DE69527400D1 - Wasserlösliche camptothecin-derivate, verfahren zu deren herstellung und deren verwendung als antitumor-mittel - Google Patents

Wasserlösliche camptothecin-derivate, verfahren zu deren herstellung und deren verwendung als antitumor-mittel

Info

Publication number
DE69527400D1
DE69527400D1 DE69527400T DE69527400T DE69527400D1 DE 69527400 D1 DE69527400 D1 DE 69527400D1 DE 69527400 T DE69527400 T DE 69527400T DE 69527400 T DE69527400 T DE 69527400T DE 69527400 D1 DE69527400 D1 DE 69527400D1
Authority
DE
Germany
Prior art keywords
production
water
camptothecin derivatives
antitumor agent
soluble camptothecin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69527400T
Other languages
English (en)
Other versions
DE69527400T2 (de
Inventor
Angelo Bedeschi
Franco Zarini
Walter Cabri
Ilaria Candiani
Sergio Penco
Laura Capolongo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Publication of DE69527400D1 publication Critical patent/DE69527400D1/de
Application granted granted Critical
Publication of DE69527400T2 publication Critical patent/DE69527400T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DE69527400T 1994-02-16 1995-02-03 Wasserlösliche camptothecin-derivate, verfahren zu deren herstellung und deren verwendung als antitumor-mittel Expired - Fee Related DE69527400T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9402934A GB9402934D0 (en) 1994-02-16 1994-02-16 Camptothecin derivatives and process for their preparation
PCT/EP1995/000393 WO1995022549A1 (en) 1994-02-16 1995-02-03 Water-soluble camptothecin derivatives, process for their preparation and their use as antitumor agents

Publications (2)

Publication Number Publication Date
DE69527400D1 true DE69527400D1 (de) 2002-08-22
DE69527400T2 DE69527400T2 (de) 2003-03-06

Family

ID=10750430

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69527400T Expired - Fee Related DE69527400T2 (de) 1994-02-16 1995-02-03 Wasserlösliche camptothecin-derivate, verfahren zu deren herstellung und deren verwendung als antitumor-mittel

Country Status (20)

Country Link
US (2) US5602141A (de)
EP (1) EP0694035B1 (de)
JP (1) JPH08509244A (de)
KR (1) KR960701878A (de)
CN (1) CN1123548A (de)
AT (1) ATE220681T1 (de)
AU (1) AU681941B2 (de)
CA (1) CA2158855C (de)
DE (1) DE69527400T2 (de)
ES (1) ES2180625T3 (de)
FI (1) FI954898A0 (de)
GB (1) GB9402934D0 (de)
HU (1) HUT73423A (de)
IL (1) IL112622A (de)
MX (1) MX9504287A (de)
NO (1) NO954072L (de)
NZ (1) NZ279813A (de)
PL (1) PL311122A1 (de)
WO (1) WO1995022549A1 (de)
ZA (1) ZA951227B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
GB9410388D0 (en) * 1994-05-24 1994-07-13 Erba Carlo Spa Method for the preparation of 9-amino camptothecin
GB9510716D0 (en) * 1995-05-26 1995-07-19 Pharmacia Spa Substituted camptothecin derivatives and process for their preparation
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
GB9601779D0 (en) * 1996-01-30 1996-04-03 Pharmacia Spa 9, 10 Disubstituted camptothecin derivatives
GB9702807D0 (en) 1997-02-12 1997-04-02 Pharmacia & Upjohn Spa Alkynyl-substituted camptothecins and process for their preparation
GB9715821D0 (en) * 1997-07-25 1997-10-01 Pharmacia & Upjohn Spa Amidino-camptothecin derivatives
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
EP1229934B1 (de) 1999-10-01 2014-03-05 Immunogen, Inc. Zusammensetzungen und verfahren zur behandlung von krebs mittels immunkonjugaten und chemotherapeutischen agenzien
IL162058A0 (en) 2001-11-30 2005-11-20 Chugai Pharmaceutical Co Ltd Hexacyclic compounds
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US7910593B2 (en) 2004-04-09 2011-03-22 Chugai Seiyaku Kabushiki Kaisha Water-soluble prodrugs
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
JP5126900B2 (ja) * 2009-02-24 2013-01-23 株式会社渡辺オイスター研究所 カキ肉エキス顆粒の製造方法。
CN101555250B (zh) * 2009-05-19 2011-05-18 重庆泰濠制药有限公司 盐酸拓扑替康的制备方法
KR20240031235A (ko) * 2021-05-27 2024-03-07 자임워크스 비씨 인코포레이티드 캄프토테신 유사체, 접합체 및 사용 방법
WO2023061393A1 (zh) 2021-10-15 2023-04-20 昆山新蕴达生物科技有限公司 包含抗肿瘤药物的组合物及其制备方法和用途
WO2023178452A1 (en) * 2022-03-25 2023-09-28 Zymeworks Bc Inc. Antibody-drug conjugates targeting folate receptor alpha and methods of use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5227380A (en) * 1987-03-31 1993-07-13 Research Triangle Institute Pharmaceutical compositions and methods employing camptothecins
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
NZ235329A (en) * 1989-09-15 1992-01-29 Res Triangle Inst 20(s or rs)-camptothecin derivatives and pharmaceutical compositions
WO1991004260A2 (en) * 1989-09-15 1991-04-04 Research Triangle Institute 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
ES2137932T3 (es) * 1990-09-28 2000-01-01 Smithkline Beecham Corp Procedimiento para la preparacion de analogos de camptotecina solubles en agua, asi como los compuestos 10-hidroxi-11-alcoxi-6-camptotecina.
US5162532A (en) * 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
US5342947A (en) * 1992-10-09 1994-08-30 Glaxo Inc. Preparation of water soluble camptothecin derivatives
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation

Also Published As

Publication number Publication date
AU1705695A (en) 1995-09-04
KR960701878A (ko) 1996-03-28
IL112622A0 (en) 1995-05-26
WO1995022549A1 (en) 1995-08-24
CA2158855A1 (en) 1995-08-24
US5801167A (en) 1998-09-01
GB9402934D0 (en) 1994-04-06
ZA951227B (en) 1996-01-19
HUT73423A (en) 1996-07-29
PL311122A1 (en) 1996-02-05
JPH08509244A (ja) 1996-10-01
MX9504287A (es) 1997-05-31
CA2158855C (en) 2006-01-31
ES2180625T3 (es) 2003-02-16
US5602141A (en) 1997-02-11
NO954072L (no) 1995-12-11
EP0694035B1 (de) 2002-07-17
AU681941B2 (en) 1997-09-11
EP0694035A1 (de) 1996-01-31
FI954898A (fi) 1995-10-13
CN1123548A (zh) 1996-05-29
FI954898A0 (fi) 1995-10-13
IL112622A (en) 1997-09-30
DE69527400T2 (de) 2003-03-06
NO954072D0 (no) 1995-10-13
NZ279813A (en) 1996-10-28
HU9503273D0 (en) 1996-01-29
ATE220681T1 (de) 2002-08-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee