhaler for powdered medicament
IT1016489B (it) * 1974-03-18 1977-05-30 Isf Spa Inalatore
US3971377A (en) * 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
IT1017153B (it) * 1974-07-15 1977-07-20 Isf Spa Apparecchio per inalazioni
US4014336A (en) * 1975-01-13 1977-03-29 Syntex Puerto Rico, Inc. Inhalation device
US3964483A (en) * 1975-01-13 1976-06-22 Syntex Puerto Rico, Inc. Inhalation device
US4005711A (en) * 1975-01-13 1977-02-01 Syntex Puerto Rico, Inc. Inhalation device
US3973566A (en) * 1975-01-13 1976-08-10 Syntex Puerto Rico Inc. Inhalation device
DE2502251A1 (de) * 1975-01-17 1976-07-22 Schering Ag Vorrichtung zur inhalation pulverfoermiger feststoffe
US3948264A (en) * 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
GB1521000A (en) * 1975-06-13 1978-08-09 Syntex Puerto Rico Inc Inhalation device
GB1562732A (en) * 1976-02-10 1980-03-12 Allen & Hanburys Ltd Device for dispensing medicaments
GB1561835A (en) * 1976-02-11 1980-03-05 Allen & Hanburys Ltd Devices for dispensing medicamtens
US4105207A (en) * 1976-08-18 1978-08-08 Ideal Toy Corporation Pinball type baseball game
DE2716323C2 (de) * 1977-04-07 1986-03-13 Schering AG, 1000 Berlin und 4709 Bergkamen Vorrichtung zur Inhalation von Arzneimitteln
IE46865B1 (en) * 1977-04-29 1983-10-19 Allen & Hanburys Ltd Device for dispensing medicaments
US4147166A (en) * 1977-05-02 1979-04-03 American Cyanamid Company Oral inhalator powder dispenser
EP0005585B1 (de) * 1978-05-03 1981-08-12 FISONS plc Inhalationsvorrichtung
DE2837040C2 (de) * 1978-08-24 1982-10-21 Siemens AG, 1000 Berlin und 8000 München Flüssigkeitstransportsystem für ein Inhalationsgerät
US4227522A (en) * 1978-09-05 1980-10-14 Syntex Puerto Rico, Inc. Inhalation device
US4192309A (en) * 1978-09-05 1980-03-11 Syntex Puerto Rico, Inc. Inhalation device with capsule opener
IT1116047B (it) * 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma
AU545574B2 (en) * 1979-10-30 1985-07-18 Riker Laboratories, Inc. Breath actuated devices for adminstering powdered medicaments
IT1124222B (it) * 1979-10-31 1986-05-07 Zanasi Nigris Spa Perfezionamenti nei dispositivi adibiti al dosaggio per aspirazione di prodotti anche finemente polverizzati
BR8007911A (pt) * 1979-12-06 1981-06-16 Glaxo Group Ltd Inalador aperfeicoado
DE3167567D1 (en) * 1980-06-06 1985-01-17 Fisons Plc Inhalation device for powdered medicaments
US4307734A (en) * 1980-06-23 1981-12-29 B & B Inventors & Marketers, Inc. Snuff dispenser
SE438261B (sv) * 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
FI79651C (fi) * 1982-10-08 1990-02-12 Glaxo Group Ltd Doseringsanordning foer medicin.
US4570630A (en) * 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
DE3345722A1 (de) * 1983-12-17 1985-06-27 Boehringer Ingelheim KG, 6507 Ingelheim Inhalator
US4709837A (en) * 1984-05-01 1987-12-01 Merck & Co., Inc. Filter assembly for dry powder filling machine
US4620847A (en) * 1984-06-01 1986-11-04 Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov Device for administering powdered substances
DE3570414D1 (en) * 1984-07-09 1989-06-29 Takeda Chemical Industries Ltd Powder-air filter and separator for use in a powder filling apparatus
US4805811A (en) * 1985-03-29 1989-02-21 Aktiebolaget Draco Dosage device
SE448277B (sv) * 1985-04-12 1987-02-09 Draco Ab Indikeringsanordning vid en doseringsanordning for lekemedel
GR861995B (en) * 1985-07-30 1986-11-04 Glaxo Group Ltd Devices for administering medicaments to patients
AT384552B (de) * 1985-08-01 1987-12-10 Hurka Wilhelm Inhalationsgeraet zur dosierung und verteilung von festkoerpern in die atemluft
DE3607187A1 (de) * 1986-03-05 1987-09-10 Battelle Institut E V Vorrichtung zur dosierten foerderung von staubfoermigen partikeln
SE453566B (sv) * 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
US4739754A (en) * 1986-05-06 1988-04-26 Shaner William T Suction resistant inhalator
JPS63143081A (ja) * 1986-12-05 1988-06-15 メクト株式会社 吸入器
IT1222509B (it) * 1987-08-17 1990-09-05 Miat Spa Insufflatore per la somministrazione di farmaci sotto forma di polvere predosata in opercoli
DK479189D0 (da) * 1989-01-06 1989-09-28 Hans Gernot Schenk Inhalator
GB8909891D0 (en) * 1989-04-28 1989-06-14 Riker Laboratories Inc Device
DE407028T1 (de) * 1989-05-31 1994-03-17 Fisons Plc Medikament und Inhalationsvorrichtung dafür.
DE3927170A1 (de) * 1989-08-17 1991-02-21 Boehringer Ingelheim Kg Inhalator
SU1692470A1 (ru) * 1989-08-23 1991-11-23 Научно-производственное объединение "Медоборудование" Устройство дл распылени порошкообразных веществ
US4991774A (en) * 1989-08-24 1991-02-12 Charged Injection Corporation Electrostatic injector using vapor and mist insulation
IT1237118B (it) * 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
DK544589D0 (da) * 1989-11-01 1989-11-01 Novo Nordisk As Manuel betjent apparat til dispensering af en forudbestemt maengde af et pulverformet stof
GB8924823D0 (en) * 1989-11-03 1989-12-20 Smith Kline French Lab Dosage inhalers
GB8925707D0 (en) * 1989-11-14 1990-01-04 Riker Laboratories Inc Device
DE4004904A1 (de) * 1990-02-16 1990-09-13 Gerhard Brendel Trommel-applikator
GB9005110D0 (en) * 1990-03-07 1990-05-02 Fisons Plc Inhalation device
IT1240750B (it) * 1990-04-12 1993-12-17 Chiesi Farma Spa Dispositivo per la somministrazione di sostanze medicamentose in polvere
US5192548A (en) * 1990-04-30 1993-03-09 Riker Laboratoires, Inc. Device
DE4015367A1 (de) * 1990-05-12 1991-11-14 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer mindestens ein medium
GB9012870D0 (en) * 1990-06-08 1990-08-01 Glaxo Group Ltd Device
IL98441A (en) * 1990-06-14 1995-12-31 Rhone Poulenc Rorer Ltd Powder inhaler
JP3307389B2 (ja) * 1990-06-28 2002-07-24 ベーリンガー インゲルハイム コマンディトゲゼルシャフト 粉末投与のための方法、装置及び担体
DE4020571A1 (de) * 1990-06-28 1992-01-02 Boehringer Ingelheim Kg Verfahren und vorrichtung zur pulverdosierung
IT1243344B (it) * 1990-07-16 1994-06-10 Promo Pack Sa Inalatore plurimonodose per medicamenti in polvere
GB9016789D0 (en) * 1990-07-31 1990-09-12 Lilly Industries Ltd Medicament administering devices
DE4027390C2 (de) * 1990-08-30 1994-11-03 Boehringer Ingelheim Kg Treibgasfreies Inhalationsgerät
DE69121105T2 (de) * 1990-09-12 1996-12-12 Hans Bisgaard Inhaliervorrichtung
DE4142238A1 (de) * 1991-12-20 1993-06-24 Boehringer Ingelheim Kg Pulverinhalator mit pulvertraeger aus regelmaessigen mikrostrukturen

Also Published As

Publication number Publication date
DE69429286D1 (de) 2002-01-10
ATE209516T1 (de) 2001-12-15
JP3573212B2 (ja) 2004-10-06
AU687101B2 (en) 1998-02-19
CN1143915A (zh) 1997-02-26
FI962272A (fi) 1996-05-30
JPH09509853A (ja) 1997-10-07
AU7839394A (en) 1995-06-19
NO962265D0 (no) 1996-05-31
DE69429286T2 (de) 2002-07-18
HUT75136A (en) 1997-04-28
US5388573A (en) 1995-02-14
CA2177703A1 (en) 1995-06-08
EP0792175A4 (de) 1997-09-03
KR960706360A (ko) 1996-12-09
HU9601485D0 (en) 1996-08-28
NZ274378A (en) 1998-01-26
FI962272A0 (fi) 1996-05-30
HU216507B (hu) 1999-07-28
BR9408206A (pt) 1997-08-26
EP0792175B1 (de) 2001-11-28
EP0792175A1 (de) 1997-09-03
WO1995015190A1 (en) 1995-06-08

Similar Documents

Publication Publication Date Title
NO962265D0 (no) Medikamentbærer for törrpulver-inhalator
CA2157584A1 (en) Dry Powder Medicament Inhalator
BR9306112A (pt) Separador para inaladores de pó
FI902706A0 (fi) Laekemedelsinhalator och -formulation.
MY137605A (en) Dry powder inhaler
GEP19991687B (en) Powder for Use in Dry Powder Inhalers and Process for Its Production
ES2092581T3 (es) Dispositivo administrador de medicamento en polvo.
ATE79284T1 (de) Zur vollstaendigen entleerung der kapsel geeigneter inhalator.
YU18300A (sh) Perforisane mikročestice i postupci za njihovu primenu
MX9701957A (es) Dispostivo de inhalacion.
MX9700034A (es) Formulacion para la aplicacion por inhalacion.
IE800361L (en) Inhalers
CY1110625T1 (el) Μεθοδος για την χορηγηση τιοτροπιου
ATE402727T1 (de) Pulverinhalator

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application