NO954072L - Vannopplöselige camptotecinderivater, fremgangsmåte for deres fremstilling og deres anvendelse som antitumormidler - Google Patents

Vannopplöselige camptotecinderivater, fremgangsmåte for deres fremstilling og deres anvendelse som antitumormidler

Info

Publication number
NO954072L
NO954072L NO954072A NO954072A NO954072L NO 954072 L NO954072 L NO 954072L NO 954072 A NO954072 A NO 954072A NO 954072 A NO954072 A NO 954072A NO 954072 L NO954072 L NO 954072L
Authority
NO
Norway
Prior art keywords
alkyl
blend
hydrogen
antitumor agents
group
Prior art date
Application number
NO954072A
Other languages
English (en)
Norwegian (no)
Other versions
NO954072D0 (no
Inventor
Angelo Bedeschi
Franco Zarini
Walter Cabri
Ilaria Candiani
Sergio Penco
Laura Capolongo
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of NO954072D0 publication Critical patent/NO954072D0/no
Publication of NO954072L publication Critical patent/NO954072L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
NO954072A 1994-02-16 1995-10-13 Vannopplöselige camptotecinderivater, fremgangsmåte for deres fremstilling og deres anvendelse som antitumormidler NO954072L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9402934A GB9402934D0 (en) 1994-02-16 1994-02-16 Camptothecin derivatives and process for their preparation
PCT/EP1995/000393 WO1995022549A1 (fr) 1994-02-16 1995-02-03 Derives de la camptothecine et leur procede de preparation

Publications (2)

Publication Number Publication Date
NO954072D0 NO954072D0 (no) 1995-10-13
NO954072L true NO954072L (no) 1995-12-11

Family

ID=10750430

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954072A NO954072L (no) 1994-02-16 1995-10-13 Vannopplöselige camptotecinderivater, fremgangsmåte for deres fremstilling og deres anvendelse som antitumormidler

Country Status (20)

Country Link
US (2) US5602141A (fr)
EP (1) EP0694035B1 (fr)
JP (1) JPH08509244A (fr)
KR (1) KR960701878A (fr)
CN (1) CN1123548A (fr)
AT (1) ATE220681T1 (fr)
AU (1) AU681941B2 (fr)
CA (1) CA2158855C (fr)
DE (1) DE69527400T2 (fr)
ES (1) ES2180625T3 (fr)
FI (1) FI954898A (fr)
GB (1) GB9402934D0 (fr)
HU (1) HUT73423A (fr)
IL (1) IL112622A (fr)
MX (1) MX9504287A (fr)
NO (1) NO954072L (fr)
NZ (1) NZ279813A (fr)
PL (1) PL311122A1 (fr)
WO (1) WO1995022549A1 (fr)
ZA (1) ZA951227B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
GB9410388D0 (en) * 1994-05-24 1994-07-13 Erba Carlo Spa Method for the preparation of 9-amino camptothecin
GB9510716D0 (en) * 1995-05-26 1995-07-19 Pharmacia Spa Substituted camptothecin derivatives and process for their preparation
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
GB9601779D0 (en) * 1996-01-30 1996-04-03 Pharmacia Spa 9, 10 Disubstituted camptothecin derivatives
GB9702807D0 (en) 1997-02-12 1997-04-02 Pharmacia & Upjohn Spa Alkynyl-substituted camptothecins and process for their preparation
GB9715821D0 (en) * 1997-07-25 1997-10-01 Pharmacia & Upjohn Spa Amidino-camptothecin derivatives
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
WO2001024763A2 (fr) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques
EP1480984B9 (fr) * 2001-11-30 2009-03-11 Chugai Seiyaku Kabushiki Kaisha Composes hexacycliques
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
TWI351284B (en) 2004-04-09 2011-11-01 Chugai Pharmaceutical Co Ltd Novel water-soluble prodrugs
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
JP5126900B2 (ja) * 2009-02-24 2013-01-23 株式会社渡辺オイスター研究所 カキ肉エキス顆粒の製造方法。
CN101555250B (zh) * 2009-05-19 2011-05-18 重庆泰濠制药有限公司 盐酸拓扑替康的制备方法
AU2022282813A1 (en) * 2021-05-27 2023-11-30 Zymeworks Bc Inc. Camptothecin analogues, conjugates and methods of use
WO2023061393A1 (fr) 2021-10-15 2023-04-20 昆山新蕴达生物科技有限公司 Composition contenant un médicament antitumoral, son procédé de préparation et son utilisation
WO2023178452A1 (fr) * 2022-03-25 2023-09-28 Zymeworks Bc Inc. Conjugués anticorps-médicament ciblant le récepteur alpha du folate et procédés d'utilisation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US5227380A (en) * 1987-03-31 1993-07-13 Research Triangle Institute Pharmaceutical compositions and methods employing camptothecins
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
DE69033880T2 (de) * 1989-09-15 2002-06-06 Res Triangle Inst Res Triangle Verfahren zur herstellung von 10,11-Methylendioxy-20(RS)-Camptothecin und 10,11-Methylendioxy-20(S)-Camptothecin-Analog
WO1991004260A2 (fr) * 1989-09-15 1991-04-04 Research Triangle Institute Analogues de 10,11-methylenedioxy-20(rs)-camptothecine et de 10,11-methylenedioxy-20(s)-camptothecine
JP2848958B2 (ja) * 1990-09-28 1999-01-20 スミスクライン・ビーチャム・コーポレイション 水溶性カンプトテシン類似体、方法および手段
US5162532A (en) * 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
US5342947A (en) * 1992-10-09 1994-08-30 Glaxo Inc. Preparation of water soluble camptothecin derivatives
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation

Also Published As

Publication number Publication date
CA2158855C (fr) 2006-01-31
FI954898A0 (fi) 1995-10-13
AU681941B2 (en) 1997-09-11
EP0694035A1 (fr) 1996-01-31
KR960701878A (ko) 1996-03-28
PL311122A1 (en) 1996-02-05
NZ279813A (en) 1996-10-28
US5602141A (en) 1997-02-11
CA2158855A1 (fr) 1995-08-24
WO1995022549A1 (fr) 1995-08-24
CN1123548A (zh) 1996-05-29
JPH08509244A (ja) 1996-10-01
IL112622A0 (en) 1995-05-26
HU9503273D0 (en) 1996-01-29
NO954072D0 (no) 1995-10-13
DE69527400T2 (de) 2003-03-06
MX9504287A (es) 1997-05-31
FI954898A (fi) 1995-10-13
ES2180625T3 (es) 2003-02-16
EP0694035B1 (fr) 2002-07-17
US5801167A (en) 1998-09-01
HUT73423A (en) 1996-07-29
AU1705695A (en) 1995-09-04
ATE220681T1 (de) 2002-08-15
GB9402934D0 (en) 1994-04-06
DE69527400D1 (de) 2002-08-22
ZA951227B (en) 1996-01-19
IL112622A (en) 1997-09-30

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