KR930700181A - 2단계 전달 프로파일을 갖는 전리요법적 약물 전달계 - Google Patents

2단계 전달 프로파일을 갖는 전리요법적 약물 전달계

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Publication number
KR930700181A
KR930700181A KR1019920702381A KR920702381A KR930700181A KR 930700181 A KR930700181 A KR 930700181A KR 1019920702381 A KR1019920702381 A KR 1019920702381A KR 920702381 A KR920702381 A KR 920702381A KR 930700181 A KR930700181 A KR 930700181A
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South Korea
Prior art keywords
level
current
therapeutic agent
electrode
interval
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KR1019920702381A
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English (en)
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KR0169084B1 (ko
Inventor
디. 소렌손 폴
디. 브랜진스키 죤
에이. 래틴 게리
에이. 맥니콜스 래리
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원본미기재
알자 코포레이션
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Application filed by 원본미기재, 알자 코포레이션 filed Critical 원본미기재
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음.

Description

2단계 전달 프로파일을 갖는 전리요법적 약물 전달계
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 두 개의 상이한 전리요법적 전류 수준에서의 약물 농도 대 시간의 플롯을 도시한 것이며,
제2도는 본 발명에 따른 2단계 전달계를 도시하는 약물농도 대 시간의 플롯을 도시한 것이고,
제3도는 전달의 제1단계와 제2단계가 지연된 본 발명에 따른 2단계 전달의 다른 방법을 도시하는 약물 농도 대 시간의 플롯을 도시한 것이다.

Claims (3)

  1. 이온화된 치료학적 약제를 전달하거나 이에 접촉된 2개 이상의 전극을 가지며, 전극 및 약제는 한 전극으로부터 다른 전극으로 전리요법적 전류 전달 동안 전기 경로를 형성시키기 위해 인체 조직에 반대로 위치하고, (a)제1수준의 전리요법적 전류를 2개 이상의 이온화된 치료학적 약제를 조직에 제1속도로 전달하는 전극 사이에 도입시켜 제1수준을 예정된 간격동안 지속시킴으로해서 약제를 급속하게 조직에 도입시키는 단계, (b)치료학적 약제의 농도가 목적하는 지속수준에 거의 근접하는 시간에서 제1수준을 목적하는 농도 수준을 지속시키기에 충분한 수준의 제2낮은 수준의 전리요법적 전류로 감소시키는 단계를 포함함을 특징으로 하는 전리요법적 약물 전달 방법.
  2. 2개 이상의 전극과 (i)예정된 간격동안 적용시킨 제1수준의 전리요법적 전류를 전극과 연결된 인체 조직을 통해 전달하고, (ⅱ)인체내에서 치료학적 약제의 농도가 대략적으로 목적하는 농도 수준에 도달하는데 소요되는 제1간격 이후에 전극과 연결된 인체 조직을 통해 실질적으로 목적하는 농도 수준을 지속시키기 위하여 낮은 수준의 제2전리요법적 전류를 전달하기 위해 전리요법적 전류 발생 기구를 포함함을 특징으로 하여, 이온화된 치료학적 약제를 인체에 도입시키기 위한 장치.
  3. 2개 이상의 전극과 하전되지 않은 치료학적 약제를 함유하는 액체 용매, (i)예정된 간격동안 적용시킨 제1수준의 전리요법적 전류를 전극과 연결된 인체 조직을 통해 전달하고, (ⅱ)인체내에서 치료학적 약제의 농도가 대략적으로 목적하는 농도 수준에 도달하는데 소요되는 제1간격 이후에 전극과 연결된 인제 조직을 통해실질적으로 목적하는 농도수준을 지속시키기 위하여 낮은 수준의 제2전리요법적 전류를 전달하기 위한 전리요법적 전류 발생 기구를 포함함을 특징으로 하여, 하전되지 않은 치료학적 약제를 인체에 도입시키기 위한 장치.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920702381A 1990-03-30 1991-03-22 2단계 전달 프로파일을 갖는 전리요법적 약물 전달계 KR0169084B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US50217690A 1990-03-30 1990-03-30
US502,176 1990-03-30
US07/671,306 US5207752A (en) 1990-03-30 1991-03-21 Iontophoretic drug delivery system with two-stage delivery profile
US671,306 1991-03-21
PCT/US1991/001941 WO1991015258A1 (en) 1990-03-30 1991-03-22 Iontophoretic drug delivery system with two-stage delivery profile

Publications (2)

Publication Number Publication Date
KR930700181A true KR930700181A (ko) 1993-03-13
KR0169084B1 KR0169084B1 (ko) 1999-01-15

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Country Status (14)

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US (1) US5207752A (ko)
EP (1) EP0522092B1 (ko)
JP (1) JP3181289B2 (ko)
KR (1) KR0169084B1 (ko)
AT (1) ATE114118T1 (ko)
AU (1) AU638581B2 (ko)
CA (1) CA2079316C (ko)
DE (1) DE69105202T2 (ko)
DK (1) DK0522092T3 (ko)
ES (1) ES2067939T3 (ko)
FI (1) FI110066B (ko)
GR (1) GR3015116T3 (ko)
NO (1) NO308025B1 (ko)
WO (1) WO1991015258A1 (ko)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0615461B1 (en) * 1991-12-03 1996-09-25 Alza Corporation Iontophoretic delivery device and power supply therefor
US5505715A (en) * 1994-02-25 1996-04-09 Bristol-Myers Squibb Company Iontophoretic transdermal delivery of deoxyspergualin compounds
US7027859B1 (en) 1994-09-26 2006-04-11 Alza Corporation Electrotransport delivery device having improved safety and reduced abuse potential
US5697896A (en) * 1994-12-08 1997-12-16 Alza Corporation Electrotransport delivery device
US5700481A (en) * 1995-03-17 1997-12-23 Takeda Chemical Industries, Ltd. Transdermal drug delivery process
JPH11503043A (ja) * 1995-04-07 1999-03-23 ノバルティス・アクチエンゲゼルシャフト 少なくとも２種の被投与物を投与するためのイオン泳動性経皮システム
IE960312A1 (en) * 1995-06-02 1996-12-11 Alza Corp An electrotransport delivery device with voltage boosting¹circuit
US5983130A (en) * 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
AU710793B2 (en) * 1995-06-07 1999-09-30 Alza Corporation Electrotransport agent delivery method and apparatus
AU7286996A (en) * 1995-10-18 1997-05-07 Ciba-Geigy Ag Thermopile powered transdermal drug delivery device
US6718201B1 (en) * 1996-06-07 2004-04-06 Alza Corporation Electrotransport agent delivery method and apparatus
US5935598A (en) * 1996-06-19 1999-08-10 Becton Dickinson Research Center Iontophoretic delivery of cell adhesion inhibitors
US5857994A (en) * 1996-10-01 1999-01-12 Becton, Dickinson And Company Awakenable iontophoretic/delivery device for reducing electrical sensation upon application thereof
FR2766093B1 (fr) * 1997-07-15 1999-09-03 Lhd Lab Hygiene Dietetique Procede de commande d'un dispositif d'administration transdermique de medicament sous champ electrique
CA2314929C (en) 1997-12-16 2008-09-02 Alza Corporation Regulator with artificial load to maintain regulated delivery
AU1622999A (en) 1997-12-17 1999-07-05 Alza Corporation Iontophoresis with programmed adjustment of electric current
CN1243578C (zh) 1998-01-30 2006-03-01 诺沃挪第克公司 注射器
BR0008123A (pt) 1999-02-10 2001-11-13 Gmp Drug Delivery Inc Dispositivo baseado em emplastro para aumentar aliberação local de um agente de tratamento paradentro de tecidos alvo, e, processo de liberaçãode um agente de tratamento para dentro detecidos alvo de uma vesìcula corporal
US6471675B1 (en) 1999-04-30 2002-10-29 Medtronic, Inc. Passive flow control devices for implantable pumps
TW453884B (en) 1999-09-16 2001-09-11 Novo Nordisk As Dose setting limiter
US6663602B2 (en) * 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
WO2002036072A2 (en) * 2000-11-03 2002-05-10 Biomedicines, Inc. Method for short-term and long-term drug dosimetry
NZ532779A (en) * 2001-11-09 2008-04-30 Intarcia Therapeutics Inc Method for treating diseases with omega interferon
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
US9205197B2 (en) * 2003-03-03 2015-12-08 Sanofi-Aventis Deutschland Gmbh Drug delivery device dose setting mechanism
GB0308267D0 (en) * 2003-04-10 2003-05-14 Dca Design Int Ltd Improvements in and relating to a pen-type injector
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
EP1595542A1 (en) * 2004-03-26 2005-11-16 Solvay Pharmaceuticals B.V. Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds
US7596407B2 (en) * 2004-03-26 2009-09-29 Solvay Pharmaceuticals, B.V. Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds
ATE444090T1 (de) 2004-10-21 2009-10-15 Novo Nordisk As Wählmechanismus für einen drehstift
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
EP1855744A1 (en) * 2005-02-28 2007-11-21 Novo Nordisk A/S A dose setting mechanism for an injection device
US7856263B2 (en) * 2005-04-22 2010-12-21 Travanti Pharma Inc. Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
CN101163514B (zh) 2005-04-24 2012-01-25 诺和诺德公司 注射装置
BRPI0616487A2 (pt) * 2005-09-30 2011-06-21 Tti Ellebeau Inc aparato e método de iontoforese para liberação sistêmica de agentes ativos
US20090221985A1 (en) * 2005-10-19 2009-09-03 Shmuel Bukshpan System for iontophoretic transdermal delivery of polymeric agents and methods of use thereof
EP1996259B1 (en) 2006-03-10 2012-08-15 Novo Nordisk A/S An injection device and a method of changing a cartridge in the device
EP1996260B1 (en) 2006-03-10 2015-09-23 Novo Nordisk A/S An injection device having a gearing arrangement
CA2650412C (en) * 2006-04-13 2016-09-27 Nupathe, Inc. Transdermal methods and systems for the delivery of anti-migraine compounds
AU2012261753B2 (en) * 2006-04-13 2015-03-05 Teva Pharmaceuticals International Gmbh Transdermal methods and systems for the delivery of anti-migraine compounds
US8226618B2 (en) * 2006-05-16 2012-07-24 Novo Nordisk A/S Gearing mechanism for an injection device
JP5226508B2 (ja) * 2006-05-16 2013-07-03 ローツェ株式会社 シャトル型搬送装置
PL2023982T3 (pl) 2006-05-18 2012-11-30 Novo Nordisk As Urządzenie wstrzykujące ze środkami blokującymi
KR101106510B1 (ko) 2006-05-30 2012-01-20 인타르시아 세라퓨틱스 인코포레이티드 투피스, 내부채널 삼투압 전달 시스템 유동 조절기
DK2049081T3 (da) 2006-08-09 2013-02-25 Intarcia Therapeutics Inc Osmotiske leveringssystemer og stempelarrangementer
US8728059B2 (en) * 2006-09-29 2014-05-20 Covidien Lp System and method for assuring validity of monitoring parameter in combination with a therapeutic device
PL2109474T5 (pl) 2007-02-05 2019-07-31 Novo Nordisk A/S Przycisk iniekcyjny
RU2468829C2 (ru) 2007-03-23 2012-12-10 Ново Нордиск А/С Инъекционное устройство, содержащее стопорную гайку
ES2402172T3 (es) 2007-04-23 2013-04-29 Intarcia Therapeutics, Inc Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
EP2164418B1 (en) * 2007-06-27 2014-01-08 The General Hospital Corporation Apparatus for optical inhibition of photodynamic therapy
US20090043244A1 (en) * 2007-08-08 2009-02-12 Inan Omer T Electrotransport Drug Delivery Device Adaptable to Skin Resistance Change
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
US20090259176A1 (en) * 2008-04-09 2009-10-15 Los Gatos Research, Inc. Transdermal patch system
US20090312689A1 (en) * 2008-06-05 2009-12-17 Alza Corporation Adjustable Current Electrotransport Fentanyl Delivery Device
US8155737B2 (en) * 2008-06-19 2012-04-10 Nupathe, Inc. Pharmacokinetics of iontophoretic sumatriptan administration
US8366600B2 (en) * 2008-06-19 2013-02-05 Nupathe Inc. Polyamine enhanced formulations for triptan compound iontophoresis
NZ622157A (en) * 2008-12-30 2015-10-30 Teva Pharmaceuticals Int Gmbh Electronic control of drug delivery system
US8961492B2 (en) 2009-02-12 2015-02-24 Incube Labs, Llc System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation
US8190252B2 (en) 2009-02-12 2012-05-29 Incube Labs, Llc Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes
US9095503B2 (en) 2009-02-12 2015-08-04 Incube Labs, Llc System and method for biphasic transdermal iontophreotic delivery of therapeutic agents
CN102573489A (zh) 2009-08-10 2012-07-11 纽帕特公司 用离子电渗疗法治疗恶心和偏头痛的方法
CN107638562B (zh) 2009-09-28 2022-12-02 精达制药公司 基本稳态药物递送的快速建立和/或终止
WO2011044175A2 (en) 2009-10-06 2011-04-14 Incube Labs, Llc Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes
WO2011046927A1 (en) * 2009-10-13 2011-04-21 Nupathe,Inc. Transdermal methods and systems for the delivery of rizatriptan
US8685038B2 (en) 2009-12-07 2014-04-01 Incube Labs, Llc Iontophoretic apparatus and method for marking of the skin
WO2011100376A2 (en) 2010-02-10 2011-08-18 Incube Labs, Llc Methods and architecture for power optimization of iontophoretic transdermal drug delivery
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US8428708B1 (en) * 2012-05-21 2013-04-23 Incline Therapeutics, Inc. Self-test for analgesic product
US8428709B1 (en) 2012-06-11 2013-04-23 Incline Therapeutics, Inc. Current control for electrotransport drug delivery
WO2012154704A2 (en) 2011-05-06 2012-11-15 Incube Labs, Llc System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings
JP6069351B2 (ja) 2011-12-29 2017-02-01 ノボ・ノルデイスク・エー／エス ダイアルアップ／ダイアルダウン投与機構を有するねじりバネ式ねじ巻き自動注射器
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
BR112018073511A2 (pt) 2016-05-16 2019-03-26 Intarcia Therapeutics, Inc. polipeptídeos seletivos do receptor de glucagon e métodos de uso dos mesmos
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
MX2019008006A (es) 2017-01-03 2019-08-29 Intarcia Therapeutics Inc Metodos que comprenden la administracion continua de un agonista del receptor de glp-1 y la co-administracion de un farmaco.
PE20211202A1 (es) 2017-08-24 2021-07-05 Novo Nordisk As Composiciones de glp-1 y sus usos
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
WO2021144476A1 (en) 2020-02-18 2021-07-22 Novo Nordisk A/S Pharmaceutical formulations

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
US3618601A (en) * 1969-10-16 1971-11-09 Thatcher W Richardson Iontophoresis unit
US3677268A (en) * 1969-11-28 1972-07-18 Sherwood Medical Ind Inc Iontophoresis electrode
US3794910A (en) * 1971-07-26 1974-02-26 Sherwood Medical Ind Inc Iontophoresis and conductivity analysis circuit
DE2339648C3 (de) * 1973-08-04 1979-09-13 Trebbin, Peter, 8833 Eichstaett Anästhesiegerät zur Behandlung der Zähne
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4211222A (en) * 1976-08-25 1980-07-08 Robert Tapper Iontophoretic burn-protection method
JPS5347192A (en) * 1976-10-13 1978-04-27 Matsushita Electric Ind Co Ltd Device for introducing fluorine ion to tooth
US4325367A (en) * 1977-06-13 1982-04-20 Robert Tapper Iontophoretic treatment apparatus
US4177817A (en) * 1978-02-01 1979-12-11 C. R. Bard, Inc. Dual terminal transcutaneous electrode
US4215696A (en) * 1978-03-20 1980-08-05 Graphic Controls Corporation Biomedical electrode with pressurized skin contact
US4209020A (en) * 1978-09-19 1980-06-24 Nielsen R Frederick Electrode assembly
US4340047A (en) * 1978-10-18 1982-07-20 Robert Tapper Iontophoretic treatment apparatus
US4301794A (en) * 1978-10-18 1981-11-24 Robert Tapper Method for iontophoretic treatment
US4292968A (en) * 1979-11-26 1981-10-06 Sybron Corporation Electric supply for ion therapy
AU546785B2 (en) * 1980-07-23 1985-09-19 Commonwealth Of Australia, The Open-loop controlled infusion of diabetics
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
US4450844A (en) * 1981-11-23 1984-05-29 Hill Top Research, Inc. Patch system for use on the skin
WO1984004045A1 (en) * 1983-04-15 1984-10-25 Jack Kenneth Ibbott Therapeutic method and appliance employing flat battery
US4731926A (en) * 1985-02-19 1988-03-22 Drug Delivery Systems Inc. Method of manufacturing disposable and/or replenishable transdermal drug applicators
US4557723A (en) * 1983-08-18 1985-12-10 Drug Delivery Systems Inc. Applicator for the non-invasive transcutaneous delivery of medicament
US4622031A (en) * 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
US4808152A (en) * 1983-08-18 1989-02-28 Drug Delivery Systems Inc. System and method for controlling rate of electrokinetic delivery of a drug
US4883457A (en) * 1983-08-18 1989-11-28 Drug Delivery Systems Inc. Disposable and/or replenishable transdermal drug applicators and methods of manufacturing same
US4640689A (en) * 1983-08-18 1987-02-03 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4708716A (en) * 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US4851229A (en) * 1983-12-01 1989-07-25 Alza Corporation Composition comprising a therapeutic agent and a modulating agent
DE3576461D1 (de) * 1985-06-10 1990-04-19 Drug Delivery Systems Inc Anlage und verfahren zur steuerung der elektrokinetischen lieferungsgeschwindigkeit einer arznei.
US4698062A (en) * 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
US4725263A (en) * 1986-07-31 1988-02-16 Medtronic, Inc. Programmable constant current source transdermal drug delivery system
US4822334A (en) * 1986-12-04 1989-04-18 Robert Tapper Electrical dosimetry control system
US4731049A (en) * 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
WO1988008729A1 (en) * 1987-05-15 1988-11-17 Newman Martin H Iontophoresis drug delivery system
US4865582A (en) * 1987-06-05 1989-09-12 Drug Delivery Systems Inc. Disposable transdermal drug applicators

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EP0522092B1 (en) 1994-11-17
NO308025B1 (no) 2000-07-10
KR0169084B1 (ko) 1999-01-15
NO923769L (no) 1992-11-30
ATE114118T1 (de) 1994-12-15
DE69105202D1 (de) 1994-12-22
DE69105202T2 (de) 1995-03-23
DK0522092T3 (da) 1995-03-13
NO923769D0 (no) 1992-09-28
WO1991015258A1 (en) 1991-10-17
ES2067939T3 (es) 1995-04-01
FI924352A0 (fi) 1992-09-28
CA2079316C (en) 2002-01-01
US5207752A (en) 1993-05-04
AU638581B2 (en) 1993-07-01
JP3181289B2 (ja) 2001-07-03
GR3015116T3 (en) 1995-05-31
EP0522092A1 (en) 1993-01-13
AU7991591A (en) 1991-10-30
CA2079316A1 (en) 1991-10-01
FI110066B (fi) 2002-11-29
JPH05505964A (ja) 1993-09-02
FI924352A (fi) 1992-09-28

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