NO923769L - System for iontoforetisk tilfoersel av et medikament - Google Patents
System for iontoforetisk tilfoersel av et medikamentInfo
- Publication number
- NO923769L NO923769L NO92923769A NO923769A NO923769L NO 923769 L NO923769 L NO 923769L NO 92923769 A NO92923769 A NO 92923769A NO 923769 A NO923769 A NO 923769A NO 923769 L NO923769 L NO 923769L
- Authority
- NO
- Norway
- Prior art keywords
- level
- current
- iontophoretic
- agent
- interval
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Electrotherapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50217690A | 1990-03-30 | 1990-03-30 | |
US07/671,306 US5207752A (en) | 1990-03-30 | 1991-03-21 | Iontophoretic drug delivery system with two-stage delivery profile |
PCT/US1991/001941 WO1991015258A1 (en) | 1990-03-30 | 1991-03-22 | Iontophoretic drug delivery system with two-stage delivery profile |
Publications (3)
Publication Number | Publication Date |
---|---|
NO923769D0 NO923769D0 (no) | 1992-09-28 |
NO923769L true NO923769L (no) | 1992-11-30 |
NO308025B1 NO308025B1 (no) | 2000-07-10 |
Family
ID=27054046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO923769A NO308025B1 (no) | 1990-03-30 | 1992-09-28 | FremgangsmÕte til Õ kontrollere et iontoforetisk medikamenttilførsel-apparat, og apparater for innføring av hhv. et ionisert terapeutisk agens og et ikke-ladet terapeutisk agens i et legeme |
Country Status (14)
Country | Link |
---|---|
US (1) | US5207752A (no) |
EP (1) | EP0522092B1 (no) |
JP (1) | JP3181289B2 (no) |
KR (1) | KR0169084B1 (no) |
AT (1) | ATE114118T1 (no) |
AU (1) | AU638581B2 (no) |
CA (1) | CA2079316C (no) |
DE (1) | DE69105202T2 (no) |
DK (1) | DK0522092T3 (no) |
ES (1) | ES2067939T3 (no) |
FI (1) | FI110066B (no) |
GR (1) | GR3015116T3 (no) |
NO (1) | NO308025B1 (no) |
WO (1) | WO1991015258A1 (no) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993010854A1 (en) * | 1991-12-03 | 1993-06-10 | Alza Corporation | Iontophoretic delivery device and power supply therefor |
US5505715A (en) * | 1994-02-25 | 1996-04-09 | Bristol-Myers Squibb Company | Iontophoretic transdermal delivery of deoxyspergualin compounds |
US7027859B1 (en) | 1994-09-26 | 2006-04-11 | Alza Corporation | Electrotransport delivery device having improved safety and reduced abuse potential |
US5697896A (en) * | 1994-12-08 | 1997-12-16 | Alza Corporation | Electrotransport delivery device |
US5700481A (en) * | 1995-03-17 | 1997-12-23 | Takeda Chemical Industries, Ltd. | Transdermal drug delivery process |
EP0819016A1 (de) * | 1995-04-07 | 1998-01-21 | Novartis AG | Iontophoretisches transdermales system zum verabreichen von mindestens zwei substanzen |
IE960312A1 (en) * | 1995-06-02 | 1996-12-11 | Alza Corp | An electrotransport delivery device with voltage boosting¹circuit |
AU710793B2 (en) * | 1995-06-07 | 1999-09-30 | Alza Corporation | Electrotransport agent delivery method and apparatus |
US5983130A (en) * | 1995-06-07 | 1999-11-09 | Alza Corporation | Electrotransport agent delivery method and apparatus |
WO1997014473A1 (en) * | 1995-10-18 | 1997-04-24 | Novartis Ag | Thermopile powered transdermal drug delivery device |
US6718201B1 (en) * | 1996-06-07 | 2004-04-06 | Alza Corporation | Electrotransport agent delivery method and apparatus |
US5961483A (en) * | 1996-06-19 | 1999-10-05 | Sage; Burton H. | Iontophoretic delivery of cell adhesion inhibitors |
US5857994A (en) * | 1996-10-01 | 1999-01-12 | Becton, Dickinson And Company | Awakenable iontophoretic/delivery device for reducing electrical sensation upon application thereof |
FR2766093B1 (fr) * | 1997-07-15 | 1999-09-03 | Lhd Lab Hygiene Dietetique | Procede de commande d'un dispositif d'administration transdermique de medicament sous champ electrique |
JP2002508228A (ja) | 1997-12-16 | 2002-03-19 | アルザ・コーポレーション | 調整された投与を維持する人為的負荷を備えた調整器 |
WO1999030775A1 (en) | 1997-12-17 | 1999-06-24 | Alza Corporation | Iontophoresis with programmed adjustment of electric current |
PT1003581E (pt) | 1998-01-30 | 2001-04-30 | Novo Nordisk As | Seringa de injeccao |
NZ513404A (en) | 1999-02-10 | 2003-01-31 | Gmp Drug Delivery Inc | Iontophoresis, electroporation and combination patches for local drug delivery |
US6471675B1 (en) | 1999-04-30 | 2002-10-29 | Medtronic, Inc. | Passive flow control devices for implantable pumps |
TW453884B (en) | 1999-09-16 | 2001-09-11 | Novo Nordisk As | Dose setting limiter |
US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
CN100420482C (zh) * | 2000-11-03 | 2008-09-24 | 精达制药公司 | ω干扰素在制备用于治疗丙型肝炎的药物中的用途 |
KR20040053291A (ko) * | 2001-11-09 | 2004-06-23 | 바이오메디신즈 인코포레이티드 | 오메가 인터페론을 이용한 질환 치료 방법 |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
US9205197B2 (en) * | 2003-03-03 | 2015-12-08 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device dose setting mechanism |
GB0308267D0 (en) * | 2003-04-10 | 2003-05-14 | Dca Design Int Ltd | Improvements in and relating to a pen-type injector |
US7220778B2 (en) * | 2003-04-15 | 2007-05-22 | The General Hospital Corporation | Methods and devices for epithelial protection during photodynamic therapy |
EP1595542A1 (en) * | 2004-03-26 | 2005-11-16 | Solvay Pharmaceuticals B.V. | Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds |
US7596407B2 (en) * | 2004-03-26 | 2009-09-29 | Solvay Pharmaceuticals, B.V. | Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds |
AU2005298944B2 (en) | 2004-10-21 | 2010-12-23 | Novo Nordisk A/S | Dial-down mechanism for wind-up pen |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
JP2008531151A (ja) * | 2005-02-28 | 2008-08-14 | ノボ・ノルデイスク・エー/エス | 注入デバイスの投与量設定機構 |
US7856263B2 (en) * | 2005-04-22 | 2010-12-21 | Travanti Pharma Inc. | Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis |
JP4979686B2 (ja) | 2005-04-24 | 2012-07-18 | ノボ・ノルデイスク・エー/エス | 注入デバイス |
EP1931416A2 (en) * | 2005-09-30 | 2008-06-18 | Tti Ellebeau, Inc. | Iontophoresis method and apparatus for systemic delivery of active agents |
US20090221985A1 (en) * | 2005-10-19 | 2009-09-03 | Shmuel Bukshpan | System for iontophoretic transdermal delivery of polymeric agents and methods of use thereof |
JP5062768B2 (ja) | 2006-03-10 | 2012-10-31 | ノボ・ノルデイスク・エー/エス | 注射装置および該装置のカートリッジを交換する方法 |
EP1996260B1 (en) | 2006-03-10 | 2015-09-23 | Novo Nordisk A/S | An injection device having a gearing arrangement |
AU2012261753B2 (en) * | 2006-04-13 | 2015-03-05 | Teva Pharmaceuticals International Gmbh | Transdermal methods and systems for the delivery of anti-migraine compounds |
CA2650412C (en) * | 2006-04-13 | 2016-09-27 | Nupathe, Inc. | Transdermal methods and systems for the delivery of anti-migraine compounds |
DE602007004972D1 (de) | 2006-05-16 | 2010-04-08 | Novo Nordisk As | Getriebemechanismus für ein injektionsgerät |
EP2022736B1 (en) * | 2006-05-16 | 2015-10-21 | Rorze Corporation | Shuttle type conveying device, microplate feeding and collecting device, pickup device for microplate, cassette for microplate, and shelf for receiving microplate |
US9192727B2 (en) | 2006-05-18 | 2015-11-24 | Novo Nordisk A/S | Injection device with mode locking means |
CA2651855C (en) | 2006-05-30 | 2011-08-02 | Intarcia Therapeutics, Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
ES2422864T3 (es) | 2006-08-09 | 2013-09-16 | Intarcia Therapeutics, Inc | Sistemas de liberación osmótica y unidades de pistón |
US8728059B2 (en) * | 2006-09-29 | 2014-05-20 | Covidien Lp | System and method for assuring validity of monitoring parameter in combination with a therapeutic device |
CA2676810C (en) | 2007-02-05 | 2016-06-21 | Novo Nordisk A/S | Injection button |
WO2008116766A1 (en) | 2007-03-23 | 2008-10-02 | Novo Nordisk A/S | An injection device comprising a locking nut |
PT2157967E (pt) | 2007-04-23 | 2013-04-03 | Intarcia Therapeutics Inc | Formulações de suspensões de péptidos insulinotrópicos e suas utilizações |
US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
ES2454974T3 (es) * | 2007-06-27 | 2014-04-14 | The General Hospital Corporation | Aparato para la inhibición óptica de la terapia fotodinámica |
US20090043244A1 (en) * | 2007-08-08 | 2009-02-12 | Inan Omer T | Electrotransport Drug Delivery Device Adaptable to Skin Resistance Change |
US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
EP2240155B1 (en) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Devices, formulations, and methods for delivery of multiple beneficial agents |
US20090259176A1 (en) * | 2008-04-09 | 2009-10-15 | Los Gatos Research, Inc. | Transdermal patch system |
US20090312689A1 (en) * | 2008-06-05 | 2009-12-17 | Alza Corporation | Adjustable Current Electrotransport Fentanyl Delivery Device |
US8155737B2 (en) * | 2008-06-19 | 2012-04-10 | Nupathe, Inc. | Pharmacokinetics of iontophoretic sumatriptan administration |
US8366600B2 (en) * | 2008-06-19 | 2013-02-05 | Nupathe Inc. | Polyamine enhanced formulations for triptan compound iontophoresis |
EP2393549B1 (en) * | 2008-12-30 | 2014-10-01 | NuPathe Inc. | Electronic control of drug delivery system |
US8961492B2 (en) | 2009-02-12 | 2015-02-24 | Incube Labs, Llc | System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation |
US8190252B2 (en) | 2009-02-12 | 2012-05-29 | Incube Labs, Llc | Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes |
US8903485B2 (en) | 2009-08-06 | 2014-12-02 | Incube Labs, Llc | Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes |
NZ598622A (en) * | 2009-08-10 | 2014-02-28 | Nupathe Inc | Methods for iontophoretically treating nausea and migraine |
KR101823699B1 (ko) | 2009-09-28 | 2018-01-30 | 인타르시아 세라퓨틱스 인코포레이티드 | 실질 항정상태 약물 전달의 신속 확립 및/또는 종결 |
WO2011046927A1 (en) * | 2009-10-13 | 2011-04-21 | Nupathe,Inc. | Transdermal methods and systems for the delivery of rizatriptan |
US8685038B2 (en) | 2009-12-07 | 2014-04-01 | Incube Labs, Llc | Iontophoretic apparatus and method for marking of the skin |
WO2011100376A2 (en) | 2010-02-10 | 2011-08-18 | Incube Labs, Llc | Methods and architecture for power optimization of iontophoretic transdermal drug delivery |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
EP3626304A1 (en) | 2011-03-24 | 2020-03-25 | Incube Labs, Llc | System and method for biphasic transdermal iontophoretic delivery of therapeutic agents |
US8428708B1 (en) * | 2012-05-21 | 2013-04-23 | Incline Therapeutics, Inc. | Self-test for analgesic product |
US8428709B1 (en) | 2012-06-11 | 2013-04-23 | Incline Therapeutics, Inc. | Current control for electrotransport drug delivery |
WO2012154704A2 (en) | 2011-05-06 | 2012-11-15 | Incube Labs, Llc | System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings |
RU2014128518A (ru) | 2011-12-29 | 2016-02-20 | Ново Нордиск А/С | Механизм увеличения/уменьшения дозы для взводимого шприца-ручки |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
KR102574993B1 (ko) | 2016-05-16 | 2023-09-06 | 인타르시아 세라퓨틱스 인코포레이티드 | 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법 |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
KR20190104039A (ko) | 2017-01-03 | 2019-09-05 | 인타르시아 세라퓨틱스 인코포레이티드 | Glp-1 수용체 효능제의 연속적인 투여 및 약물의 동시-투여를 포함하는 방법 |
AR112480A1 (es) | 2017-08-24 | 2019-10-30 | Novo Nordisk As | Composiciones de glp-1 y sus usos |
USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
AU2021208601A1 (en) | 2020-02-18 | 2022-07-28 | Novo Nordisk A/S | Glp-1 compositions and uses thereof |
Family Cites Families (34)
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---|---|---|---|---|
US3163166A (en) * | 1961-04-28 | 1964-12-29 | Colgate Palmolive Co | Iontophoresis apparatus |
US3618601A (en) * | 1969-10-16 | 1971-11-09 | Thatcher W Richardson | Iontophoresis unit |
US3677268A (en) * | 1969-11-28 | 1972-07-18 | Sherwood Medical Ind Inc | Iontophoresis electrode |
US3794910A (en) * | 1971-07-26 | 1974-02-26 | Sherwood Medical Ind Inc | Iontophoresis and conductivity analysis circuit |
DE2339648C3 (de) * | 1973-08-04 | 1979-09-13 | Trebbin, Peter, 8833 Eichstaett | Anästhesiegerät zur Behandlung der Zähne |
US4141359A (en) * | 1976-08-16 | 1979-02-27 | University Of Utah | Epidermal iontophoresis device |
US4211222A (en) * | 1976-08-25 | 1980-07-08 | Robert Tapper | Iontophoretic burn-protection method |
JPS5347192A (en) * | 1976-10-13 | 1978-04-27 | Matsushita Electric Ind Co Ltd | Device for introducing fluorine ion to tooth |
US4325367A (en) * | 1977-06-13 | 1982-04-20 | Robert Tapper | Iontophoretic treatment apparatus |
US4177817A (en) * | 1978-02-01 | 1979-12-11 | C. R. Bard, Inc. | Dual terminal transcutaneous electrode |
US4215696A (en) * | 1978-03-20 | 1980-08-05 | Graphic Controls Corporation | Biomedical electrode with pressurized skin contact |
US4209020A (en) * | 1978-09-19 | 1980-06-24 | Nielsen R Frederick | Electrode assembly |
US4301794A (en) * | 1978-10-18 | 1981-11-24 | Robert Tapper | Method for iontophoretic treatment |
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US4292968A (en) * | 1979-11-26 | 1981-10-06 | Sybron Corporation | Electric supply for ion therapy |
AU546785B2 (en) * | 1980-07-23 | 1985-09-19 | Commonwealth Of Australia, The | Open-loop controlled infusion of diabetics |
JPS5810066A (ja) * | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | イオントフオレ−ゼ用プラスタ−構造体 |
US4450844A (en) * | 1981-11-23 | 1984-05-29 | Hill Top Research, Inc. | Patch system for use on the skin |
US4619252A (en) * | 1983-04-15 | 1986-10-28 | Ibbott Jack Kenneth | Therapeutic method and therapeutic means using a sheetlike battery |
US4731926A (en) * | 1985-02-19 | 1988-03-22 | Drug Delivery Systems Inc. | Method of manufacturing disposable and/or replenishable transdermal drug applicators |
US4622031A (en) * | 1983-08-18 | 1986-11-11 | Drug Delivery Systems Inc. | Indicator for electrophoretic transcutaneous drug delivery device |
US4557723A (en) * | 1983-08-18 | 1985-12-10 | Drug Delivery Systems Inc. | Applicator for the non-invasive transcutaneous delivery of medicament |
US4708716A (en) * | 1983-08-18 | 1987-11-24 | Drug Delivery Systems Inc. | Transdermal drug applicator |
US4808152A (en) * | 1983-08-18 | 1989-02-28 | Drug Delivery Systems Inc. | System and method for controlling rate of electrokinetic delivery of a drug |
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US4851229A (en) * | 1983-12-01 | 1989-07-25 | Alza Corporation | Composition comprising a therapeutic agent and a modulating agent |
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US4698062A (en) * | 1985-10-30 | 1987-10-06 | Alza Corporation | Medical device for pulsatile transdermal delivery of biologically active agents |
US4725263A (en) * | 1986-07-31 | 1988-02-16 | Medtronic, Inc. | Programmable constant current source transdermal drug delivery system |
US4822334A (en) * | 1986-12-04 | 1989-04-18 | Robert Tapper | Electrical dosimetry control system |
US4731049A (en) * | 1987-01-30 | 1988-03-15 | Ionics, Incorporated | Cell for electrically controlled transdermal drug delivery |
EP0313638A4 (en) * | 1987-05-15 | 1989-06-14 | Martin H Newman | IONTOPHORESIS INOPHORESIS DRUG ADMINISTRATION SYSTEM. |
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-
1991
- 1991-03-21 US US07/671,306 patent/US5207752A/en not_active Expired - Lifetime
- 1991-03-22 WO PCT/US1991/001941 patent/WO1991015258A1/en active IP Right Grant
- 1991-03-22 AT AT91911198T patent/ATE114118T1/de not_active IP Right Cessation
- 1991-03-22 EP EP91911198A patent/EP0522092B1/en not_active Revoked
- 1991-03-22 AU AU79915/91A patent/AU638581B2/en not_active Expired
- 1991-03-22 DE DE69105202T patent/DE69105202T2/de not_active Expired - Fee Related
- 1991-03-22 JP JP51059091A patent/JP3181289B2/ja not_active Expired - Lifetime
- 1991-03-22 DK DK91911198.9T patent/DK0522092T3/da active
- 1991-03-22 KR KR1019920702381A patent/KR0169084B1/ko not_active IP Right Cessation
- 1991-03-22 ES ES91911198T patent/ES2067939T3/es not_active Expired - Lifetime
- 1991-03-22 CA CA002079316A patent/CA2079316C/en not_active Expired - Lifetime
-
1992
- 1992-09-28 NO NO923769A patent/NO308025B1/no not_active IP Right Cessation
- 1992-09-28 FI FI924352A patent/FI110066B/fi active
-
1995
- 1995-02-20 GR GR950400340T patent/GR3015116T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE114118T1 (de) | 1994-12-15 |
NO308025B1 (no) | 2000-07-10 |
EP0522092B1 (en) | 1994-11-17 |
FI110066B (fi) | 2002-11-29 |
FI924352A0 (fi) | 1992-09-28 |
DK0522092T3 (da) | 1995-03-13 |
KR0169084B1 (ko) | 1999-01-15 |
DE69105202D1 (de) | 1994-12-22 |
AU7991591A (en) | 1991-10-30 |
JPH05505964A (ja) | 1993-09-02 |
AU638581B2 (en) | 1993-07-01 |
ES2067939T3 (es) | 1995-04-01 |
JP3181289B2 (ja) | 2001-07-03 |
GR3015116T3 (en) | 1995-05-31 |
NO923769D0 (no) | 1992-09-28 |
CA2079316C (en) | 2002-01-01 |
KR930700181A (ko) | 1993-03-13 |
CA2079316A1 (en) | 1991-10-01 |
FI924352A (fi) | 1992-09-28 |
DE69105202T2 (de) | 1995-03-23 |
EP0522092A1 (en) | 1993-01-13 |
US5207752A (en) | 1993-05-04 |
WO1991015258A1 (en) | 1991-10-17 |
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